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    • NPJ Breast Cancer. 2019 Nov 1;5:38. doi: 10.1038/s41523-019-0127-5. eCollection 2019.
    • Differences in cysteine peptidases-like activity in sera of patients with breast cancer.
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    • Cancer Biomark. 2019 Oct 25. doi: 10.3233/CBM-190327. [Epub ahead of print]
    • PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells.
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    • Mol Cell. 2019 Oct 23. pii: S1097-2765(19)30768-3. doi: 10.1016/j.molcel.2019.10.008. [Epub ahead of print]

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    • Amplification of the mutation-carrying BRCA2 allele promotes RAD51 loading and PARP inhibitor resistance in the absence of reversion mutations.
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    • Clinical Impact of RANK Signalling in Ovarian Cancer.
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    • Discovery of naphthacemycins as a novel class of PARP1 inhibitors.
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    • BRCA gene mutations do not shape the extent and organization of tumor infiltrating lymphocytes in triple negative breast cancer.
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    • Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.
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    • Novel poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitor, AZD2461, down-regulates VEGF and induces apoptosis in prostate cancer cells.
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    • Commentary
    • Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51.
    • Kaplan AR, Gueble SE, Liu Y, Oeck S, Kim H, Yun Z, Glazer PM.
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    • Talazoparib Loaded Solid Lipid Nanoparticles: Preparation, Characterization and Evaluation the Therapeutic Efficacy In Vitro.
    • Eskilera GG, Cecener G, Dikmen G, Egeli U, Tunca B.
    • Curr Drug Deliv. 2019 May 14. doi: 10.2174/1567201816666190515105532. [Epub ahead of print]
    • Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model.
    • Baldwin P, Ohman AW, Medina JE, McCarthy ET, Dinulescu DM, Sridhar S.
    • Front Oncol. 2019 May 10;9:353. doi: 10.3389/fonc.2019.00353. eCollection 2019.
    • Veliparib: a new therapeutic option in ovarian cancer?
    • Ghisoni E, Giannone G, Tuninetti V, Genta S, Scotto G, Aglietta M, Sangiolo D, Mittica G, Valabrega G.
    • Future Oncol. 2019 May 10. doi: 10.2217/fon-2018-0883. [Epub ahead of print]
    • Review
    • Associating expression and genomic data using co-occurrence measures.
    • Larmuseau M, Verbeke LPC, Marchal K.
    • Biol Direct. 2019 May 9;14(1):10. doi: 10.1186/s13062-019-0240-2.
    • The mechanism of cancer cell death by PARP inhibitors goes beyond DNA damage alone.
    • Macciò A, Madeddu C.
    • Int J Cancer. 2019 May 9. doi: 10.1002/ijc.32392. [Epub ahead of print]
    • Letter
    • WIP1 Contributes to the Adaptation of Fanconi Anemia Cells to DNA Damage as Determined by the Regulatory Network of the Fanconi Anemia and Checkpoint Recovery Pathways.
    • Rodríguez A, Naveja JJ, Torres L, García de Teresa B, Juárez-Figueroa U, Ayala-Zambrano C, Azpeitia E, Mendoza L, Frías S.
    • Front Genet. 2019 May 3;10:411. doi: 10.3389/fgene.2019.00411. eCollection 2019.
    • Design and Synthesis of Poly(ADP-ribose) polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.
    • Velagapudi UK, Langelier MF, Delgado-Martin C, Diolaiti ME, Bakker S, Ashworth A, Patel BA, Shao X, Pascal JM, Talele TT.
    • J Med Chem. 2019 May 1. doi: 10.1021/acs.jmedchem.8b01709. [Epub ahead of print]
    • BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile.
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    • J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
    • Association of BRCA1- and BRCA2-deficiency with mutation burden, expression of PD-L1/PD-1, immune infiltrates, and T cell-inflamed signature in breast cancer.
    • Wen WX, Leong CO.
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    • DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors.
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    • Neoplasia. 2019 Apr 24;21(6):533-544. doi: 10.1016/j.neo.2019.04.001. [Epub ahead of print]
    • Cellular responses of BRCA1-defective HCC1937 breast cancer cells induced by the antimetastasis ruthenium(II) arene compound RAPTA-T.
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    • Apoptosis. 2019 Apr 23. doi: 10.1007/s10495-019-01544-w. [Epub ahead of print]
    • PARP inhibitor efficacy depends on CD8+ T cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer.
    • Pantelidou C, Sonzogni O, de Oliveira Taveira M, Mehta AK, Kothari A, Wang D, Visal T, Li MK, Pinto J, Castrillon JA, Cheney EM, Bouwman P, Jonkers J, Rottenberg S, Guerriero JL, Wulf GM, Shapiro GI.
    • Cancer Discov. 2019 Apr 23. pii: CD-18-1218. doi: 10.1158/2159-8290.CD-18-1218. [Epub ahead of print]
    • Fluorescent C-NanoDots for rapid detection of BRCA1, CFTR and MRP3 gene mutations.
    • García-Mendiola T, Elosegui CG, Bravo I, Pariente F, Jacobo-Martin A, Navio C, Rodriguez I, Wannemacher R, Lorenzo E.
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    • Dual TGFβ/BMP pathway inhibition enables expansion and characterization of multiple epithelial cell types of the normal and cancerous breast.
    • Prasad M, Kumar B, Bhat-Nakshatri P, Anjanappa M, Sandusky G, Miller KD, Storniolo AM, Nakshatri H.
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    • Downregulation of APE1 potentiates breast cancer cells to olaparib by inhibiting PARP-1 expression.
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    • MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells.
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    • Therapeutic targeting of BRCA1 and TP53 mutant breast cancer through mutant p53 reactivation.
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    • BRCA1 and EZH2 cooperate in regulation of prostate cancer stem cell phenotype.
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    • N6-methylation of adenosine (m6A) of FZD10 mRNA contributes to PARP inhibitor resistance.
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    • β-hCG induced mutant BRCA1 ignites drug resistance in susceptible breast tissue.
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    • Beyond Trophic Factors: Exploiting the Intrinsic Regenerative Properties of Adult Neurons.
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    • Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.
    • Ordonez LD, Hay T, McEwen R, Polanska UM, Hughes A, Delpuech O, Cadogan E, Powell S, Dry J, Tornillo G, Silcock L, Leo E, O'Connor MJ, Clarke AR, Smalley MJ.
    • Oncotarget. 2019 Apr 5;10(27):2586-2606. doi: 10.18632/oncotarget.26830. eCollection 2019 Apr 5.
    • Dissecting PARP inhibitor resistance with functional genomics.
    • Pettitt SJ, Lord CJ.
    • Curr Opin Genet Dev. 2019 Apr 4;54:55-63. doi: 10.1016/j.gde.2019.03.001. [Epub ahead of print]
    • Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke.
    • Xu P, Shi X, Zhang X, Liu Q, Xie Y, Hong Y, Li J, Peng M, Liu X, Xu G.
    • Oxid Med Cell Longev. 2019 Apr 3;2019:8739730. doi: 10.1155/2019/8739730. eCollection 2019.
    • Metformin reverses PARP inhibitors-induced epithelial-mesenchymal transition and PD-L1 upregulation in triple-negative breast cancer.
    • Han Y, Li CW, Hsu JM, Hsu JL, Chan LC, Tan X, He GJ.
    • Am J Cancer Res. 2019 Apr 1;9(4):800-815. eCollection 2019.
    • 4-Hydroxytamoxifen enhances sensitivity of estrogen receptor α-positive breast cancer to docetaxel in an estrogen and ZNF423 SNP-dependent fashion.
    • Wang G, Qin S, Zayas J, Ingle JN, Liu M, Weinshilboum RM, Shen K, Wang L.
    • Breast Cancer Res Treat. 2019 Apr 1. doi: 10.1007/s10549-019-05194-z. [Epub ahead of print]
    • Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial.
    • Moore KN, Secord AA, Geller MA, Miller DS, Cloven N, Fleming GF, Wahner Hendrickson AE, Azodi M, DiSilvestro P, Oza AM, Cristea M, Berek JS, Chan JK, Rimel BJ, Matei DE, Li Y, Sun K, Luptakova K, Matulonis UA, Monk BJ.
    • Lancet Oncol. 2019 Apr 1. pii: S1470-2045(19)30029-4. doi: 10.1016/S1470-2045(19)30029-4. [Epub ahead of print]

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    • The estrogen receptor-alpha S118P variant does not affect breast cancer incidence or response to endocrine therapies.
    • Button B, Croessmann S, Chu D, Rosen DM, Zabransky DJ, Dalton WB, Cravero K, Kyker-Snowman K, Waters I, Karthikeyan S, Christenson ES, Donaldson J, Hunter T, Dennison L, Ramin C, May B, Roden R, Petry D, Armstrong DK, Visvanathan K, Park BH.
    • Breast Cancer Res Treat. 2019 Apr;174(2):401-412. doi: 10.1007/s10549-018-05087-7. Epub 2018 Dec 17.
    • RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.
    • Baldock RA, Pressimone CA, Baird JM, Khodakov A, Luong TT, Grundy MK, Smith CM, Karpenshif Y, Bratton-Palmer DS, Prakash R, Jasin M, Garcin EB, Gon S, Modesti M, Bernstein KA.
    • DNA Repair (Amst). 2019 Apr;76:99-107. doi: 10.1016/j.dnarep.2019.02.008. Epub 2019 Feb 23.
    • 53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer.
    • Hurley RM, Wahner Hendrickson AE, Visscher DW, Ansell P, Harrell MI, Wagner JM, Negron V, Goergen KM, Maurer MJ, Oberg AL, Meng XW, Flatten KS, De Jonge MJA, Van Herpen CD, Gietema JA, Koornstra RHT, Jager A, den Hollander MW, Dudley M, Shepherd SP, Swisher EM, Kaufmann SH.
    • Gynecol Oncol. 2019 Apr;153(1):127-134. doi: 10.1016/j.ygyno.2019.01.015. Epub 2019 Jan 25.
    • The SuprMam1 breast cancer susceptibility locus disrupts the vitamin D/ calcium/ parathyroid hormone pathway and alters bone structure in congenic mice.
    • Ratnadiwakara M, Rooke M, Ohms SJ, French HJ, Williams RBH, Li RW, Zhang D, Lucas RM, Blackburn AC.
    • J Steroid Biochem Mol Biol. 2019 Apr;188:48-58. doi: 10.1016/j.jsbmb.2018.12.004. Epub 2018 Dec 7.
    • GnRH-R targeted lytic peptide sensitizes BRCA wild-type ovarian cancer to PARP inhibition.
    • Ma S, Pradeep S, Villar-Prados A, Wen Y, Bayraktar E, Mangala LS, Kim MS, Wu SY, Hu W, Rodriguez-Aguayo C, Leuschner C, Liang X, Ram PT, Schlacher K, Coleman RL, Sood AK.
    • Mol Cancer Ther. 2019 Mar 29. pii: molcanther.0770.2018. doi: 10.1158/1535-7163.MCT-18-0770. [Epub ahead of print]
    • The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination.
    • Zhao W, Wiese C, Kwon Y, Hromas R, Sung P.
    • Annu Rev Biochem. 2019 Mar 27. doi: 10.1146/annurev-biochem-013118-111058. [Epub ahead of print]
    • Review
    • Genomic signatures predict the immunogenicity of BRCA-deficient breast cancer.
    • Kraya AA, Maxwell KN, Wubbenhorst B, Wenz BM, Pluta J, Rech AJ, Dorfman LM, Lunceford N, Barrett A, Mitra N, Morrissette JJ, Feldman M, Nayak A, Domchek SM, Vonderheide RH, Nathanson KL.
    • Clin Cancer Res. 2019 Mar 26. pii: clincanres.0468.2018. doi: 10.1158/1078-0432.CCR-18-0468. [Epub ahead of print]
    • Integrating Germline and Somatic Mutation Information for the Discovery of Biomarkers in Triple-Negative Breast Cancer.
    • Wu J, Mamidi TKK, Zhang L, Hicks C.
    • Int J Environ Res Public Health. 2019 Mar 23;16(6). pii: E1055. doi: 10.3390/ijerph16061055.
    • BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.
    • Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A.
    • Mol Cell. 2019 Mar 21;73(6):1267-1281.e7. doi: 10.1016/j.molcel.2018.12.010. Epub 2019 Jan 28.

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    Context Matters: RNF168 Connects with PALB2 to Rewire Homologous Recombination in BRCA1 Haploinsufficiency.

    • Polo-like Kinase 1 inhibition as a therapeutic approach to selectively target BRCA1-deficient cancer cells by synthetic lethality induction.
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    • Pietzner K, Nasser S, Alavi S, Darb-Esfahani S, Passler M, Muallem MZ, Sehouli J.
    • J Gynecol Oncol. 2018 Nov;29(6):e93. doi: 10.3802/jgo.2018.29.e93.
    • Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors.
    • Choi EK, Lim JA, Kim JK, Jang MS, Kim SE, Baek HJ, Park EJ, Kim TH, Deng CX, Wang RH, Kim SS.
    • Exp Mol Med. 2018 Oct 16;50(10):136. doi: 10.1038/s12276-018-0169-z.
    • Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors.
    • Baek HJ, Kim SE, Kim JK, Shin DH, Kim TH, Kim KG, Deng CX, Kim SS.
    • Int J Biol Sci. 2018 Oct 3;14(13):1769-1781. doi: 10.7150/ijbs.29242. eCollection 2018.
    • Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation.
    • Baek HJ, Kim SE, Choi EK, Kim JK, Shin DH, Park EJ, Kim TH, Kim JY, Kim KG, Deng CX, Kim SS.
    • Int J Biol Sci. 2018 Oct 3;14(12):1755-1768. doi: 10.7150/ijbs.28142. eCollection 2018.
    • Immunotherapy for Breast Cancer is Finally at the Doorstep: Immunotherapy in Breast Cancer.
    • De La Cruz LM, Czerniecki BJ.
    • Ann Surg Oncol. 2018 Oct;25(10):2852-2857. doi: 10.1245/s10434-018-6620-5. Epub 2018 Jul 16.
    • Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1.
    • Jain MR, Mohapatra J, Bandhyopadhyay D, Chatterjee A, Ghoshdastidar K, Patel D, Patel A, Bhayani H, Srivastava BK, Shedage SA, Kadam P, Sundar R, Patel H, Giri P, Patel P, Gupta L, Srinivas NR, Patel PR, Desai RC.
    • Cancer Chemother Pharmacol. 2018 Oct;82(4):635-647. doi: 10.1007/s00280-018-3653-1. Epub 2018 Jul 25.
    • Copper-CX-5461: A novel liposomal formulation for a small molecule rRNA synthesis inhibitor.
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    • J Control Release. 2018 Sep 28;286:1-9. doi: 10.1016/j.jconrel.2018.07.025. Epub 2018 Jul 18.
    • Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells.
    • Clements KE, Thakar T, Nicolae CM, Liang X, Wang HG, Moldovan GL.
    • Nucleic Acids Res. 2018 Sep 28;46(17):8898-8907. doi: 10.1093/nar/gky657.
    • BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
    • Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N.
    • Cell Rep. 2018 Sep 25;24(13):3513-3527.e7. doi: 10.1016/j.celrep.2018.08.086.
    • Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks.
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    • Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas.
    • Buckley AR, Ideker T, Carter H, Harismendy O, Schork NJ.
    • Genome Med. 2018 Sep 14;10(1):69. doi: 10.1186/s13073-018-0579-5.
    • MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancer.
    • Milevskiy MJG, Sandhu GK, Wronski A, Korbie D, Brewster BL, Shewan A, Edwards SL, French JD, Brown MA.
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    Related:

    Comment:

    MiRNAs prognostic for basal and BRCA1 breast cancer.

    • Radiosensitization by the PARP inhibitor olaparib in BRCA1-proficient and deficient high-grade serous ovarian carcinomas.
    • Bi Y, Verginadis II, Dey S, Lin L, Guo L, Zheng Y, Koumenis C.
    • Gynecol Oncol. 2018 Sep;150(3):534-544. doi: 10.1016/j.ygyno.2018.07.002. Epub 2018 Jul 17.
    • Evaluation of Microscopic Changes in Fallopian Tubes of BRCA Mutation Carriers by Morphometric Analysis of Histologic Slides: A Preliminary Pilot Study.
    • Amit A, Sabo E, Zohar Y, Trugman E, Pranovich I, Reiss A, Matanes E, Klorin G.
    • Int J Gynecol Pathol. 2018 Sep;37(5):460-467. doi: 10.1097/PGP.0000000000000440.
    • BRCA2 protects mammalian cells from heat shock.
    • Nakagawa Y, Kajihara A, Takahashi A, Murata AS, Matsubayashi M, Ito SS, Ota I, Nakagawa T, Hasegawa M, Kirita T, Ohnishi T, Mori E.
    • Int J Hyperthermia. 2018 Sep;34(6):795-801. doi: 10.1080/02656736.2017.1370558. Epub 2017 Sep 10.
    • BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling.
    • van de Ven M, Liu X, van der Burg E, Klarenbeek S, Alexi X, Zwart W, Dijcks F, Bouwman P, Jonkers J.
    • J Pathol. 2018 Sep;246(1):41-53. doi: 10.1002/path.5105. Epub 2018 Jul 4.
    • Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.
    • Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, Shiah YJ, Barsyte-Lovejoy D, Hofer S, Bader G, Lupien M, Arrowsmith C, Knapp S, De Carvalho D, Berman H, Boutros PC, Kislinger T, Khokha R.
    • J Cell Biol. 2018 Aug 6;217(8):2951-2974. doi: 10.1083/jcb.201804042. Epub 2018 Jun 19.

    Related:

    Press: Breast Cancer Epigenetics Study Reveals Potential Drug Targets. (Clinical OMICs)

    • Genetic dissection of the BRCA2 promoter and transcriptional impact of DNA variants.
    • Fraile-Bethencourt E, Valenzuela-Palomo A, Díez-Gómez B, Infante M, Durán M, Marcos G, Lastra E, Gómez-Barrero S, Velasco EA.
    • Breast Cancer Res Treat. 2018 Aug;171(1):53-63. doi: 10.1007/s10549-018-4826-7. Epub 2018 May 15.
    • Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.
    • Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L, Jacobs JJL, Galanty Y, Jackson SP.
    • Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18.
    • PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells.
    • Yin L, Liu Y, Peng Y, Peng Y, Yu X, Gao Y, Yuan B, Zhu Q, Cao T, He L, Gong Z, Sun L, Fan X, Li X.
    • J Exp Clin Cancer Res. 2018 Jul 16;37(1):153. doi: 10.1186/s13046-018-0810-7.
    • Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-κB in Mice with Disengaged BRCA1-PALB2 Interaction.
    • Mahdi AH, Huo Y, Tan Y, Simhadri S, Vincelli G, Gao J, Ganesan S, Xia B.
    • Cancer Res. 2018 Jul 15;78(14):3969-3981. doi: 10.1158/0008-5472.CAN-18-0388. Epub 2018 May 8.
    • Inhibition of mTOR downregulates expression of DNA repair proteins and is highly efficient against BRCA2-mutated breast cancer in combination to PARP inhibition.
    • El Botty R, Coussy F, Hatem R, Assayag F, Chateau-Joubert S, Servely JL, Leboucher S, Fouillade C, Vacher S, Ouine B, Cartier A, de Koning L, Cottu P, Bièche I, Marangoni E.
    • Oncotarget. 2018 Jul 3;9(51):29587-29600. doi: 10.18632/oncotarget.25640. eCollection 2018 Jul 3.
    • BRCA Status Does Not Predict Synergism of a Carboplatin and Olaparib Combination in High-Grade Serous Ovarian Cancer Cell Lines.
    • Shen YT, Evans JC, Zafarana G, Allen C, Piquette-Miller M.
    • Mol Pharm. 2018 Jul 2;15(7):2742-2753. doi: 10.1021/acs.molpharmaceut.8b00246. Epub 2018 Jun 1.
    • An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations.
    • Pulliam N, Fang F, Ozes AR, Tang J, Adewuyi A, Keer HN, Lyons JF, Baylin SB, Matei D, Nakshatri H, Rassool FV, Miller KD, Nephew KP.
    • Clin Cancer Res. 2018 Jul 1;24(13):3163-3175. doi: 10.1158/1078-0432.CCR-18-0204. Epub 2018 Apr 3.
    • Recapitulating the clinical scenario of BRCA-associated pancreatic cancer in pre-clinical models.
    • Golan T, Stossel C, Atias D, Buzhor E, Halperin S, Cohen K, Raitses-Gurevich M, Glick Y, Raskin S, Yehuda D, Feldman A, Schvimer M, Friedman E, Karni R, Wilson JM, Denroche RE, Lungu I, Bartlett JMS, Mbabaali F, Gallinger S, Berger R.
    • Int J Cancer. 2018 Jul 1;143(1):179-183. doi: 10.1002/ijc.31292. Epub 2018 Feb 23.
    • Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent.
    • Sizemore ST, Mohammad R, Sizemore GM, Nowsheen S, Yu H, Ostrowski MC, Chakravarti A, Xia F.
    • Mol Cancer Res. 2018 Jul;16(7):1092-1102. doi: 10.1158/1541-7786.MCR-18-0106. Epub 2018 Mar 28.
    • A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition.
    • Trenner A, Godau J, Sartori AA.
    • Mol Cancer Ther. 2018 Jul;17(7):1392-1404. doi: 10.1158/1535-7163.MCT-17-1156. Epub 2018 Apr 13.
    • BRCA1 Mutation Status and Follicular Fluid Exposure Alters NFκB Signaling and ISGylation in Human Fallopian Tube Epithelial Cells.
    • Hollingsworth J, Lau A, Tone A, Kollara A, Allen L, Colgan TJ, Dube V, Rosen B, Murphy KJ, Greenblatt EM, Feigenberg T, Virtanen C, Brown TJ.
    • Neoplasia. 2018 Jul;20(7):697-709. doi: 10.1016/j.neo.2018.05.005. Epub 2018 May 28.
    • Interleukin enhancer binding factor 2 is a prognostic biomarker for breast cancer that also predicts neoadjuvant chemotherapy responses.
    • Jin Z, Xu L, Zhang L, Zhao M, Li D, Ye L, Ma Y, Ren S, Yu H, Wang D, Liang C, Chen B.
    • Am J Transl Res. 2018 Jun 15;10(6):1677-1689. eCollection 2018.
    • Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells.
    • Sullivan-Reed K, Bolton-Gillespie E, Dasgupta Y, Langer S, Siciliano M, Nieborowska-Skorska M, Hanamshet K, Belyaeva EA, Bernhardy AJ, Lee J, Moore M, Zhao H, Valent P, Matlawska-Wasowska K, Müschen M, Bhatia S, Bhatia R, Johnson N, Wasik MA, Mazin AV, Skorski T.
    • Cell Rep. 2018 Jun 12;23(11):3127-3136. doi: 10.1016/j.celrep.2018.05.034.
    • Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
    • Gogola E, Duarte AA, de Ruiter JR, Wiegant WW, Schmid JA, de Bruijn R, James DI, Guerrero Llobet S, Vis DJ, Annunziato S, van den Broek B, Barazas M, Kersbergen A, van de Ven M, Tarsounas M, Ogilvie D, van Vugt M, Wessels LFA, Bartkova J, Gromova I, Andújar-Sánchez M, Bartek J, Lopes M, van Attikum H, Borst P, Jonkers J, Rottenberg S.
    • Cancer Cell. 2018 Jun 11;33(6):1078-1093.e12. doi: 10.1016/j.ccell.2018.05.008.
    • Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer.
    • Zhu Q, Hoong N, Aslanian A, Hara T, Benner C, Heinz S, Miga KH, Ke E, Verma S, Soroczynski J, Yates JR 3rd, Hunter T, Verma IM.
    • Mol Cell. 2018 Jun 7;70(5):842-853.e7. doi: 10.1016/j.molcel.2018.04.023. Epub 2018 May 31.
    • Capecitabine Efficacy Is Correlated with TYMP and RB1 Expression in PDX Established from Triple-Negative Breast Cancers.
    • Marangoni E, Laurent C, Coussy F, El-Botty R, Château-Joubert S, Servely JL, de Plater L, Assayag F, Dahmani A, Montaudon E, Nemati F, Fleury J, Vacher S, Gentien D, Rapinat A, Foidart P, Sounni NE, Noel A, Vincent-Salomon A, Lae M, Decaudin D, Roman-Roman S, Bièche I, Piccart M, Reyal F.
    • Clin Cancer Res. 2018 Jun 1;24(11):2605-2615. doi: 10.1158/1078-0432.CCR-17-3490. Epub 2018 Feb 20.
    • Reparameterization of PAM50 Expression Identifies Novel Breast Tumor Dimensions and Leads to Discovery of a Genome-Wide Significant Breast Cancer Locus at 12q15.
    • Madsen MJ, Knight S, Sweeney C, Factor R, Salama M, Stijleman IJ, Rajamanickam V, Welm BE, Arunachalam S, Jones B, Rachamadugu R, Rowe K, Cessna MH, Thomas A, Kushi LH, Caan BJ, Bernard PS, Camp NJ.
    • Cancer Epidemiol Biomarkers Prev. 2018 Jun;27(6):644-652. doi: 10.1158/1055-9965.EPI-17-0887. Epub 2018 Apr 12.
    • Targeting Tissue Factor for Immunotherapy of Triple-Negative Breast Cancer Using a Second-Generation ICON.
    • Hu Z, Shen R, Campbell A, McMichael E, Yu L, Ramaswamy B, London CA, Xu T, Carson WE 3rd.
    • Cancer Immunol Res. 2018 Jun;6(6):671-684. doi: 10.1158/2326-6066.CIR-17-0343. Epub 2018 Apr 5.
    • Increased centrosome number in BRCA-related breast cancer specimens determined by immunofluorescence analysis.
    • Watanabe G, Chiba N, Nomizu T, Furuta A, Sato K, Miyashita M, Tada H, Suzuki A, Ohuchi N, Ishida T.
    • Cancer Sci. 2018 Jun;109(6):2027-2035. doi: 10.1111/cas.13595. Epub 2018 May 15.
    • The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer.
    • Wilson AJ, Stubbs M, Liu P, Ruggeri B, Khabele D.
    • Gynecol Oncol. 2018 Jun;149(3):575-584. doi: 10.1016/j.ygyno.2018.03.049. Epub 2018 Mar 20.
    • Heat-induced BRCA2 degradation in human tumors provides rationale for hyperthermia-PARP-inhibitor combination therapies.
    • van den Tempel N, Odijk H, van Holthe N, Naipal K, Raams A, Eppink B, van Gent D, Hardillo J, Verduijn G, Drooger J, van Rhoon G, Smedts D, van Doorn H, Boormans J, Jager A, Franckena M, Kanaar R.
    • Int J Hyperthermia. 2018 Jun;34(4):407-414. doi: 10.1080/02656736.2017.1355487. Epub 2017 Jul 31.
    • Olaparib-induced Adaptive Response Is Disrupted by FOXM1 Targeting that Enhances Sensitivity to PARP Inhibition.
    • Fang P, Madden JA, Neums L, Moulder RK, Forrest ML, Chien J.
    • Mol Cancer Res. 2018 Jun;16(6):961-973. doi: 10.1158/1541-7786.MCR-17-0607. Epub 2018 Mar 15.
    • APTO-253 Is a New Addition to the Repertoire of Drugs that Can Exploit DNA BRCA1/2 Deficiency.
    • Tsai CY, Sun S, Zhang H, Local A, Su Y, Gross LA, Rice WG, Howell SB.
    • Mol Cancer Ther. 2018 Jun;17(6):1167-1176. doi: 10.1158/1535-7163.MCT-17-0834. Epub 2018 Apr 6.
    • Distinct DNA Methylation Profiles in Ovarian Tumors: Opportunities for Novel Biomarkers.
    • Losi L, Fonda S, Saponaro S, Chelbi ST, Lancellotti C, Gozzi G, Alberti L, Fabbiani L, Botticelli L, Benhattar J.
    • Int J Mol Sci. 2018 May 24;19(6). pii: E1559. doi: 10.3390/ijms19061559.
    • Compound F779-0434 causes synthetic lethality in BRCA2-deficient cancer cells by disrupting RAD52-ssDNA association.
    • Li J, Yang Q, Zhang Y, Huang K, Sun R, Zhao Q.
    • RSC Adv. 2018 May 23;8(34):18859-18869. doi: 10.1039/c8ra01919c.
    • Leucocytes telomere length and breast cancer risk/ susceptibility: A case-control study.
    • Pavanello S, Varesco L, Gismondi V, Bruzzi P, Bolognesi C.
    • PLoS One. 2018 May 21;13(5):e0197522. doi: 10.1371/journal.pone.0197522. eCollection 2018.
    • Tumor xenograft modeling identifies an association between TCF4 loss and breast cancer chemoresistance.
    • Ruiz de Garibay G, Mateo F, Stradella A, Valdés-Mas R, Palomero L, Serra-Musach J, Puente DA, Díaz-Navarro A, Vargas-Parra G, Tornero E, Morilla I, Farré L, Martinez-Iniesta M, Herranz C, McCormack E, Vidal A, Petit A, Soler T, Lázaro C, Puente XS, Villanueva A, Pujana MA.
    • Dis Model Mech. 2018 May 18;11(5). pii: dmm032292. doi: 10.1242/dmm.032292.
    • Role of BRCA1 in Neuronal Death in Alzheimer's Disease.
    • Wezyk M, Zekanowski C.
    • ACS Chem Neurosci. 2018 May 16;9(5):870-872. doi: 10.1021/acschemneuro.8b00149. Epub 2018 Apr 10.
    • Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.
    • Pettitt SJ, Krastev DB, Brandsma I, Dréan A, Song F, Aleksandrov R, Harrell MI, Menon M, Brough R, Campbell J, Frankum J, Ranes M, Pemberton HN, Rafiq R, Fenwick K, Swain A, Guettler S, Lee JM, Swisher EM, Stoynov S, Yusa K, Ashworth A, Lord CJ.
    • Nat Commun. 2018 May 10;9(1):1849. doi: 10.1038/s41467-018-03917-2.
    • DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
    • Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, Typas D, Lammers M, Mailand N, Nussenzweig A, Lukas J, Choudhary C.
    • Cell. 2018 May 3;173(4):972-988.e23. doi: 10.1016/j.cell.2018.03.050. Epub 2018 Apr 12.
    • BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development.
    • Kitami K, Kitami M, Kaku M, Wang B, Komatsu Y.
    • PLoS Genet. 2018 May 2;14(5):e1007340. doi: 10.1371/journal.pgen.1007340. eCollection 2018 May.
    • A PET imaging agent for evaluating PARP-1 expression in ovarian cancer.
    • Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL.
    • J Clin Invest. 2018 May 1;128(5):2116-2126. doi: 10.1172/JCI97992. Epub 2018 Apr 16.

    Related:

    Identifier: NCT02637934: Phase I Pilot Study of Biodistribution, Metabolism and Excretion of Novel Radiotracer [18F]Fluorthanatrace (FTT) by PET/CT. (ClinicalTrials.gov)

    Commentary:

    The evolving landscape of predictive biomarkers of response to PARP inhibitors.

    • SIRT5 as a biomarker for response to anthracycline-taxane-based neoadjuvant chemotherapy in triple-negative breast cancer.
    • Xu L, Che X, Wu Y, Song N, Shi S, Wang S, Li C, Zhang L, Zhang X, Qu X, Teng Y.
    • Oncol Rep. 2018 May;39(5):2315-2323. doi: 10.3892/or.2018.6319. Epub 2018 Mar 16.
    • Brca1 Is Upregulated by 5-Aza-CdR and Promotes DNA Repair and Cell Survival, and Inhibits Neurite Outgrowth in Rat Retinal Neurons.
    • Wang Q, Xu L, Chen P, Xu Z, Qiu J, Ge J, Yu K, Zhuang J.
    • Int J Mol Sci. 2018 Apr 17;19(4). pii: E1214. doi: 10.3390/ijms19041214.
    • PARP inhibitors in breast cancer: Bringing synthetic lethality to the bedside.
    • Turk AA, Wisinski KB.
    • Cancer. 2018 Jun 15;124(12):2498-2506. doi: 10.1002/cncr.31307. Epub 2018 Apr 16.
    • Targeting Brain-Adaptive Cancer Stem Cells Prohibits Brain Metastatic Colonization of Triple-Negative Breast Cancer.
    • Ren D, Zhu X, Kong R, Zhao Z, Sheng J, Wang J, Xu X, Liu J, Cui K, Zhang XH, Zhao H, Wong STC.
    • Cancer Res. 2018 Apr 15;78(8):2052-2064. doi: 10.1158/0008-5472.CAN-17-2994. Epub 2018 Mar 22.
    • Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer.
    • Dasa SSK, Diakova G, Suzuki R, Mills AM, Gutknecht MF, Klibanov AL, Slack-Davis JK, Kelly KA.
    • Theranostics. 2018 Apr 11;8(10):2782-2798. doi: 10.7150/thno.23050. eCollection 2018.
    • Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas.
    • Meghani K, Fuchs W, Detappe A, Drané P, Gogola E, Rottenberg S, Jonkers J, Matulonis U, Swisher EM, Konstantinopoulos PA, Chowdhury D.
    • Cell Rep. 2018 Apr 3;23(1):100-111. doi: 10.1016/j.celrep.2018.03.038.
    • Observations on the origin of ovarian cortical inclusion cysts in women undergoing risk-reducing salpingo-oophorectomy.
    • Park KJ, Patel P, Linkov I, Jotwani A, Kauff N, Pike MC.
    • Histopathology. 2018 Apr;72(5):766-776. doi: 10.1111/his.13444. Epub 2018 Jan 29.
    • PARP1-siRNA suppresses human prostate cancer cell growth and progression.
    • Lai Y, Kong Z, Zeng T, Xu S, Duan X, Li S, Cai C, Zhao Z, Wu W.
    • Oncol Rep. 2018 Apr;39(4):1901-1909. doi: 10.3892/or.2018.6238. Epub 2018 Jan 26.
    • Proteomics Analysis to Assess the Role of Mitochondria in BRCA1-Mediated Breast Tumorigenesis.
    • Concolino A, Olivo E, Tammè L, Fiumara CV, De Angelis MT, Quaresima B, Agosti V, Costanzo FS, Cuda G, Scumaci D.
    • Proteomes. 2018 Mar 27;6(2). pii: E16. doi: 10.3390/proteomes6020016.
    • Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.
    • Tang YC, Ho SC, Tan E, Ng AWT, McPherson JR, Goh GYL, Teh BT, Bard F, Rozen SG.
    • Breast Cancer Res. 2018 Mar 22;20(1):22. doi: 10.1186/s13058-018-0949-3.
    • Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.
    • Carvajal R, Fernández J, García N, López A, Gutiérrez-Enríquez S, Diez O, Benítez J, Salinas M, Teulé A, Brunet J, Radice P, Peterlongo P, Schindler D, Huertas P, Puente XS, Lázaro C, Pujana MÀ, Surrallés J.
    • Nat Commun. 2018 Mar 6;9(1):967. doi: 10.1038/s41467-018-03433-3.
    • Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer.
    • Dávila-González D, Choi DS, Rosato RR, Granados-Principal SM, Kuhn JG, Li WF, Qian W, Chen W, Kozielski AJ, Wong H, Dave B, Chang JC.
    • Clin Cancer Res. 2018 Mar 1;24(5):1152-1162. doi: 10.1158/1078-0432.CCR-17-1437. Epub 2018 Jan 4.
    • Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer.
    • Chen CC, Feng W, Lim PX, Kass EM, Jasin M.
    • Annu Rev Cancer Biol. 2018 Mar;2:313-336. doi: 10.1146/annurev-cancerbio-030617-050502. Epub 2017 Dec 1.
    • Co-targeting poly(ADP-ribose) polymerase (PARP) and histone deacetylase (HDAC) in triple-negative breast cancer: Higher synergism in BRCA mutated cells.
    • Marijon H, Lee DH, Ding L, Sun H, Gery S, de Gramont A, Koeffler HP.
    • Biomed Pharmacother. 2018 Mar;99:543-551. doi: 10.1016/j.biopha.2018.01.045. Epub 2018 Feb 20.
    • Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer.
    • Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC.
    • Cancer Discov. 2018 Mar;8(3):354-369. doi: 10.1158/2159-8290.CD-17-0679. Epub 2017 Dec 4.
    • BRCA1 and MAD2 Are Coexpressed and Are Prognostic Indicators in Tubo-ovarian High-Grade Serous Carcinoma.
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    Targeting "Retired Antigens" for Cancer Immunoprevention.

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    • Review
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    • Research news
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    Research report, Commentary:

    Thwarting endogenous stress: BRCA protects against aldehyde toxicity.

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    Aldehydes Pose a Threat to BRCA2 Mutation Carriers.

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    Aldehydes Promote BRCA2 Haploinsufficiency and Genomic Instability.

    Research report, Commentary:

    Thwarting endogenous stress: BRCA protects against aldehyde toxicity.

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    • Sci Signal. 2017 May 23;10(480). pii: eaam7479. doi: 10.1126/scisignal.aam7479.

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    Research news: Expanding the use of PARP inhibitors. (Nature Reviews Cancer)

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    • Responsiveness of Brca1 and Trp53 Deficiency-Induced Mammary Preneoplasia to Selective Estrogen Modulators versus an Aromatase Inhibitor in Mus musculus.
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    • Prophylactic window therapy with the clinical PARP inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice.
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    • The EMSY threonine 207 phospho-site is required for EMSYdriven suppression of DNA damage repair.
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    • Oncotarget. 2017 Feb 21;8(8):13792-13804. doi: 10.18632/oncotarget.14637.
    • CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
    • Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S.
    • Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432.
    • Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions.
    • Zámborszky J, Szikriszt B, Gervai JZ, Pipek O, Póti Á, Krzystanek M, Ribli D, Szalai-Gindl JM, Csabai I, Szallasi Z, Swanton C, Richardson AL, Szüts D.
    • Oncogene. 2017 Feb 9;36(6):746-755. doi: 10.1038/onc.2016.243. Epub 2016 Jul 25.
    • PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer.
    • Song W, Tang L, Xu Y, Xu J, Zhang W, Xie H, Wang S, Guan X.
    • Sci Rep. 2017 Feb 8;7:42319. doi: 10.1038/srep42319.
    • BRCA1-IRIS overexpression promotes and maintains the tumor initiating phenotype: implications for triple negative breast cancer early lesions.
    • Sinha A, Paul BT, Sullivan LM, Sims H, Bastawisy AE, Yousef HF, Zekri AN, Bahnassy AA, ElShamy WM.
    • Oncotarget. 2017 Feb 7;8(6):10114-10135. doi: 10.18632/oncotarget.14357.
    • Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.
    • Piao J, Takai S, Kamiya T, Inukai T, Sugita K, Ohyashiki K, Delia D, Masutani M, Mizutani S, Takagi M.
    • Cancer Lett. 2017 Feb 1;386:131-140. doi: 10.1016/j.canlet.2016.11.021. Epub 2016 Nov 25.
    • PARP-1 Expression Quantified by [18F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy.
    • Sander Effron S, Makvandi M, Lin L, Xu K, Li S, Lee H, Hou C, Pryma DA, Koch C, Mach RH.
    • Cancer Biother Radiopharm. 2017 Feb;32(1):9-15. doi: 10.1089/cbr.2016.2133. Epub 2017 Jan 24.
    • Updates on the role of receptor activator of nuclear factor κB/receptor activator of nuclear factor κB ligand/osteoprotegerin pathway in breast cancer risk and treatment.
    • Bayer CM, Beckmann MW, Fasching PA.
    • Curr Opin Obstet Gynecol. 2017 Feb;29(1):4-11. doi: 10.1097/GCO.0000000000000333.
    • Review
    • A novel hysteroscopic approach for ovarian cancer screening/early diagnosis.
    • Gizzo S, Noventa M, Quaranta M, Vitagliano A, Saccardi C, Litta P, Antona D.
    • Oncol Lett. 2017 Feb;13(2):549-553. doi: 10.3892/ol.2016.5493. Epub 2016 Dec 14.
    • Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer.
    • Wilkerson PM, Dedes KJ, Samartzis EP, Dedes I, Lambros MB, Natrajan R, Gauthier A, Piscuoglio S, Töpfer C, Vukovic V, Daley F, Weigelt B, Reis-Filho JS.
    • Oncotarget. 2017 Jan 24;8(4):6057-6066. doi: 10.18632/oncotarget.14011.
    • Chemopreventive effects of ROS targeting in a murine model of BRCA1-deficient breast cancer.
    • Li M, Yu X, Chen Q.
    • Cancer Res. 2017 Jan 15;77(2):448-458. doi: 10.1158/0008-5472.CAN-16-2350. Epub 2016 Nov 4.
    • A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers.
    • George E, Kim H, Krepler C, Wenz B, Makvandi M, Tanyi JL, Brown E, Zhang R, Brafford P, Jean S, Mach RH, Lu Y, Mills GB, Herlyn M, Morgan M, Zhang X, Soslow R, Drapkin R, Johnson N, Zheng Y, Cotsarelis G, Nathanson KL, Simpkins F.
    • JCI Insight. 2017 Jan 12;2(1):e89760. doi: 10.1172/jci.insight.89760.
    • Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.
    • Brandt S, Samartzis EP, Zimmermann AK, Fink D, Moch H, Noske A, Dedes KJ.
    • BMC Cancer. 2017 Jan 10;17(1):44. doi: 10.1186/s12885-016-3026-2.
    • Mutant p53: a novel target for the treatment of patients with triple-negative breast cancer?
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    • Int J Cancer. 2017 Jan 1;140(1):234-246. doi: 10.1002/ijc.30425. Epub 2016 Sep 24.
    • Can we prevent BRCA1-associated breast cancer by RANKL inhibition?
    • Kotsopoulos J, Singer C, Narod SA.
    • Breast Cancer Res Treat. 2017 Jan;161(1):11-16. doi: 10.1007/s10549-016-4029-z. Epub 2016 Oct 25.
    • Review
    • Differential expression of parental alleles of BRCA1 in human preimplantation embryos.
    • Tulay P, Doshi A, Serhal P, SenGupta SB.
    • Eur J Hum Genet. 2017 Jan;25(1):37-42. doi: 10.1038/ejhg.2016.121. Epub 2016 Sep 28.
    • Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes.
    • Kurozumi S, Yamaguchi Y, Kurosumi M, Ohira M, Matsumoto H, Horiguchi J.
    • J Hum Genet. 2017 Jan;62(1):15-24. doi: 10.1038/jhg.2016.89. Epub 2016 Jul 21.
    • MicroRNA in breast cancer: The association with BRCA1/2.
    • Nina P, Radoslav D, Vladan B, Milan O, Esma IR.
    • Cancer Biomark. 2017;19(2):119-128. doi: 10.3233/CBM-160319.
    • Review
    • Fork Protection and Therapy Resistance in Hereditary Breast Cancer.
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    • Cold Spring Harb Symp Quant Biol. 2017;82:339-348. doi: 10.1101/sqb.2017.82.034413. Epub 2018 Feb 22.
    • Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays.
    • Na Z, Pan S, Uttamchandani M, Yao SQ.
    • Methods Mol Biol. 2017;1518:139-156.
    • Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression.
    • Guimarães DAB, De Castro DDSB, de Oliveira FL, Nogueira EM, da Silva MAM, Teodoro AJ.
    • Oxid Med Cell Longev. 2017;2017:7865073. doi: 10.1155/2017/7865073. Epub 2017 Jul 6.
    • Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts.
    • Lohse I, Kumareswaran R, Cao P, Pitcher B, Gallinger S, Bristow RG, Hedley DW.
    • PLoS One. 2016 Dec 29;11(12):e0167272. doi: 10.1371/journal.pone.0167272. eCollection 2016.
    • Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor Olaparib by a dominant negative effect.
    • Vaclová T, Woods NT, Megías D, Gomez-Lopez S, Setién F, García Bueno JM, Macías JA, Barroso A, Urioste M, Esteller M, Monteiro AN, Benítez J, Osorio A.
    • Hum Mol Genet. 2016 Dec 15;25(24):5287-5299. doi: 10.1093/hmg/ddw343.
    • Yeast cells reveal the misfolding and the cellular mislocalisation of the human BRCA1 protein.
    • Thouvenot P, Fourrière L, Dardillac E, Ben Yamin B, Lescure A, Lejour V, Heiligenstein X, Boulé JB, Romao M, Raposo-Benedetti G, Lopez BS, Nicolas A, Millot GA.
    • J Cell Sci. 2016 Dec 1;129(23):4366-4378. Epub 2016 Oct 17.

    Related:

    "In This Issue":

    Yeast cells detect human BRCA1 misfolding.

    • Iodinated benzimidazole PARP radiotracer for evaluating PARP1/2 expression in vitro and in vivo.
    • Anderson RC, Makvandi M, Xu K, Lieberman BP, Zeng C, Pryma DA, Mach RH.
    • Nucl Med Biol. 2016 Dec;43(12):752-758. doi: 10.1016/j.nucmedbio.2016.08.007. Epub 2016 Aug 12.
    • The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer.
    • Luo J, Jin J, Yang F, Sun Z, Zhang W, Shi Y, Xu J, Guan X.
    • Int J Biol Sci. 2016 Nov 25;12(12):1500-1510. eCollection 2016.
    • Accurate clinical detection of exon copy number variants in a targeted NGS panel using DECoN.
    • Fowler A, Mahamdallie S, Ruark E, Seal S, Ramsay E, Clarke M, Uddin I, Wylie H, Strydom A, Lunter G, Rahman N.
    • Wellcome Open Res. 2016 Nov 25;1:20. doi: 10.12688/wellcomeopenres.10069.1.
    • CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.
    • Johnson SF, Cruz C, Greifenberg AK, Dust S, Stover DG, Chi D, Primack B, Cao S, Bernhardy AJ, Coulson R, Lazaro JB, Kochupurakkal B, Sun H, Unitt C, Moreau LA, Sarosiek KA, Scaltriti M, Juric D, Baselga J, Richardson AL, Rodig SJ, D'Andrea AD, Balmaña J, Johnson N, Geyer M, Serra V, Lim E, Shapiro GI.
    • Cell Rep. 2016 Nov 22;17(9):2367-2381. doi: 10.1016/j.celrep.2016.10.077.
    • Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition.
    • Murai J, Feng Y, Yu GK, Ru Y, Tang SW, Shen Y, Pommier Y.
    • Oncotarget. 2016 Nov 22;7(47):76534-76550. doi: 10.18632/oncotarget.12266.
    • Blood-based DNA methylation as biomarker for breast cancer: a systematic review.
    • Tang Q, Cheng J, Cao X, Surowy H, Burwinkel B.
    • Clin Epigenetics. 2016 Nov 14;8:115. eCollection 2016.
    • LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.
    • Wang YS, Chen J, Cui F, Wang H, Wang S, Hang W, Zeng Q, Quan CS, Zhai YX, Wang JW, Shen XF, Jian YP, Zhao RX, Werle KD, Cui R, Liang J, Li YL, Xu ZX.
    • Oncotarget. 2016 Nov 8;7(45):73389-73401. doi: 10.18632/oncotarget.12334.
    • The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells.
    • Bhute VJ, Ma Y, Bao X, Palecek SP.
    • Sci Rep. 2016 Nov 4;6:36061. doi: 10.1038/srep36061.
    • Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers.
    • Dunkel Y, Diao K, Aznar N, Swanson L, Liu L, Zhu W, Mi X, Ghosh P.
    • FASEB J. 2016 Nov;30(11):3702-3713. Epub 2016 Jul 20.
    • In vitro model for DNA double-strand break repair analysis in breast cancer reveals cell type-specific associations with age and prognosis.
    • Deniz M, Kaufmann J, Stahl A, Gundelach T, Janni W, Hoffmann I, Keimling M, Hampp S, Ihle M, Wiesmüller L.
    • FASEB J. 2016 Nov;30(11):3786-3799. Epub 2016 Aug 5.
    • Analysis of alternative lengthening of telomere markers in BRCA1 defective cells.
    • Kargaran PK, Yasaei H, Anjomani-Virmouni S, Mangiapane G, Slijepcevic P.
    • Genes Chromosomes Cancer. 2016 Nov;55(11):864-76. doi: 10.1002/gcc.22386. Epub 2016 Jul 26.
    • In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma.
    • AlHilli MM, Becker MA, Weroha SJ, Flatten KS, Hurley RM, Harrell MI, Oberg AL, Maurer MJ, Hawthorne KM, Hou X, Harrington SC, McKinstry S, Meng XW, Wilcoxen KM, Kalli KR, Swisher EM, Kaufmann SH, Haluska P.
    • Gynecol Oncol. 2016 Nov;143(2):379-388. doi: 10.1016/j.ygyno.2016.08.328. Epub 2016 Sep 8.
    • Neoplastic cellularity is associated with clinical and molecular features of high-grade serous ovarian carcinoma.
    • Morse CB, Norquist BM, Harrell MI, Agnew KJ, Gray HJ, Urban RR, Garcia RL, Goff BA, Swisher EM.
    • Gynecol Oncol. 2016 Nov;143(2):389-392. doi: 10.1016/j.ygyno.2016.08.324. Epub 2016 Aug 27.
    • RANKL/RANK: from bone loss to the prevention of breast cancer.
    • Sigl V, Jones LP, Penninger JM.
    • Open Biol. 2016 Nov;6(11). pii: 160230.
    • Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation.
    • Kass EM, Lim PX, Helgadottir HR, Moynahan ME, Jasin M.
    • Nat Commun. 2016 Oct 25;7:13241. doi: 10.1038/ncomms13241.
    • Expression of cancer related BRCA1 missense variants decreases MMS-induced recombination in Saccharomyces cerevisiae without altering its nuclear localization.
    • Lodovichi S, Vitello M, Cervelli T, Galli A.
    • Cell Cycle. 2016 Oct 17;15(20):2723-31. doi: 10.1080/15384101.2016.1215389. Epub 2016 Aug 2.
    • The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models.
    • Oplustil O'Connor L, Rulten SL, Cranston AN, Odedra R, Brown H, Jaspers JE, Jones L, Knights C, Evers B, Ting A, Bradbury RH, Pajic M, Rottenberg S, Jonkers J, Rudge D, Martin NM, Caldecott KW, Lau A, O'Connor MJ.
    • Cancer Res. 2016 Oct 15;76(20):6084-6094. Epub 2016 Aug 22.
    • The current status of PARP inhibitors in ovarian cancer.
    • McLachlan J, George A, Banerjee S.
    • Tumori. 2016 Oct 13;102(5):433-440. doi: 10.5301/tj.5000558. Epub 2016 Sep 24.
    • Review
    • Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.
    • Muvarak NE, Chowdhury K, Xia L, Robert C, Choi EY, Cai Y, Bellani M, Zou Y, Singh ZN, Duong VH, Rutherford T, Nagaria P, Bentzen SM, Seidman MM, Baer MR, Lapidus RG, Baylin SB, Rassool FV.
    • Cancer Cell. 2016 Oct 10;30(4):637-650. doi: 10.1016/j.ccell.2016.09.002.
    • Dysregulation of the BRCA1/long non-coding RNA NEAT1 signaling axis contributes to breast tumorigenesis.
    • Lo PK, Zhang Y, Wolfson B, Gernapudi R, Yao Y, Duru N, Zhou Q.
    • Oncotarget. 2016 Oct 4;7(40):65067-65089. doi: 10.18632/oncotarget.11364.
    • RING-less BRCA1 Induces PARP Inhibitor and Platinum Resistance.
    • [No authors listed]
    • Cancer Discov. 2016 Oct;6(10):OF6. Epub 2016 Aug 12.
    • BRCA2: a grown-up cancer susceptibility gene.
    • Foulkes WD, Sugano K.
    • Endocr Relat Cancer. 2016 Oct;23(10):E1-E3.

    Related:

    Review:

    BRCA2 functions: from DNA repair to replication fork stabilization.

    Review:

    Defects in homologous recombination repair behind the human diseases: FA and HBOC.

    Review:

    Synthetic lethality: the road to novel therapies for breast cancer.

    Review:

    Pancreatic ductal adenocarcinoma in BRCA2 mutation carriers.

    Review:

    Modifiers of breast and ovarian cancer risks for BRCA1 and BRCA2 mutation carriers.

    • BRCA2 functions: from DNA repair to replication fork stabilization.
    • Fradet-Turcotte A, Sitz J, Grapton D, Orthwein A.
    • Endocr Relat Cancer. 2016 Oct;23(10):T1-T17. Epub 2016 Aug 16.

    Related:

    Introductory article, Editorial:

    BRCA2: a grown-up cancer susceptibility gene.

    • Defects in homologous recombination repair behind the human diseases: FA and HBOC.
    • Katsuki Y, Takata M.
    • Endocr Relat Cancer. 2016 Oct;23(10):T19-T37. Epub 2016 Aug 22.

    Related:

    Introductory article, Editorial:

    BRCA2: a grown-up cancer susceptibility gene.

    • Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib.
    • Wilson AJ, Sarfo-Kantanka K, Barrack T, Steck A, Saskowski J, Crispens MA, Khabele D.
    • Gynecol Oncol. 2016 Oct;143(1):143-51. doi: 10.1016/j.ygyno.2016.07.088. Epub 2016 Jul 19.
    • Linking genotoxicity and cytotoxicity with membrane fluidity: A comparative study in ovarian cancer cell lines following exposure to auranofin.
    • Oommen D, Dodd NJ, Yiannakis D, Moyeed R, Jha AN.
    • Mutat Res. 2016 Oct;809:43-49. doi: 10.1016/j.mrgentox.2016.09.003. Epub 2016 Sep 4.
    • Tumor Cell Recovery from Senescence Induced by Radiation with PARP Inhibition.
    • Gewirtz DA, Alotaibi M, Yakovlev VA, Povirk LF.
    • Radiat Res. 2016 Oct;186(4):327-332. Epub 2016 Sep 2.
    • Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
    • Warmoes M, Lam SW, der Groep PV, Jaspers JE, Smolders YH, de Boer L, Pham TV, Piersma SR, Rottenberg S, Boven E, Jonkers J, van Diest PJ, Jimenez CR.
    • Oncotarget. 2016 Sep 27;7(39):63537-63548. doi: 10.18632/oncotarget.11535.
    • A second DNA binding site in human BRCA2 promotes homologous recombination.
    • von Nicolai C, Ehlén Å, Martin C, Zhang X, Carreira A.
    • Nat Commun. 2016 Sep 15;7:12813. doi: 10.1038/ncomms12813.
    • 53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
    • Hong R, Ma F, Zhang W, Yu X, Li Q, Luo Y, Zhu C, Jiang W, Xu B.
    • BMC Cancer. 2016 Sep 9;16(1):725. doi: 10.1186/s12885-016-2754-7.
    • Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective study.
    • Kim SJ, Zuchniak A, Sohn KJ, Lubinski J, Demsky R, Eisen A, Akbari MR, Kim YI, Narod SA, Kotsopoulos J.
    • Am J Clin Nutr. 2016 Sep;104(3):671-7. doi: 10.3945/ajcn.116.133470. Epub 2016 Jul 27.
    • PTIP Loss Protects BRCA-Deficient Cells from DNA Damage and Cell Death.
    • [No authors listed]
    • Cancer Discov. 2016 Sep;6(9):944. doi: 10.1158/2159-8290.CD-RW2016-142. Epub 2016 Jul 29.
    • Research Watch
    • A Review of Whole Exome Sequencing Efforts Toward Hereditary Breast Cancer Susceptibility Gene Discovery.
    • Chandler MR, Bilgili EP, Merner ND.
    • Hum Mutat. 2016 Sep;37(9):835-46. doi: 10.1002/humu.23017. Epub 2016 Jun 27.
    • Review
    • Post-transcriptional Regulation of BRCA2 through Interactions with miR-19a and miR-19b.
    • Mogilyansky E, Clark P, Quann K, Zhou H, Londin E, Jing Y, Rigoutsos I.
    • Front Genet. 2016 Aug 31;7:143. doi: 10.3389/fgene.2016.00143. eCollection 2016.
    • NCI Launches Large Study of Breast Cancer Genetics in Black Women
    • Jennifer Abbasi
    • JAMA. 2016 Aug 23;316(8):808. doi:10.1001/jama.2016.11180.
    • News
    • Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specific.
    • Chehade R, Pettapiece-Phillips R, Salmena L, Kotlyar M, Jurisica I, Narod SA, Akbari MR, Kotsopoulos J.
    • Breast Cancer Res. 2016 Aug 17;18(1):87. doi: 10.1186/s13058-016-0739-8.
    • Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: Evidence for metformin-based "starvation" strategies in BRCA1 carriers.
    • Cuyàs E, Fernández-Arroyo S, Alarcón T, Lupu R, Joven J, Menendez JA.
    • Oncotarget. 2016 Aug 16;7(33):52974-52992. doi: 10.18632/oncotarget.9732.
    • Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.
    • Hartford SA, Chittela R, Ding X, Vyas A, Martin B, Burkett S, Haines DC, Southon E, Tessarollo L, Sharan SK.
    • PLoS Genet. 2016 Aug 4;12(8):e1006236. doi: 10.1371/journal.pgen.1006236. eCollection 2016.
    • BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.
    • Drost R, Dhillon KK, van der Gulden H, van der Heijden I, Brandsma I, Cruz C, Chondronasiou D, Castroviejo-Bermejo M, Boon U, Schut E, van der Burg E, Wientjens E, Pieterse M, Klijn C, Klarenbeek S, Loayza-Puch F, Elkon R, van Deemter L, Rottenberg S, van de Ven M, Dekkers DH, Demmers JA, van Gent DC, Agami R, Balmaña J, Serra V, Taniguchi T, Bouwman P, Jonkers J.
    • J Clin Invest. 2016 Aug 1;126(8):2903-18. doi: 10.1172/JCI70196. Epub 2016 Jul 25.

    Related:

    Editorial / Commentary

    BRCA1 loses the ring but lords over resistance.

    • RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance.
    • Wang Y, Krais JJ, Bernhardy AJ, Nicolas E, Cai KQ, Harrell MI, Kim HH, George E, Swisher EM, Simpkins F, Johnson N.
    • J Clin Invest. 2016 Aug 1;126(8):3145-57. doi: 10.1172/JCI87033. Epub 2016 Jul 25.

    Related:

    Editorial / Commentary

    BRCA1 loses the ring but lords over resistance.

    • Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein.
    • Alshareeda AT, Negm OH, Aleskandarany MA, Green AR, Nolan C, TigHhe PJ, Madhusudan S, Ellis IO, Rakha EA.
    • Breast Cancer Res Treat. 2016 Aug;159(1):41-53. doi: 10.1007/s10549-016-3915-8. Epub 2016 Jul 27.
    • Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies.
    • Hellner K, Miranda F, Fotso Chedom D, Herrero-Gonzalez S, Hayden DM, Tearle R, Artibani M, KaramiNejadRanjbar M, Williams R, Gaitskell K, Elorbany S, Xu R, Laios A, Buiga P, Ahmed K, Dhar S, Zhang RY, Campo L, Myers KA, Lozano M, Ruiz-Miró M, Gatius S, Mota A, Moreno-Bueno G, Matias-Guiu X, Benítez J, Witty L, McVean G, Leedham S, Tomlinson I, Drmanac R, Cazier JB, Klein R, Dunne K, Bast RC Jr, Kennedy SH, Hassan B, Lise S, Garcia MJ, Peters BA, Yau C, Sauka-Spengler T, Ahmed AA.
    • EBioMedicine. 2016 Aug;10:137-49. doi: 10.1016/j.ebiom.2016.06.048. Epub 2016 Jul 2.
    • Tumour cell membrane laminin expression is associated with basal-like phenotype and poor survival in Nigerian breast cancer.
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    • Malays J Pathol. 2016 Aug;38(2):83-92.
    • RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.
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    • Nat Med. 2016 Aug;22(8):933-9. doi: 10.1038/nm.4118. Epub 2016 Jun 20.
    • FANCD2 limits replication stress and genome instability in cells lacking BRCA2.
    • Michl J, Zimmer J, Buffa FM, McDermott U, Tarsounas M.
    • Nat Struct Mol Biol. 2016 Aug;23(8):755-7. doi: 10.1038/nsmb.3252. Epub 2016 Jun 20.

    Related:

    Editorial / Commentary

    A route to new cancer therapies: the FA pathway is essential in BRCA1- or BRCA2-deficient cells.

    • MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib.
    • Whicker ME, Lin ZP, Hanna R, Sartorelli AC, Ratner ES.
    • BMC Cancer. 2016 Jul 27;16(1):550. doi: 10.1186/s12885-016-2598-1.
    • Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
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    • PLoS One. 2016 Jul 27;11(7):e0158801. doi: 10.1371/journal.pone.0158801.
    • Levels of DNA Methylation Vary at CpG Sites across the BRCA1 Promoter, and Differ According to Triple Negative and "BRCA-Like" Status, in Both Blood and Tumour DNA.
    • Daniels SL, Burghel GJ, Chambers P, Al-Baba S, Connley DD, Brock IW, Cramp HE, Dotsenko O, Wilks O, Wyld L, Cross SS, Cox A
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    • Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells.
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    • Elife. 2016 Jul 19;5. pii: e14740. doi: 10.7554/eLife.14740.
    • Proliferation and ovarian hormone signaling are impaired in normal breast tissues from women with BRCA1 mutations: benefit of a progesterone receptor modulator treatment as a breast cancer preventive strategy in women with inherited BRCA1 mutations.
    • Communal L, Vilasco M, Hugon-Rodin J, Courtin A, Mourra N, Lahlou N, Le Guillou M, Perrault de Jotemps M, Chauvet MP, Chaouat M, Pujol P, Feunteun J, Delaloge S, Forgez P, Gompel A.
    • Oncotarget. 2016 Jul 19;7(29):45317-45330. doi: 10.18632/oncotarget.9638.
    • Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.
    • Sau A, Lau R, Cabrita MA, Nolan E, Crooks PA, Visvader JE, Pratt MA.
    • Cell Stem Cell. 2016 Jul 7;19(1):52-65. doi: 10.1016/j.stem.2016.05.003. Epub 2016 Jun 9.
    • NIH launches largest-ever study of breast cancer genetics in black women.
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    • Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer.
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    • J Natl Cancer Inst. 2016 Jul 5;108(11). pii: djw148. Print 2016 Nov.
    • RANKL/RANK control Brca1 mutation-driven mammary tumors.
    • Sigl V, Owusu-Boaitey K, Joshi PA, Kavirayani A, Wirnsberger G, Novatchkova M, Kozieradzki I, Schramek D, Edokobi N, Hersl J, Sampson A, Odai-Afotey A, Lazaro C, Gonzalez-Suarez E, Pujana MA, Cimba F, Heyn H, Vidal E, Cruickshank J, Berman H, Sarao R, Ticevic M, Uribesalgo I, Tortola L, Rao S, Tan Y, Pfeiler G, Lee EY, Bago-Horvath Z, Kenner L, Popper H, Singer C, Khokha R, Jones LP, Penninger JM.
    • Cell Res. 2016 Jul;26(7):761-74. doi: 10.1038/cr.2016.69. Epub 2016 May 31.

    Related:

    Prevention of breast cancer by RANKL/RANK blockade.

    • BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine.
    • Gu Y, Helenius M, Väänänen K, Bulanova D, Saarela J, Sokolenko A, Martens J, Imyanitov E, Kuznetsov S.
    • Sci Rep. 2016 Jun 17;6:28217. doi: 10.1038/srep28217.
    • Targeted Vaccination against Human α-Lactalbumin for Immunotherapy and Primary Immunoprevention of Triple Negative Breast Cancer.
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    • Cancers (Basel). 2016 Jun 16;8(6). pii: E56. doi: 10.3390/cancers8060056.
    • FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.
    • Kais Z, Rondinelli B, Holmes A, O'Leary C, Kozono D, D'Andrea AD, Ceccaldi R.
    • Cell Rep. 2016 Jun 14;15(11):2488-99. doi: 10.1016/j.celrep.2016.05.031. Epub 2016 Jun 2.
    • An In Vivo Gain-of-Function Screen Identifies the Williams-Beuren Syndrome Gene GTF2IRD1 as a Mammary Tumor Promoter.
    • Huo Y, Su T, Cai Q, Macara IG.
    • Cell Rep. 2016 Jun 7;15(10):2089-96. doi: 10.1016/j.celrep.2016.05.011. Epub 2016 May 26.
    • Prolactin inhibits a major tumor-suppressive function of wild type BRCA1.
    • Chen KH, Walker AM.
    • Cancer Lett. 2016 Jun 1;375(2):293-302. doi: 10.1016/j.canlet.2016.03.007. Epub 2016 Mar 9.
    • Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells.
    • Somasundaram V, Hemalatha SK, Pal K, Sinha S, Nair AS, Mukhopadhyay D, Srinivas P.
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    • Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.
    • Huang F, Goyal N, Sullivan K, Hanamshet K, Patel M, Mazina OM, Wang CX, An WF, Spoonamore J, Metkar S, Emmitte KA, Cocklin S, Skorski T, Mazin AV.
    • Nucleic Acids Res. 2016 May 19;44(9):4189-99. doi: 10.1093/nar/gkw087. Epub 2016 Feb 11.
    • BRCA2 minor transcript lacking exons4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation.
    • Thirthagiri E, Klarmann KD, Shukla AK, Southon E, Biswas K, Martin BK, North SL, Magidson V, Burkett S, Haines DC, Noer K, Matthai R, Tessarollo L, Loncarek J, Keller JR, Sharan SK.
    • Hum Mol Genet. 2016 May 15;25(10):1934-1945. Epub 2016 Feb 26.
    • Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients.
    • Hamam D, Abdouh M, Gao ZH, Arena V, Arena M, Arena GO.
    • J Exp Clin Cancer Res. 2016 May 14;35(1):80. doi: 10.1186/s13046-016-0360-9.
    • The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.
    • Wang Y, Bernhardy AJ, Cruz C, Krais JJ, Nacson J, Nicolas E, Peri S, van der Gulden H, van der Heijden I, O'Brien SW, Zhang Y, Harrell MI, Johnson SF, Candido Dos Reis FJ, Pharoah PD, Karlan B, Gourley C, Lambrechts D, Chenevix-Trench G, Olsson H, Benitez JJ, Greene MH, Gore M, Nussbaum R, Sadetzki S, Gayther SA, Kjaer SK; kConFab Investigators, D'Andrea AD, Shapiro GI, Wiest DL, Connolly DC, Daly MB, Swisher EM, Bouwman P, Jonkers J, Balmaña J, Serra V, Johnson N.
    • Cancer Res. 2016 May 1;76(9):2778-90. doi: 10.1158/0008-5472.CAN-16-0186.

    Related:

    News: Preventing Drug Resistance in Patients With Germline BRCA1 Mutations. (OncoTherapy Network)

    • Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer.
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    • Gene. 2016 Apr 15;580(2):159-68. doi: 10.1016/j.gene.2016.01.023. Epub 2016 Jan 16.
    • MicroRNA deregulation in triple negative breast cancer reveals a role of miR-498 in regulating BRCA1 expression.
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    • Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2.
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    • miR-342 overexpression results in a synthetic lethal phenotype in BRCA1-mutant HCC1937 breast cancer cells.
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    • Inhibition of Poly(ADP-Ribose) Polymerase by Nucleic Acid Metabolite 7-Methylguanine.
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    • Examining the Relationship between Pre-Malignant Breast Lesions, Carcinogenesis and Tumor Evolution in the Mammary Epithelium Using an Agent-Based Model.
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    • Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome.
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    • Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.
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    • Mol Cell. 2016 Feb 18;61(4):535-46. doi: 10.1016/j.molcel.2015.12.026. Epub 2016 Jan 28.
    • BRCA1 deficiency increases the sensitivity of ovarian cancer cells to auranofin.
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    • Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
    • Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR 4th, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC.
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    • Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice.
    • Vasanthakumar A, Arnovitz S, Marquez R, Lepore J, Rafidi G, Asom A, Weatherly M, Davis EM, Neistadt B, Duszynski R, Vardiman JW, Le Beau MM, Godley LA, Churpek JE.
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    • It's Totally Tubular…Riding The New Wave of Ovarian Cancer Research.
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    • Review
    • Regulators of genetic risk of breast cancer identified by integrative network analysis.
    • Castro MA, de Santiago I, Campbell TM, Vaughn C, Hickey TE, Ross E, Tilley WD, Markowetz F, Ponder BA, Meyer KB.
    • Nat Genet. 2016 Jan;48(1):12-21. doi: 10.1038/ng.3458. Epub 2015 Nov 30.
    • DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.
    • Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, Masliah E, Mucke L.
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    • Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.
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    • Chem Biol. 2015 Nov 19;22(11):1491-504. doi: 10.1016/j.chembiol.2015.10.003. Epub 2015 Nov 5.
    • Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response.
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    • Brca1 Mutations Enhance Mouse Reproductive Functions by Increasing Responsiveness to Male-Derived Scent.
    • Liu Y, Pike MC, Wu N, Lin YG, Mucowski S, Punj V, Tang Y, Yen HY, Stanczyk FZ, Enbom E, Austria T, Widschwendter M, Maxson R, Dubeau L.
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    • Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential.
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    • Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties.
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    • The role of Rak in the regulation of stability and function of BRCA1.
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    • MSH2 role in BRCA1-driven tumorigenesis: A preliminary study in yeast and in human tumors from BRCA1-VUS carriers.
    • Maresca L, Spugnesi L, Lodovichi S, Cozzani C, Naccarato AG, Tancredi M, Collavoli A, Falaschi E, Rossetti E, Aretini P, Cervelli T, Galli A, Caligo MA.
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    • YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.
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    • Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition.
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    • A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State.
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    Related:

    Comment

    A Quest for Better Mouse Models of Breast and Ovarian Cancers.

    • Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers.
    • Widschwendter M, Burnell M, Fraser L, Rosenthal AN, Philpott S, Reisel D, Dubeau L, Cline M, Pan Y, Yi PC, Gareth Evans D, Jacobs IJ, Menon U, Wood CE, Dougall WC.
    • EBioMedicine. 2015 Sep 9;2(10):1331-9. doi: 10.1016/j.ebiom.2015.08.037. eCollection 2015.

    Related:

    Commentary

    RANKL/OPG in Breast Cancer - Extending Its Territory to BRCA Mutation Carriers.

    • Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease.
    • Fleury H, Communal L, Carmona E, Portelance L, Arcand SL, Rahimi K, Tonin PN, Provencher D, Mes-Masson AM.
    • Genes Cancer. 2015 Sep;6(9-10):378-398.
    • Ethnicity-Dependent and -Independent Heterogeneity in Healthy Normal Breast Hierarchy Impacts Tumor Characterization.
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    • The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1(-/-) murine model of ovarian cancer.
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    • BRCA1: Beyond double-strand break repair.
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    • Review
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    • Deciphering the BRCA1 Tumor Suppressor Network.
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    • Review
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    • FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis.
    • Huang YL, Chou WC, Hsiung CN, Hu LY, Chu HW, Shen CY.
    • Hum Mol Genet. 2015 Jun 15;24(12):3506-17. doi: 10.1093/hmg/ddv102. Epub 2015 Mar 18.
    • Mislocalization of BRCA1-complex due to ABRAXAS Arg361Gln mutation.
    • Vikrant, Kumar R, Siddiqui Q, Singh N, Waghmare SK, Varma AK.
    • J Biomol Struct Dyn. 2015 Jun;33(6):1291-301. doi: 10.1080/07391102.2014.945484. Epub 2014 Aug 8.
    • Autoimmune response to PARP and BRCA1/BRCA2 in cancer.
    • Zhu Q, Han SX, Zhou CY, Cai MJ, Dai LP, Zhang JY.
    • Oncotarget. 2015 May 10;6(13):11575-84.
    • Microarray analysis of differentially expressed genes in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies.
    • Veskimäe K, Staff S, Tabaro F, Nykter M, Isola J, Mäenpää J.
    • Genes Chromosomes Cancer. 2015 May;54(5):276-87. doi: 10.1002/gcc.22241. Epub 2015 Feb 23.
    • Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins.
    • Prakash R, Zhang Y, Feng W, Jasin M.
    • Cold Spring Harb Perspect Biol. 2015 Apr 1;7(4). pii: a016600. doi: 10.1101/cshperspect.a016600.
    • Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer.
    • Boerner JL, Nechiporchik N, Mueller KL, Polin L, Heilbrun L, Boerner SA, Zoratti GL, Stark K, LoRusso PM, Burger A.
    • PLoS One. 2015 Mar 16;10(3):e0119614. doi: 10.1371/journal.pone.0119614. eCollection 2015.
    • BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance.
    • Jaspers JE, Sol W, Kersbergen A, Schlicker A, Guyader C, Xu G, Wessels L, Borst P, Jonkers J, Rottenberg S.
    • Cancer Res. 2015 Feb 15;75(4):732-41. doi: 10.1158/0008-5472.CAN-14-0839. Epub 2014 Dec 15.
    • BRCA mutations cause reduction in miR-200c expression in triple negative breast cancer.
    • Erturk E, Cecener G, Tezcan G, Egeli U, Tunca B, Gokgoz S, Tolunay S, Tasdelen I.
    • Gene. 2015 Feb 10;556(2):163-9. doi: 10.1016/j.gene.2014.11.047. Epub 2014 Nov 22.
    • BRCA1, a 'complex' protein involved in the maintenance of genomic stability.
    • Savage KI, Harkin DP.
    • FEBS J. 2015 Feb;282(4):630-46. doi: 10.1111/febs.13150. Epub 2014 Dec 2.
    • It is not all about BRCA: Cullin-Ring ubiquitin Ligases in ovarian cancer.
    • Carlucci A, D'Angiolella V.
    • Br J Cancer. 2015 Jan 6;112(1):9-13. doi: 10.1038/bjc.2014.594. Epub 2014 Dec 9.
    • MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis.
    • Danza K, De Summa S, Pinto R, Pilato B, Palumbo O, Merla G, Simone G, Tommasi S.
    • Oncotarget. 2015 Jan 1;6(1):471-83.
    • Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase.
    • Somyajit K, Mishra A, Jameei A, Nagaraju G.
    • Carcinogenesis. 2015 Jan;36(1):13-24. doi: 10.1093/carcin/bgu211. Epub 2014 Oct 7.
    • BRCA1 185delAG Mutation Enhances Interleukin-1β Expression in Ovarian Surface Epithelial Cells.
    • Woolery KT, Mohamed M, Linger RJ, Dobrinski KP, Roman J, Kruk PA.
    • Biomed Res Int. 2015;2015:652017. doi: 10.1155/2015/652017. Epub 2015 Aug 19.
    • Orchestration of DSB repair: a novel BRCA2 connection.
    • Gatti L, Perego P.
    • Cell Cycle. 2015;14(14):2195-6. doi: 10.1080/15384101.2015.1056614. Epub 2015 Jun 1.

    Related:

    BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.

    • Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites.
    • Desai A, Xu J, Aysola K, Akinbobuyi O, White M, Reddy VE, Okoli J, Clark C, Partridge EE, Childs E, Beech DJ, Rice MV, Reddy E, Rao VN.
    • J Gynecol Res. 2015;1(1). pii: 103. Epub 2015 Apr 24.
    • Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation.
    • Niskakoski A, Kaur S, Staff S, Renkonen-Sinisalo L, Lassus H, Järvinen HJ, Mecklin JP, Bützow R, Peltomäki P.
    • Epigenetics. 2014 Dec 2;9(12):1577-87. doi: 10.4161/15592294.2014.983374.
    • Morphological and immunohistochemical pattern of tubo-ovarian dysplasia and serous tubal intraepithelial carcinoma.
    • Chene G, Cayre A, Raoelfils I, Lagarde N, Dauplat J, Penault-Llorca F.
    • Eur J Obstet Gynecol Reprod Biol. 2014 Dec;183:89-95. doi: 10.1016/j.ejogrb.2014.10.003. Epub 2014 Oct 14.
    • TGFβ Induces "BRCAness" and Sensitivity to PARP Inhibition in Breast Cancer by Regulating DNA-Repair Genes.
    • Liu L, Zhou W, Cheng CT, Ren X, Somlo G, Fong MY, Chin AR, Li H, Yu Y, Xu Y, O'Connor ST, O'Connor TR, Ann DK, Stark JM, Wang SE.
    • Mol Cancer Res. 2014 Nov;12(11):1597-609. doi: 10.1158/1541-7786.MCR-14-0201. Epub 2014 Aug 7.
    • A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer.
    • Li D, Bi FF, Chen NN, Cao JM, Sun WP, Zhou YM, Li CY, Yang Q.
    • Sci Rep. 2014 Oct 17;4:6666. doi: 10.1038/srep06666.
    • Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer.
    • García-Parra J, Dalmases A, Morancho B, Arpí O, Menendez S, Sabbaghi M, Zazo S, Chamizo C, Madoz J, Eroles P, Servitja S, Tusquets I, Yelamos J, Lluch A, Arribas J, Rojo F, Rovira A, Albanell J.
    • Eur J Cancer. 2014 Oct;50(15):2725-34. doi: 10.1016/j.ejca.2014.07.004. Epub 2014 Aug 12.
    • BRCA1 mRNA levels following a 4-6-week intervention with oral 3,3'-diindolylmethane.
    • Kotsopoulos J, Zhang S, Akbari M, Salmena L, Llacuachaqui M, Zeligs M, Sun P, Narod SA.
    • Br J Cancer. 2014 Sep 23;111(7):1269-1274. doi: 10.1038/bjc.2014.391. Epub 2014 Jul 15.
    • Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors.
    • Vassilopoulos A, Xiao C, Chisholm C, Chen W, Xu X, Lahusen TJ, Bewley C, Deng CX.
    • J Biol Chem. 2014 Aug 29;289(35):24202-14. doi: 10.1074/jbc.M114.567552. Epub 2014 Jul 8.
    • Male Fertility Defect Associated with Disrupted BRCA1-PALB2 Interaction in Mice.
    • Simhadri S, Peterson S, Patel DS, Huo Y, Cai H, Bowman-Colin C, Miller S, Ludwig T, Ganesan S, Bhaumik M, Bunting SF, Jasin M, Xia B.
    • J Biol Chem. 2014 Aug 29;289(35):24617-29. doi: 10.1074/jbc.M114.566141. Epub 2014 Jul 11.
    • Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: a report from the ENIGMA consortium.
    • Colombo M, Blok MJ, Whiley P, Santamariña M, Gutiérrez-Enríquez S, Romero A, Garre P, Becker A, Smith LD, De Vecchi G, Brandão RD, Tserpelis D, Brown M, Blanco A, Bonache S, Menéndez M, Houdayer C, Foglia C, Fackenthal JD, Baralle D, Wappenschmidt B; kConFaB Investigators, Díaz-Rubio E, Caldés T, Walker L, Díez O, Vega A, Spurdle AB, Radice P, De La Hoya M.
    • Hum Mol Genet. 2014 Jul 15;23(14):3666-80. doi: 10.1093/hmg/ddu075. Epub 2014 Feb 25.
    • Rapid evolution of BRCA1 and BRCA2 in humans and other primates.
    • Lou DI, McBee RM, Le UQ, Stone AC, Wilkerson GK, Demogines AM, Sawyer SL.
    • BMC Evol Biol. 2014 Jul 11;14:155. doi: 10.1186/1471-2148-14-155.
    • Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line.
    • Schröder-Heurich B, Bogdanova N, Wieland B, Xie X, Noskowicz M, Park-Simon TW, Hillemanns P, Christiansen H, Dörk T.
    • BMC Cancer. 2014 Jun 13;14:434. doi: 10.1186/1471-2407-14-434.
    • BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability.
    • Savage KI, Matchett KB, Barros EM, Cooper KM, Irwin GW, Gorski JJ, Orr KS, Vohhodina J, Kavanagh JN, Madden AF, Powell A, Manti L, McDade SS, Park BH, Prise KM, McIntosh SA, Salto-Tellez M, Richard DJ, Elliott CT, Harkin DP.
    • Cancer Res. 2014 May 15;74(10):2773-84. doi: 10.1158/0008-5472.CAN-13-2611. Epub 2014 Mar 17.
    • BRCA1 and estrogen/estrogen receptor in breast cancer: where they interact?
    • Wang L, Di LJ.
    • Int J Biol Sci. 2014 May 14;10(5):566-75. doi: 10.7150/ijbs.8579. eCollection 2014.
    • Stakeholder consultation insights on the future of genomics at the clinical-public health interface.
    • Modell SM, Kardia SL2, Citrin T3.
    • Transl Res. 2014 May;163(5):466-77. doi: 10.1016/j.trsl.2013.12.007. Epub 2013 Dec 25.
    • Review
    • BRCA1 deficiency induces protective autophagy to mitigate stress and provides a mechanism for BRCA1 haploinsufficiency in tumorigenesis.
    • Tang MK, Kwong A, Tam KF, Cheung AN, Ngan HY, Xia W, Wong A.
    • Cancer Lett. 2014 Apr 28;346(1):139-47. doi: 10.1016/j.canlet.2013.12.026. Epub 2013 Dec 28.
    • BRCA1 and Oxidative Stress.
    • Yi YW, Kang HJ, Bae I.
    • Cancers (Basel). 2014 Apr 3;6(2):771-95. doi: 10.3390/cancers6020771.
    • Role of BRCA1 in brain development.
    • Pao GM, Zhu Q, Perez-Garcia CG, Chou SJ, Suh H, Gage FH, O'Leary DD, Verma IM.
    • Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1240-8. doi: 10.1073/pnas.1400783111. Epub 2014 Mar 17.
    • Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2.
    • Venkitaraman AR.
    • Science. 2014 Mar 28;343(6178):1470-5. doi: 10.1126/science.1252230.
    • Editorial / Commentary
    • Epigenetic Reprogramming of HOXC10 in Endocrine-Resistant Breast Cancer.
    • Pathiraja TN, Nayak SR, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ, Gannon F, Kangaspeska S, Jelinek J, Issa JP, Richer JK, Elias A, McIlroy M, Young LS, Davidson NE, Schiff R, Li W, Oesterreich S.
    • Sci Transl Med. 2014 Mar 26;6(229):229ra41. doi: 10.1126/scitranslmed.3008326.
    • Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.
    • Gorrini C, Gang BP, Bassi C, Wakeham A, Baniasadi SP, Hao Z, Li WY, Cescon DW, Li YT, Molyneux S, Penrod N, Lupien M, Schmidt EE, Stambolic V, Gauthier ML, Mak TW.
    • Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4472-7. doi: 10.1073/pnas.1324136111. Epub 2014 Feb 24.

    Related:

    Comment:

    Tissue-specific tumor suppression by BRCA1.

    • PCAT-1, a Long Noncoding RNA, Regulates BRCA2 and Controls Homologous Recombination in Cancer.
    • Prensner JR, Chen W, Iyer MK, Cao Q, Ma T, Han S, Sahu A, Malik R, Wilder-Romans K, Navone N, Logothetis CJ, Araujo JC, Pisters LL, Tewari AK, Canman CE, Knudsen KE, Kitabayashi N, Rubin MA, Demichelis F, Lawrence TS, Chinnaiyan AM, Feng FY.
    • Cancer Res. 2014 Mar 15;74(6):1651-60. doi: 10.1158/0008-5472.CAN-13-3159. Epub 2014 Jan 28.
    • Epigenetic repression of phosphatidylethanolamine, N-methyltransferase (PEMT) in BRCA1-mutated breast cancer.
    • Li D, Bi FF, Chen NN, Cao JM, Sun WP, Zhou YM, Cao C, Li CY, Yang Q.
    • Oncotarget. 2014 Mar 15;5(5):1315-25.
    • Chromosome instability and carcinogenesis: insights from murine models of human pancreatic cancer associated with BRCA2 inactivation.
    • Cassidy LD, Liau SS, Venkitaraman AR.
    • Mol Oncol. 2014 Mar;8(2):161-8. doi: 10.1016/j.molonc.2013.10.005. Epub 2013 Nov 6.
    • HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.
    • Wang X, Lu G, Li L, Yi J, Yan K, Wang Y, Zhu B, Kuang J, Lin M, Zhang S, Shao G.
    • Biochem Biophys Res Commun. 2014 Feb 21;444(4):549-54. doi: 10.1016/j.bbrc.2014.01.075. Epub 2014 Jan 25.
    • Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer.
    • De Summa S, Pinto R, Pilato B, Sambiasi D, Porcelli L, Guida G, Mattioli E, Paradiso A, Merla G, Micale L, De Nittis P, Tommasi S.
    • Cell Death Dis. 2014 Feb 20;5:e1076. doi: 10.1038/cddis.2014.30.
    • Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation.
    • Li D, Bi FF, Cao JM, Cao C, Liu B, Yang Q.
    • Mol Cancer. 2014 Feb 6;13:26. doi: 10.1186/1476-4598-13-26.
    • Retraction: BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220.
    • [No authors listed]
    • Oncogene. 2014 Feb 6;33(6):804. doi: 10.1038/onc.2013.526.
    • Compensatory Functions and Interdependency of the DNA-Binding Domain of BRCA2 with the BRCA1-PALB2-BRCA2 Complex.
    • Al Abo M, Dejsuphong D, Hirota K, Yonetani Y, Yamazoe M, Kurumizaka H, Takeda S.
    • Cancer Res. 2014 Feb 1;74(3):797-807. doi: 10.1158/0008-5472.CAN-13-1443. Epub 2013 Nov 27.

    Related:

    Comments from NSGC Discussion Forum Cancer SIG

    Subject: BRCA2 and PALB2 mutation

    • Clinical significance of CYLD downregulation in breast cancer.
    • Hayashi M, Jono H, Shinriki S, Nakamura T, Guo J, Sueta A, Tomiguchi M, Fujiwara S, Yamamoto-Ibusuki M, Murakami K, Yamashita S, Yamamoto Y, Li JD, Iwase H, Ando Y.
    • Breast Cancer Res Treat. 2014 Feb;143(3):447-57. doi: 10.1007/s10549-013-2824-3. Epub 2014 Jan 8.
    • Circulating estrogens and estrogens within the breast among postmenopausal BRCA1/2 mutation carriers.
    • Loud JT, Gierach GL, Veenstra TD, Falk RT, Nichols K, Guttmann A, Xu X, Greene MH, Gail MH.
    • Breast Cancer Res Treat. 2014 Feb;143(3):517-29. doi: 10.1007/s10549-013-2821-6. Epub 2014 Jan 18.

    Related:

    Letter, Comment:

    Circulating estrogens and estrogens within the breast among postmenopausal BRCA1/2 mutation carriers.

    Letter, Comment:

    Concerns about methods for determination of estrogens in body fluids.

    • Generation of iPSCs from Genetically Corrected Brca2 Hypomorphic Cells: Implications in Cell Reprogramming and Stem Cell Therapy.
    • Navarro S, Moleiro V, Molina-Estevez FJ, Lozano ML, Chinchon R, Almarza E, Quintana-Bustamante O, Mostoslavsky G, Maetzig T, Galla M, Heinz N, Schiedlmeier B, Torres Y, Modlich U, Samper E, Río P, Segovia JC, Raya A, Güenechea G, Izpisua-Belmonte JC, Bueren JA.
    • Stem Cells. 2014 Feb;32(2):436-46. doi: 10.1002/stem.1586.
    • DNA methylation and miRNAs regulation in hereditary breast cancer: epigenetic changes, players in transcriptional and post- transcriptional regulation in hereditary breast cancer.
    • Pinto R, De Summa S, Pilato B, Tommasi S.
    • Curr Mol Med. 2014 Jan;14(1):45-57.
    • Review
    • BRCA1 as a nicotinamide adenine dinucleotide (NAD)-dependent metabolic switch in ovarian cancer.
    • Li D, Chen NN, Cao JM, Sun WP, Zhou YM, Li CY, Wang XX.
    • Cell Cycle. 2014;13(16):2564-71. doi: 10.4161/15384101.2015.942208.
    • Epigenetic mechanisms of breast cancer: an update of the current knowledge.
    • Karsli-Ceppioglu S, Dagdemir A, Judes G, Ngollo M, Penault-Llorca F, Pajon A, Bignon YJ, Bernard-Gallon D.
    • Epigenomics. 2014;6(6):651-64. doi: 10.2217/epi.14.59.
    • Review
    • Network-based analysis of omics with multi-objective optimization.
    • Mosca E, Milanesi L.
    • Mol Biosyst. 2013 Dec 29;9(12):2971-80. doi: 10.1039/c3mb70327d. Epub 2013 Oct 14.
    • BRCA2: one small step for DNA repair, one giant protein purified.
    • Jensen RB.
    • Yale J Biol Med. 2013 Dec 13;86(4):479-89.
    • Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.
    • Perets R, Wyant GA, Muto KW, Bijron JG, Poole BB, Chin KT, Chen JY, Ohman AW, Stepule CD, Kwak S, Karst AM, Hirsch MS, Setlur SR, Crum CP, Dinulescu DM, Drapkin R.
    • Cancer Cell. 2013 Dec 9;24(6):751-65. doi: 10.1016/j.ccr.2013.10.013.

    Related:

    Research news:

    Ovarian cancer: A better mimic.

    • Refining the role of BRCA1 in combating oxidative stress.
    • Marks JR.
    • Breast Cancer Res. 2013 Dec 5;15(6):320. doi: 10.1186/bcr3583.
    • Interest of individuals from BRCA families to participate in research studies focused on male BRCA carriers.
    • Pal T, Vadaparampil S, Kim J, Xu Y, Friedman S, Narod SA, Metcalfe K.
    • Fam Cancer. 2013 Dec;12(4):615-9. doi: 10.1007/s10689-013-9624-0.
    • Synthetic lethality between CCNE1 amplification and loss of BRCA1.
    • Etemadmoghadam D, Weir BA, Au-Yeung G, Alsop K, Mitchell G, George J; Australian Ovarian Cancer Study Group, Davis S, D'Andrea AD, Simpson K, Hahn WC, Bowtell DD.
    • Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19489-94. doi: 10.1073/pnas.1314302110. Epub 2013 Nov 11.
    • Breast cancer risk in BRCA1 mutation carriers: insight from mouse models.
    • Barcellos-Hoff MH, Kleinberg DL.
    • Ann Oncol. 2013 Nov;24 Suppl 8:viii8-viii12. doi: 10.1093/annonc/mdt305.
    • BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis.
    • Singh KK, Shukla PC, Quan A, Al-Omran M, Lovren F, Pan Y, Brezden-Masley C, Ingram AJ, Stanford WL, Teoh H, Verma S.
    • J Thorac Cardiovasc Surg. 2013 Oct;146(4):949-960.e4. doi: 10.1016/j.jtcvs.2012.12.064. Epub 2013 Feb 14.
    • A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.
    • Jeyasekharan AD, Liu Y, Hattori H, Pisupati V, Jonsdottir AB, Rajendra E, Lee M, Sundaramoorthy E, Schlachter S, Kaminski CF, Ofir-Rosenfeld Y, Sato K, Savill J, Ayoub N, Venkitaraman AR.
    • Nat Struct Mol Biol. 2013 Oct;20(10):1191-8. doi: 10.1038/nsmb.2666. Epub 2013 Sep 8.
    • BRCA1 and p53 regulate critical prostate cancer pathways.
    • De Luca P, Moiola CP, Zalazar F, Gardner K, Vazquez ES, De Siervi A.
    • Prostate Cancer Prostatic Dis. 2013 Sep;16(3):233-8. doi: 10.1038/pcan.2013.12. Epub 2013 May 14.
    • Fallopian tube intraluminal tumor spread from noninvasive precursor lesions: a novel metastatic route in early pelvic carcinogenesis.
    • Bijron JG, Seldenrijk CA, Zweemer RP, Lange JG, Verheijen RH, van Diest PJ.
    • Am J Surg Pathol. 2013 Aug;37(8):1123-30. doi: 10.1097/PAS.0b013e318282da7f.
    • Case report

    Related:

    Letter, Comment:

    Fallopian tube intraluminal tumor spread.

    Letter, Comment:

    Serous carcinogenesis: a classic causality dilemma or which came first... ?

    • Angiogenetic axis angiopoietins/Tie2 and VEGF in familial breast cancer.
    • Danza K, Pilato B, Lacalamita R, Addati T, Giotta F, Bruno A, Paradiso A, Tommasi S.
    • Eur J Hum Genet. 2013 Aug;21(8):824-30. doi: 10.1038/ejhg.2012.273. Epub 2012 Dec 12.
    • RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination.
    • Lok BH, Carley AC, Tchang B, Powell SN.
    • Oncogene. 2013 Jul 25;32(30):3552-8. doi: 10.1038/onc.2012.391. Epub 2012 Sep 10.
    • Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations.
    • Tulchin N, Ornstein L, Dikman S, Strauchen J, Jaffer S, Nagi C, Bleiweiss I, Kornreich R, Edelmann L, Brown K, Bodian C, Nair VD, Chambon M, Woods NT, Monteiro AN.
    • Cancer Cell Int. 2013 Jul 15;13(1):70. doi: 10.1186/1475-2867-13-70.
    • COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration.
    • COMPLEXO, Southey MC, Park DJ, Nguyen-Dumont T, Campbell I, Thompson E, Trainer AH, Chenevix-Trench G, Simard J, Dumont M, Soucy P, Thomassen M, Jønson L, Pedersen IS, Hansen TV, Nevanlinna H, Khan S, Sinilnikova O, Mazoyer S, Lesueur F, Damiola F, Schmutzler R, Meindl A, Hahnen E, Dufault MR, Chris Chan T, Kwong A, Barkardóttir R, Radice P, Peterlongo P, Devilee P, Hilbers F, Benitez J, Kvist A, Törngren T, Easton D, Hunter D, Lindstrom S, Kraft P, Zheng W, Gao YT, Long J, Ramus S, Feng BJ, Weitzel JN, Nathanson K, Offit K, Joseph V, Robson M, Schrader K, Wang S, Kim YC, Lynch H, Snyder C, Tavtigian S, Neuhausen S, Couch FJ, Goldgar DE.
    • Breast Cancer Res. 2013 Jun 21;15(3):402. doi: 10.1186/bcr3434.
    • BRCA1 in the DNA damage response and at telomeres.
    • Rosen EM.
    • Front Genet. 2013 Jun 21;4:85. doi: 10.3389/fgene.2013.00085. eCollection 2013.
    • BRCA1-Dependent Translational Regulation in Breast Cancer Cells.
    • Dacheux E, Vincent A, Nazaret N, Combet C, Wierinckx A, Mazoyer S, Diaz JJ, Lachuer J, Venezia ND.
    • PLoS One. 2013 Jun 21;8(6):e67313. Print 2013.
    • From integrative genomics to therapeutic targets.
    • Natrajan R, Wilkerson P.
    • Cancer Res. 2013 Jun 15;73(12):3483-8. doi: 10.1158/0008-5472.CAN-12-4717. Epub 2013 Jun 5.
    • The PPARγ agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency.
    • Nakles RE, Kallakury BV, Furth PA.
    • Am J Pathol. 2013 Jun;182(6):1976-85. doi: 10.1016/j.ajpath.2013.02.006. Epub 2013 May 8.

    Related:

    Commentary:

    Anticancer activities of PPARγ in breast cancer are context-dependent.

    • Mouse models of BRCA1 and their application to breast cancer research.
    • Dine J, Deng CX.
    • Cancer Metastasis Rev. 2013 Jun;32(1-2):25-37. doi: 10.1007/s10555-012-9403-7.
    • Review
    • Identification of a non-canonical nuclear localization signal (NLS) in BRCA1 that could mediate nuclear localization of splice variants lacking the classical NLS.
    • Korlimarla A, Bhandary L, Prabhu JS, Shankar H, Sankaranarayanan H, Kumar P, Remacle J, Natarajan D, Sridhar TS.
    • Cell Mol Biol Lett. 2013 Jun;18(2):284-96. doi: 10.2478/s11658-013-0088-x. Epub 2013 May 15.
    • Does cancer start in the womb? altered mammary gland development and predisposition to breast cancer due to in utero exposure to endocrine disruptors.
    • Soto AM, Brisken C, Schaeberle C, Sonnenschein C.
    • J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):199-208. doi: 10.1007/s10911-013-9293-5. Epub 2013 May 24.
    • Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer.
    • Alvarez C, Tapia T, Cornejo V, Fernandez W, Muñoz A, Camus M, Alvarez M, Devoto L, Carvallo P.
    • Mol Carcinog. 2013 Jun;52(6):475-87. doi: 10.1002/mc.21881. Epub 2012 Feb 7.
    • BRCA2 affects the efficiency of DNA double-strand break repair in response to N-nitroso compounds with differing carcinogenic potentials.
    • Zhao WT, Wang YT, Huang ZW, Fang J.
    • Oncol Lett. 2013 Jun;5(6):1948-1954. Epub 2013 Mar 22.
    • BRCA1 mutations and luminal-basal transformation.
    • Ng T, Irshad S, Stebbing J.
    • Oncogene. 2013 May 30;32(22):2712-4. doi: 10.1038/onc.2012.379. Epub 2012 Aug 27.
    • Comment

    Related:

    Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation.

    • Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation.
    • Bai F, Smith MD, Chan HL, Pei XH.
    • Oncogene. 2013 May 30;32(22):2715-25. doi: 10.1038/onc.2012.293. Epub 2012 Jul 9.

    Related:

    Comment:

    BRCA1 mutations and luminal-basal transformation.

    • Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.
    • Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM.
    • Proc Natl Acad Sci U S A. 2013 May 21;110(21):8632-7. doi: 10.1073/pnas.1305362110. Epub 2013 May 8.
    • Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation.
    • Li M, Yu X.
    • Cancer Cell. 2013 May 13;23(5):693-704. doi: 10.1016/j.ccr.2013.03.025.
    • A Protein Prioritization Approach Tailored for the FA/BRCA Pathway.
    • Haitjema A, Brandt BW, Ameziane N, May P, Heringa J, de Winter JP, Joenje H, Dorsman JC.
    • PLoS One. 2013 Apr 19;8(4):e62017. doi: 10.1371/journal.pone.0062017. Print 2013.
    • Opportunities for public health communication, intervention, and future research on breast cancer in younger women.
    • Buchanan N, Roland KB, Rodriguez JL, Miller JW, Fairley T.
    • J Womens Health (Larchmt). 2013 Apr;22(4):293-8. doi: 10.1089/jwh.2012.4239. Epub 2013 Mar 20.
    • A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers.
    • Guinan EM, Hussey J, McGarrigle SA, Healy LA, O'Sullivan JN, Bennett K, Connolly EM.
    • BMC Cancer. 2013 Mar 21;13:138. doi: 10.1186/1471-2407-13-138.
    • The role of BRCA1 in DNA double-strand repair: past and present.
    • Caestecker KW, Van de Walle GR.
    • Exp Cell Res. 2013 Mar 10;319(5):575-87. doi: 10.1016/j.yexcr.2012.11.013. Epub 2012 Nov 29.
    • Review
    • Functional analysis-Make or break for cancer predictability.
    • Deniz M, Holzmann K, Wiesmüller L.
    • Mutat Res. 2013 Mar-Apr;743-744:132-41. doi: 10.1016/j.mrfmmm.2013.03.009. Epub 2013 Mar 28.
    • Value of bilateral breast cancer for identification of rare recessive at-risk alleles: evidence for the role of homozygous GEN1 c.2515_2519delAAGTT mutation.
    • Kuligina ESh, Sokolenko AP, Mitiushkina NV, Abysheva SN, Preobrazhenskaya EV, Gorodnova TV, Yanus GA, Togo AV, Cherdyntseva NV, Bekhtereva SA, Dixon JM, Larionov AA, Kuznetsov SG, Imyanitov EN.
    • Fam Cancer. 2013 Mar;12(1):129-32. doi: 10.1007/s10689-012-9575-x.
    • Letter
    • Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer.
    • Bi FF, Li D, Yang Q.
    • BMC Cancer. 2013 Feb 26;13:90. doi: 10.1186/1471-2407-13-90.
    • HIF-1α overexpression in ductal carcinoma in situ of the breast in BRCA1 and BRCA2 mutation carriers.
    • van der Groep P, van Diest PJ, Smolders YH, Ausems MG, van der Luijt RB, Menko FH, Bart J, de Vries EG, van der Wall E.
    • PLoS One. 2013;8(2):e56055. doi: 10.1371/journal.pone.0056055. Epub 2013 Feb 8.
    • The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells.
    • Promkan M, Dakeng S, Chakrabarty S, Bögler O, Patmasiriwat P.
    • PLoS One. 2013;8(2):e55732. doi: 10.1371/journal.pone.0055732. Epub 2013 Feb 5.
    • BRCA2 Dysfunction Promotes Malignant Transformation of Pancreatic Intraepithelial Neoplasia.
    • Wang Q, Liu H, Liu T, Shu S, Jiang H, Cheng S, Yuan Y, Yang W, Wang L.
    • Anticancer Agents Med Chem. 2013 Feb 1;13(2):261-9.
    • Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor.
    • Barber LJ, Sandhu S, Chen L, Campbell J, Kozarewa I, Fenwick K, Assiotis I, Rodrigues DN, Filho JS, Moreno V, Mateo J, Molife LR, De Bono J, Kaye S, Lord CJ, Ashworth A.
    • J Pathol. 2013 Feb;229(3):422-9. doi: 10.1002/path.4140.
    • Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer Registry.
    • Mulligan AM, Raitman I, Feeley L, Pinnaduwage D, Nguyen LT, O'Malley FP, Ohashi PS, Andrulis IL.
    • Clin Cancer Res. 2013 Jan 15;19(2):336-46. doi: 10.1158/1078-0432.CCR-11-3314. Epub 2012 Dec 4.
    • VEGF, HIF-1α expression and MVD as an angiogenic network in familial breast cancer.
    • http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053070Saponaro C, Malfettone A, Ranieri G, Danza K, Simone G, Paradiso A, Mangia A.
    • PLoS One. 2013;8(1):e53070. doi: 10.1371/journal.pone.0053070. Epub 2013 Jan 11.
    • BRCA1 and Its Network of Interacting Partners.
    • Christou CM, Kyriacou K.
    • Biology (Basel). 2013 Jan 2;2(1):40-63. doi: 10.3390/biology2010040.
    • BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.
    • Sotiropoulou PA, Karambelas AE, Debaugnies M, Candi A, Bouwman P, Moers V, Revenco T, Rocha AS, Sekiguchi K, Jonkers J, Blanpain C.
    • Genes Dev. 2013 Jan 1;27(1):39-51. doi: 10.1101/gad.206573.112. Epub 2012 Dec 27.
    • Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors.
    • Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A, Doroshow JH, Cranston A, Martin NM, Lau A, O'Connor MJ, Ganesan S, Borst P, Jonkers J, Rottenberg S.
    • Cancer Discov. 2013 Jan;3(1):68-81. doi: 10.1158/2159-8290.CD-12-0049. Epub 2012 Oct 25.

    Related:

    Commentary:

    Mechanisms of resistance to PARP inhibitors--three and counting.

    • BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis.
    • Teoh H, Quan A, Creighton AK, Annie Bang KW, Singh KK, Shukla PC, Gupta N, Pan Y, Lovren F, Leong-Poi H, Al-Omran M, Verma S.
    • Gene Ther. 2013 Jan;20(1):51-61. doi: 10.1038/gt.2011.214. Epub 2012 Jan 19.
    • Implication of the Strand-Specific Imprinting and Segregation Model: Integrating in utero Hormone Exposure, Stem Cell and Lateral Asymmetry Hypotheses in Breast Cancer Aetiology.
    • Harbinder S, Lazzara CA, Klar AJ.
    • Hereditary Genet. 2013;2013(Suppl 2):005. doi: 10.4172/2161-1041.s2-005. Epub 2013 Aug 13.
    • Deletion of chromosomes 13q and 14q is a common feature of tumors with BRCA2 mutations.
    • Rouault A, Banneau G, Macgrogan G, Jones N, Elarouci N, Barouk-Simonet E, Venat L, Coupier I, Letouzé E, de Reyniès A, Bonnet F, Iggo R, Sévenet N, Longy M.
    • PLoS One. 2012;7(12):e52079. doi: 10.1371/journal.pone.0052079. Epub 2012 Dec 21.
    • Evidence That BRCA1- or BRCA2-Associated Cancers Are Not Inevitable.
    • Levin B, Lech D, Friedenson B.
    • Mol Med. 2012 Dec 6;18:1327-37. doi: 10.2119/molmed.2012.00280.
    • BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies.
    • Martinez-Outschoorn UE, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, Pavlides S, Lamb R, Sneddon S, Howell A, Sotgia F, Lisanti MP.
    • Cell Cycle. 2012 Dec 1;11(23):4402-13. doi: 10.4161/cc.22776. Epub 2012 Nov 21.
    • Molecular pathways: understanding the role of rad52 in homologous recombination for therapeutic advancement.
    • Lok BH, Powell SN.
    • Clin Cancer Res. 2012 Dec 1;18(23):6400-6. doi: 10.1158/1078-0432.CCR-11-3150. Epub 2012 Oct 15.
    • IGF-1 and BRCA1 signalling pathways in familial cancer.
    • Werner H, Bruchim I.
    • Lancet Oncol. 2012 Dec;13(12):E537-44. doi: 10.1016/S1470-2045(12)70362-5.
    • Review
    • Ring Finger Nuclear Factor RNF168 Is Important for Defects in Homologous Recombination Caused by Loss of the Breast Cancer Susceptibility Factor BRCA1.
    • Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM.
    • J Biol Chem. 2012 Nov 23;287(48):40618-28. doi: 10.1074/jbc.M112.410951. Epub 2012 Oct 10.
    • Hereditary ovarian cancer and two-compartment tumor metabolism: Epithelial loss of BRCA1 induces hydrogen peroxide production, driving oxidative stress and NFκB activation in the tumor stroma.
    • Martinez-Outschoorn UE, Balliet RM, Lin Z, Whitaker-Menezes D, Howell A, Sotgia F, Lisanti MP.
    • Cell Cycle. 2012 Nov 15;11(22):4152-66. doi: 10.4161/cc.22226. Epub 2012 Oct 9.
    • E2F3b over-expression in ovarian carcinomas and in BRCA1 haploinsufficient fallopian tube epithelium.
    • Smith NL, Welcsh P, Press JZ, Agnew KJ, Garcia R, Swisher EM.
    • Genes Chromosomes Cancer. 2012 Nov;51(11):1054-62. doi: 10.1002/gcc.21990. Epub 2012 Aug 9.
    • BRCA1 and microRNAs: emerging networks and potential therapeutic targets.
    • Chang S, Sharan SK.
    • Mol Cells. 2012 Nov;34(5):425-32. doi: 10.1007/s10059-012-0118-y. Epub 2012 Jul 24.
    • Effects of the missense mutations in canine BRCA2 on BRC repeat 3 functions and comparative analyses between canine and human BRC repeat 3.
    • Yoshikawa Y, Ochiai K, Morimatsu M, Suzuki Y, Wada S, Taoda T, Iwai S, Chikazawa S, Orino K, Watanabe K.
    • PLoS One. 2012;7(10):e45833. doi: 10.1371/journal.pone.0045833. Epub 2012 Oct 12.
    • Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells.
    • Nowsheen S, Cooper T, Stanley JA, Yang ES.
    • PLoS One. 2012;7(10):e46614. doi: 10.1371/journal.pone.0046614. Epub 2012 Oct 11.
    • Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier.
    • Chiang HC, Nair SJ, Yeh IT, Santillan AA, Hu Y, Elledge R, Li R.
    • Exp Hematol Oncol. 2012 Oct 8;1(1):31. doi: 10.1186/2162-3619-1-31.
    • PPARγ agonists target aromatase via both PGE2 and BRCA1.
    • Margalit O, Wang D, Dubois RN.
    • Cancer Prev Res (Phila). 2012 Oct;5(10):1169-72. doi: 10.1158/1940-6207.CAPR-12-0365.
    • Links between genome integrity and BRCA1 tumor suppression.
    • Li ML, Greenberg RA.
    • Trends Biochem Sci. 2012 Oct;37(10):418-24. doi: 10.1016/j.tibs.2012.06.007. Epub 2012 Jul 24.
    • EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors.
    • Zander SA, Sol W, Greenberger L, Zhang Y, van Tellingen O, Jonkers J, Borst P, Rottenberg S.
    • PLoS One. 2012;7(9):e45248. doi: 10.1371/journal.pone.0045248. Epub 2012 Sep 17.
    • BRCA1--conductor of the breast stem cell orchestra: the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast cancer.
    • Buckley NE, Mullan PB.
    • Stem Cell Rev. 2012 Sep;8(3):982-93. doi: 10.1007/s12015-012-9354-y.
    • Review
    • Prolonged postovulatory proinflammatory signaling in the fallopian tube epithelium may be mediated through a BRCA1/DAB2 axis.
    • Tone AA, Virtanen C, Shaw P, Brown TJ.
    • Clin Cancer Res. 2012 Aug 15;18(16):4334-44. doi: 10.1158/1078-0432.CCR-12-0199. Epub 2012 Jul 2.
    • BRCA1 exon 11 alternative splicing, multiple functions and the association with cancer.
    • Tammaro C, Raponi M, Wilson DI, Baralle D.
    • Biochem Soc Trans. 2012 Aug;40(4):768-72. doi: 10.1042/BST20120140.
    • Mechanisms of BRCA1 tumor suppression.
    • Silver DP, Livingston DM.
    • Cancer Discov. 2012 Aug;2(8):679-84. doi: 10.1158/2159-8290.CD-12-0221. Epub 2012 Jul 27.
    • New insights on the pathogenesis of ovarian carcinoma: molecular basis and clinical implications.
    • Gadducci A, Guerrieri ME, Riccardo Genazzani A.
    • Gynecol Endocrinol. 2012 Aug;28(8):582-6. doi: 10.3109/09513590.2011.649595. Epub 2012 Feb 4.
    • RAS, cellular senescence and transformation: the BRCA1 DNA repair pathway at the crossroads.
    • Tu Z, Aird KM, Zhang R.
    • Small GTPases. 2012 Jul-Sep;3(3):163-7. doi: 10.4161/sgtp.19884. Epub 2012 Jul 1.
    • HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.
    • Tierney BJ, McCann GA, Cohn DE, Eisenhauer E, Sudhakar M, Kuppusamy P, Hideg K, Selvendiran K.
    • Cancer Biol Ther. 2012 Jul;13(9):766-75. doi: 10.4161/cbt.20559.
    • Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer.
    • Warmoes M, Jaspers JE, Pham TV, Piersma SR, Oudgenoeg G, Massink MP, Waisfisz Q, Rottenberg S, Boven E, Jonkers J, Jimenez CR.
    • Mol Cell Proteomics. 2012 Jul;11(7):M111.013334. doi: 10.1074/mcp.M111.013334. Epub 2012 Feb 24.
    • RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo.
    • Wu J, Liu C, Chen J, Yu X.
    • J Biol Chem. 2012 Jun 29;287(27):22919-26. doi: 10.1074/jbc.M112.351007. Epub 2012 Apr 25.
    • Deregulated miRNAs in hereditary breast cancer revealed a role for miR-30c in regulating KRAS oncogene.
    • Tanic M, Yanowsky K, Rodriguez-Antona C, Andrés R, Márquez-Rodas I, Osorio A, Benitez J, Martinez-Delgado B.
    • PLoS One. 2012;7(6):e38847. doi: 10.1371/journal.pone.0038847. Epub 2012 Jun 11.
    • Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells.
    • Yu VM, Marion CM, Austria TM, Yeh J, Schönthal AH, Dubeau L.
    • Int J Cancer. 2012 Jun 1;130(11):2495-504. doi: 10.1002/ijc.26309. Epub 2011 Aug 29.
    • Evolutionary pathways in BRCA1-associated breast tumors.
    • Martins FC, De S, Almendro V, Gönen M, Park SY, Blum JL, Herlihy W, Ethington G, Schnitt SJ, Tung N, Garber JE, Fetten K, Michor F, Polyak K.
    • Cancer Discov. 2012 Jun;2(6):503-11. doi: 10.1158/2159-8290.CD-11-0325. Epub 2012 Apr 10.

    Related:

    Comment:

    Tracking evolution of BRCA1-associated breast cancer.

    • BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls.
    • Bosviel R, Garcia S, Lavediaux G, Michard E, Dravers M, Kwiatkowski F, Bignon YJ, Bernard-Gallon DJ.
    • Cancer Epidemiol. 2012 Jun;36(3):e177-82. doi: 10.1016/j.canep.2012.02.001. Epub 2012 Mar 7.
    • BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype.
    • Santarosa M, Maestro R.
    • Cancer Metastasis Rev. 2012 Jun;31(1-2):131-42. doi: 10.1007/s10555-011-9336-6.
    • Review
    • Evolutionary constraint helps unmask a splicing regulatory region in BRCA1 exon 11.
    • Raponi M, Douglas AG, Tammaro C, Wilson DI, Baralle D.
    • PLoS One. 2012;7(5):e37255. doi: 10.1371/journal.pone.0037255. Epub 2012 May 16.
    • [Cellular functions of BRCA genes - from basic science to therapeutics].
    • Miki Y.
    • Gan To Kagaku Ryoho. 2012 Apr;39(4):498-501.
    • [Article in Japanese]
    • BRCA1 haploinsufficiency: consequences for breast cancer.
    • Salmena L, Narod S.
    • Womens Health (Lond Engl). 2012 Mar;8(2):127-9. doi: 10.2217/whe.12.2.
    • Commentary

    Related:

    Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.

    • BRCA1 tumor suppressor network: focusing on its tail.
    • Wang B.
    • Cell Biosci. 2012 Feb 27;2(1):6. doi: 10.1186/2045-3701-2-6.
    • c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.
    • Regan JL, Kendrick H, Magnay FA, Vafaizadeh V, Groner B, Smalley MJ.
    • Oncogene. 2012 Feb 16;31(7):869-83. doi: 10.1038/onc.2011.289. Epub 2011 Jul 18.
    • BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies.
    • Dever SM, White ER, Hartman MC, Valerie K.
    • Cell Cycle. 2012 Feb 15;11(4):687-94. doi: 10.4161/cc.11.4.19212. Epub 2012 Feb 15.
    • Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis.
    • Cardinale F, Bruzzi P, Bolognesi C.
    • Br J Cancer. 2012 Feb 14;106(4):780-90. doi: 10.1038/bjc.2011.567. Epub 2011 Dec 20.
    • Promoter hypermethylation patterns in fallopian tube epithelium of BRCA1 and BRCA2 germ line mutation carriers.
    • Bijron JG, van der Groep P, van Dorst EB, Seeber LM, Sie-Go DM, Verheijen RH, van Diest PJ.
    • Endocr Relat Cancer. 2012 Feb 13;19(1):69-81. doi: 10.1530/ERC-11-0338. Print 2012 Feb.

    Related:

    Comment:

    Epigenetic modification and cancer: mark or stamp?

    • The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.
    • Min J, Choi ES, Hwang K, Kim J, Sampath S, Venkitaraman AR, Lee H.
    • J Biol Chem. 2012 Feb 10;287(7):5091-101. doi: 10.1074/jbc.M111.278994. Epub 2011 Dec 20.
    • Functional differences among BRCA1 missense mutations in the control of centrosome duplication.
    • Kais Z, Chiba N, Ishioka C, Parvin JD.
    • Oncogene. 2012 Feb 9;31(6):799-804. doi: 10.1038/onc.2011.271. Epub 2011 Jul 4.
    • Characterization of BARD1 targeting and dynamics at the centrosome: the role of CRM1, BRCA1 and the Q564H mutation.
    • Brodie KM, Mok MT, Henderson BR.
    • Cell Signal. 2012 Feb;24(2):451-9. doi: 10.1016/j.cellsig.2011.09.024. Epub 2011 Oct 1.
    • Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
    • Somyajit K, Subramanya S, Nagaraju G.
    • J Biol Chem. 2012 Jan 27;287(5):3366-80. doi: 10.1074/jbc.M111.311241. Epub 2011 Dec 13.
    • CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.
    • Kim EH, Deng C, Sporn MB, Royce DB, Risingsong R, Williams CR, Liby KT.
    • Cancer Prev Res (Phila). 2012 Jan;5(1):89-97. doi: 10.1158/1940-6207.CAPR-11-0359. Epub 2011 Sep 20.
    • A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.
    • Feng Z, Zhang J.
    • Nucleic Acids Res. 2012 Jan;40(2):726-38. doi: 10.1093/nar/gkr748. Epub 2011 Sep 27.