Author: Steve Kopczak

• Unexpected Findings in Hereditary Breast and Ovarian Cancer Syndrome: Low-Level Constitutional Mosaicism in BRCA2.
• Mayoral I, Almeida Santiago A, Sánchez-Zapardiel JM, Hidalgo Calero B, de la Hoya M, Gómez-Sanz A, de Miguel Reyes M, Robles L.
• Genes (Basel). 2023 Feb 15;14(2):502. doi: 10.3390/genes14020502.

• Free Full Text

• PARP inhibitor-related hemorrhages:What does the real-world study say?
• Wang S, Guo M, Fan P, Jin Z.
• Front Oncol. 2023 Feb 14;13:1070343. doi: 10.3389/fonc.2023.1070343.

• Free Full Text

• Improving Uptake of Cancer Genetic Risk Assessment in a Remote Tailored Risk Communication and Navigation Intervention: Large Effect Size but Room to Grow.
• Kinney AY, Walters ST, Lin Y, Lu SE, Kim A, Ani J, Heidt E, Le Compte CJG, O'Malley D, Stroup A, Paddock LE, Grumet S, Boyce TW, Toppmeyer DL, McDougall JA.
• J Clin Oncol. 2023 Feb 14:JCO2200751. doi: 10.1200/JCO.22.00751. Epub ahead of print.

• PMID: 36787512
• PubMed abstract

• Free Full Text

Related:

•• Identifier: NCT03326713: Genetic Risk Assessment for Cancer Education and Empowerment (GRACE) Project (GRACE). (ClinicalTrials.gov . Accessed 2023 Feb 14.)

• Survey Reveals Changing Genetic Testing Patterns, Persistent Disparities in Precision Oncology.
• Ray T.
• Precision Oncology News. 2023 Feb 1.

• Source abstract

• News

• OlympiAD extended follow-up for overall survival and safety: olaparib versus chemotherapy treatment of physician’s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer.
• Robson ME, Im SA, Senkus E, Xu B, Domchek SM, Masuda N, Delaloge S, Tung N, Armstrong A, Dymond M, Fielding A, Allen A, Conte P.
• Eur J Cancer. 2023 Feb 14. doi: 10.1016/j.ejca.2023.01.031. Epub ahead of print.

• Source abstract

• Long-term Data for Niraparib Support Continued Use of PARP Inhibitors in HRD+ Ovarian Cancer.
• Roque DR, Scott R.
• OncLive. 2023 Feb 14.

• Review. Conference report
• Free Full Text

• Mainstream genetic testing for high-grade ovarian, tubal and peritoneal cancers: A tertiary referral centre experience.
• Srinivasa S, Bowman M, Titterton L, Harnett P, Brand A, Kirk J, Ragunathan A.
• Aust N Z J Obstet Gynaecol. 2023 Feb 13. doi: 10.1111/ajo.13650. Epub ahead of print.

• PMID: 36785489
• PubMed abstract
• Source abstract

• [Expert consensus on the diagnosis and treatment of young breast cancer in China (2022 Edition)].
• Chinese Society of Clinical Oncology, Experts Committee on Breast Cancer; China Anti-Cancer Association, the Society of Breast Cancer; Chinese Medical Association, Chinese Society of Breast Surgery.
• Zhonghua Yi Xue Za Zhi. 2023 Feb 14;103(6):387-403. Chinese. doi: 10.3760/cma.j.cn112137-20220907-01895.

• PMID: 36775264
• PubMed abstract

• [Article in Chinese]

• Preventative Surgeries at Age 32 Because of My BRCA1 Gene Mutation.
• Clem E.
• FORCE. Blog. 2023 Feb 13.

• Blog post
• Free Full Text

• Women's Metaphors About BRCA Gene Testing and How They Can Inform Health Communication Theory and Practice.
• Martin SC, Scott AM, Stone AM.
• Health Commun. 2023 Feb 12:1-13. doi: 10.1080/10410236.2023.2178051. Epub ahead of print.

• PMID: 36775863
• PubMed abstract
• Source abstract

• Molecular dynamics simulations reveal the effect of mutations in the RING domains of BRCA1-BARD1 complex and its relevance to the prognosis of breast cancer.
• Kiewhuo K, Priyadarsinee L, Sarma H, Sastry GN.
• J Biomol Struct Dyn. 2023 Feb 12:1-19. doi: 10.1080/07391102.2023.2175383. Epub ahead of print.

• PMID: 36775657
• PubMed abstract
• Source abstract

• Psychological distress and decision-making factors for prophylactic bilateral mastectomy in cancer-unaffected BRCA1/2 pathogenic variant carriers.
• Isselhard A, Tüchler A, Dick J, Scherer A, Aue V, Schmutzler RK, Rhiem K.
• Psychooncology. 2023 Feb 12. doi: 10.1002/pon.6111. Epub ahead of print.

• PMID: 36774644
• PubMed abstract
• Source abstract

• Targeting Breast Cancer: An Overlook on Current Strategies.
• Iacopetta D, Ceramella J, Baldino N, Sinicropi MS, Catalano A.
• Int J Mol Sci. 2023 Feb 11;24(4):3643. doi: 10.3390/ijms24043643.

• Review
• Free Full Text

• Challenges in periodic revision of genetic testing results: comparison of the main classification guidelines and report of a retrospective analysis involving BRCA1/BRCA2 Variants of Uncertain Significance.
• Finger Andreis T, Isabel Weber de Souza K, Araujo Vieira I, Alemar B, Sinigaglia M, Marinho de Araújo Rocha Y, Artigalás O, Bittar C, Brinckmann Oliveira Netto C, Ashton-Prolla P, Rosset C.
• Gene. 2023 Feb 10:147281. doi: 10.1016/j.gene.2023.147281. Epub ahead of print.

• PMID: 36775216
• PubMed abstract
• Source abstract

• A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE).
• Pan E, Xie W, Ajmera A, Araneta A, Jamieson C, Folefac E, Hussain A, Kyriakopoulos CE, Olson A, Parikh M, Parikh R, Saraiya B, Ivy SP, Van Allen EM, Lindeman NI, Kochupurakkal BS, Shapiro GI, McKay RR.
• Mol Cancer Ther. 2023 Feb 10:MCT-22-0583. doi: 10.1158/1535-7163.MCT-22-0583. Epub ahead of print.

• PMID: 36780008
• PubMed abstract
• Source abstract

• Evaluation of AlphaFold Structure-based Protein Stability Prediction on Missense Variations in Cancer.
• Karakoyun HK, Yuksel SK, Amanoglu I, Naserikhojasteh L, Yakicier C, Yesilyurt A, Timucin E, Akyerli CB.
• Front Genet. 2023 Feb 8;14:1052383. doi: 10.3389/fgene.2023.1052383.

• Free Full Text

• [Expert consensus on the diagnosis and treatment of young breast cancer in China (2022 Edition)].
• Chinese Society of Clinical Oncology, Experts Committee on Breast Cancer; China Anti-Cancer Association, the Society of Breast Cancer; Chinese Medical Association, Chinese Society of Breast Surgery.
• Zhonghua Yi Xue Za Zhi. 2023 Feb 14;103(6):387-403. Chinese. doi: 10.3760/cma.j.cn112137-20220907-01895.

• PMID: 36775264
• PubMed abstract

• [Article in Chinese]

• Women's Metaphors About BRCA Gene Testing and How They Can Inform Health Communication Theory and Practice.
• Martin SC, Scott AM, Stone AM.
• Health Commun. 2023 Feb 12:1-13. doi: 10.1080/10410236.2023.2178051. Epub ahead of print.

• PMID: 36775863
• PubMed abstract
• Source abstract

• Molecular dynamics simulations reveal the effect of mutations in the RING domains of BRCA1-BARD1 complex and its relevance to the prognosis of breast cancer.
• Kiewhuo K, Priyadarsinee L, Sarma H, Sastry GN.
• J Biomol Struct Dyn. 2023 Feb 12:1-19. doi: 10.1080/07391102.2023.2175383. Epub ahead of print.

• PMID: 36775657
• PubMed abstract
• Source abstract

• Psychological distress and decision-making factors for prophylactic bilateral mastectomy in cancer-unaffected BRCA1/2 pathogenic variant carriers.
• Isselhard A, Tüchler A, Dick J, Scherer A, Aue V, Schmutzler RK, Rhiem K.
• Psychooncology. 2023 Feb 12. doi: 10.1002/pon.6111. Epub ahead of print.

• PMID: 36774644
• PubMed abstract
• Source abstract

• Targeting Breast Cancer: An Overlook on Current Strategies.
• Iacopetta D, Ceramella J, Baldino N, Sinicropi MS, Catalano A.
• Int J Mol Sci. 2023 Feb 11;24(4):3643. doi: 10.3390/ijms24043643.

• Review
• Free Full Text

• Challenges in periodic revision of genetic testing results: comparison of the main classification guidelines and report of a retrospective analysis involving BRCA1/BRCA2 Variants of Uncertain Significance.
• Finger Andreis T, Isabel Weber de Souza K, Araujo Vieira I, Alemar B, Sinigaglia M, Marinho de Araújo Rocha Y, Artigalás O, Bittar C, Brinckmann Oliveira Netto C, Ashton-Prolla P, Rosset C.
• Gene. 2023 Feb 10:147281. doi: 10.1016/j.gene.2023.147281. Epub ahead of print.

• PMID: 36775216
• PubMed abstract
• Source abstract

• Evaluation of AlphaFold Structure-based Protein Stability Prediction on Missense Variations in Cancer.
• Karakoyun HK, Yuksel SK, Amanoglu I, Naserikhojasteh L, Yakicier C, Yesilyurt A, Timucin E, Akyerli CB.
• Front Genet. 2023 Feb 8;14:1052383. doi: 10.3389/fgene.2023.1052383.

• Free Full Text