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    • Germline cancer gene expression quantitative trait loci are associated with local and global tumor mutations.
    • Liu Y, Gusev A, Kraft P.
    • Cancer Res. 2023 Feb 6:CAN-22-2624. doi: 10.1158/0008-5472.CAN-22-2624. Epub ahead of print.
    • Suppression of GCH1 Sensitizes Ovarian Cancer and Breast Cancer to PARP Inhibitor.
    • Wang S, Xia Y, Huang P, Xu C, Qian Y, Fang T, Gao Q.
    • J Oncol. 2023 Feb 6;2023:1453739. doi: 10.1155/2023/1453739.
    • A phase 1 dose-escalation study of the poly(ADP-ribose) polymerase inhibitor senaparib in Australian patients with advanced solid tumors.
    • Gao B, Voskoboynik M, Cooper A, Wilkinson K, Hoon S, Hsieh CY, Cai S, Tian YE, Bao J, Ma N, Wang C, Zhang M, Li B, Guo M, Zhou R, Wang X, Xu C, de Souza P.
    • Cancer. 2023 Jan 31. doi: 10.1002/cncr.34662. Epub ahead of print.

    •• Identifier: NCT03507543: The Safety and Pharmacokinetics of IMP4297 in Patients With Advanced Solid Tumors. (ClinicalTrials.gov . Accessed 2023 Jan 31.)

  • LitAlert ~~ GeneLit.com

    • LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma.
    • Sato S, Gillette M, de Santiago PR, Kuhn E, Burgess M, Doucette K, Feng Y, Mendez-Dorantes C, Ippoliti PJ, Hobday S, Mitchell MA, Doberstein K, Gysler SM, Hirsch MS, Schwartz L, Birrer MJ, Skates SJ, Burns KH, Carr SA, Drapkin R.
    • Sci Rep. 2023 Jan 27;13(1):1537. doi: 10.1038/s41598-023-28840-5.
    • Inflammatory cytokines-enriched microenvironment plays key roles for the development of breast cancers.
    • Takeuchi Y, Gotoh N.
    • Cancer Sci. 2023 Jan 26. doi: 10.1111/cas.15734. Epub ahead of print.
    • Review
    • Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency.
    • Guantay L, Garro C, Siri S, Pansa MF, Ghidelli-Disse S, Paviolo N, Racca A, Nicotra V, Radu C, Bocco JL, Felice R, Jansson KH, Remlinger K, Amador A, Stronach E, Coleman K, Muelbaier M, Drewes G, Gloger I, Madauss K, García M, Gottifredi V, Soria G.
    • Drug Resist Updat. 2023 Jan 22;67:100932. doi: 10.1016/j.drup.2023.100932. Epub ahead of print.
    • PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage.
    • Kim C, Wang XD, Jang S, Yu Y.
    • Biochem Biophys Res Commun. 2023 Jan 20;646:78-85. doi: 10.1016/j.bbrc.2023.01.055. Epub ahead of print.
    • Curcumin enhances the anti-cancer efficacy of paclitaxel in ovarian cancer by regulating the miR-9-5p/BRCA1 axis.
    • Liu Y, Shen Z, Zhu T, Lu W, Fu Y.
    • Front Pharmacol. 2023 Jan 10;13:1014933. doi: 10.3389/fphar.2022.1014933.
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    • We All Love a Good Book or Movie.
    • [No author given]
    • FORCE. Blog. 2023 Jan 23.
    • Whole-exome sequencing and bioinformatic analyses revealed differences in gene mutation profiles in papillary thyroid cancer patients with and without benign thyroid goitre background.
    • Eng ZH, Abdullah MI, Ng KL, Abdul Aziz A, Arba'ie NH, Mat Rashid N, Mat Junit S.
    • Front Endocrinol (Lausanne). 2023 Jan 4;13:1039494. doi: 10.3389/fendo.2022.1039494.
    • Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3).
    • Aleissa MS, Al-Zharani M, Alneghery LM, Aleissa AM.
    • Saudi Pharm J. 2023 Jan;31(1):110-118. doi: 10.1016/j.jsps.2022.11.009. Epub 2022 Nov 15.
    • Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance.
    • Wang LM, Wang P, Chen XM, Yang H, Song SS, Song Z, Jia L, Chen HD, Bao XB, Guo N, Huan XJ, Xi Y, Shen YY, Yang XY, Su Y, Sun YM, Gao YL, Chen Y, Ding J, Lang JY, Miao ZH, Zhang A, He JX.
    • EMBO Mol Med. 2023 Jan 18:e16235. doi: 10.15252/emmm.202216235. Epub ahead of print.
    • CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer.
    • Tsujino T, Takai T, Hinohara K, Gui F, Tsutsumi T, Bai X, Miao C, Feng C, Gui B, Sztupinszki Z, Simoneau A, Xie N, Fazli L, Dong X, Azuma H, Choudhury AD, Mouw KW, Szallasi Z, Zou L, Kibel AS, Jia L.
    • Nat Commun. 2023 Jan 17;14(1):252. doi: 10.1038/s41467-023-35880-y.
    • Shallow Whole-Genome Sequencing of Cell-Free DNA (cfDNA) Detects Epithelial Ovarian Cancer and Predicts Patient Prognosis.
    • Bak SE, Kim H, Ho JY, Cho EH, Lee J, Youn SM, Park SW, Han MR, Hur SY, Lee SJ, Choi YJ.
    • Cancers (Basel). 2023 Jan 15;15(2):530. doi: 10.3390/cancers15020530.
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    • Lestaurtinib induces DNA damage that is related to estrogen receptor activation.
    • Ooka M, Yang S, Zhang L, Kojima K, Huang R, Hirota K, Takeda S, Xia M.
    • Curr Res Toxicol. 2022 Dec 24;4:100102. doi: 10.1016/j.crtox.2022.100102.
    • Ferroptosis synergistically sensitizes wee1 inhibitors: a bibliometric study.
    • Xu R, Wu X, Zhao Q, Yang Q.
    • Am J Transl Res. 2022 Dec 15;14(12):8473-8488.
  • LitAlert ~~ GeneLit.com

    • Environmental impact on carcinogenesis under BRCA1 haploinsufficiency.
    • Toyokuni S, Kong Y, Motooka Y, Akatsuka S.
    • Genes Environ. 2023 Jan 13;45(1):2. doi: 10.1186/s41021-023-00258-5.
    • Retarding breast tumor growth with nanoparticle-facilitated intravenous delivery of BRCA1 and BRCA2 tumor suppressor genes.
    • Ibnat N, Chowdhury EH.
    • Sci Rep. 2023 Jan 11;13(1):536. doi: 10.1038/s41598-022-25511-9.
    • Retarding breast tumor growth with nanoparticle-facilitated intravenous delivery of BRCA1 and BRCA2 tumor suppressor genes.
    • Ibnat N, Chowdhury EH.
    • Sci Rep. 2023 Jan 11;13(1):536. doi: 10.1038/s41598-022-25511-9.