Surgical Outcome ~ Risk-Reducing Mastectomy
~ Genetics of Breast & Ovarian Cancer

List was last updated on Sep 24, 2020 @ 6:18 pm.


    • Persistent nipple discharge after nipple-sparing mastectomy secondary to unincorporated AlloDerm: a case report.
    • Laarakker AS, Rich A, Wu J, Fine S.
    • J Med Case Rep. 2020 Sep 24;14(1):164. doi: 10.1186/s13256-020-02476-9.
    • Outcomes of breast reconstruction following prophylactic bilateral mastectomy.
    • Lim DW, Narod SA.
    • Breast J. 2020 Aug 11. doi: 10.1111/tbj.14016. Epub ahead of print.
    • Editorial
    • Re: Risk-reducing mastectomy: a case series of 124 procedures in Brazilian patients.
    • Goncalves R.
    • Breast Cancer Res Treat. 2020 Aug;182(3):763-764. doi: 10.1007/s10549-020-05742-y. Epub 2020 Jun 13.
    • Letter, Commentary

    Original research:

    Risk-reducing mastectomy: a case series of 124 procedures in Brazilian patients.

    • The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate - Retrospective Single-centre 10-Year Experience.
    • Munder B, Andree C, Witzel C, Fertsch S, Stambera P, Schulz T, Fleischer O, Hagouan M, Grüter L, Aufmesser B, Staemmler K, Kornetka J, Aldeeri M, Seidenstücker K, Abu-Ghazaleh A, Wolter A.
    • Geburtshilfe Frauenheilkd. 2020 Jun;80(6):628-638. doi: 10.1055/a-1116-2102. Epub 2020 Apr 16.
    • Secondary Angiosarcoma With C-MYC Amplification Following Prophylactic Bilateral Mastectomy and Autologous Breast Reconstruction: Report of a Case and Review of the Literature.
    • Webb C, Partain N, Koduru P, Hwang H, Sarode VR.
    • Int J Surg Pathol. 2020 Jun 18:1066896920930100. doi: 10.1177/1066896920930100. Epub ahead of print.
    • Case report
    • Male bilateral risk-reducing mastectomy: Report of a case.
    • Combi F, Razzaboni E, Toss A, Gambini A, Papi S, Cortesi L, Tazzioli G.
    • Breast J. 2020 Jun 9. doi: 10.1111/tbj.13928. Epub ahead of print.
    • Case report
    • RED BREAST SYNDROME (RBS) ASSOCIATED TO THE USE OF POLYGLYCOLIC MESH IN BREAST RECONSTRUCTION: A CASE REPORT.
    • Mayer, Perez C, Stoppani I.
    • Acta Chir Plast. 2020 Summer;62(1-2):50-52. English.
    • Case report
    • Nouvelle stratégie chirurgicale dans les mastectomies bilatérales prophylactiques avec reconstruction par prothèses chez les patientes présentant une mutation du gène BRCA [New surgical strategy in breast reconstruction with implants for bilateral prophylactic mastectomies with BRCA gene mutation].
    • Deveaux C, Calibre C, Duquennoy-Martinot V, Guerreschi P, Dumont A.
    • Ann Chir Plast Esthet. 2020 May 29:S0294-1260(20)30077-7. French. doi: 10.1016/j.anplas.2020.05.004. Epub ahead of print.
    • [Article in French]
    • Complication rates among women undergoing preventive mastectomy: An Austrian registry.
    • Leser C, Deutschmann C, Dorffner G, Gschwantler-Kaulich D, Castillo DM, Abayev S, Stübler M, Reitsamer R, Singer C.
    • Breast J. 2020 May 25. doi: 10.1111/tbj.13877. Epub ahead of print.
    • Use of bilateral prophylactic nipple-sparing mastectomy in patients with high risk of breast cancer.
    • Valero MG, Moo TA, Muhsen S, Zabor EC, Stempel M, Pusic A, Gemignani ML, Morrow M, Sacchini V.
    • Br J Surg. 2020 May 20. doi: 10.1002/bjs.11616. Epub ahead of print.
    • Risk-reducing mastectomy: a case series of 124 procedures in Brazilian patients.
    • Frasson AL, Lichtenfels M, de Souza AAB, Vollbrecht B, Falcone AB, Frasson MARM, Barbosa F.
    • Breast Cancer Res Treat. 2020 May;181(1):69-75. doi: 10.1007/s10549-020-05582-w. Epub 2020 Mar 25.

    Letter, Commentary:

    Re: Risk-reducing mastectomy: a case series of 124 procedures in Brazilian patients.

    • The Impact of Combined Risk-Reducing Gynecological Surgeries on Outcomes in DIEP Flap and Tissue-Expander Breast Reconstruction.
    • Jayaraman AP, Boyd T, Hampton SN, Haddock NT, Teotia SS.
    • Plast Surg (Oakv). 2020 May;28(2):112-116. doi: 10.1177/2292550320925905. Epub 2020 May 22.
    • Lumbar Flap versus the Gold Standard: Comparison to the DIEP Flap.
    • Opsomer D, Vyncke T, Depypere B, Stillaert F, Blondeel P, Van Landuyt K.
    • Plast Reconstr Surg. 2020 Apr;145(4):706e-714e. doi: 10.1097/PRS.0000000000006681.
    • Prophylactic Mastectomy: Postoperative Skin Flap Thickness Evaluated by MRT, Ultrasound and Clinical Examination.
    • Wiberg R, Andersson MN, Svensson J, Rosén A, Koch F, Björkgren A, Sund M.
    • Ann Surg Oncol. 2020 Jan 6. doi: 10.1245/s10434-019-08157-2. [Epub ahead of print]
    • Geisinger MyCode® detects BRCA2 mutation prior to abdominal panniculectomy allowing for DIEP flap breast reconstruction.
    • Kauffman CA.
    • Case Reports Plast Surg Hand Surg. 2019 Nov 6;6(1):145-147. doi: 10.1080/23320885.2019.1684824. eCollection 2019.
    • Oncological Safety of Lipofilling in Healthy BRCA Carriers After Bilateral Prophylactic Mastectomy: A Case Series.
    • Quoc CH, Dias LPN, Braghiroli OFM, Martella N, Giovinazzo V, Piat JM.
    • Eur J Breast Health. 2019 Oct 1;15(4):217-221. doi: 10.5152/ejbh.2019.5013. eCollection 2019 Oct.
    • Is nipple sparing mastectomy associated with increased complications, readmission and length of stay compared to skin sparing mastectomy?
    • Wang M, Huang J, Chagpar AB.
    • Am J Surg. 2019 Sep 13. pii: S0002-9610(19)31023-2. doi: 10.1016/j.amjsurg.2019.09.011. [Epub ahead of print]
    • Use of Mammographic Measurements to Predict Complications After Nipple-Sparing Mastectomy in BRCA Mutation Carriers.
    • Park KU, Weiss A, Rosso K, Yi M, Hunt K, Kuerer H, Hanson SE, Candelaria R, Tevis S, Thompson A.
    • Ann Surg Oncol. 2019 Aug 9. doi: 10.1245/s10434-019-07704-1. [Epub ahead of print]
    • The Importance of Risk-Reducing Prophylactic Mastectomy in Breast Cancer (BRCA) Carriers: A Case Report.
    • Ochaney P, Patel K, Haq F, Reese R, Igel S.
    • Cureus. 2019 Aug 2;11(8):e5311. doi: 10.7759/cureus.5311.
    • Patient-Reported Satisfaction after Prophylactic Operations of the Breast.
    • Keller K, Meisel C, Grübling N, Petzold A, Wimberger P, Kast K.
    • Breast Care (Basel). 2019 Aug;14(4):217-223. doi: 10.1159/000496398. Epub 2019 Feb 15.
    • [A CASE REPORT OF THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP) IN A BREAST CANCER PATIENT].
    • Ben Naftali Y, Duek OS, Ullmann Y.
    • Harefuah. 2019 Aug;158(8):503-505.
    • Case report, [Article in Hebrew]
    • Breast reconstruction after risk-reducing mastectomy in BRCA mutation carriers.
    • Nagura N, Hayashi N, Takei J, Yoshida A, Ochi T, Iwahira Y, Yamauchi H.
    • Breast Cancer. 2019 Jul 10. doi: 10.1007/s12282-019-00995-y. [Epub ahead of print]
    • Residual glandular tissue (RGT) in BRCA1/2 germline mutation carriers with unilateral and bilateral prophylactic mastectomies.
    • Grinstein O, Krug B, Hellmic M, Siedek F, Malter W, Burke C, Schmutzler R, Maintz D, Rhiem K.
    • Surg Oncol. 2019 Jun;29:126-133. doi: 10.1016/j.suronc.2019.04.009. Epub 2019 May 3.
    • Sentinel lymph node biopsy following previous axillary surgery in recurrent breast cancer.
    • Sávolt Á, Cserni G, Lázár G, Maráz R, Kelemen P, Kovács E, Győrffy B, Udvarhelyi N, Vörös A, Ormándi K, Mátrai Z.
    • Eur J Surg Oncol. 2019 May 16. pii: S0748-7983(19)30454-8. doi: 10.1016/j.ejso.2019.05.016. [Epub ahead of print]
    • The Evolution of Breast Implant Infections: Serratia marcescens Is an Emerging Pathogen in Implant-Based Breast Reconstruction.
    • Gui JL, Lin KY.
    • Plast Surg (Oakv). 2019 May;27(2):182-188. doi: 10.1177/2292550319826098. Epub 2019 Feb 21.
    • What The Surgeons Should Know About The Bilateral Prophylactic Mastectomy in BRCA Mutation Carriers.
    • Franceschini G, Masetti R.
    • Eur J Breast Health. 2019 Apr 1;15(2):135-136. doi: 10.5152/ejbh.2019.4651. eCollection 2019 Apr.

    Review:

    Risk-Reducing Options for Women with a Hereditary Breast Cancer Predisposition.

    • Comparison of venous couplers versus hand-sewn technique in free flap breast reconstruction.
    • Dimitropoulos G, Efanov JI, Paek L, Bou-Merhi J, Danino MA.
    • Ann Chir Plast Esthet. 2019 Apr;64(2):150-156. doi: 10.1016/j.anplas.2018.10.002. Epub 2018 Dec 5.
    • Evolving indications and long-term oncological outcomes of risk-reducing bilateral nipple-sparing mastectomy.
    • Grobmyer SR, Pederson HJ, Valente SA, Al-Hilli Z, Radford D, Djohan R, Yetman R, Eng C, Crowe JP.
    • BJS Open. 2018 Nov 26;3(2):169-173. doi: 10.1002/bjs5.50117. eCollection 2019 Apr.
    • Prophylactic Versus Therapeutic Mastectomy: A Contemporary Analysis of the ACS-NSQIP Database.
    • Hendrix RJ, Lee C, Friedrich AK, Rouanet E, Larkin AC, LaFemina J.
    • Clin Breast Cancer. 2019 Jan 31. pii: S1526-8209(19)30050-3. doi: 10.1016/j.clbc.2019.01.008. [Epub ahead of print]
    • Risk-Reducing Mastectomy in BRCA1 and BRCA2 Mutation Carriers: A Complex Discussion.
    • Domchek SM.
    • JAMA. 2019 Jan 1;321(1):27. doi: 10.1001/jama.2018.18942.
    • Review, Commentary
    • Bilateral prophylactic mastectomy in BRCA mutation carriers: what surgeons need to know.
    • Franceschini G, Di Leone A, Terribile D, Sanchez MA, Masetti R.
    • Ann Ital Chir. 2019;90:1-2.
    • Review
    • Surgery for BRCA, TP53 and PALB2: a literature review.
    • Song CV, Teo SH, Taib NA, Yip CH.
    • Ecancermedicalscience. 2018 Aug 29;12:863. doi: 10.3332/ecancer.2018.863. eCollection 2018.
    • Concurrent risk-reduction surgery in patients with increased lifetime risk for breast and ovarian cancer: an analysis of the National Surgical Quality Improvement Program (NSQIP) database.
    • Elmi M, Azin A, Elnahas A, McCready DR, Cil TD.
    • Breast Cancer Res Treat. 2018 Aug;171(1):217-223. doi: 10.1007/s10549-018-4818-7. Epub 2018 May 14.
    • Bilateral mastectomies: can a co-surgeon technique offer improvements over the single-surgeon method?
    • Mallory MA, Tarabanis C, Schneider E, Nimbkar S, Golshan M.
    • Breast Cancer Res Treat. 2018 Aug;170(3):641-646. doi: 10.1007/s10549-018-4794-y. Epub 2018 Apr 23.
    • Influences on Satisfaction with Reconstructed Breasts and Intimacy in Younger Women Following Bilateral Prophylactic Mastectomy: a Qualitative Analysis.
    • Glassey R, O'Connor M, Ives A, Saunders C, Hardcastle SJ; kConFab Investigators.
    • Int J Behav Med. 2018 Aug;25(4):390-398. doi: 10.1007/s12529-018-9722-3.
    • Complications, risk factors, and patients-reported outcomes after skin-sparing mastectomy followed by breast reconstruction in women with BRCA mutations.
    • Moberg IO, Schou Bredal I, Schneider MR, Tønseth KA, Schlichting E.
    • J Plast Surg Hand Surg. 2018 Aug;52(4):234-239. doi: 10.1080/2000656X.2018.1470093. Epub 2018 May 9.
    • Long-term outcomes of bilateral direct-to-implant breast reconstruction in women at high breast cancer risk.
    • van Verschuer VMT, Mureau MAM, Heemskerk-Gerritsen BAM, Gadjradj PS, Rogier C, Verhoef C, Gopie JP, Seynaeve C, Koppert LB.
    • J Plast Surg Hand Surg. 2018 Aug;52(4):245-252. doi: 10.1080/2000656X.2018.1476364. Epub 2018 May 28.
    • The Lumbar Artery Perforator Flap in Autologous Breast Reconstruction: Initial Experience with 100 Cases.
    • Opsomer D, Stillaert F, Blondeel P, Van Landuyt K.
    • Plast Reconstr Surg. 2018 Jul;142(1):1e-8e. doi: 10.1097/PRS.0000000000004522.
    • Oncological safety of nipple-sparing prophylactic mastectomy: A review of the literature on 3716 cases.
    • Muller T, Baratte A, Bruant-Rodier C, Bodin F, Mathelin C.
    • Ann Chir Plast Esthet. 2018 Jun;63(3):e6-e13. doi: 10.1016/j.anplas.2017.09.005. Epub 2017 Oct 10.
    • Review
    • Nipple-sparing bilateral prophylactic mastectomy and immediate reconstruction with TiLoop® Bra mesh in BRCA1/2 mutation carriers: A prospective study of long-term and patient reported outcomes using the BREAST-Q.
    • Casella D, Di Taranto G, Marcasciano M, Sordi S, Kothari A, Kovacs T, Lo Torto F, Cigna E, Ribuffo D, Calabrese C.
    • Breast. 2018 Jun;39:8-13. doi: 10.1016/j.breast.2018.02.001. Epub 2018 Feb 18.
    • Nipple-sparing mastectomy in women at high risk of developing breast cancer.
    • Lewis RS, George A, Rusby JE.
    • Gland Surg. 2018 Jun;7(3):325-336. doi: 10.21037/gs.2018.04.01.
    • Risk-reducing mastectomy for the prevention of primary breast cancer.
    • Carbine NE, Lostumbo L, Wallace J, Ko H.
    • Cochrane Database Syst Rev. 2018 Apr 5;4:CD002748. doi: 10.1002/14651858.CD002748.pub4.
    • Review, Meta-Analysis

    Summary: Women should be aware of their true risk of developing breast cancer and the limitations of current evidence when considering risk-reducing mastectomy. (Cochrane Library)

    • When BRCA Mutations Meet Complications.
    • Clausen AM.
    • Global Health NOW. 2018 Mar 20.
    • Prophylactic mastectomy for BRCA mutation carriers after ovarian cancer treatment: is it beneficial?
    • Kotsopoulos J, Narod SA.
    • Expert Rev Anticancer Ther. 2018 Mar;18(3):199-200. doi: 10.1080/14737140.2018.1424547. Epub 2018 Jan 8.
    • Patient experience with breast reconstruction process following bilateral mastectomy in BRCA mutation carriers.
    • Nurudeen S, Guo H, Chun Y, Coopey S, Barry W, Garber J, Dominici LS.
    • Am J Surg. 2017 Oct;214(4):687-694. doi: 10.1016/j.amjsurg.2017.06.017. Epub 2017 Jun 28.
    • Outcomes of Concurrent Breast and Gynecologic Risk Reduction Surgery.
    • Ma IT, Gray RJ, Wasif N, Butler KA, Cornella JL, Magrina JF, Magtibay PM, Casey WJ, Mahabir R, Rebecca AM, Hunt KS, Pockaj BA.
    • Ann Surg Oncol. 2017 Jan;24(1):77-83. doi: 10.1245/s10434-016-5479-6. Epub 2016 Aug 31.
    • Occult Histopathology and Its Predictors in Contralateral and Bilateral Prophylactic Mastectomies.
    • Mattos D, Gfrerer L, Ling IT, Reish RG, Hughes KS, Halpern EF, Cetrulo C, Colwell AS, Winograd JM, Yaremchuk MJ, Austen WG Jr, Liao EC.
    • Ann Surg Oncol. 2016 Mar;23(3):767-75. doi: 10.1245/s10434-015-4896-2. Epub 2015 Nov 17.
    • Risk-reducing, conservative mastectomy-analysis of surgical outcome and quality of life in 272 implant-based reconstructions using TiLoop(®) Bra versus autologous corial flaps.
    • Rezai M, Strauß S, Kimmig R, Kern P.
    • Gland Surg. 2016 Feb;5(1):1-8. doi: 10.3978/j.issn.2227-684X.2015.07.03.
  1. Author
    • Conservative mastectomies for breast cancer and risk-reducing surgery: the Memorial Sloan Kettering Cancer Center experience.
    • Manning AT, Sacchini VS.
    • Gland Surg. 2016 Feb;5(1):55-62. doi: 10.3978/j.issn.2227-684X.2015.10.02.
    • Nipple-sparing mastectomy in patients with BRCA1/2 mutations and variants of uncertain significance.
    • Manning AT, Wood C, Eaton A, Stempel M, Capko D, Pusic A, Morrow M, Sacchini V.
    • Br J Surg. 2015 Oct;102(11):1354-9. doi: 10.1002/bjs.9884. Epub 2015 Aug 27.
    • Breast cancer after prophylactic mastectomy (bilateral or contralateral prophylactic mastectomy), a clinical entity: presentation, management, and outcomes.
    • Mutter RW, Frost MH, Hoskin TL, Johnson JL, Hartmann LC, Boughey JC.
    • Breast Cancer Res Treat. 2015 Aug;153(1):183-90. doi: 10.1007/s10549-015-3515-z. Epub 2015 Jul 26.
    • Nipple-sparing mastectomy in BRCA1/2 mutation carriers: an interim analysis and review of the literature.
    • Yao K, Liederbach E, Tang R, Lei L, Czechura T, Sisco M, Howard M, Hulick PJ, Weissman S, Winchester DJ, Coopey SB, Smith BL.
    • Ann Surg Oncol. 2015 Feb;22(2):370-6. doi: 10.1245/s10434-014-3883-3. Epub 2014 Jul 15.
    • Review

    Comment / Editorial

    Safely expanding the use of nipple-sparing mastectomy in BRCA mutation carriers.

    • Use of and mortality after bilateral mastectomy compared with other surgical treatments for breast cancer in California, 1998-2011.
    • Kurian AW, Lichtensztajn DY, Keegan TH, Nelson DO, Clarke CA, Gomez SL.
    • JAMA. 2014 Sep 3;312(9):902-14. doi: 10.1001/jama.2014.10707.

    Editorial, Comment:

    Contralateral prophylactic mastectomy: is it a reasonable option?

    • Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation.
    • Nelson HD, Pappas M, Zakher B, Mitchell JP, Okinaka-Hu L, Fu R.
    • Ann Intern Med. 2014 Feb 18;160(4):255-66.
    • Assessing the Genetic Risk for BRCA-Related Breast or Ovarian Cancer in Women: Recommendations From the U.S. Preventive Services Task Force.
    • [No authors listed]
    • Ann Intern Med. 2014 Feb 18;160(4). doi: 10.7326/P14-9008.

    Systematic Review:

    Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation.

    • Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women: U.S. Preventive Services Task Force Recommendation Statement.
    • Moyer VA; U.S. Preventive Services Task Force.
    • Ann Intern Med. 2014 Feb 18;160(4):271-81.

    Patient Education Handout:

    Summaries for patients. Assessing the genetic risk for BRCA-related breast or ovarian cancer in women: recommendations from the U.S. Preventive Services Task Force.

    • Summaries for patients. Assessing the genetic risk for BRCA-related breast or ovarian cancer in women: recommendations from the U.S. Preventive Services Task Force.
    • [No authors listed]
    • Ann Intern Med. 2014 Feb 18;160(4):I-16.

    Practice Guideline:

    Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women: U.S. Preventive Services Task Force Recommendation Statement.

    • Body image issues after bilateral prophylactic mastectomy with breast reconstruction in healthy women at risk for hereditary breast cancer.
    • Gopie JP, Mureau MA, Seynaeve C, Ter Kuile MM, Menke-Pluymers MB, Timman R, Tibben A.
    • Fam Cancer. 2013 Sep;12(3):479-87. doi: 10.1007/s10689-012-9588-5.
    • Substantial breast cancer risk reduction and potential survival benefit after bilateral mastectomy when compared with surveillance in healthy BRCA1 and BRCA2 mutation carriers: a prospective analysis.
    • Heemskerk-Gerritsen BA, Menke-Pluijmers MB, Jager A, Tilanus-Linthorst MM, Koppert LB, Obdeijn IM, van Deurzen CH, Collée JM, Seynaeve C, Hooning MJ.
    • Ann Oncol. 2013 Aug;24(8):2029-35. doi: 10.1093/annonc/mdt134. Epub 2013 Apr 10.
    • Pulmonary embolism after abdominal flap breast reconstruction: prediction and prevention.
    • Enajat M, Damen TH, Geenen A, Timman R, van der Hulst RR, Mureau MA.
    • Plast Reconstr Surg. 2013 Jun;131(6):1213-22. doi: 10.1097/PRS.0b013e31828bd35e.
    • Reducing the risk of nipple necrosis: technical observations in 340 nipple-sparing mastectomies.
    • Stolier AJ, Levine EA.
    • Breast J. 2013 Mar-Apr;19(2):173-9. doi: 10.1111/tbj.12078. Epub 2013 Jan 22.
    • Breast reconstruction with deep inferior epigastric perforator flaps.
    • Cubitt J, Barber Z, Khan AA, Tyler M.
    • Ann R Coll Surg Engl. 2012 Nov;94(8):552-8. doi: 10.1308/003588412X13373405386457.
    • Breast and ovarian cancer risk management in a French cohort of 158 women carrying a BRCA1 or BRCA2 germline mutation: patient choices and outcome.
    • This P, de la Rochefordière A, Savignoni A, Falcou MC, Tardivon A, Thibault F, Alran S, Fourchotte V, Fitoussi A, Couturaud B, Dolbeault S, Salmon RJ, Sigal-Zafrani B, Asselain B, Stoppa-Lyonnet D.
    • Fam Cancer. 2012 Sep;11(3):473-82. doi: 10.1007/s10689-012-9539-1.
    • Comparison of patient characteristics and outcomes of contralateral prophylactic mastectomy and unilateral total mastectomy in breast cancer patients.
    • Chung A, Huynh K, Lawrence C, Sim MS, Giuliano A.
    • Ann Surg Oncol. 2012 Aug;19(8):2600-6. doi: 10.1245/s10434-012-2299-1. Epub 2012 Mar 7.
    • Pre-expansion before risk reducing mastectomy combined with lipomodelling to enhance results from implant based reconstruction.
    • Katerinaki E, Sircar T, Fatah F.
    • J Plast Reconstr Aesthet Surg. 2012 Feb;65(2):182-6. doi: 10.1016/j.bjps.2011.09.016. Epub 2011 Sep 16.