Quality of Life ~ Risk-Reducing Mastectomy
~ Genetics of Breast & Ovarian Cancer

List was last updated on Nov 19, 2019 @ 8:31 pm.


    • Prophylactic nipple-sparing mastectomy in young previvors: Examining decision-making, reconstructive outcomes, and patient satisfaction in BRCA+ patients under 30.
    • Salibian AA, Bekisz JM, Frey JD, Miller B, Choi M, Karp NS.
    • Breast J. 2019 Nov 17. doi: 10.1111/tbj.13692. [Epub ahead of print]
    • Patient-Reported Satisfaction after Prophylactic Operations of the Breast.
    • Keller K, Meisel C, Grübling N, Petzold A, Wimberger P, Kast K.
    • Breast Care (Basel). 2019 Aug;14(4):217-223. doi: 10.1159/000496398. Epub 2019 Feb 15.
    • Choosing high-risk screening vs. surgery and the effect of treatment modality on anxiety and breast-specific sensuality in BRCA mutation carriers.
    • Rojas KE, Butler E, Gutierrez J, Kwait R, Laprise J, Wilbur JS, Spinette S, Raker CA, Robison K, Legare R, Gass J, Stuckey A.
    • Gland Surg. 2019 Jun;8(3):249-257. doi: 10.21037/gs.2019.04.08.
    • Body image problems in women with and without breast cancer 6-20 years after bilateral risk-reducing surgery - A prospective follow-up study.
    • Bai L, Arver B, Johansson H, Sandelin K, Wickman M, Brandberg Y.
    • Breast. 2019 Apr;44:120-127. doi: 10.1016/j.breast.2019.01.013. Epub 2019 Feb 1.
    • Concerns and Expectations of Risk-Reducing Surgery in Women with Hereditary Breast and Ovarian Cancer Syndrome.
    • Modaffari P, Ponzone R, Ferrari A, Cipullo I, Liberale V, D'Alonzo M, Maggiorotto F, Biglia N.
    • J Clin Med. 2019 Mar 5;8(3). pii: E313. doi: 10.3390/jcm8030313.
    • Risk-Reducing Mastectomy in BRCA1 and BRCA2 Mutation Carriers: A Complex Discussion.
    • Domchek SM.
    • JAMA. 2019 Jan 1;321(1):27. doi: 10.1001/jama.2018.18942.
    • Review, Commentary
    • Bilateral prophylactic mastectomy in BRCA mutation carriers: what surgeons need to know.
    • Franceschini G, Di Leone A, Terribile D, Sanchez MA, Masetti R.
    • Ann Ital Chir. 2019;90:1-2.
    • Review
    • Satisfaction and Impact on Quality of Life of Clinical and Instrumental Surveillance and Prophylactic Surgery in BRCA-mutation Carriers.
    • D'Alonzo M, Piva E, Pecchio S, Liberale V, Modaffari P, Ponzone R, Biglia N.
    • Clin Breast Cancer. 2018 Dec;18(6):e1361-e1366. doi: 10.1016/j.clbc.2018.07.015. Epub 2018 Jul 26.
    • Adaptation of couples living with a high risk of breast/ovarian cancer and the association with risk-reducing surgery.
    • Shapira R, Turbitt E, Erby LH, Biesecker BB, Klein WMP3, Hooker GW.
    • Fam Cancer. 2018 Oct;17(4):485-493. doi: 10.1007/s10689-017-0065-z.
    • A comparison of patient satisfaction (using the BREAST-Q questionnaire) with bilateral breast reconstruction following risk-reducing or therapeutic mastectomy.
    • Kazzazi F, Haggie R, Forouhi P, Kazzazi N, Wyld L, Malata CM.
    • J Plast Reconstr Aesthet Surg. 2018 Sep;71(9):1324-1331. doi: 10.1016/j.bjps.2018.06.011. Epub 2018 Jun 28.
    • Surgery for BRCA, TP53 and PALB2: a literature review.
    • Song CV, Teo SH, Taib NA, Yip CH.
    • Ecancermedicalscience. 2018 Aug 29;12:863. doi: 10.3332/ecancer.2018.863. eCollection 2018.
    • Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations.
    • Eleje GU, Eke AC, Ezebialu IU, Ikechebelu JI, Ugwu EO, Okonkwo OO.
    • Cochrane Database Syst Rev. 2018 Aug 24;8:CD012464. doi: 10.1002/14651858.CD012464.pub2.
    • Meta-Analysis, Review
    • Influences on Satisfaction with Reconstructed Breasts and Intimacy in Younger Women Following Bilateral Prophylactic Mastectomy: a Qualitative Analysis.
    • Glassey R, O'Connor M, Ives A, Saunders C, Hardcastle SJ; kConFab Investigators.
    • Int J Behav Med. 2018 Aug;25(4):390-398. doi: 10.1007/s12529-018-9722-3.
    • Complications, risk factors, and patients-reported outcomes after skin-sparing mastectomy followed by breast reconstruction in women with BRCA mutations.
    • Moberg IO, Schou Bredal I, Schneider MR, Tønseth KA, Schlichting E.
    • J Plast Surg Hand Surg. 2018 Aug;52(4):234-239. doi: 10.1080/2000656X.2018.1470093. Epub 2018 May 9.
    • Long-term outcomes of bilateral direct-to-implant breast reconstruction in women at high breast cancer risk.
    • van Verschuer VMT, Mureau MAM, Heemskerk-Gerritsen BAM, Gadjradj PS, Rogier C, Verhoef C, Gopie JP, Seynaeve C, Koppert LB.
    • J Plast Surg Hand Surg. 2018 Aug;52(4):245-252. doi: 10.1080/2000656X.2018.1476364. Epub 2018 May 28.
    • Nipple-sparing bilateral prophylactic mastectomy and immediate reconstruction with TiLoop® Bra mesh in BRCA1/2 mutation carriers: A prospective study of long-term and patient reported outcomes using the BREAST-Q.
    • Casella D, Di Taranto G, Marcasciano M, Sordi S, Kothari A, Kovacs T, Lo Torto F, Cigna E, Ribuffo D, Calabrese C.
    • Breast. 2018 Jun;39:8-13. doi: 10.1016/j.breast.2018.02.001. Epub 2018 Feb 18.
    • Nipple-sparing mastectomy in women at high risk of developing breast cancer.
    • Lewis RS, George A, Rusby JE.
    • Gland Surg. 2018 Jun;7(3):325-336. doi: 10.21037/gs.2018.04.01.
    • Risk-reducing mastectomy for the prevention of primary breast cancer.
    • Carbine NE, Lostumbo L, Wallace J, Ko H.
    • Cochrane Database Syst Rev. 2018 Apr 5;4:CD002748. doi: 10.1002/14651858.CD002748.pub4.
    • Review, Meta-Analysis

    Summary: Women should be aware of their true risk of developing breast cancer and the limitations of current evidence when considering risk-reducing mastectomy. (Cochrane Library)

    • When BRCA Mutations Meet Complications.
    • Clausen AM.
    • Global Health NOW. 2018 Mar 20.
    • Perceived influence of psychological consultation on psychological well-being, body image, and intimacy following bilateral prophylactic mastectomy: A qualitative analysis.
    • Glassey R, Hardcastle SJ, O'Connor M, Ives A; kConFab Investigators, Saunders C.
    • Psychooncology. 2018 Feb;27(2):633-639. doi: 10.1002/pon.4558. Epub 2017 Oct 16.
    • Quality-of-life implications of risk-reducing cancer surgery.
    • Altman AM, Hui JYC, Tuttle TM.
    • Br J Surg. 2018 Jan;105(2):e121-e130. doi: 10.1002/bjs.10725.
    • Heightened perception of breast cancer risk in young women at risk of familial breast cancer.
    • Glassey R, O'Connor M, Ives A, Saunders C; kConFab Investigators, O'Sullivan S, Hardcastle SJ.
    • Fam Cancer. 2018 Jan;17(1):15-22. doi: 10.1007/s10689-017-0001-2.
    • Genetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version. Psychosocial Issues in Inherited Breast and Ovarian Cancer Syndromes. Psychosocial Outcome Studies.
    • PDQ Cancer Genetics Editorial Board.
    • PDQ Cancer Information Summaries [Internet]. Bethesda, MD: National Cancer Institute. Updated 2017 Nov 30. Accessed 2017 Dec 8.
    • [Satisfaction and overall quality of life in BRCA positive women after prophylactic surgeries].
    • Šašková P, Pavlišta D, Dostálek L.
    • Rozhl Chir. 2017 Fall;96(8):328-333.
    • Review, [Article in Czech]
    • "The Absence Doubled?" Photo-Poetic Narratives of Prophylactic Mastectomy.
    • Bolaki S.
    • Lit Med. [2017 Spring;]35(1):1-26. doi: 10.1353/lm.2017.0000.
    • Commentary
    • Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes.
    • Razdan SN, Patel V, Jewell S, McCarthy CM.
    • Qual Life Res. 2016 Jun;25(6):1409-21. doi: 10.1007/s11136-015-1181-6. Epub 2015 Nov 14.
    • Risk-reducing, conservative mastectomy-analysis of surgical outcome and quality of life in 272 implant-based reconstructions using TiLoop(®) Bra versus autologous corial flaps.
    • Rezai M, Strauß S, Kimmig R, Kern P.
    • Gland Surg. 2016 Feb;5(1):1-8. doi: 10.3978/j.issn.2227-684X.2015.07.03.
    • Risk-reducing mastectomy for BRCA gene mutation carriers.
    • Euhus DM.
    • Ann Surg Oncol. 2015 Sep;22(9):2807-9. doi: 10.1245/s10434-015-4537-9. Epub 2015 Mar 28.
    • Editorial
    • Long-term outcomes of risk-reducing surgery in unaffected women at increased familial risk of breast and/or ovarian cancer.
    • Heiniger L, Butow PN, Coll J, Bullen T, Wilson J, Baylock B, Meiser B, Price MA.
    • Fam Cancer. 2015 Mar;14(1):105-15. doi: 10.1007/s10689-014-9759-7.
    • [Prophylactic surgery in patients mutated BRCA or high risk: Retrospective study of 61 patients in the ICO].
    • Oger AS, Classe JM, Ingster O, Morin-Meschin ME, Sauterey B, Lorimier G, Wernert R, Paillocher N, Raro P.
    • Ann Chir Plast Esthet. 2015 Feb;60(1):19-25. doi: 10.1016/j.anplas.2014.10.001. Epub 2014 Nov 18.
    • [Article in French]
    • Long-term satisfaction and quality of life following risk reducing surgery in BRCA1/2 mutation carriers.
    • Hooker GW, King L, Vanhusen L, Graves K, Peshkin BN, Isaacs C, Taylor KL, Poggi E, Schwartz MD.
    • Hered Cancer Clin Pract. 2014 Apr 2;12(1):9. doi: 10.1186/1897-4287-12-9.
    • Risk reducing mastectomy, breast reconstruction and patient satisfaction in Norwegian BRCA1/2 mutation carriers.
    • Hagen AI, Mæhle L, Vedå N, Vetti HH, Stormorken A, Ludvigsen T, Guntvedt B, Isern AE, Schlichting E, Kleppe G, Bofin A, Gullestad HP, Møller P.
    • Breast. 2014 Feb;23(1):38-43. doi: 10.1016/j.breast.2013.10.002. Epub 2013 Nov 5.
    • Before Angelina: Portraits of Breast Cancer Previvors and Survivors.
    • [No author given]
    • Yale Cancer Genetic Counseling. 2013 Nov 1.
    • Body image issues after bilateral prophylactic mastectomy with breast reconstruction in healthy women at risk for hereditary breast cancer.
    • Gopie JP, Mureau MA, Seynaeve C, Ter Kuile MM, Menke-Pluymers MB, Timman R, Tibben A.
    • Fam Cancer. 2013 Sep;12(3):479-87. doi: 10.1007/s10689-012-9588-5.
    • Body Image and Sexuality After Surgery, Cancer and/or Treatment, for Survivors and Previvors.
    • Sharon Bober
    • FORCE. Be Empowered Webinars. 2013 Aug 28.
    • [The effect of prophylactic mastectomy with recontruction on quality of life in BRCA positive women].
    • Spurná Z, Dražan L, Foretová L, Dvorská L.
    • Klin Onkol. [2012 Aug;]25 Suppl:S74-7.
    • [Article in Czech]
    • Body image and psychological distress after prophylactic mastectomy and breast reconstruction in genetically predisposed women: a prospective long-term follow-up study.
    • den Heijer M, Seynaeve C, Timman R, Duivenvoorden HJ, Vanheusden K, Tilanus-Linthorst M, Menke-Pluijmers MB, Tibben A.
    • Eur J Cancer. 2012 Jun;48(9):1263-8. doi: 10.1016/j.ejca.2011.10.020. Epub 2011 Nov 19.
    • Looking different, feeling different: women's reactions to risk-reducing breast and ovarian surgery.
    • Hallowell N, Baylock B, Heiniger L, Butow PN, Patel D, Meiser B, Saunders C; kConFab Psychosocial Group on behalf of the kConFab Investigators, Price MA.
    • Fam Cancer. 2012 Jun;11(2):215-24. doi: 10.1007/s10689-011-9504-4.