Surgical Outcome ~ Contralateral Prophylactic Mastectomy
~ Genetics of Breast & Ovarian Cancer

List was last updated on Oct 20, 2019 @ 2:07 pm.


    • Assessing the additional surgical risk of contralateral prophylactic mastectomy and immediate breast implant reconstruction.
    • Nealon KP, Sobti N, Gadd M, Specht M, Liao EC.
    • Breast Cancer Res Treat. 2019 Oct 11. doi: 10.1007/s10549-019-05460-0. [Epub ahead of print]
    • Residual glandular tissue (RGT) in BRCA1/2 germline mutation carriers with unilateral and bilateral prophylactic mastectomies.
    • Grinstein O, Krug B, Hellmic M, Siedek F, Malter W, Burke C, Schmutzler R, Maintz D, Rhiem K.
    • Surg Oncol. 2019 Jun;29:126-133. doi: 10.1016/j.suronc.2019.04.009. Epub 2019 May 3.
    • Feasibility study of contralateral risk-reducing mastectomy with breast reconstruction for breast cancer patients with BRCA mutations in Japan.
    • Yoshimura A, Okumura S, Sawaki M, Hattori M, Ishiguro J, Adachi Y, Kotani H, Gondo N, Kataoka A, Iwase M, Onishi S, Sugino K, Terada M, Horisawa N, Mori M, Takaiso N, Hyodo I, Iwata H.
    • Breast Cancer. 2018 Sep;25(5):539-546. doi: 10.1007/s12282-018-0850-z. Epub 2018 Mar 8.
    • Evolving surgical treatment decisions for male breast cancer: an analysis of the National Surgical Quality Improvement Program (NSQIP) database.
    • Elmi M, Sequeira S, Azin A, Elnahas A, McCready DR, Cil TD.
    • Breast Cancer Res Treat. 2018 Sep;171(2):427-434. doi: 10.1007/s10549-018-4830-y. Epub 2018 May 28.
    • Surgery for BRCA, TP53 and PALB2: a literature review.
    • Song CV, Teo SH, Taib NA, Yip CH.
    • Ecancermedicalscience. 2018 Aug 29;12:863. doi: 10.3332/ecancer.2018.863. eCollection 2018.
    • Risk-reducing mastectomy for the prevention of primary breast cancer.
    • Carbine NE, Lostumbo L, Wallace J, Ko H.
    • Cochrane Database Syst Rev. 2018 Apr 5;4:CD002748. doi: 10.1002/14651858.CD002748.pub4.
    • Review, Meta-Analysis

    Summary: Women should be aware of their true risk of developing breast cancer and the limitations of current evidence when considering risk-reducing mastectomy. (Cochrane Library)

    • Clinical and molecular characterization of BRCA-associated breast cancer: results from the DBCG.
    • Soenderstrup IMH, Laenkholm AV, Jensen MB, Eriksen JO, Gerdes AM, Hansen TVO, Kruse TA, Larsen MJ, Pedersen IS, Rossing M, Thomassen M, Ejlertsen B.
    • Acta Oncol. 2018 Jan;57(1):95-101. doi: 10.1080/0284186X.2017.1398415. Epub 2017 Nov 22.
    • Contralateral Prophylactic Mastectomy (CPM) Consensus Statement from the American Society of Breast Surgeons: Data on CPM Outcomes and Risks.
    • Boughey JC, Attai DJ, Chen SL, Cody HS, Dietz JR, Feldman SM, Greenberg CC, Kass RB, Landercasper J, Lemaine V, MacNeill F, Song DH, Staley AC, Wilke LG, Willey SC, Yao KA, Margenthaler JA.
    • Ann Surg Oncol. 2016 Oct;23(10):3100-5. doi: 10.1245/s10434-016-5443-5. Epub 2016 Jul 28.

    Clinical Guideline

    Contralateral Prophylactic Mastectomy Consensus Statement from the American Society of Breast Surgeons: Additional Considerations and a Framework for Shared Decision Making.

    News: Contralateral Prophylactic Mastectomy Discouraged: ASBrS (Medscape Oncology)

    • Contralateral prophylactic mastectomy (CPM): A systematic review of patient reported factors and psychological predictors influencing choice and satisfaction.
    • Ager B, Butow P, Jansen J, Phillips KA, Porter D; CPM DA Advisory Group.
    • Breast. 2016 Aug;28:107-20. doi: 10.1016/j.breast.2016.04.005. Epub 2016 Jun 9.
    • Review
    • Patient-Reported Outcomes After Choice for Contralateral Prophylactic Mastectomy.
    • Hwang ES, Locklear TD, Rushing CN, Samsa G, Abernethy AP, Hyslop T, Atisha DM.
    • J Clin Oncol. 2016 May 1;34(13):1518-27. doi: 10.1200/JCO.2015.61.5427. Epub 2016 Mar 7.
    • Associations between Reoperations and Psychological Factors after Contralateral Risk-Reducing Mastectomy: A Two-Year Follow-Up Study.
    • Unukovych D, Wickman M, Sandelin K, Arver B, Johansson H, Brandberg Y.
    • Int J Breast Cancer. 2016;2016:4604852. doi: 10.1155/2016/4604852. Epub 2016 May 26.
    • Local Therapy Decision-Making and Contralateral Prophylactic Mastectomy in Young Women with Early-Stage Breast Cancer.
    • Rosenberg SM, Sepucha K, Ruddy KJ, Tamimi RM, Gelber S, Meyer ME, Schapira L, Come SE, Borges VF, Golshan M, Winer EP, Partridge AH.
    • Ann Surg Oncol. 2015 Nov;22(12):3809-15. doi: 10.1245/s10434-015-4572-6. Epub 2015 May 1.
    • Contralateral Prophylactic Mastectomy: Challenging Considerations for the Surgeon.
    • Angelos P, Bedrosian I, Euhus DM, Herrmann VM, Katz SJ, Pusic A.
    • Ann Surg Oncol. 2015 Oct;22(10):3208-12. doi: 10.1245/s10434-015-4758-y. Epub 2015 Aug 11.
    • Negative Genetic Testing Does Not Deter Contralateral Prophylactic Mastectomy in Younger Patients with Greater Family Histories of Breast Cancer.
    • Wang F, Amara D, Peled AW, Sbitany H, Foster RD, Ewing CA, Alvarado M, Esserman LJ.
    • Ann Surg Oncol. 2015 Oct;22(10):3338-45. doi: 10.1245/s10434-015-4745-3. Epub 2015 Jul 28.
    • Improved overall survival after contralateral risk-reducing mastectomy in BRCA1/2 mutation carriers with a history of unilateral breast cancer: A prospective analysis.
    • A M Heemskerk-Gerritsen B, Rookus MA, Aalfs CM, Ausems MG, Collée JM, Jansen L, Kets CM, Keymeulen KB, Koppert LB, Meijers-Heijboer HE, Mooij TM, Tollenaar RA, Vasen HF, Hebon, Hooning MJ, Seynaeve C.
    • Int J Cancer. 2015 Feb 15;136(3):668-677. doi: 10.1002/ijc.29032. Epub 2014 Jul 8.
    • Better contralateral breast cancer risk estimation and alternative options to contralateral prophylactic mastectomy.
    • Davies KR, Cantor SB, Brewster AM.
    • Int J Womens Health. 2015 Feb 4;7:181-7. doi: 10.2147/IJWH.S52380. eCollection 2015.
    • Contralateral prophylactic mastectomy after unilateral breast cancer: a systematic review and meta-analysis.
    • Fayanju OM, Stoll CR, Fowler S, Colditz GA, Margenthaler JA.
    • Ann Surg. 2014 Dec;260(6):1000-10. doi: 10.1097/SLA.0000000000000769.
    • Rate of contralateral prophylactic mastectomy is influenced by preoperative MRI recommendations.
    • Xia C, Schroeder MC, Weigel RJ, Sugg SL, Thomas A.
    • Ann Surg Oncol. 2014 Dec;21(13):4133-8. doi: 10.1245/s10434-014-3852-x. Epub 2014 Jun 17.
    • Contralateral prophylactic mastectomy and its association with reduced mortality: evidence for selection bias.
    • Jatoi I, Parsons HM.
    • Breast Cancer Res Treat. 2014 Nov;148(2):389-96. doi: 10.1007/s10549-014-3160-y. Epub 2014 Oct 10.
    • Predictors of contralateral prophylactic mastectomy and the impact on breast reconstruction.
    • Pinell-White XA, Kolegraff K, Carlson GW.
    • Ann Plast Surg. 2014 Jun;72(6):S153-7. doi: 10.1097/SAP.0000000000000099.
    • Threshold for genetic testing in women with breast cancer needs to be determined.
    • Basu NN, Barr L, Evans DG, Ross GL.
    • BMJ. 2014 Mar 6;348:g1863. doi: 10.1136/bmj.g1863.
    • Letter

    Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis.

    • Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis.
    • Metcalfe K, Gershman S, Ghadirian P, Lynch HT, Snyder C, Tung N, Kim-Sing C, Eisen A, Foulkes WD, Rosen B, Sun P, Narod SA.
    • BMJ. 2014 Feb 11;348:g226. doi: 10.1136/bmj.g226.

    Comment, Editorial:

    Contralateral mastectomy for women with hereditary breast cancer.

    Letter, Comment:

    Threshold for genetic testing in women with breast cancer needs to be determined.

    Research News:

    Women with BRCA mutation have better survival rates after double mastectomy.

    Press: Bilateral Mastectomy Ups Survival in BRCA Carriers. (Medscape/Reuters)

    • Improved long-term survival with contralateral prophylactic mastectomy among young women.
    • Zeichner SB, Zeichner SB, Ruiz AL, Markward NJ, Rodriguez E.
    • Asian Pac J Cancer Prev. 2014;15(3):1155-62.
    • Contralateral prophylactic mastectomy and survival: report from the National Cancer Data Base, 1998-2002.
    • Yao K, Winchester DJ, Czechura T, Huo D.
    • Breast Cancer Res Treat. 2013 Dec;142(3):465-76. doi: 10.1007/s10549-013-2745-1. Epub 2013 Nov 12.
    • Meta-Analysis, Review
    • Association between contralateral prophylactic mastectomy and breast cancer outcomes by hormone receptor status.
    • Brewster AM, Bedrosian I, Parker PA, Dong W, Peterson SK, Cantor SB, Crosby M, Shen Y.
    • Cancer. 2012 Nov 15;118(22):5637-43. doi: 10.1002/cncr.27574. Epub 2012 Apr 19.
    • Breast reconstruction with deep inferior epigastric perforator flaps.
    • Cubitt J, Barber Z, Khan AA, Tyler M.
    • Ann R Coll Surg Engl. 2012 Nov;94(8):552-8. doi: 10.1308/003588412X13373405386457.
    • Breast reconstruction in patients with personal and family history of breast cancer undergoing contralateral prophylactic mastectomy, a 10-year experience.
    • Unukovych D, Sandelin K, Wickman M, Arver B, Johansson H, Brandberg Y, Liljegren A.
    • Acta Oncol. 2012 Sep;51(7):934-41. doi: 10.3109/0284186X.2012.666000. Epub 2012 Mar 12.
    • Comparison of patient characteristics and outcomes of contralateral prophylactic mastectomy and unilateral total mastectomy in breast cancer patients.
    • Chung A, Huynh K, Lawrence C, Sim MS, Giuliano A.
    • Ann Surg Oncol. 2012 Aug;19(8):2600-6. doi: 10.1245/s10434-012-2299-1. Epub 2012 Mar 7.