Category: Misc

• A First-in-Class Clinical G-Quadruplex-Targeting Drug. The Bench-to-Bedside Translation of the Fluoroquinolone QQ58 to CX-5461 (Pidnarulex).
• Xu H, Hurley LH.
• Bioorg Med Chem Lett. 2022 Oct 1:129016. doi: 10.1016/j.bmcl.2022.129016. Epub ahead of print.

• PMID: 36195286
• PubMed abstract
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Original research:

Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies.

• PMID: 35750695
• PubMed abstract
• Free Full Text

Identifier: NCT04890613: Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation. (ClinicalTrials.gov)

• A bibliometric analysis of the top 100 most cited papers and research trends in breast cancer related BRCA1 and BRCA2 genes.
• Alkhayyat S, Khan M, Ahmad T, Haroon, Tariq H, Baig M.
• Medicine (Baltimore). 2022 Sep 23;101(38):e30576. doi: 10.1097/MD.0000000000030576.

• PMID: 36197199
• PubMed abstract

• Free Full Text