• Preventative Surgeries at Age 32 Because of My BRCA1 Gene Mutation.
    • Clem E.
    • FORCE. Blog. 2023 Feb 13.
    • Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on cognition in women with high familial risk of ovarian cancer: A cross-sectional study.
    • Terra L, Lee Meeuw Kjoe PR, Agelink Van Rentergem JA, Beekman MJ, Heemskerk-Gerritsen BAM, Van Beurden M, Roeters Van Lennep JE, Van Doorn HC, De Hullu JA, Mourits MJE, Van Dorst EBL, Mom CH, Slangen BFM, Gaarenstroom KN, van der Kolk LE, Collée JM, Wevers MR, Ausems MGEM, Van Engelen K, Van De Beek I, Berger LPV, Van Asperen CJ, Gomez Garcia EB, Maas AHEM, Hooning MJ, Van Der Wall E, Van Leeuwen FE, Schagen SB.
    • BJOG. 2023 Jan 30. doi: 10.1111/1471-0528.17415. Epub ahead of print.
    • Long-Term Non-Cancer Risks in People with BRCA Mutations following Risk-Reducing Bilateral Salpingo-Oophorectomy and the Role of Hormone Replacement Therapy: A Review.
    • Nitschke AS, Abreu do Valle H, Dawson L, Kwon JS, Hanley GE.
    • Cancers (Basel). 2023 Jan 24;15(3):711. doi: 10.3390/cancers15030711.
    • Hormone replacement therapy in BRCA mutation carriers: how shall we do no harm?
    • Loizzi V, Dellino M, Cerbone M, Arezzo F, Chiariello G, Lepera A, Cazzato G, Cascardi E, Damiani GR, Cicinelli E, Cormio G.
    • Hormones (Athens). 2023 Jan 13. doi: 10.1007/s42000-022-00427-1. Epub ahead of print.
    • Review
    • The Role of Hormonal Replacement Therapy in BRCA Mutated Patients: Lights and Shadows.
    • Loizzi V, Dellino M, Cerbone M, Arezzo F, Cazzato G, Damiani GR, Pinto V, Silvestris E, Kardhashi A, Cicinelli E, Cascardi E, Cormio G.
    • Int J Mol Sci. 2023 Jan 1;24(1):764. doi: 10.3390/ijms24010764.
    • Risk-Reducing Salpingo-Oophorectomy (RRSO) Combined with Simultaneous Mastectomy in Women with BRCA 1-2 Mutation Carriers: The Surgical Technique, the Feasibility and Patients' Satisfaction of Multiple Surgeries.
    • Saccardi C, Spagnol G, Saibene T, De Lorenzo LS, Marchetti M, Bonaldo G, Michieletto S, Toffanin MC, Noventa M, Tozzi R.
    • J Clin Med. 2022 Dec 18;11(24):7502. doi: 10.3390/jcm11247502.
    • Sexual functioning more than 15 years after premenopausal risk-reducing salpingo-oophorectomy.
    • Terra L, Beekman MJ, Engelhardt EG, Heemskerk-Gerritsen BAM, Van Beurden M, Roeters Van Lennep JE, Van Doorn HC, De Hullu JA, Van Dorst EBL, Mom CH, Slangen BFM, Gaarenstroom KN, van der Kolk LE, Margriet Collée J, Wevers MR, Ausems MGEM, Van Engelen K, Van De Beek I, Berger LPV, Van Asperen CJ, Gomez Garcia EB, Maas AHEM, Hooning MJ, Aaronson NK, Mourits MJE, Van Leeuwen FE.
    • Am J Obstet Gynecol. 2022 Nov 17:S0002-9378(22)02177-9. doi: 10.1016/j.ajog.2022.11.1289. Epub ahead of print.

    Related:

    •• Identifier: NCT03835793: Health After eaRly Menopause Due to Oophorectomy (HARMOny). (ClinicalTrials.gov . Accessed 2022 Nov 17.)

    • What happens after menopause? (WHAM): A prospective controlled study of symptom profiles up to 12 months after pre-menopausal risk-reducing salpingo-oophorectomy.
    • Moss KM, Mishra GD, Krejany EO, Hickey M.
    • Gynecol Oncol. 2022 Oct;167(1):58-64. doi: 10.1016/j.ygyno.2022.07.029. Epub 2022 Aug 4.
    • Surgical Menopause and Bilateral Oophorectomy: Effect of Estrogen-Progesterone and Testosterone Replacement Therapy on Psychological Well-being and Sexual Functioning; A Systematic Literature Review.
    • Stuursma A, Lanjouw L, Idema DL, de Bock GH, Mourits MJE.
    • J Sex Med. 2022 Sep 26:S1743-6095(22)01769-6. doi: 10.1016/j.jsxm.2022.08.191. Epub ahead of print.

    Related:

    Review registration number: CRD42019136698: The effect of hormone replacement therapy on psychological well-being and sexual functioning in women after treatment-induced menopause. (PROSPERO register)

    • Scene memory and hippocampal volume in middle-aged women with early hormone loss.
    • Gervais NJ, Gravelsins L, Brown A, Reuben R, Karkaby L, Baker-Sullivan E, Mendoza L, Lauzon C, Almey A, Foulkes WD, Bernardini MQ, Jacobson M, Velsher L, Rajah MN, Olsen RK, Grady C, Einstein G.
    • Neurobiol Aging. 2022 Sep;117:97-106. doi: 10.1016/j.neurobiolaging.2022.05.003. Epub 2022 May 13.
    • Study: Risk-reducing ovarian cancer surgery and quality of life.
    • [No author given]
    • FORCE. XRAY. 2022 Jul 26.

    Related:

    Original research:

    Association of Salpingectomy With Delayed Oophorectomy Versus Salpingo-oophorectomy With Quality of Life in BRCA1/2 Pathogenic Variant Carriers: A Nonrandomized Controlled Trial.

    • Cost-utility analysis of risk-reducing strategies to prevent breast and ovarian cancer in BRCA-mutation carriers in Switzerland.
    • Bommer C, Lupatsch J, Bürki N, Schwenkglenks M.
    • Eur J Health Econ. 2022 Jul;23(5):807-821. doi: 10.1007/s10198-021-01396-9. Epub 2021 Nov 12.
    • Needleoscopic-assisted risk-reducing bilateral salpingo-oophorectomy in BRCA1/2 mutation carriers: Peri-operative outcomes and psychological impact.
    • Rosati A, Fedele C, Fagotti A, Lafuenti L, Gioè A, Chieffo DPR, Vizzielli G, D'Ippolito G, Salutari V, Paris I, Marchetti C, Scambia G, Gueli Alletti S.
    • Eur J Obstet Gynecol Reprod Biol. 2022 Jun;273:1-6. doi: 10.1016/j.ejogrb.2022.03.040. Epub 2022 Mar 30.
    • Prophylactic Salpingo-Opphorectomy in Patients With Hereditary Predisposition Genes for Ovarian Cancer.
    • Garrett AA, Mahdi H.
    • JCO Oncol Pract. 2022 Jun;18(6):e846-e848. doi: 10.1200/OP.22.00069. Epub 2022 Mar 8.

    Related:

    Original research:

    Risk-Reducing Bilateral Salpingo-Oophorectomy for Ovarian Cancer: A Review and Clinical Guide for Hereditary Predisposition Genes.

    • Changes in Sex Steroids and Relation With Menopausal Complaints in Women Undergoing Risk-reducing Salpingo-oophorectomy.
    • van Winden LJ, Vermeulen RFM, van den Noort V, Gaarenstroom KN, Kenter GG, Brood-van Zanten MMA, Korse CM, van Beurden M, van Rossum HH.
    • J Endocr Soc. 2022 Apr 25 [eCollection 2022 Jun];6(6):bvac069. doi: 10.1210/jendso/bvac069.
    • Information needs of women undergoing gynaecological risk reduction surgery: Applying patient-reported findings to improve service delivery.
    • Jennings B, Ramis MA, Kynoch K, Jagasia N.
    • Aust N Z J Obstet Gynaecol. 2022 Apr;62(2):286-293. doi: 10.1111/ajo.13456. Epub 2021 Nov 9.
    • Cancer worry among BRCA1/2 pathogenic variant carriers choosing surgery to prevent tubal/ovarian cancer: course over time and associated factors.
    • van Bommel MHD, Steenbeek MP, IntHout J, Hermens RPMG, Hoogerbrugge N, Harmsen MG, van Doorn HC, Mourits MJE, van Beurden M, Zweemer RP, Gaarenstroom KN, Slangen BFM, Brood-van Zanten MMA, Vos MC, Piek JM, van Lonkhuijzen LRCW, Apperloo MJA, Coppus SFPJ, Prins JB, Custers JAE, de Hullu JA.
    • Support Care Cancer. 2022 Apr;30(4):3409-3418. doi: 10.1007/s00520-021-06726-4. Epub 2022 Jan 8.
    • Cancer Anxiety Mediates the Association Between Satisfaction With Medical Communication and Psychological Quality of Life After Prophylactic Bilateral Salpingo-Oophorectomy.
    • Zarbo C, Brugnera A, Frigerio L, Celi C, Compare A, Dessì V, Giordano R, Malandrino C, Sina FP, Strepparava MG, Tessitore IV, Ventura M, Fruscio R.
    • Front Psychol. 2022 Mar 9;13:840931. doi: 10.3389/fpsyg.2022.840931.
    • Risk-Reducing Bilateral Salpingo-Oophorectomy for Ovarian Cancer: A Review and Clinical Guide for Hereditary Predisposition Genes.
    • Liu YL, Breen K, Catchings A, Ranganathan M, Latham A, Goldfrank DJ, Grisham RN, Long Roche K, Frey MK, Chi DS, Abu-Rustum N, Aghajanian C, Offit K, Stadler ZK.
    • JCO Oncol Pract. 2022 Mar;18(3):201-209. doi: 10.1200/OP.21.00382. Epub 2021 Sep 28.

    Related:

    Commentary:

    Prophylactic Salpingo-Opphorectomy in Patients With Hereditary Predisposition Genes for Ovarian Cancer.

    • Major clinical research advances in gynecologic cancer in 2021.
    • Park JY, Lee JY, Lee YY, Shim SH, Suh DH, Kim JW.
    • J Gynecol Oncol. 2022 Mar;33(2):e43. doi: 10.3802/jgo.2022.33.e43.
    • Patient reported outcomes after risk-reducing surgery in patients at increased risk of ovarian cancer.
    • Philp L, Alimena S, Ferris W, Saini A, Bregar AJ, Del Carmen MG, Eisenhauer EL, Growdon WB, Goodman A, Dorney K, Mazina V, Sisodia RC.
    • Gynecol Oncol. 2022 Feb;164(2):421-427. doi: 10.1016/j.ygyno.2021.12.017. Epub 2021 Dec 23.
    • Risk-Reducing Salpingo-Oophorectomy and the Use of Hormone Replacement Therapy Below the Age of Natural Menopause: Scientific Impact Paper No. 66 October 2021: Scientific Impact Paper No. 66.
    • Manchanda R, Gaba F, Talaulikar V, Pundir J, Gessler S, Davies M, Menon U; Royal College of Obstetricians and Gynaecologists.
    • BJOG. 2022 Jan;129(1):e16-e34. doi: 10.1111/1471-0528.16896. Epub 2021 Oct 20.
    • Body Image in BRCA-Positive Young Women Following Bilateral Risk-Reducing Mastectomy: A Review of the Literature.
    • Torrisi C.
    • Front Psychol. 2021 Dec 16;12:778484. doi: 10.3389/fpsyg.2021.778484.
    • Effect of Inquiry-Based Stress Reduction on Well-being and Views on Risk-Reducing Surgery Among Women With BRCA Variants in Israel: A Randomized Clinical Trial.
    • Landau C, Novak AM, Ganz AB, Rolnik B, Friedman E, Lev-Ari S.
    • JAMA Netw Open. 2021 Dec 1;4(12):e2139670. doi: 10.1001/jamanetworkopen.2021.39670.
    • Association of Premenopausal Bilateral Oophorectomy With Cognitive Performance and Risk of Mild Cognitive Impairment.
    • Rocca WA, Lohse CM, Smith CY, Fields JA, Machulda MM, Mielke MM.
    • JAMA Netw Open. 2021 Nov 1;4(11):e2131448. doi: 10.1001/jamanetworkopen.2021.31448.

    Related:

    Commentary:

    Long-term Risk of Cognitive Impairment and Dementia Following Bilateral Oophorectomy in Premenopausal Women-Time to Rethink Policies?

    • Study Seeks to Prevent Cancer and Extend Quality of Life for Women at Increased Genetic Risk of Ovarian Cancer.
    • Jenks S.
    • FORCE. Blog. 2021 Oct 12.
    • What happens after menopause? (WHAM): A prospective controlled study of vasomotor symptoms and menopause-related quality of life 12 months after premenopausal risk-reducing salpingo-oophorectomy.
    • Hickey M, Moss KM, Krejany EO, Wrede CD, Brand A, Kirk J, Symecko HL, Domchek SM, Tejada-Berges T, Trainer A, Mishra GD.
    • Gynecol Oncol. 2021 Oct;163(1):148-154. doi: 10.1016/j.ygyno.2021.07.029. Epub 2021 Jul 24.
    • The impact of risk reducing bilateral salpingo-oophorectomy on sexual function in BRCA1/2 mutation carriers and women with Lynch syndrome: A systematic review and meta-analysis.
    • Kershaw V, Hickey I, Wyld L, Jha S.
    • Eur J Obstet Gynecol Reprod Biol. 2021 Aug 8;265:7-17. doi: 10.1016/j.ejogrb.2021.08.001. Epub ahead of print.
    • Review
    • Association of Salpingectomy With Delayed Oophorectomy Versus Salpingo-oophorectomy With Quality of Life in BRCA1/2 Pathogenic Variant Carriers: A Nonrandomized Controlled Trial.
    • Steenbeek MP, Harmsen MG, Hoogerbrugge N, de Jong MA, Maas AHEM, Prins JB, Bulten J, Teerenstra S, van Bommel MHD, van Doorn HC, Mourits MJE, van Beurden M, Zweemer RP, Gaarenstroom KN, Slangen BFM, Brood-van Zanten MMA, Vos MC, Piek JMJ, van Lonkhuijzen LRCW, Apperloo MJA, Coppus SFPJ, Massuger LFAG, IntHout J, Hermens RPMG, de Hullu JA.
    • JAMA Oncol. 2021 Aug 1;7(8):1203-1212. doi: 10.1001/jamaoncol.2021.1590.

    Related:

    Identifier: NCT02321228: Early Salpingectomy (Tubectomy) With Delayed Oophorectomy in BRCA1/2 Gene Mutation Carriers (TUBA). (ClinicalTrials.gov)

    Research news: Study: Risk-reducing ovarian cancer surgery and quality of life. (FORCE. XRAY.)

    • What happens after menopause? (WHAM): A prospective controlled study of sleep quality up to 12 months after premenopausal risk-reducing salpingo-oophorectomy.
    • Hickey M, Moss KM, Krejany EO, Wrede CD, Domchek SM, Kirk J, Brand A, Trainer A, Mishra GD, Baker FC.
    • Gynecol Oncol. 2021 Aug;162(2):447-453. doi: 10.1016/j.ygyno.2021.05.036. Epub 2021 Jun 8.
    • What Happens After Menopause? (WHAM): A prospective controlled study of cardiovascular and metabolic risk 12 months after premenopausal risk-reducing bilateral salpingo-oophorectomy.
    • Hickey M, Moss KM, Mishra GD, Krejany EO, Domchek SM, Wark JD, Trainer A, Wild RA.
    • Gynecol Oncol. 2021 Jul;162(1):88-96. doi: 10.1016/j.ygyno.2021.04.038. Epub 2021 May 7.
    • An evaluation of memory and attention in BRCA mutation carriers using an online cognitive assessment tool.
    • Kotsopoulos J, Kim SJ, Armel S, Bordeleau L, Foulkes WD, McKinnon W, Panchal S, Cohen SA, Sun S, Sun P, McKetton L, Troyer AK, Narod SA.
    • Cancer. 2021 Jun 2. doi: 10.1002/cncr.33654. Epub ahead of print.
    • Hormone Replacement Therapy After Gynaecological Malignancies: a Review Article.
    • Sourouni M, Kiesel L.
    • Geburtshilfe Frauenheilkd. 2021 May;81(5):549-554. doi: 10.1055/a-1390-4353. Epub 2021 May 20.
    • What happens after menopause? (WHAM): A prospective controlled study of depression and anxiety up to 12 months after premenopausal risk-reducing bilateral salpingo-oophorectomy.
    • Hickey M, Moss KM, Brand A, Wrede CD, Domchek SM, Meiser B, Mishra GD, Joffe H.
    • Gynecol Oncol. 2021 May;161(2):527-534. doi: 10.1016/j.ygyno.2021.02.001. Epub 2021 Feb 11.
    • Hormone replacement therapy in BRCA mutation carriers and risk of ovarian, endometrial, and breast cancer: a systematic review.
    • Huber D, Seitz S, Kast K, Emons G, Ortmann O.
    • J Cancer Res Clin Oncol. 2021 Apr 22. doi: 10.1007/s00432-021-03629-z. Epub ahead of print.
    • Controversies in Hereditary Cancer Management.
    • AlHilli MM, Pederson HJ.
    • Obstet Gynecol. 2021 Apr 8. doi: 10.1097/AOG.0000000000004364. Epub ahead of print.
    • A prospective controlled study of sexual function and sexually related personal distress up to 12 months after premenopausal risk-reducing bilateral salpingo-oophorectomy.
    • Islam RM, Davis SR, Bell RJ, Tejada-Berges T, Wrede CD, Domchek SM, Meiser B, Kirk J, Krejany EO, Hickey M.
    • Menopause. 2021 Mar 15;28(7):748-755. doi: 10.1097/GME.0000000000001766.
    • Surgical decision making in premenopausal BRCA carriers considering risk-reducing early salpingectomy or salpingo-oophorectomy: a qualitative study.
    • Gaba F, Goyal S, Marks D, Chandrasekaran D, Evans O, Robbani S, Tyson C, Legood R, Saridogan E, McCluggage WG, Hanson H, Singh N, Evans DG, Menon U, Manchanda R; PROTECTOR team.
    • J Med Genet. 2021 Feb 10:jmedgenet-2020-107501. doi: 10.1136/jmedgenet-2020-107501. Epub ahead of print.

    Related:

    Research news: Ovarian Cancer Prevention: How Patients Decide on Surgery. (Medscape)

    • Effect of risk-reducing salpingo-oophorectomy on quality of life in Korean BRCA mutation carriers.
    • Chae S, Kim EK, Jang YR, Lee AS, Kim SK, Suh DH, Kim K, No JH, Kim YB, Kim SW, Kang E.
    • Asian J Surg. 2021 Feb 8:S1015-9584(21)00047-6. doi: 10.1016/j.asjsur.2021.01.007. Epub ahead of print.
    • Satisfaction with prophylactic risk-reducing salpingo-oophorectomy in BRCA mutation carriers is very high and little dependent on the participants' characteristics at surgery: a prospective study.
    • Grandi G, Sammarini M, Cortesi L, Toss A, Botticelli L, Varliero F, Sighinolfi G, Barbieri E, Facchinetti F.
    • Menopause. 2021 Feb 1. doi: 10.1097/GME.0000000000001737. Epub ahead of print.
    • Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study).
    • Terra L, Hooning MJ, Heemskerk-Gerritsen BAM, van Beurden M, Roeters van Lennep JE, van Doorn HC, de Hullu JA, Mom C, van Dorst EBL, Mourits MJE, Slangen BFM, Gaarenstroom KN, Zillikens MC, Leiner T, van der Kolk L, Collee M, Wevers M, Ausems MGEM, van Engelen K, Berger LP, van Asperen CJ, Gomez-Garcia EB, van de Beek I, Rookus MA, Hauptmann M, Bleiker EM, Schagen SB, Aaronson NK, Maas AHEM, van Leeuwen FE.
    • JMIR Res Protoc. 2021 Jan 22;10(1):e24414. doi: 10.2196/24414.

    Related:

    Study Record Detail: Health After eaRly Menopause Due to Oophorectomy (HARMOny). (ClinicalTrials.gov)

    • Study: Women support delayed removal of ovaries.
    • [No author given]
    • FORCE. XRAY. 2020 Dec 24.

    Related:

    Original research:

    Attitudes towards risk-reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention: a cohort study.

    • The psychosexual effects of risk-reducing bilateral salpingo-oophorectomy in female BRCA1/2 mutation carriers: A systematic review of qualitative studies.
    • Hickey I, Jha S, Wyld L.
    • Gynecol Oncol. 2020 Dec 11:S0090-8258(20)34164-0. doi: 10.1016/j.ygyno.2020.12.001. Epub ahead of print.
    • Review
    • Can personality traits affect the quality of life of women with the BRCA1/BRCA2 mutations before and after prophylactic adnexectomy?
    • Stanisz M, Schneider-Matyka D, Panczyk M, Branecka-Wozniak D, Kurzawa R, Knyszynska A, Grochans E.
    • Eur Rev Med Pharmacol Sci. 2020 Dec;24(23):12342-12349. doi: 10.26355/eurrev_202012_24028.
    • No signs of subclinical atherosclerosis after risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers.
    • van Bommel MHD, de Jong MA, Steenbeek MP, Bots ML, van Westerop LLM, Hopman MTE, Hoogerbrugge N, de Hullu JA, Maas AHEM.
    • J Cardiol. 2020 Nov 20:S0914-5087(20)30364-6. doi: 10.1016/j.jjcc.2020.11.005. Epub ahead of print.
    • Two-Stage Surgery to Reduce Ovarian Cancer Risk Piques Interest.
    • Worcester S.
    • Medscape. News & Perspective. 2020 Oct 16.

    Related:

    Original research:

    Attitudes towards risk-reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention: a cohort study.

    • Patient reported experiences following laparoscopic prophylactic bilateral salpingo-oophorectomy or salpingectomy in an ambulatory care hospital.
    • Trister R, Jacobson M, Nguyen P, Sobel M, Allen L, Narod SA, Kotsopoulos J.
    • Fam Cancer. 2020 Sep 23. doi: 10.1007/s10689-020-00208-y. Epub ahead of print.
    • Attitudes towards risk-reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention: a cohort study.
    • Gaba F, Blyuss O, Chandrasekaran D, Osman M, Goyal S, Gan C, Izatt L, Tripathi V, Esteban I, McNicol L, Ragupathy K, Crawford R, Evans DG, Legood R, Menon U, Manchanda R.
    • BJOG. 2020 Aug 16. doi: 10.1111/1471-0528.16424. Epub ahead of print.

    Related:

    Commentary:

    Attitudes towards risk-reducing salpingectomy: listen to the patients.

    Press: Two-Stage Surgery to Reduce Ovarian Cancer Risk Piques Interest (Medscape. News & Perspective.)

    Research news: Study: Women support delayed removal of ovaries (FORCE. XRAY.)

    • BRCA1/2 genes mutations, ovarian reserve and female reproductive outcomes: a systematic literature review.
    • Merlino L, Chiné A, Galli C, Piccioni MG.
    • Minerva Ginecol. 2020 Aug 3. doi: 10.23736/S0026-4784.20.04624-9. Epub ahead of print.
    • Review
    • Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety.
    • Silva Filho ALD, Carvalho GM, Sena LC, Gomes LPG, Valério MFH, Martins RIL, Cândido EB.
    • Rev Assoc Med Bras (1992). 2020 Aug;66(8):1134-1138. doi: 10.1590/1806-9282.66.8.1134.
    • Factors associated with counseling and postoperative hormone therapy use in surgically menopausal women.
    • Verrilli L, Brown H, Williams M.
    • Menopause. 2020 May 11. doi: 10.1097/GME.0000000000001560. Epub ahead of print.
    • Cognitive markers of dementia risk in middle-aged women with bilateral salpingo-oophorectomy prior to menopause.
    • Gervais NJ, Au A, Almey A, Duchesne A, Gravelsins L, Brown A, Reuben R, Baker-Sullivan E, Schwartz DH, Evans K, Bernardini MQ, Eisen A, Meschino WS, Foulkes WD, Hampson E, Einstein G.
    • Neurobiol Aging. 2020 Apr 29;94:1-6. doi: 10.1016/j.neurobiolaging.2020.04.019. Epub ahead of print.
    • Risk of cardiovascular disease after preventive salpingo-oophorectomy.
    • Johansen N, Tonstad S, Liavaag AH, Selmer RM, Tanbo TG, Michelsen TM.
    • Int J Gynecol Cancer. 2020 Apr 23. pii: ijgc-2019-000856. doi: 10.1136/ijgc-2019-000856. [Epub ahead of print]
    • Executive function after risk-reducing salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: does current mood and early life adversity matter?
    • Shanmugan S, Sammel MD, Loughead J, Ruparel K, Gur RC, Brown TE, Faust J, Domchek S, Epperson CN.
    • Menopause. 2020 Mar 16. doi: 10.1097/GME.0000000000001535. [Epub ahead of print]
    • Hormone therapy (HT) in women with gynecologic cancers and in women at high risk for developing a gynecologic cancer: A Society of Gynecologic Oncology (SGO) clinical practice statement: This practice statement has been endorsed by The North American Menopause Society.
    • Sinno AK, Pinkerton J, Febbraro T, Jones N, Khanna N, Temkin S, Iglesias D, Pothuri B.
    • Gynecol Oncol. 2020 Feb 14. pii: S0090-8258(20)30088-3. doi: 10.1016/j.ygyno.2020.01.035. [Epub ahead of print]
    • Guidelines
    • Systematic review of acceptability, cardiovascular, neurological, bone health and HRT outcomes following risk reducing surgery in BRCA carriers.
    • Gaba F, Manchanda R.
    • Best Pract Res Clin Obstet Gynaecol. 2020 Feb 4. pii: S1521-6934(20)30018-3. doi: 10.1016/j.bpobgyn.2020.01.006. [Epub ahead of print]
    • The Effect of Prophylactic Adnexectomy on the Quality of Life and Psychosocial Functioning of Women with the BRCA1/BRCA2 Mutations.
    • Stanisz M, Panczyk M, Kurzawa R, Grochans E.
    • Int J Environ Res Public Health. 2019 Dec 9;16(24). pii: E4995. doi: 10.3390/ijerph16244995.
    • Prospective follow-up of quality of life for participants undergoing risk-reducing salpingo-oophorectomy or ovarian cancer screening in GOG-0199: An NRG Oncology/GOG study.
    • Mai PL, Huang HQ, Wenzel LB, Han PK, Moser RP, Rodriguez GC, Boggess J, Rutherford TJ, Cohn DE, Kauff ND, Phillips KA, Wilkinson K, Wenham RM, Hamilton C, Powell MA, Walker JL, Greene MH, Hensley ML.
    • Gynecol Oncol. 2019 Nov 21. pii: S0090-8258(19)31613-0. doi: 10.1016/j.ygyno.2019.10.026. [Epub ahead of print]
    • Use of antidepressants in women after prophylactic bilateral oophorectomy: A Danish national cohort study.
    • Abildgaard J, Ahlström MG, Nielsen DL, Daugaard G, Lindegaard B, Obel N, Lidegaard Ø.
    • Psychooncology. 2019 Nov 16. doi: 10.1002/pon.5290. [Epub ahead of print]
    • Sexual function, menopausal symptoms, depression and cancer worry in women with BRCA mutations.
    • Powell CB, Alabaster A, Le A, Stoller N, Armstrong MA, Raine-Bennett T.
    • Psychooncology. 2019 Oct 26. doi: 10.1002/pon.5253. [Epub ahead of print]
    • Does preventive oophorectomy increase the risk of depression in BRCA mutation carriers?
    • Kotsopoulos J, Gronwald J, Lubinski J, McCuaig J, Lynch HT, Neuhausen SL, Foulkes WD, Weitzel JN, Senter L, Tung N, Eng C, Karlan B, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group.
    • Menopause. 2019 Oct 21. doi: 10.1097/GME.0000000000001437. [Epub ahead of print]
    • Exploring factors that impact uptake of risk-reducing bilateral salpingo-oophorectomy (RRBSO) in high-risk women.
    • Hickey M, Rio I, Trainer A, Marino JL, Wrede CD, Peate M.
    • Menopause. 2019 Oct 14. doi: 10.1097/GME.0000000000001422. [Epub ahead of print]
    • Interventions to improve psychosocial well-being in female BRCA-mutation carriers following risk-reducing surgery.
    • Jeffers L, Reid J, Fitzsimons D, Morrison PJ, Dempster M.
    • Cochrane Database Syst Rev. 2019 Oct 9;10:CD012894. doi: 10.1002/14651858.CD012894.pub2. [Epub ahead of print]
    • Review

    Related:

    Original research:

    Mindfulness-based stress reduction for menopausal symptoms after risk-reducing salpingo-oophorectomy (PURSUE study): a randomised controlled trial.

    Original research:

    Addressing sexual dysfunction after risk-reducing salpingo-oophorectomy: effects of a brief, psychosexual intervention.

    • How Safe Is Hormone Replacement Therapy After Risk-Reducing Salpingo-oophorectomy in Women With BRCA Mutations?
    • Markman M.
    • Medscape Oncology. 2019 Jun 14.

    Related:

    Original research:

    Hormone replacement therapy after risk reducing salpingo-oophorectomy in patients with BRCA1 or BRCA2 mutations; a systematic review of risks and benefits.

    • Long-term morbidity and health after early menopause due to oophorectomy in women at increased risk of ovarian cancer: rationale and design of the harmony study.
    • Terra L, Hooning MJ, Heemskerk-Gerritsen BAM, Maas AHEM, van Leeuwen FE, HARMOny investigators.
    • Maturitas. 2019 Jun;124:159-160. doi: 10.1016/j.maturitas.2019.04.136.
    • Conference abstract, Review
    • Hormone replacement therapy after risk reducing salpingo-oophorectomy in patients with BRCA1 or BRCA2
    • Gordhandas S, Norquist BM, Pennington KP, Yung RL, Laya MB, Swisher EM.
    • Gynecol Oncol. 2019 Apr;153(1):192-200. doi: 10.1016/j.ygyno.2018.12.014. Epub 2019 Jan 17.
    • Review

    Related:

    Commentary: How Safe Is Hormone Replacement Therapy After Risk-Reducing Salpingo-oophorectomy in Women With BRCA Mutations? (Medscape Oncology)

    • Surgery to Reduce Ovarian Cancer Risk — One Step or Two?
    • Harrison P
    • Medscape. Medscape Oncology. 2019 Mar 25.
    • Concerns and Expectations of Risk-Reducing Surgery in Women with Hereditary Breast and Ovarian Cancer Syndrome.
    • Modaffari P, Ponzone R, Ferrari A, Cipullo I, Liberale V, D'Alonzo M, Maggiorotto F, Biglia N.
    • J Clin Med. 2019 Mar 5;8(3). pii: E313. doi: 10.3390/jcm8030313.
    • Mindfulness-based stress reduction for menopausal symptoms after risk-reducing salpingo-oophorectomy (PURSUE study): a randomised controlled trial.
    • van Driel C, de Bock GH, Schroevers MJ, Mourits MJ.
    • BJOG. 2019 Feb;126(3):402-411. doi: 10.1111/1471-0528.15471. Epub 2018 Oct 23.

    Related:

    Review:

    Interventions to improve psychosocial well-being in female BRCA-mutation carriers following risk-reducing surgery.

    • Risk factors for sexual dysfunction in BRCA mutation carriers after risk-reducing salpingo-oophorectomy.
    • Chan JL, Senapati S, Johnson LNC, DiGiovanni L, Voong C, Butts SF, Domchek SM.
    • Menopause. 2019 Feb;26(2):132-139. doi: 10.1097/GME.0000000000001176.
    • Effects of bilateral salpingo-oophorectomy on menopausal symptoms and sexual functioning among women with a BRCA1 or BRCA2 mutation.
    • Hall E, Finch A, Jacobson M, Rosen B, Metcalfe K, Sun P, Narod SA, Kotsopoulos J.
    • Gynecol Oncol. 2019 Jan;152(1):145-150. doi: 10.1016/j.ygyno.2018.10.040. Epub 2018 Nov 7.
    • Does anti-Müllerian hormone predict change in menopausal symptoms following risk-reducing salpingo-oophorectomy? A prospective observational study.
    • Vermeulen RFM, van Beurden M, Gaarenstroom KN, Teunis T, Kieffer JM, Aaronson NK, Kenter GG, Korse CM.
    • Climacteric. 2018 Dec;21(6):574-580. doi: 10.1080/13697137.2018.1512965. Epub 2018 Oct 8.
    • Satisfaction and Impact on Quality of Life of Clinical and Instrumental Surveillance and Prophylactic Surgery in BRCA-mutation Carriers.
    • D'Alonzo M, Piva E, Pecchio S, Liberale V, Modaffari P, Ponzone R, Biglia N.
    • Clin Breast Cancer. 2018 Dec;18(6):e1361-e1366. doi: 10.1016/j.clbc.2018.07.015. Epub 2018 Jul 26.
    • Adaptation of couples living with a high risk of breast/ovarian cancer and the association with risk-reducing surgery.
    • Shapira R, Turbitt E, Erby LH, Biesecker BB, Klein WMP3, Hooker GW.
    • Fam Cancer. 2018 Oct;17(4):485-493. doi: 10.1007/s10689-017-0065-z.
    • Surgical prevention strategies in ovarian cancer.
    • Mallen A, Soong TR, Townsend MK, Wenham RM, Crum CP, Tworoger SS.
    • Gynecol Oncol. 2018 Oct;151(1):166-175. doi: 10.1016/j.ygyno.2018.08.005. Epub 2018 Aug 4.
    • Review
    • Surgery for BRCA, TP53 and PALB2: a literature review.
    • Song CV, Teo SH, Taib NA, Yip CH.
    • Ecancermedicalscience. 2018 Aug 29;12:863. doi: 10.3332/ecancer.2018.863. eCollection 2018.
    • Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations.
    • Eleje GU, Eke AC, Ezebialu IU, Ikechebelu JI, Ugwu EO, Okonkwo OO.
    • Cochrane Database Syst Rev. 2018 Aug 24;8:CD012464. doi: 10.1002/14651858.CD012464.pub2.
    • Meta-Analysis, Review
    • Bilateral salpingectomy with delayed oophorectomy for ovarian cancer risk reduction: A pilot study in women with BRCA1/2 mutations.
    • Nebgen DR, Hurteau J, Holman LL, Bradford A, Munsell MF, Soletsky BR, Sun CC, Chisholm GB, Lu KH.
    • Gynecol Oncol. 2018 Jul;150(1):79-84. doi: 10.1016/j.ygyno.2018.04.564. Epub 2018 May 4.
    • Hormone Levels and Sexual Functioning After Risk-Reducing Salpingo-Oophorectomy.
    • Johansen N, Liavaag AH, Mørkrid L, Michelsen TM.
    • Sex Med. 2018 Jun;6(2):143-153. doi: 10.1016/j.esxm.2018.02.002. Epub 2018 Apr 7.
    • Severity and duration of menopausal symptoms after risk-reducing salpingo-oophorectomy.
    • Stuursma A, van Driel CMG, Wessels NJ, de Bock GH, Mourits MJE.
    • Maturitas. 2018 May;111:69-76. doi: 10.1016/j.maturitas.2018.01.012. Epub 2018 Jan 13.
    • A12 Quality of life of BRCA1 carriers after preventive adnexectomy.
    • Sawicka J, Jasiewicz A, Gronwald J.
    • Hered Cancer Clin Pract. 2018 Feb 28;16(Suppl 1):A12. Meeting abstracts from Clinical Genetics of Cancer 2017; Szczecin, Poland. 21-22 September 2017. doi: 10.1186/s13053-018-0087-z.
    • Conference abstract
    • Self-compassion, physical fitness and climacteric symptoms in oophorectomized BRCA1/2 mutation carriers.
    • Arts-de Jong M, van Westerop LL, Hoogerbrugge N, Massuger LF, Maas AH, van Beek MH, de Hullu JA.
    • Maturitas. 2018 Feb;108:13-17. doi: 10.1016/j.maturitas.2017.11.002. Epub 2017 Nov 3.
    • Severity and duration of menopausal symptoms after risk-reducing salpingo-oophorectomy.
    • Stuursma A, van Driel CMG, Wessels NJ, de Bock GH, Mourits MJE.
    • Maturitas. 2018 Jan 12. pii: S0378-5122(17)30950-7. doi: 10.1016/j.maturitas.2018.01.012. [Epub ahead of print]

    Related:

    Press: Menopausal Symptoms May Last Over 10 Years After Risk-reducing Ovarian Surgery. (Medscape/Reuters)

    • Quality-of-life implications of risk-reducing cancer surgery.
    • Altman AM, Hui JYC, Tuttle TM.
    • Br J Surg. 2018 Jan;105(2):e121-e130. doi: 10.1002/bjs.10725.
    • Genetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version. Psychosocial Issues in Inherited Breast and Ovarian Cancer Syndromes. Psychosocial Outcome Studies.
    • PDQ Cancer Genetics Editorial Board.
    • PDQ Cancer Information Summaries [Internet]. Bethesda, MD: National Cancer Institute. Updated 2017 Nov 30. Accessed 2017 Dec 8.
    • What Happens After Menopause? (WHAM): protocol for a prospective, multicentre, age-matched cohort trial of risk-reducing bilateral salpingo-oophorectomy in high-risk premenopausal women.
    • Hickey M, Trainer A, Braat S, Davey MA, Krejany E, Wark J.
    • BMJ Open. 2017 Nov 14;7(11):e018758. doi: 10.1136/bmjopen-2017-018758.
    • Sexual Health Is Paramount in the Counseling of Women at Risk for Breast or Ovarian Cancer Undergoing Risk-Reducing Surgery.
    • Rullo JE, Pruthi S.
    • J Natl Compr Canc Netw. 2017 Nov 1;15(11):1297. doi: 10.6004/jnccn.2017.7016.
    • Commentary
    • [Satisfaction and overall quality of life in BRCA positive women after prophylactic surgeries].
    • Šašková P, Pavlišta D, Dostálek L.
    • Rozhl Chir. 2017 Fall;96(8):328-333.
    • Review, [Article in Czech]
    • Impact of risk-reducing salpingo-oophorectomy in premenopausal women.
    • Vermeulen RFM, Beurden MV, Korse CM, Kenter GG.
    • Climacteric. 2017 Jun;20(3):212-221. doi: 10.1080/13697137.2017.1285879. Epub 2017 Mar 2.
    • Use of hormone replacement therapy after risk-reducing salpingo-oophorectomy.
    • Johansen N, Liavaag AH, Iversen OE, Dørum A, Braaten T, Michelsen TM.
    • Acta Obstet Gynecol Scand. 2017 May;96(5):547-555. doi: 10.1111/aogs.13120. Epub 2017 Mar 27.
    • Review Article: Sexuality and Risk-Reducing Salpingo-oophorectomy.
    • Tucker PE, Cohen PA.
    • Int J Gynecol Cancer. 2017 May;27(4):847-852. doi: 10.1097/IGC.0000000000000943.
    • Review
    • Risk-Reducing Strategies for Ovarian Cancer in BRCA Mutation Carriers: A Balancing Act.
    • Tschernichovsky R, Goodman A.
    • Oncologist. 2017 Apr;22(4):450-459. doi: 10.1634/theoncologist.2016-0444. Epub 2017 Mar 17.
    • The effect of hormone therapy on quality of life and breast cancer risk after risk-reducing salpingo-oophorectomy: a systematic review.
    • Siyam T, Ross S, Campbell S, Eurich DT, Yuksel N.
    • BMC Womens Health. 2017 Mar 21;17(1):22. doi: 10.1186/s12905-017-0370-6.
    • High demoralization in a minority of oophorectomized BRCA1/2 mutation carriers influences quality of life.
    • Arts-de Jong M, DeJong CA, Hermens RP, Kissane DW, Massuger LM, Hoogerbrugge N, Prins JB, deHullu JA.
    • J Psychosom Obstet Gynaecol. 2017 Mar 10:1-9. doi: 10.1080/0167482X.2017.1296429. [Epub ahead of print]
    • Sexuality and quality of life in women with a prior diagnosis of breast cancer after risk-reducing salpingo-oophorectomy.
    • Tucker PE, Saunders C, Bulsara MK, Tan JJ, Salfinger SG, Green H, Cohen PA.
    • Breast. 2016 Dec;30:26-31. doi: 10.1016/j.breast.2016.08.005. Epub 2016 Sep 2.
    • Study on the psychosocial aspects of risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 mutation carriers in Japan: a preliminary report.
    • Shigehiro M, Kita M, Takeuchi S, Ashihara Y, Arai M, Okamura H.
    • Jpn J Clin Oncol. 2016 Mar;46(3):254-9. doi: 10.1093/jjco/hyv190. Epub 2015 Dec 18.
    • The effects of pre-operative menopausal status and hormone replacement therapy (HRT) on sexuality and quality of life after risk-reducing salpingo-oophorectomy.
    • Tucker PE, Bulsara MK, Salfinger SG, Tan JJ, Green H, Cohen PA.
    • Maturitas. 2016 Mar;85:42-8. doi: 10.1016/j.maturitas.2015.12.004. Epub 2015 Dec 12.
    • Prevalence of sexual dysfunction after risk-reducing salpingo-oophorectomy.
    • Tucker PE, Bulsara MK, Salfinger SG, Tan JJ, Green H, Cohen PA.
    • Gynecol Oncol. 2016 Jan;140(1):95-100. doi: 10.1016/j.ygyno.2015.11.002. Epub 2015 Nov 3.
    • Sexual activity and functioning after risk-reducing salpingo-oophorectomy: Impact of hormone replacement therapy.
    • Johansen N, Liavaag AH, Tanbo TG, Dahl AA, Pripp AH, Michelsen TM.
    • Gynecol Oncol. 2016 Jan;140(1):101-106. doi: 10.1016/j.ygyno.2015.11.016. Epub 2015 Nov 18.
    • Laparoendoscopic Single-site Surgery (LESS) for Prophylactic Salpingo-oophorectomy Improves Cosmetic Satisfaction Compared to Standard Laparoscopy.
    • Miailhe G, Dauchy S, Bentivegna E, Gouy S, Charles C, Delaloge S, Morice P, Uzan C.
    • Anticancer Res. 2015 Nov;35(11):6105-10.
    • Early salpingectomy (TUbectomy) with delayed oophorectomy to improve quality of life as alternative for risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers (TUBA study): a prospective non-randomised multicentre study.
    • Harmsen MG, Arts-de Jong M, Hoogerbrugge N, Maas AH, Prins JB, Bulten J, Teerenstra S, Adang EM, Piek JM, van Doorn HC, van Beurden M, Mourits MJ, Zweemer RP, Gaarenstroom KN, Slangen BF, Vos MC, van Lonkhuijzen LR, Massuger LF, Hermens RP, de Hullu JA.
    • BMC Cancer. 2015 Aug 19;15(1):593. doi: 10.1186/s12885-015-1597-y.
    • Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation.
    • Kotsopoulos J, Lubinski J, Neuhausen SL, Gronwald J, Lynch HT, Huzarski T, Demsky R, Foulkes WD, Senter L, Friedman S, Ainsworth P, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group.
    • Womens Health (Lond Engl). 2015 Jul;11(4):453-9. doi: 10.2217/WHE.15.4. Epub 2015 Aug 10.
    • Long-term outcomes of risk-reducing surgery in unaffected women at increased familial risk of breast and/or ovarian cancer.
    • Heiniger L, Butow PN, Coll J, Bullen T, Wilson J, Baylock B, Meiser B, Price MA.
    • Fam Cancer. 2015 Mar;14(1):105-15. doi: 10.1007/s10689-014-9759-7.
    • Addressing sexual dysfunction after risk-reducing salpingo-oophorectomy: effects of a brief, psychosexual intervention.
    • Bober SL, Recklitis CJ, Bakan J, Garber JE, Patenaude AF.
    • J Sex Med. 2015 Jan;12(1):189-97. doi: 10.1111/jsm.12713. Epub 2014 Oct 14.

    Related:

    Review:

    Interventions to improve psychosocial well-being in female BRCA-mutation carriers following risk-reducing surgery.

    • Relationship satisfaction predicts sexual activity following risk-reducing salpingo-oophorectomy.
    • Lorenz T, McGregor B, Swisher E.
    • J Psychosom Obstet Gynaecol. 2014 Jun;35(2):62-8. doi: 10.3109/0167482X.2014.899577. Epub 2014 Apr 3.
    • Long-term satisfaction and quality of life following risk reducing surgery in BRCA1/2 mutation carriers.
    • Hooker GW, King L, Vanhusen L, Graves K, Peshkin BN, Isaacs C, Taylor KL, Poggi E, Schwartz MD.
    • Hered Cancer Clin Pract. 2014 Apr 2;12(1):9. doi: 10.1186/1897-4287-12-9.
    • Oophorectomy can reduce ovarian cancer risk in women with BRCA mutations: Patients benefit from counseling, support.
    • Printz C.
    • Cancer. 2013 Nov 15;119(22):3897-8. doi: 10.1002/cncr.28455.
    • Body Image and Sexuality After Surgery, Cancer and/or Treatment, for Survivors and Previvors.
    • Sharon Bober
    • FORCE. Be Empowered Webinars. 2013 Aug 28.
    • Association of bilateral oophorectomy and body fatness in a representative sample of US women.
    • McCarthy AM, Menke A, Visvanathan K.
    • Gynecol Oncol. 2013 Jun;129(3):559-64. doi: 10.1016/j.ygyno.2013.02.016. Epub 2013 Feb 18.
    • Prophylactic Salpingectomy and Delayed Oophorectomy as an Alternative for BRCA Mutation Carriers.
    • Kwon JS, Tinker A, Pansegrau G, McAlpine J, Housty M, McCullum M, Gilks CB.
    • Obstet Gynecol. 2013 Jan;121(1):14-24. doi: http://10.1097/AOG.0b013e3182783c2f.

    Related:

    Editorial/Comment:

    Ideal Risk Reduction Management for Women With BRCA Gene Mutations: Still Not There Yet.

    • The impact of prophylactic salpingo-oophorectomy on quality of life and psychological distress in women with a BRCA mutation.
    • Finch A, Metcalfe KA, Chiang J, Elit L, McLaughlin J, Springate C, Esplen MJ, Demsky R, Murphy J, Rosen B, Narod SA.
    • Psychooncology. 2013 Jan;22(1):212-9. doi: 10.1002/pon.2041. Epub 2011 Sep 13.
    • BRCA carriers, prophylactic salpingo-oophorectomy and menopause: clinical management considerations and recommendations.
    • Finch A, Evans G, Narod SA.
    • Womens Health (Lond Engl). 2012 Sep;8(5):543-55. doi: 10.2217/whe.12.41.

    Related:

    Free text: BRCA Carriers, Prophylactic Salpingo-Oophorectomy and Menopause: Clinical Management Considerations and Recommendations (Medscape)

    • New findings presented on metastatic breast cancer and bilateral oophorectomy.
    • Printz C.
    • Cancer. 2012 Jun 1;118(11):2778. doi: 10.1002/cncr.27643.
    • Looking different, feeling different: women's reactions to risk-reducing breast and ovarian surgery.
    • Hallowell N, Baylock B, Heiniger L, Butow PN, Patel D, Meiser B, Saunders C; kConFab Psychosocial Group on behalf of the kConFab Investigators, Price MA.
    • Fam Cancer. 2012 Jun;11(2):215-24. doi: 10.1007/s10689-011-9504-4.
    • Non-cancer endpoints in BRCA1/2 carriers after risk-reducing salpingo-oophorectomy.
    • Cohen JV, Chiel L, Boghossian L, Jones M, Stopfer JE, Powers J, Rebbeck TR, Nathanson KL, Domchek SM.
    • Fam Cancer. 2012 Mar;11(1):69-75. doi: 10.1007/s10689-011-9480-8.
    • Risk-reducing bilateral salpingo-oophorectomy and sexual health: a qualitative study.
    • Brotto LA, Branco N, Dunkley C, McCullum M, McAlpine JN.
    • J Obstet Gynaecol Can. 2012 Feb;34(2):172-8.