Category: Genetic Counseling

• Oncology clinic-based germline genetic testing for exocrine pancreatic cancer enables timely return of results and unveils low uptake of cascade testing.
• Wang Y, Golesworthy B, Cuggia A, Domecq C, Chaudhury P, Barkun J, Metrakos P, Asselah J, Bouganim N, Gao ZH, Chong G, Foulkes WD, Zogopoulos G.
• J Med Genet. 2021 Sep 23:jmedgenet-2021-108054. doi: 10.1136/jmedgenet-2021-108054. Epub ahead of print.

• PMID: 34556502
• PubMed abstract
• Source abstract

• Genetic testing in women with early-onset breast cancer: a Traceback pilot study.
• Augustinsson A, Nilsson MP, Ellberg C, Kristoffersson U, Olsson H, Ehrencrona H.
• Breast Cancer Res Treat. 2021 Sep 16. doi: 10.1007/s10549-021-06351-z. Epub ahead of print.

• PMID: 34529195
• PubMed abstract

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• Genetic testing in patients with triple-negative or hereditary breast cancer.
• Bernstein-Molho R, Evron E, Yerushalmi R, Paluch-Shimon S.
• Curr Opin Oncol. 2021 Sep 1. doi: 10.1097/CCO.0000000000000784. Epub ahead of print.

• PMID: 34474437
• PubMed abstract
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• Review

• Pretest Genetic Education Video Versus Genetic Counseling for Men Considering Prostate Cancer Germline Testing: A Patient-Choice Study to Address Urgent Practice Needs.
• Russo J, McDougall C, Bowler N, Shimada A, Gross L, Hyatt C, Kelly WK, Calvaresi A, Handley NR, Hirsch IH, Izes JK, Lallas CD, Mann M, Mark JR, Mille PJ, Preate Jr D, Trabulsi EJ, Tsang M, Chandrasekar T, Weiner PR, Gomella LG, Giri VN.
• JCO Precis Oncol. 2021;5:1377. doi: 10.1200/PO.21.00238. Epub 2021 Sep 1.

• Source abstract

• Cascade Genetic Testing for Hereditary Cancer Risk: An Underutilized Tool for Cancer Prevention.
• Whitaker KD, Obeid E, Daly MB, Hall MJ.
• JCO Precis Oncol. 2021;5:1387. doi: 10.1200/PO.21.00163. Epub 2021 Sep 1.

• Source abstract

• Review

• Information needs on breast cancer genetic and non-genetic risk factors in relatives of women with a BRCA1/2 or PALB2 pathogenic variant.
• Brédart A, De Pauw A, Anota A, Tüchler A, Dick J, Müller A, Kop JL, Rhiem K, Schmutzler R, Devilee P, Stoppa-Lyonnet D, Dolbeault S.
• Breast. 2021 Aug 23:S0960-9776(21)00441-0. doi: 10.1016/j.breast.2021.08.011. Epub ahead of print.

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• Increasing referral of at-risk women for genetic counseling and BRCA testing using a screening tool in a community breast imaging center.
• Arun BK, Peterson SK, Sweeney LE, Bluebond RD, Tidwell RSS, Makhnoon S, Kushwaha Ac.
• Cancer. 2021 Aug 23. doi: 10.1002/cncr.33866. Epub ahead of print

• Source abstract

Related:

Editorial:

Population screening to identify women at risk for hereditary breast cancer syndromes: The path forward or the road not taken?

• Source abstract

• Understanding the Clinical Implications of Low Penetrant Genes and Breast Cancer Risk.
• Vaidyanathan A, Kaklamani V.
• Curr Treat Options Oncol. 2021 Aug 23;22(10):85. doi: 10.1007/s11864-021-00887-4.

• PMID: 34424438
• PubMed abstract
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• Review

• Breast Cancer Risk Assessment and Primary Prevention Advice in Primary Care: A Systematic Review of Provider Attitudes and Routine Behaviours.
• Bellhouse S, Hawkes RE, Howell SJ, Gorman L, French DP.
• Cancers (Basel). 2021 Aug 18;13(16):4150. doi: 10.3390/cancers13164150.

• Source abstract

• Review
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• Genetic Testing Challenges in Oncology: Consumer Genomics Reveals More Than Fun Traits.
• Ray T.
• Precision Oncology News. Biomarkers. BRCA. 2021 Aug 3.

• Press

• Breast cancer polygenic risk scores: a 12-month prospective study of patient reported outcomes and risk management behavior.
• Yanes T, Meiser B, Kaur R, Young MA, Mitchell PB, Scheepers-Joynt M, McInerny S, Taylor S, Barlow-Stewart K, Antill Y, Salmon L, Smyth C, Betz-Stablein B, James PA.
• Genet Med. 2021 Aug 2. doi: 10.1038/s41436-021-01288-6. Epub ahead of print.

• PMID: 34341522
• PubMed abstract
• Source abstract

• Oncologists' Perceptions of Tumor Genomic Profiling and the Communication of Test Results and Risks.
• Hall MJ, D'Avanzo P, Chertock Y, Brajuha J, Bass SB.
• Public Health Genomics. 2021 Jul 29:1-6. doi: 10.1159/000517486. Epub ahead of print.

• PMID: 34325422
• PubMed abstract
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• Breast cancer incidence and early diagnosis in a family history risk and prevention clinic: 33-year experience in 14,311 women.
• Evans DG, Howell SJ, Gandhi A, van Veen EM, Woodward ER, Harvey J, Barr L, Wallace A, Lalloo F, Wilson M, Hurley E, Lim Y, Maxwell AJ, Harkness EF, Howell A.
• Breast Cancer Res Treat. 2021 Jul 26. doi: 10.1007/s10549-021-06333-1. Epub ahead of print.

• PMID: 34312777
• PubMed abstract

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• Implementing Primary Care Mediated Population Genetic Screening Within an Integrated Health System.
• David SP, Dunnenberger HM, Ali R, Matsil A, Lemke AA, Singh L, Zimmer A, Hulick PJ.
• J Am Board Fam Med. 2021 Jul-Aug;34(4):861-865. doi: 10.3122/jabfm.2021.04.200381.

• PMID: 34312282
• PubMed abstract

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• Risk-Stratified Approach to Breast Cancer Screening in Canada: Women’s Knowledge of the Legislative Context and Concerns about Discrimination from Genetic and Other Predictive Health Data.
• Alarie S, Hagan J, Dalpé G, Faraji S, Mbuya-Bienge C, Nabi H, Pashayan N, Brooks JD, Dorval M, Chiquette J, Eloy L, Turgeon A, Lambert-Côté L, Paquette JS, Walker MJ, Lapointe J, Granados Moreno P, Blackmore K, Wolfson M, Broeders M, The PERSPECTIVE I&I Study Group, Knoppers BM, Chiarelli AM, Simard J, Joly Y.
• J Pers Med. 2021 Jul 27;11(8):726. doi: 10.3390/jpm11080726.

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• Uptake and acceptability of a mainstreaming model of hereditary cancer multigene panel testing among patients with ovarian, pancreatic, and prostate cancer.
• Hamilton JG, Symecko H, Spielman K, Breen K, Mueller R, Catchings A, Trottier M, Salo-Mullen EE, Shah I, Arutyunova A, Batson M, Gebert R, Pundock S, Schofield E, Offit K, Stadler ZK, Cadoo K, Carlo MI, Narayan V, Reiss KA, Robson ME, Domchek SM.
• Genet Med. 2021 Jul 13. doi: 10.1038/s41436-021-01262-2. Epub ahead of print.

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• Challenges in genetic testing: clinician variant interpretation processes and the impact on clinical care
• Berrios C, Hurley EA, Willig L, Thiffault I, Saunders C, Pastinen T, Goggin K, Farrow E.
• Genet Med. 2021 Jul 13. doi: 10.1038/s41436-021-01267-x. Epub ahead of print.

• Source abstract

• Success Factors and Barriers in Combining Personalized Medicine and Patient Centered Care in Breast Cancer. Results from a Systematic Review and Proposal of Conceptual Framework.
• Giulio de Belvis A, Pellegrino R, Castagna C, Morsella A, Pastorino R, Boccia S.
• J Pers Med. 2021 Jul 13;11(7):654. doi: 10.3390/jpm11070654.

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• Review
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• Polygenic risk in familial breast cancer: Changing the dynamics of communicating genetic risk.
• Gregory G, Gupta KD, Meiser B, Barlow-Stewart K, Geelan-Small P, Kaur R, Scheepers-Joynt M, McInerny S, Taylor S, Antill Y, Salmon L, Smyth C, Young MA, James PA, Yanes T.
• J Genet Couns. 2021 Jul 5. doi: 10.1002/jgc4.1458. Epub ahead of print.

• PMID: 34223688
• PubMed abstract
• Source abstract

• Genetic Testing Challenges in Oncology: Inaccurate Patient Claims Complicate Cancer Risk Management.
• Ray T.
• Precision Oncology News. Biomarkers. BRCA. 2021 Jun 30.

• Press, Case report
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