All manner of testing of somatic tumor tissue in HBOC-related cancers for the purposes of making treatment decisions; Includes papers concerning testing of circulating tumor DNA (ctDNA) for treatment decisions.
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- Homologous recombination deficiency: how genomic signatures are generated.
- Setton J, Reis-Filho JS, Powell SN.
- Curr Opin Genet Dev. 2021 Jan 18;66:93-100. doi: 10.1016/j.gde.2021.01.002. Epub ahead of print.
- PMID: 33477018
- PubMed abstract
- Source abstract
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- Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer.
- Lotan TL, Kaur HB, Salles DC, Murali S, Schaeffer EM, Lanchbury JS, Isaacs WB, Brown R, Richardson AL, Cussenot O, Cancel-Tassin G, Timms KM, Antonarakis ES.
- Mod Pathol. 2021 Jan 18. doi: 10.1038/s41379-020-00731-4. Epub ahead of print.
- PMID: 33462368
- PubMed abstract
- Source abstract
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- Current Ovarian Cancer Maintenance Strategies and Promising New Developments.
- Gogineni V, Morand S, Staats H, Royfman R, Devanaboyina M, Einloth K, Dever D, Stanbery L, Aaron P, Manning L, Walter A, Edelman G, Dworkin L, Nemunaitis J.
- J Cancer. 2021 Jan 1;12(1):38-53. doi: 10.7150/jca.49406.
- PMID: 33391401
- PubMed abstract
- Source abstract
- Review
- Free PMC article
- Free Full Text
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- PARP inhibitor resistance and TP53 mutations in patients treated with olaparib for BRCA-mutated cancer: Four case reports.
- Collot T, Niogret J, Carnet M, Chevrier S, Humblin E, Favier L, Bengrine-Lefevre L, Desmoulins I, Arnould L, Boidot R.
- Mol Med Rep. 2021 Jan;23(1):75. doi: 10.3892/mmr.2020.11713. Epub 2020 Nov 25.
- PMID: 33236159
- PubMed abstract
- Source abstract
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- Concordance between Tumor and Germline BRCA Status in High-Grade Ovarian Carcinoma Patients in the Phase III PAOLA-1/ENGOT-ov25 Trial.
- Callens C, Vaur D, Soubeyran I, Rouleau E, Just PA, Guillerm E, Golmard L, Goardon N, Sevenet N, Cabaret O, Harter P, Gonzalez-Martin A, Fujiwara K, Cecere SC, Colombo N, Marth C, Vergote I, Maenpaa J, Pujade-Lauraine E, Ray-Coquard I.
- J Natl Cancer Inst. 2020 Dec 29:djaa193. doi: 10.1093/jnci/djaa193. Epub ahead of print.
- PMID: 33372675
- PubMed abstract
- Source abstract
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- Characterizing TP53 mutations in ovarian carcinomas with and without concurrent BRCA1 or BRCA2 mutations.
- Ghezelayagh TS, Pennington KP, Norquist BM, Khasnavis N, Radke MR, Kilgore MR, Garcia RL, Lee M, Katz R, Leslie KK, Risques RA, Swisher EM.
- Gynecol Oncol. 2020 Dec 26:S0090-8258(20)34178-0. doi: 10.1016/j.ygyno.2020.12.007. Epub ahead of print.
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- Motivations and barriers to pursue cancer genomic testing: a systematic review.
- Smith-Uffen M, Bartley N, Davies G, Best M.
- Patient Educ Couns. 2020 Dec 25:S0738-3991(20)306881. doi: 10.1016/j.pec.2020.12.024. Epub ahead of print.
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- Biomarkers in Her2- Positive Disease.
- Klocker EV, Suppan C.
- Breast Care (Basel). 2020 Dec;15(6):586-593. doi: 10.1159/000512283. Epub 2020 Oct 28.
- PMID: 000512283
- PubMed abstract
- Source abstract
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- PARP Inhibitors in Prostate Cancer: Practical Guidance for Busy Clinicians.
- VanderWeele DJ, Hussain M.
- Clin Adv Hematol Oncol. 2020 Dec;18(12).
- Review
- Free Full Text
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- Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer.
- Jang A, Sartor O, Barata PC, Paller CJ.
- Cancers (Basel). 2020 Nov 21;12(11):E3467. doi: 10.3390/cancers12113467.
- Review
- Free Full Text
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- Tumor BRCA Testing in High Grade Serous Carcinoma: Mutation Rates and Optimal Tissue Requirements.
- Turashvili G, Lazaro C, Ying S, Charames G, Wong A, Hamilton K, Yee D, Agro E, Chang M, Pollett A, Lerner-Ellis J.
- Cancers (Basel). 2020 Nov 21;12(11):E3468. doi: 10.3390/cancers12113468.
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- Beware Liquid Biopsies to Guide PARP Blockade.
- [No author given]
- Cancer Discov. 2020 Nov 18. doi: 10.1158/2159-8290.CD-NB2020-105. Epub ahead of print.
- PMID: 33208392
- PubMed abstract
- Source abstract
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- Triple-negative breast cancer: promising prognostic biomarkers currently in development.
- Sukumar J, Gast K, Quiroga D, Lustberg M, Williams N.
- Expert Rev Anticancer Ther. 2020 Nov 16. doi: 10.1080/14737140.2021.1840984. Epub ahead of print.
- PMID: 33198517
- PubMed abstract
- Source abstract
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- Myriad Genetics Expands MyChoice CDx Access Through Partnerships in Europe, China.
- [No author given]
- Precision Oncology News. 2020 Nov 16.
- News
- Free Full Text
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- Clinical Challenges in the Management of Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: A Literature Review.
- Nagaraj G, Ma CX.
- Adv Ther. 2020 Nov 15. doi: 10.1007/s12325-020-01552-2. Epub ahead of print.
- PMID: 33190190
- PubMed abstract
- Review
- Free Full Text
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- Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors.
- Gachechiladze M, Skarda J, Bouchalova K, Soltermann A, Joerger M.
- Front Oncol. 2020 Nov 3;10:581217. doi: 10.3389/fonc.2020.581217.
- PMID: 33224881
- PubMed abstract
- Review
- Free PMC article
- Free Full Text
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- Genomic Profiling Comparison of Germline BRCA and Non-BRCA Carriers Reveals CCNE1 Amplification as a Risk Factor for Non-BRCA Carriers in Patients With Triple-Negative Breast Cancer.
- Huang X, Shao D, Wu H, Zhu C, Guo D, Zhou Y, Chen C, Lin Y, Lu T, Zhao B, Wang C, Sun Q.
- Front Oncol. 2020 Oct 30;10:583314. doi: 10.3389/fonc.2020.583314. PMID: 33194720; PMCID: PMC7662137.
- PMID: 33194720
- PubMed abstract
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- Genetic and clinical landscape of breast cancers with germline BRCA1/2 variants.
- Inagaki-Kawata Y, Yoshida K, Kawaguchi-Sakita N, Kawashima M, Nishimura T, Senda N, Shiozawa Y, Takeuchi Y, Inoue Y, Sato-Otsubo A, Fujii Y, Nannya Y, Suzuki E, Takada M, Tanaka H, Shiraishi Y, Chiba K, Kataoka Y, Torii M, Yoshibayashi H, Yamagami K, Okamura R, Moriguchi Y, Kato H, Tsuyuki S, Yamauchi A, Suwa H, Inamoto T, Miyano S, Ogawa S, Toi M.
- Commun Biol. 2020 Oct 16;3(1):578. doi: 10.1038/s42003-020-01301-9.
- PMID: 33067557
- PubMed abstract
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- Pulmonary metastasis secondary to abiraterone-resistant prostate cancer with homozygous deletions of BRCA2: First Japanese case.
- Izawa M, Kosaka T, Nakamura K, Oba J, Hishida T, Hongo H, Mikami S, Nishihara H, Oya M.
- IJU Case Rep. 2020 Oct 15;4(1):14-17. doi: 10.1002/iju5.12224.
- PMID: 33426488
- PubMed abstract
- Source abstract
- Case Report
- Free PMC article
- Free Full Text
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- ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer.
- Miller RE, Leary A, Scott CL, Serra V, Lord CJ, Bowtell D, Chang DK, Garsed DW, Jonkers J, Ledermann JA, Nik-Zainal S, Ray-Coquard I, Shah SP, Matias-Guiu X, Swisher EM, Yates LR.
- Ann Oncol. 2020 Sep 28:S0923-7534(20)42164-7. doi: 10.1016/j.annonc.2020.08.2102. Epub ahead of print.
- PMID: 33004253
- PubMed abstract
- Guideline
- Free Full Text
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- First-in-Human Trial of the Oral Ataxia Telangiectasia and Rad3-Related Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors.
- Yap TA, Tan DSP, Terbuch A, Caldwell R, Guo C, Goh BC, Heong V, Haris NR, Bashir S, Drew Y, Hong DS, Meric-Bernstam F, Wilkinson G, Hreiki J, Wengner AM, Bladt F, Schlicker A, Ludwig M, Zhou Y, Liu L, Bordia S, Plummer R, Lagkadinou E, de Bono JS.
- Cancer Discov. 2020 Sep 28. doi: 10.1158/2159-8290.CD-20-0868. Epub ahead of print.
Press: Bayer's ATR Inhibitor May Benefit Cancers With ATM Aberrations, Early Data Suggest (Precision Oncology News)
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- A novel signature of two long non-coding RNAs in BRCA mutant ovarian cancer to predict prognosis and efficiency of chemotherapy.
- Pan Y, Jia LP, Liu Y, Han Y, Li Q, Zou Q, Zhang Z, Huang J, Deng Q.
- J Ovarian Res. 2020 Sep 19;13(1):112. doi: 10.1186/s13048-020-00712-w.
- PMID: 32950050
- PubMed abstract
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- Predicted chemotherapy benefit for breast cancer patients with germline pathogenic variants in cancer susceptibility genes.
- Kurian AW, Ward KC, Abrahamse P, Hamilton AS, Katz SJ.
- JNCI Cancer Spectr. 2020 Sep 18; pkaa083. doi: 10.1093/jncics/pkaa083. eCollection 2020 Sep.
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- What is the role of PARP inhibitors in pancreatic cancer?
- Halder R, T Shroff R.
- Expert Rev Anticancer Ther. 2020 Sep 11:1-6. doi: 10.1080/14737140.2020.1816174. Epub ahead of print.
- PMID: 32865047
- PubMed abstract
- Editorial
- Free Full Text
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- Implementing NGS-based BRCA tumour tissue testing in FFPE ovarian carcinoma specimens: hints from a real-life experience within the framework of expert recommendations.
- Rivera D, Paudice M, Gismondi V, Anselmi G, Vellone VG, Varesco L; Ligurian BRCA Working Group.
- J Clin Pathol. 2020 Sep 7:jclinpath-2020-206840. doi: 10.1136/jclinpath-2020-206840. Epub ahead of print.
- PMID: 32895300
- PubMed abstract
- Source abstract
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- FoundationOne® CDx gene profiling in Japanese pancreatic ductal adenocarcinoma patients: a single-institution experience.
- Kimura R, Ohtsuka T, Kubo M, Kajihara A, Fujii A, Watanabe Y, Mori Y, Ikenaga N, Nakata K, Shindo K, Ohuchida K, Nakamura M.
- Surg Today. 2020 Sep 4. doi: 10.1007/s00595-020-02123-2. Epub ahead of print.
- PMID: 32885350
- PubMed abstract
- Source abstract
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- Molecular Biomarkers for Early Detection and Prevention of Ovarian Cancer-A Gateway for Good Prognosis: A Narrative Review.
- Yadav G, Vashisht M, Yadav V, Shyam R.
- Int J Prev Med. 2020 Sep 3;11:135. doi: 10.4103/ijpvm.IJPVM_75_19.
- PMID: 33088463
- PubMed abstract
- Source abstract
- Review
- Free PMC article
- Free Full Text
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- Biomarkers in Breast Cancer: An Integrated Analysis of Comprehensive Genomic Profiling and PD-L1 Immunohistochemistry Biomarkers in 312 Patients with Breast Cancer.
- Huang RSP, Li X, Haberberger J, Sokol E, Severson E, Duncan DL, Hemmerich A, Edgerly C, Ferguson NL, Williams E, Elvin J, Vergilio JA, Killian JK, Lin D, Hiemenz M, Xiao J, McEwan D, Holmes O, Danziger N, Erlich R, Frampton G, Cohen MB, McGregor K, Reddy P, Cardeiro D, Anhorn R, Venstrom PJ, Alexander B, Brown C, Pusztai L, Ross JS, Ramkissoon SH.
- Oncologist. 2020 Sep 1. doi: 10.1634/theoncologist.2020-0449. Epub ahead of print.
- PMID: 32869930
- PubMed abstract
- Source abstract
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- Moving Beyond BRCA - Incorporating Molecular Assays into Ovarian Cancer trials.
- McMullen M, Karakasis K, Oza AM.
- Clin Cancer Res. 2020 Aug 14. doi: 10.1158/1078-0432.CCR-20-2429. Epub ahead of print.
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- Somatic BRCA Mutation in a Cholangiocarcinoma Patient for HBOC Syndrome Detection.
- Paradiso AV, Patruno M, Digennaro M, Tommasi S, Pilato B, Argentiero A, Brunetti O, Silvestris N.
- Front Oncol. 2020 Aug 12;10:1292. doi: 10.3389/fonc.2020.01292.
- PMID: 32903564
- PubMed abstract
- Case report
- Free Full Text
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- BRCA sequencing of tumors: understanding its implications in the oncology community.
- Wong RSJ, Lee SC.
- Chin Clin Oncol. 2020 Aug 10:cco-19-198. doi: 10.21037/cco-19-198. Epub ahead of print.
- PMID: 32787342
- PubMed abstract
- Source abstract
- Review
- Free Full Text (PDF)
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- Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing.
- Nanki Y, Chiyoda T, Hirasawa A, Ookubo A, Itoh M, Ueno M, Akahane T, Kameyama K, Yamagami W, Kataoka F, Aoki D.
- Sci Rep. 2020 Jul 28;10(1):12581. doi: 10.1038/s41598-020-69488-9.
- PMID: 32724113
- PubMed abstract
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- Homologous repair deficiency score for identifying breast cancers with defective DNA damage response.
- Min A, Kim K, Jeong K, Choi S, Kim S, Suh KJ, Lee KH, Kim S, Im SA.
- Sci Rep. 2020 Jul 27;10(1):12506. doi: 10.1038/s41598-020-68176-y.
- PMID: 32719318
- PubMed abstract
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- BRCAness digitalMLPA profiling predicts benefit of intensified platinum-based chemotherapy in triple-negative and luminal-type breast cancer.
- Lips EH, Benard-Slagter A, Opdam M, Scheerman CE, Wesseling J, Hogervorst FBL, Linn SC, Savola S, Nederlof PM.
- Breast Cancer Res. 2020 Jul 25;22(1):79. doi: 10.1186/s13058-020-01313-7.
- PMID: 32711554
- PubMed abstract
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- PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies.
- Lee EK, Matulonis UA.
- Cancers (Basel). 2020 Jul 25;12(8):E2054. doi: 10.3390/cancers12082054.
- PMID: 32722408
- PubMed abstract
- Source abstract
- Review
- Free Full Text
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- Disclosure of secondary findings in exome sequencing of 2480 Japanese cancer patients.
- Horiuchi Y, Matsubayashi H, Kiyozumi Y, Nishimura S, Higashigawa S, Kado N, Nagashima T, Mizuguchi M, Ohnami S, Arai M, Urakami K, Kusuhara M, Yamaguchi K.
- Hum Genet. 2020 Jul 24. doi: 10.1007/s00439-020-02207-6. Epub ahead of print.
- PMID: 32710294
- PubMed abstract
- Source abstract
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- Clinical implications of breast cancer tumor genomic testing.
- Damodaran S, Sember QC, Arun BK.
- Breast J. 2020 Jul 22. doi: 10.1111/tbj.13966. Epub ahead of print.
- PMID: 32696498
- PubMed abstract
- Source abstract
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- Clinical BRCA1/2 reversion analysis identifies hotspot mutations and predicted neoantigens associated with therapy resistance.
- Pettitt SJ, Frankum JR, Punta M, Lise S, Alexander J, Chen Y, Yap TA, Haider S, Tutt ANJ, Lord CJ.
- Cancer Discov. 2020 Jul 22:CD-19-1485. doi: 10.1158/2159-8290.CD-19-1485. Epub ahead of print.
- PMID: 32699032
- PubMed abstract
- Source abstract
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- Clinical characteristics and exploratory genomic analyses of germline BRCA1 or BRCA2 mutations in breast cancer.
- Park S, Lee E, Park S, Lee S, Nam SJ, Kim SW, Lee JE, Yu JH, Kim JY, Ahn JS, Im YH, Park WY, Park K, Park YH.
- Mol Cancer Res. 2020 Jun 17:molcanres.1108.2019. doi: 10.1158/1541-7786.MCR-19-1108. Epub ahead of print.
- PMID: 32554602
- PubMed abstract
- Source abstract
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- Feasibility of tumor testing for BRCA status in high-grade serous ovarian cancer using fresh-frozen tissue based approach.
- Marchetti C, Minucci A, D'Indinosante M, Ergasti R, Arcieri M, Capoluongo ED, Pietragalla A, Caricato C, Scambia G, Fagotti A.
- Gynecol Oncol. 2020 Jun 15:S0090-8258(20)32294-0. doi: 10.1016/j.ygyno.2020.06.479. Epub ahead of print.
- PMID: 32553590
- PubMed abstract
- Source abstract
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- Simple prediction model for homologous recombination deficiency in breast cancers in adolescents and young adults.
- Watanabe T, Honda T, Totsuka H, Yoshida M, Tanioka M, Shiraishi K, Shimada Y, Arai E, Ushiama M, Tamura K, Yoshida T, Kanai Y, Kohno T.
- Breast Cancer Res Treat. 2020 Jun 3. doi: 10.1007/s10549-020-05716-0. Epub ahead of print.
- PMID: 32488393
- PubMed abstract
- Source abstract
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- Germline Testing In Advanced Cancer Can Lead to Targeted Tx.
- Nelson R.
- Medscape. Conference News. 2020 Jun 2.
- Conference news, Research news
- Free Full Text
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- Germline Insights from NGS Somatic Testing: Clinical Challenges and Controversies.
- Matloff ET, Giri VN, Nowak JA, Sotelo J, Silver DP.
- Precision Oncology News. Resources: Webinars. 2020 Jun 1.
- Webinar
- Overview/Registration
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- Establishing a framework for the clinical translation of germline findings in precision oncology.
- Dixon K, Young S, Shen Y, Thibodeau ML, Fok A, Pleasance E, Zhao E, Jones M, Aubert G, Armstrong L, Virani A, Regier D, Gelmon K, Renouf D, Chia S, Bosdet I, Rassekh SR, Deyell RJ, Yip S, Fisic A, Titmuss E, Abadi S, Jones SJM, Sun S, Karsan A, Marra M, Laskin J, Lim H, Schrader KA.
- JNCI Cancer Spectr. 2020 May 29; pkaa045. doi: 10.1093/jncics/pkaa045. eCollection 2020 May.
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- Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.
- Chopra N, Tovey H, Pearson A, Cutts R, Toms C, Proszek P, Hubank M, Dowsett M, Dodson A, Daley F, Kriplani D, Gevensleben H, Davies HR, Degasperi A, Roylance R, Chan S, Tutt A, Skene A, Evans A, Bliss JM, Nik-Zainal S, Turner NC.
- Nat Commun. 2020 May 29;11(1):2662. doi: 10.1038/s41467-020-16142-7.
- PMID: 32471999
- PubMed abstract
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- Constitutional mosaicism for a BRCA2 mutation as a cause of early-onset breast cancer.
- Alhopuro P, Vainionpää R, Anttonen AK, Aittomäki K, Nevanlinna H, Pöyhönen M.
- Fam Cancer. 2020 May 28. doi: 10.1007/s10689-020-00186-1. Epub ahead of print.
- PMID: 32468491
- PubMed abstract
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- High resolution melting profiles (HRMPs) obtained by magnetic induction cycler (MIC) have been used to monitor the BRCA2 status highlighted by next generation tumor sequencing (NGTS): a combined approach in a diagnostic environment.
- Mazzuccato G, De Bonis M, Carboni V, Marchetti C, Urbani A, Scambia G, Capoluongo E, Fagotti A, Minucci A.
- Mol Biol Rep. 2020 May 28. doi: 10.1007/s11033-020-05504-5. Epub ahead of print.
- PMID: 32468256
- PubMed abstract
- Source abstract
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- Genetic Testing Challenges in Oncology: Missed Mutations Highlight Somatic, Germline Test Difference.
- Ray T.
- Precision Oncology News. 2020 May 26.
- Case report
- Free Full Text
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- High-throughput functional evaluation of BRCA2 variants of unknown significance.
- Ikegami M, Kohsaka S, Ueno T, Momozawa Y, Inoue S, Tamura K, Shimomura A, Hosoya N, Kobayashi H, Tanaka S, Mano H.
- Nat Commun. 2020 May 22;11(1):2573. doi: 10.1038/s41467-020-16141-8.
- PMID: 32444794
- PubMed abstract
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- Q&A: ACMG Work Group Hoping to Spark Discussion on Reporting Germline Findings From Tumor Testing.
- Ray T.
- Precision Oncology News. 2020 May 21.
Guidelines:
Points to consider for reporting of germline variation in patients undergoing tumor testing: a statement of the American College of Medical Genetics and Genomics (ACMG).
- PMID: 32321997
- PubMed abstract
- Free Full Text
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- FDA Approves Lynparza With Myriad, Foundation Med CDx Tests in HRR-Mutated Prostate Cancer
- [No author given]
- GenomeWeb. 2020 May 20.
- News
- Free Full Text
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- FDA approves olaparib for HRR gene-mutated metastatic castration-resistant prostate cancer.
- [No author given]
- U.S. Food & Drug Administration. Drug Approvals. 2020 May 20.
- Drug Approval
- Free Full Text
News: Update: PARP inhibitors, rucaparib (Rubraca) and olaparib (Lynparza) receive FDA approval for metastatic prostate cancer (FORCE. XRAYS.)
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- Biomarker-Guided Development of DNA Repair Inhibitors.
- Cleary JM, Aguirre AJ, Shapiro GI, D'Andrea AD.
- Mol Cell. 2020 May 17:S1097-2765(20)30277-X. doi: 10.1016/j.molcel.2020.04.035. Epub ahead of print.
- PMID: 32459988
- PubMed abstract
- Source abstract
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- Combined CCNE1 high-level amplification and overexpression is associated with unfavourable outcome in tubo-ovarian high-grade serous carcinoma.
- Chan AM, Enwere E, McIntyre JB, Wilson H, Nwaroh C, Wiebe N, Ou Y, Liu S, Wiedemeyer K, Rambau PF, Grevers X, Morris DG, Neri P, Gilks CB, Visser F, Le N, Luo L, Cook LS, Köbel M.
- J Pathol Clin Res. 2020 May 11. doi: 10.1002/cjp2.168. Epub ahead of print.
- PMID: 32391646
- PubMed abstract
- Source abstract
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- The Impact of Whole Genome Data on Therapeutic Decision-Making in Metastatic Prostate Cancer: A Retrospective Analysis.
- Crumbaker M, Chan EKF, Gong T, Corcoran N, Jaratlerdsiri W, Lyons RJ, Haynes AM, Kulidjian AA, Kalsbeek AMF, Petersen DC, Stricker PD, Jamieson CAM, Croucher PI, Hovens CM, Joshua AM, Hayes VM.
- Cancers (Basel). 2020 May 7;12(5):E1178. doi: 10.3390/cancers12051178.
- PMID: 32392735
- PubMed abstract
- Source abstract
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- Points to consider for reporting of germline variation in patients undergoing tumor testing: a statement of the American College of Medical Genetics and Genomics (ACMG).
- Li MM, Chao E, Esplin ED, Miller DT, Nathanson KL, Plon SE, Scheuner MT, Stewart DR; ACMG Professional Practice and Guidelines Committee.
- Genet Med. 2020 Apr 23. doi: 10.1038/s41436-020-0783-8. Epub ahead of print.
- PMID: 32321997
- PubMed abstract
- Guidelines
- Free Full Text
News, Interview: Q&A: ACMG Work Group Hoping to Spark Discussion on Reporting Germline Findings From Tumor Testing. (Precision Oncology News)
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- Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial.
- McDonald ES, Doot RK, Pantel AR, Farwell MD, Mach RH, Maxwell KN, Mankoff DA.
- JAMA Oncol. 2020 Apr 16. doi: 10.1001/jamaoncol.2020.0334. [Epub ahead of print]
- PMID: 32297911
- PubMed abstract
- Source abstract
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- Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma.
- Choi MC, Hwang S, Kim S, Jung SG, Park H, Joo WD, Song SH, Lee C, Kim TH, Kang H, An HJ.
- Cancer Res Treat. 2020 Apr;52(2):634-644. doi: 10.4143/crt.2019.207. Epub 2020 Jan 6.
- PMID: 32019284
- PubMed abstract
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- An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers.
- Przybytkowski E, Davis T, Hosny A, Eismann J, Matulonis UA, Wulf GM, Nabavi S.
- BMC Cancer. 2020 Mar 12;20(1):197. doi: 10.1186/s12885-020-6605-1.
- PMID: 32164626
- PubMed abstract
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- Mutation landscape of germline and somatic BRCA1/2 in patients with high-grade serous ovarian cancer.
- Eoh KJ, Kim HM, Lee JY, Kim S, Kim SW, Kim YT, Nam EJ.
- BMC Cancer. 2020 Mar 12;20(1):204. doi: 10.1186/s12885-020-6693-y.
- PMID: 32164585
- PubMed abstract
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- Germline and Somatic BRCA1/2 Mutations in 172 Chinese Women With Epithelial Ovarian Cancer.
- You Y, Li L, Lu J, Wu H, Wang J, Gao J, Wu M, Liang Z.
- Front Oncol. 2020 Mar 10;10:295. doi: 10.3389/fonc.2020.00295. eCollection 2020.
- PMID: 32211327
- PubMed abstract
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- Involving patients and their families in deciding to use next generation sequencing: Results from a nationally representative survey of U.S. oncologists.
- Spees LP, Roberts MC, Freedman AN, Butler EN, Klein WMP, Prabhu Das I, de Moor JS.
- Patient Educ Couns. 2020 Mar 3. pii: S0738-3991(20)30116-6. doi: 10.1016/j.pec.2020.03.001. [Epub ahead of print]
- PMID: 32197930
- PubMed abstract
- Source abstract
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- Somatic mRNA Analysis of BRCA1 Splice Variants Provides a Direct Theranostic Impact on PARP Inhibitors.
- Chevalier LM, Billaud A, Fronteau S, Dauvé J, Patsouris A, Verriele V, Morel A.
- Mol Diagn Ther. 2020 Mar 2. doi: 10.1007/s40291-020-00452-z. [Epub ahead of print]
- PMID: 32124385
- PubMed abstract
- Source abstract
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- A profile on the FoundationFocus CDxBRCA tests.
- Ford L, Wolford JE, Brown SM, Randall LM.
- Expert Rev Mol Diagn. 2020 Mar;20(3):285-292. doi: 10.1080/14737159.2020.1701438. Epub 2020 Feb 6.
- PMID: 32028808
- PubMed abstract
- Source abstract
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- Precision Medicine Tumor Boards: Clinical Applicability of Personalized Treatment Concepts in Ovarian Cancer.
- Aust S, Schwameis R, Gagic T, Müllauer L, Langthaler E, Prager G, Grech C, Reinthaller A, Krainer M, Pils D, Grimm C, Polterauer S.
- Cancers (Basel). 2020 Feb 27;12(3). pii: E548. doi: 10.3390/cancers12030548.
- PMID: 32120793
- PubMed abstract
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