Research Topics — Basic / Pre-Clinical ~ Miscellaneous Topics
~ Genetics of Breast & Ovarian Cancer

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    • Deletion of chromosomes 13q and 14q is a common feature of tumors with BRCA2 mutations.
    • Rouault A, Banneau G, Macgrogan G, Jones N, Elarouci N, Barouk-Simonet E, Venat L, Coupier I, Letouzé E, de Reyniès A, Bonnet F, Iggo R, Sévenet N, Longy M.
    • PLoS One. 2012;7(12):e52079. doi: 10.1371/journal.pone.0052079. Epub 2012 Dec 21.
    • Evidence That BRCA1- or BRCA2-Associated Cancers Are Not Inevitable.
    • Levin B, Lech D, Friedenson B.
    • Mol Med. 2012 Dec 6;18:1327-37. doi: 10.2119/molmed.2012.00280.
    • BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies.
    • Martinez-Outschoorn UE, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, Pavlides S, Lamb R, Sneddon S, Howell A, Sotgia F, Lisanti MP.
    • Cell Cycle. 2012 Dec 1;11(23):4402-13. doi: 10.4161/cc.22776. Epub 2012 Nov 21.
    • Molecular pathways: understanding the role of rad52 in homologous recombination for therapeutic advancement.
    • Lok BH, Powell SN.
    • Clin Cancer Res. 2012 Dec 1;18(23):6400-6. doi: 10.1158/1078-0432.CCR-11-3150. Epub 2012 Oct 15.
    • IGF-1 and BRCA1 signalling pathways in familial cancer.
    • Werner H, Bruchim I.
    • Lancet Oncol. 2012 Dec;13(12):E537-44. doi: 10.1016/S1470-2045(12)70362-5.
    • Review
    • Ring Finger Nuclear Factor RNF168 Is Important for Defects in Homologous Recombination Caused by Loss of the Breast Cancer Susceptibility Factor BRCA1.
    • Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM.
    • J Biol Chem. 2012 Nov 23;287(48):40618-28. doi: 10.1074/jbc.M112.410951. Epub 2012 Oct 10.
    • Hereditary ovarian cancer and two-compartment tumor metabolism: Epithelial loss of BRCA1 induces hydrogen peroxide production, driving oxidative stress and NFκB activation in the tumor stroma.
    • Martinez-Outschoorn UE, Balliet RM, Lin Z, Whitaker-Menezes D, Howell A, Sotgia F, Lisanti MP.
    • Cell Cycle. 2012 Nov 15;11(22):4152-66. doi: 10.4161/cc.22226. Epub 2012 Oct 9.
    • E2F3b over-expression in ovarian carcinomas and in BRCA1 haploinsufficient fallopian tube epithelium.
    • Smith NL, Welcsh P, Press JZ, Agnew KJ, Garcia R, Swisher EM.
    • Genes Chromosomes Cancer. 2012 Nov;51(11):1054-62. doi: 10.1002/gcc.21990. Epub 2012 Aug 9.
    • BRCA1 and microRNAs: emerging networks and potential therapeutic targets.
    • Chang S, Sharan SK.
    • Mol Cells. 2012 Nov;34(5):425-32. doi: 10.1007/s10059-012-0118-y. Epub 2012 Jul 24.
    • Effects of the missense mutations in canine BRCA2 on BRC repeat 3 functions and comparative analyses between canine and human BRC repeat 3.
    • Yoshikawa Y, Ochiai K, Morimatsu M, Suzuki Y, Wada S, Taoda T, Iwai S, Chikazawa S, Orino K, Watanabe K.
    • PLoS One. 2012;7(10):e45833. doi: 10.1371/journal.pone.0045833. Epub 2012 Oct 12.
    • Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells.
    • Nowsheen S, Cooper T, Stanley JA, Yang ES.
    • PLoS One. 2012;7(10):e46614. doi: 10.1371/journal.pone.0046614. Epub 2012 Oct 11.
    • Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier.
    • Chiang HC, Nair SJ, Yeh IT, Santillan AA, Hu Y, Elledge R, Li R.
    • Exp Hematol Oncol. 2012 Oct 8;1(1):31. doi: 10.1186/2162-3619-1-31.
    • PPARγ agonists target aromatase via both PGE2 and BRCA1.
    • Margalit O, Wang D, Dubois RN.
    • Cancer Prev Res (Phila). 2012 Oct;5(10):1169-72. doi: 10.1158/1940-6207.CAPR-12-0365.
    • Links between genome integrity and BRCA1 tumor suppression.
    • Li ML, Greenberg RA.
    • Trends Biochem Sci. 2012 Oct;37(10):418-24. doi: 10.1016/j.tibs.2012.06.007. Epub 2012 Jul 24.
    • EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors.
    • Zander SA, Sol W, Greenberger L, Zhang Y, van Tellingen O, Jonkers J, Borst P, Rottenberg S.
    • PLoS One. 2012;7(9):e45248. doi: 10.1371/journal.pone.0045248. Epub 2012 Sep 17.
    • BRCA1--conductor of the breast stem cell orchestra: the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast cancer.
    • Buckley NE, Mullan PB.
    • Stem Cell Rev. 2012 Sep;8(3):982-93. doi: 10.1007/s12015-012-9354-y.
    • Review
    • Prolonged postovulatory proinflammatory signaling in the fallopian tube epithelium may be mediated through a BRCA1/DAB2 axis.
    • Tone AA, Virtanen C, Shaw P, Brown TJ.
    • Clin Cancer Res. 2012 Aug 15;18(16):4334-44. doi: 10.1158/1078-0432.CCR-12-0199. Epub 2012 Jul 2.
    • BRCA1 exon 11 alternative splicing, multiple functions and the association with cancer.
    • Tammaro C, Raponi M, Wilson DI, Baralle D.
    • Biochem Soc Trans. 2012 Aug;40(4):768-72. doi: 10.1042/BST20120140.
    • Mechanisms of BRCA1 tumor suppression.
    • Silver DP, Livingston DM.
    • Cancer Discov. 2012 Aug;2(8):679-84. doi: 10.1158/2159-8290.CD-12-0221. Epub 2012 Jul 27.
    • New insights on the pathogenesis of ovarian carcinoma: molecular basis and clinical implications.
    • Gadducci A, Guerrieri ME, Riccardo Genazzani A.
    • Gynecol Endocrinol. 2012 Aug;28(8):582-6. doi: 10.3109/09513590.2011.649595. Epub 2012 Feb 4.
    • RAS, cellular senescence and transformation: the BRCA1 DNA repair pathway at the crossroads.
    • Tu Z, Aird KM, Zhang R.
    • Small GTPases. 2012 Jul-Sep;3(3):163-7. doi: 10.4161/sgtp.19884. Epub 2012 Jul 1.
    • HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.
    • Tierney BJ, McCann GA, Cohn DE, Eisenhauer E, Sudhakar M, Kuppusamy P, Hideg K, Selvendiran K.
    • Cancer Biol Ther. 2012 Jul;13(9):766-75. doi: 10.4161/cbt.20559.
    • Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer.
    • Warmoes M, Jaspers JE, Pham TV, Piersma SR, Oudgenoeg G, Massink MP, Waisfisz Q, Rottenberg S, Boven E, Jonkers J, Jimenez CR.
    • Mol Cell Proteomics. 2012 Jul;11(7):M111.013334. doi: 10.1074/mcp.M111.013334. Epub 2012 Feb 24.
    • RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo.
    • Wu J, Liu C, Chen J, Yu X.
    • J Biol Chem. 2012 Jun 29;287(27):22919-26. doi: 10.1074/jbc.M112.351007. Epub 2012 Apr 25.
    • Deregulated miRNAs in hereditary breast cancer revealed a role for miR-30c in regulating KRAS oncogene.
    • Tanic M, Yanowsky K, Rodriguez-Antona C, Andrés R, Márquez-Rodas I, Osorio A, Benitez J, Martinez-Delgado B.
    • PLoS One. 2012;7(6):e38847. doi: 10.1371/journal.pone.0038847. Epub 2012 Jun 11.
    • Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells.
    • Yu VM, Marion CM, Austria TM, Yeh J, Schönthal AH, Dubeau L.
    • Int J Cancer. 2012 Jun 1;130(11):2495-504. doi: 10.1002/ijc.26309. Epub 2011 Aug 29.
    • Evolutionary pathways in BRCA1-associated breast tumors.
    • Martins FC, De S, Almendro V, Gönen M, Park SY, Blum JL, Herlihy W, Ethington G, Schnitt SJ, Tung N, Garber JE, Fetten K, Michor F, Polyak K.
    • Cancer Discov. 2012 Jun;2(6):503-11. doi: 10.1158/2159-8290.CD-11-0325. Epub 2012 Apr 10.

    Comment:

    Tracking evolution of BRCA1-associated breast cancer.

    • BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls.
    • Bosviel R, Garcia S, Lavediaux G, Michard E, Dravers M, Kwiatkowski F, Bignon YJ, Bernard-Gallon DJ.
    • Cancer Epidemiol. 2012 Jun;36(3):e177-82. doi: 10.1016/j.canep.2012.02.001. Epub 2012 Mar 7.
    • BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype.
    • Santarosa M, Maestro R.
    • Cancer Metastasis Rev. 2012 Jun;31(1-2):131-42. doi: 10.1007/s10555-011-9336-6.
    • Review
    • Evolutionary constraint helps unmask a splicing regulatory region in BRCA1 exon 11.
    • Raponi M, Douglas AG, Tammaro C, Wilson DI, Baralle D.
    • PLoS One. 2012;7(5):e37255. doi: 10.1371/journal.pone.0037255. Epub 2012 May 16.
    • [Cellular functions of BRCA genes - from basic science to therapeutics].
    • Miki Y.
    • Gan To Kagaku Ryoho. 2012 Apr;39(4):498-501.
    • [Article in Japanese]
    • BRCA1 haploinsufficiency: consequences for breast cancer.
    • Salmena L, Narod S.
    • Womens Health (Lond Engl). 2012 Mar;8(2):127-9. doi: 10.2217/whe.12.2.
    • Commentary

    Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.

    • BRCA1 tumor suppressor network: focusing on its tail.
    • Wang B.
    • Cell Biosci. 2012 Feb 27;2(1):6. doi: 10.1186/2045-3701-2-6.
    • c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.
    • Regan JL, Kendrick H, Magnay FA, Vafaizadeh V, Groner B, Smalley MJ.
    • Oncogene. 2012 Feb 16;31(7):869-83. doi: 10.1038/onc.2011.289. Epub 2011 Jul 18.
    • BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies.
    • Dever SM, White ER, Hartman MC, Valerie K.
    • Cell Cycle. 2012 Feb 15;11(4):687-94. doi: 10.4161/cc.11.4.19212. Epub 2012 Feb 15.
    • Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis.
    • Cardinale F, Bruzzi P, Bolognesi C.
    • Br J Cancer. 2012 Feb 14;106(4):780-90. doi: 10.1038/bjc.2011.567. Epub 2011 Dec 20.
    • Promoter hypermethylation patterns in fallopian tube epithelium of BRCA1 and BRCA2 germ line mutation carriers.
    • Bijron JG, van der Groep P, van Dorst EB, Seeber LM, Sie-Go DM, Verheijen RH, van Diest PJ.
    • Endocr Relat Cancer. 2012 Feb 13;19(1):69-81. doi: 10.1530/ERC-11-0338. Print 2012 Feb.

    Comment:

    Epigenetic modification and cancer: mark or stamp?

    • The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.
    • Min J, Choi ES, Hwang K, Kim J, Sampath S, Venkitaraman AR, Lee H.
    • J Biol Chem. 2012 Feb 10;287(7):5091-101. doi: 10.1074/jbc.M111.278994. Epub 2011 Dec 20.
    • Functional differences among BRCA1 missense mutations in the control of centrosome duplication.
    • Kais Z, Chiba N, Ishioka C, Parvin JD.
    • Oncogene. 2012 Feb 9;31(6):799-804. doi: 10.1038/onc.2011.271. Epub 2011 Jul 4.
    • Characterization of BARD1 targeting and dynamics at the centrosome: the role of CRM1, BRCA1 and the Q564H mutation.
    • Brodie KM, Mok MT, Henderson BR.
    • Cell Signal. 2012 Feb;24(2):451-9. doi: 10.1016/j.cellsig.2011.09.024. Epub 2011 Oct 1.
    • Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
    • Somyajit K, Subramanya S, Nagaraju G.
    • J Biol Chem. 2012 Jan 27;287(5):3366-80. doi: 10.1074/jbc.M111.311241. Epub 2011 Dec 13.
    • CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.
    • Kim EH, Deng C, Sporn MB, Royce DB, Risingsong R, Williams CR, Liby KT.
    • Cancer Prev Res (Phila). 2012 Jan;5(1):89-97. doi: 10.1158/1940-6207.CAPR-11-0359. Epub 2011 Sep 20.
    • A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.
    • Feng Z, Zhang J.
    • Nucleic Acids Res. 2012 Jan;40(2):726-38. doi: 10.1093/nar/gkr748. Epub 2011 Sep 27.