• Risk-Reducing Salpingo-Oophorectomy (RRSO) Combined with Simultaneous Mastectomy in Women with BRCA 1-2 Mutation Carriers: The Surgical Technique, the Feasibility and Patients' Satisfaction of Multiple Surgeries.
    • Saccardi C, Spagnol G, Saibene T, De Lorenzo LS, Marchetti M, Bonaldo G, Michieletto S, Toffanin MC, Noventa M, Tozzi R.
    • J Clin Med. 2022 Dec 18;11(24):7502. doi: 10.3390/jcm11247502.
    • Mastectomy with one-stage or two-stage reconstruction in breast cancer: analysis of early outcomes and patient's satisfaction.
    • Angela G, Alessandro P, Alessia T, Michele M, Rossella E, Marco M, Michele T, Giuseppe Massimiliano L, Walter L, Elisabetta P, Paolo PF, Ilaria SL, Giuseppe G, Mario T.
    • Updates Surg. 2022 Nov 19. doi: 10.1007/s13304-022-01416-0. Epub ahead of print.
    • Revision Rate of Direct-to-Implant Breast Reconstruction: Is it Truly a Single-Stage Reconstruction? A Single-Surgeon Experience.
    • Adler N, Carmon E, Houri P.
    • Aesthetic Plast Surg. 2022 Oct 28. doi: 10.1007/s00266-022-03136-7. Epub ahead of print.
    • Satisfaction après mastectomie de réduction de risque associée à une reconstruction chez les patiente porteuses d’une mutation génétique [Satisfaction after risk reducing mastectomy related to breast reconstruction surgery in patient with hereditary genetic mutation].
    • Manivit C, Dannepond A, Brun JL, Pinsolle V, Casoli V, Charitansky H, Babin-Commeny J.
    • Gynecol Obstet Fertil Senol. 2022 Oct;50(10):650-656. French. doi: 10.1016/j.gofs.2022.06.007. Epub 2022 Jun 28.
    • [Article in French]
    • Risk-reducing mastectomy for unaffected women with a strong family history of breast cancer.
    • Willson ML, Srinivasa S, Fatema K, Lostumbo L, Carbine NE, Egger SJ, Goodwin A.
    • Cochrane Database Syst Rev. 2022 Sep 6;9(9):CD015020. doi: 10.1002/14651858.CD015020.pub2.
    • Satisfaction and Quality of Life of Healthy and Unilateral Diseased BRCA1/2 Pathogenic Variant Carriers after Risk-Reducing Mastectomy and Reconstruction Using the BREAST-Q Questionnaire.
    • Herold N, Hellmich M, Lichtenheldt F, Ataseven B, Hillebrand V, Wappenschmidt B, Schmutzler RK, Rhiem K.
    • Genes (Basel). 2022 Jul 28;13(8):1357. doi: 10.3390/genes13081357.
    • Satisfaction with Long-Term Aesthetic and 10 Years Oncologic Outcome following Risk-Reducing Mastectomy and Implant-Based Breast Reconstruction with or without Nipple Preservation.
    • O'Connell RL, Tasoulis MK, Hristova E, Teoh V, Agusti A, Ward A, Montgomery C, Mohammed K, Self J, Rusby JE, Gui G.
    • Cancers (Basel). 2022 Jul 24;14(15):3607. doi: 10.3390/cancers14153607.
    • A Randomized Trial of Robotic Mastectomy Versus Open Surgery in Women With Breast Cancer or BrCA Mutation.
    • Toesca A, Sangalli C, Maisonneuve P, Massari G, Girardi A, Baker JL, Lissidini G, Invento A, Farante G, Corso G, Rietjens M, Peradze N, Gottardi A, Magnoni F, Bottiglieri L, Lazzeroni M, Montagna E, Labo P, Orecchia R, Galimberti V, Intra M, Sacchini V, Veronesi P.
    • Ann Surg. 2022 Jul 1;276(1):11-19. doi: 10.1097/SLA.0000000000004969. Epub 2021 Jun 9.

    Related:

    Identifier: NCT03440398: Robotic Nipple-Sparing Mastectomy Vs Conventional Open Technique. (ClinicalTrials.gov)

    Commentary:

    Editorial on Toesca et al's "A Randomized Trial of Robotic Mastectomy Versus Open Surgery in Women With Breast Cancer or BRCA Mutation".

    • Cost-utility analysis of risk-reducing strategies to prevent breast and ovarian cancer in BRCA-mutation carriers in Switzerland.
    • Bommer C, Lupatsch J, Bürki N, Schwenkglenks M.
    • Eur J Health Econ. 2022 Jul;23(5):807-821. doi: 10.1007/s10198-021-01396-9. Epub 2021 Nov 12.
    • Effect of Inquiry-Based Stress Reduction on Well-being and Views on Risk-Reducing Surgery Among Women With BRCA Variants in Israel: A Randomized Clinical Trial.
    • Landau C, Novak AM, Ganz AB, Rolnik B, Friedman E, Lev-Ari S.
    • JAMA Netw Open. 2021 Dec 1;4(12):e2139670. doi: 10.1001/jamanetworkopen.2021.39670.
    • Prepectoral breast reconstruction: an ideal approach to bilateral risk-reducing mastectomy.
    • Maruccia M, Elia R, Tedeschi P, Gurrado A, Moschetta M, Testini M, Giudice G.
    • Gland Surg. 2021 Oct;10(10):2997-3006. doi: 10.21037/gs-21-339.
    • Psychological implications of risk-reducing mastectomies in BRCA1/2 mutation carriers.
    • Luque Suárez S, Olivares Crespo ME, Brenes Sánchez JM, Herrera de la Muela M.
    • Cir Esp (Engl Ed). 2021 Jun 30:S2173-5077(21)00184-8. doi: 10.1016/j.cireng.2021.06.014. Epub ahead of print.
    • Review
    • Psychological implications of risk-reducing mastectomies in BRCA1/2 mutation carriers.
    • Luque Suárez S, Olivares Crespo ME, Brenes Sánchez JM, Herrera de la Muela M.
    • Cir Esp. 2021 Jun 14:S0009-739X(21)00180-9. English, Spanish. doi: 10.1016/j.ciresp.2021.05.003. Epub ahead of print.
    • Review
    • An evaluation of memory and attention in BRCA mutation carriers using an online cognitive assessment tool.
    • Kotsopoulos J, Kim SJ, Armel S, Bordeleau L, Foulkes WD, McKinnon W, Panchal S, Cohen SA, Sun S, Sun P, McKetton L, Troyer AK, Narod SA.
    • Cancer. 2021 Jun 2. doi: 10.1002/cncr.33654. Epub ahead of print.
    • Risk-Reducing Mastectomy and Reconstruction Following Prophylactic Breast Irradiation: Hope Sustained.
    • Ben David MA, Evron E, Rasco AF, Shai A, Corn BW.
    • Cancers (Basel). 2021 May 30;13(11):2694. doi: 10.3390/cancers13112694.
    • Management of patients with BRCA mutation from the point of view of a breast surgeon.
    • Riis ML.
    • Ann Med Surg (Lond). 2021 Apr 16;65:102311. doi: 10.1016/j.amsu.2021.102311.
    • Quality of Life After Bilateral Risk-Reducing Mastectomy and Simultaneous Reconstruction Using Pre-Pectoral Silicone Implants.
    • Spindler N, Ebel F, Briest S, Wallochny S, Langer S.
    • Patient Prefer Adherence. 2021 Apr 13;15:741-750. doi: 10.2147/PPA.S303208.
    • Controversies in Hereditary Cancer Management.
    • AlHilli MM, Pederson HJ.
    • Obstet Gynecol. 2021 Apr 8. doi: 10.1097/AOG.0000000000004364. Epub ahead of print.
    • Nipple Sparing Mastectomy as a Risk-Reducing Procedure for BRCA-Mutated Patients.
    • Rocco N, Montagna G, Criscitiello C, Nava MB, Privitera F, Taher W, Gloria A, Catanuto G.
    • Genes (Basel). 2021 Feb 10;12(2):253. doi: 10.3390/genes12020253.
    • Long-Term Evaluation of Women Referred to a Breast Cancer Family History Clinic (Manchester UK 1987-2020).
    • Howell A, Gandhi A, Howell S, Wilson M, Maxwell A, Astley S, Harvie M, Pegington M, Barr L, Baildam A, Harkness E, Hopwood P, Wisely J, Wilding A, Greenhalgh R, Affen J, Maurice A, Cole S, Wiseman J, Lalloo F, French DP, Evans DG.
    • Cancers (Basel). 2020 Dec 9;12(12):3697. doi: 10.3390/cancers12123697.
    • Quality of Life after Bilateral and Contralateral Prophylactic Mastectomy with Implant Reconstruction.
    • Klapdor R, Weiß C, Kuehnle E, Kohls F, von Ehr J, Philippeit A, Hille-Betz U.
    • Breast Care (Basel). 2020 Oct;15(5):519-526. doi: 10.1159/000505449. Epub 2020 Jan 24.
    • How to Prepare for a Mastectomy Amid COVID and Other Life Events.
    • Wheaton J.
    • FORCE Blog. 2020 Jul 8.
    • Patient-Reported Outcome Measures may optimize shared decision-making for cancer risk management in BRCA mutation carriers.
    • van Egdom LSE, de Kock MA, Apon I, Mureau MAM, Verhoef C, Hazelzet JA, Koppert LB.
    • Breast Cancer. 2019 Dec 12. doi: 10.1007/s12282-019-01033-7. [Epub ahead of print]
    • Prophylactic nipple-sparing mastectomy in young previvors: Examining decision-making, reconstructive outcomes, and patient satisfaction in BRCA+ patients under 30.
    • Salibian AA, Bekisz JM, Frey JD, Miller B, Choi M, Karp NS.
    • Breast J. 2019 Nov 17. doi: 10.1111/tbj.13692. [Epub ahead of print]
    • Patient-Reported Satisfaction after Prophylactic Operations of the Breast.
    • Keller K, Meisel C, Grübling N, Petzold A, Wimberger P, Kast K.
    • Breast Care (Basel). 2019 Aug;14(4):217-223. doi: 10.1159/000496398. Epub 2019 Feb 15.
    • Choosing high-risk screening vs. surgery and the effect of treatment modality on anxiety and breast-specific sensuality in BRCA mutation carriers.
    • Rojas KE, Butler E, Gutierrez J, Kwait R, Laprise J, Wilbur JS, Spinette S, Raker CA, Robison K, Legare R, Gass J, Stuckey A.
    • Gland Surg. 2019 Jun;8(3):249-257. doi: 10.21037/gs.2019.04.08.
    • Body image problems in women with and without breast cancer 6-20 years after bilateral risk-reducing surgery - A prospective follow-up study.
    • Bai L, Arver B, Johansson H, Sandelin K, Wickman M, Brandberg Y.
    • Breast. 2019 Apr;44:120-127. doi: 10.1016/j.breast.2019.01.013. Epub 2019 Feb 1.
    • Concerns and Expectations of Risk-Reducing Surgery in Women with Hereditary Breast and Ovarian Cancer Syndrome.
    • Modaffari P, Ponzone R, Ferrari A, Cipullo I, Liberale V, D'Alonzo M, Maggiorotto F, Biglia N.
    • J Clin Med. 2019 Mar 5;8(3). pii: E313. doi: 10.3390/jcm8030313.
    • Risk-Reducing Mastectomy in BRCA1 and BRCA2 Mutation Carriers: A Complex Discussion.
    • Domchek SM.
    • JAMA. 2019 Jan 1;321(1):27. doi: 10.1001/jama.2018.18942.
    • Review, Commentary
    • Bilateral prophylactic mastectomy in BRCA mutation carriers: what surgeons need to know.
    • Franceschini G, Di Leone A, Terribile D, Sanchez MA, Masetti R.
    • Ann Ital Chir. 2019;90:1-2.
    • Review
    • Satisfaction and Impact on Quality of Life of Clinical and Instrumental Surveillance and Prophylactic Surgery in BRCA-mutation Carriers.
    • D'Alonzo M, Piva E, Pecchio S, Liberale V, Modaffari P, Ponzone R, Biglia N.
    • Clin Breast Cancer. 2018 Dec;18(6):e1361-e1366. doi: 10.1016/j.clbc.2018.07.015. Epub 2018 Jul 26.
    • Adaptation of couples living with a high risk of breast/ovarian cancer and the association with risk-reducing surgery.
    • Shapira R, Turbitt E, Erby LH, Biesecker BB, Klein WMP3, Hooker GW.
    • Fam Cancer. 2018 Oct;17(4):485-493. doi: 10.1007/s10689-017-0065-z.
    • A comparison of patient satisfaction (using the BREAST-Q questionnaire) with bilateral breast reconstruction following risk-reducing or therapeutic mastectomy.
    • Kazzazi F, Haggie R, Forouhi P, Kazzazi N, Wyld L, Malata CM.
    • J Plast Reconstr Aesthet Surg. 2018 Sep;71(9):1324-1331. doi: 10.1016/j.bjps.2018.06.011. Epub 2018 Jun 28.
    • Surgery for BRCA, TP53 and PALB2: a literature review.
    • Song CV, Teo SH, Taib NA, Yip CH.
    • Ecancermedicalscience. 2018 Aug 29;12:863. doi: 10.3332/ecancer.2018.863. eCollection 2018.
    • Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations.
    • Eleje GU, Eke AC, Ezebialu IU, Ikechebelu JI, Ugwu EO, Okonkwo OO.
    • Cochrane Database Syst Rev. 2018 Aug 24;8:CD012464. doi: 10.1002/14651858.CD012464.pub2.
    • Meta-Analysis, Review
    • Influences on Satisfaction with Reconstructed Breasts and Intimacy in Younger Women Following Bilateral Prophylactic Mastectomy: a Qualitative Analysis.
    • Glassey R, O'Connor M, Ives A, Saunders C, Hardcastle SJ; kConFab Investigators.
    • Int J Behav Med. 2018 Aug;25(4):390-398. doi: 10.1007/s12529-018-9722-3.
    • Complications, risk factors, and patients-reported outcomes after skin-sparing mastectomy followed by breast reconstruction in women with BRCA mutations.
    • Moberg IO, Schou Bredal I, Schneider MR, Tønseth KA, Schlichting E.
    • J Plast Surg Hand Surg. 2018 Aug;52(4):234-239. doi: 10.1080/2000656X.2018.1470093. Epub 2018 May 9.
    • Long-term outcomes of bilateral direct-to-implant breast reconstruction in women at high breast cancer risk.
    • van Verschuer VMT, Mureau MAM, Heemskerk-Gerritsen BAM, Gadjradj PS, Rogier C, Verhoef C, Gopie JP, Seynaeve C, Koppert LB.
    • J Plast Surg Hand Surg. 2018 Aug;52(4):245-252. doi: 10.1080/2000656X.2018.1476364. Epub 2018 May 28.
    • Nipple-sparing bilateral prophylactic mastectomy and immediate reconstruction with TiLoop® Bra mesh in BRCA1/2 mutation carriers: A prospective study of long-term and patient reported outcomes using the BREAST-Q.
    • Casella D, Di Taranto G, Marcasciano M, Sordi S, Kothari A, Kovacs T, Lo Torto F, Cigna E, Ribuffo D, Calabrese C.
    • Breast. 2018 Jun;39:8-13. doi: 10.1016/j.breast.2018.02.001. Epub 2018 Feb 18.
    • Nipple-sparing mastectomy in women at high risk of developing breast cancer.
    • Lewis RS, George A, Rusby JE.
    • Gland Surg. 2018 Jun;7(3):325-336. doi: 10.21037/gs.2018.04.01.
    • Risk-reducing mastectomy for the prevention of primary breast cancer.
    • Carbine NE, Lostumbo L, Wallace J, Ko H.
    • Cochrane Database Syst Rev. 2018 Apr 5;4:CD002748. doi: 10.1002/14651858.CD002748.pub4.
    • Review, Meta-Analysis

    Related:

    Summary: Women should be aware of their true risk of developing breast cancer and the limitations of current evidence when considering risk-reducing mastectomy. (Cochrane Library)

    • When BRCA Mutations Meet Complications.
    • Clausen AM.
    • Global Health NOW. 2018 Mar 20.
    • Perceived influence of psychological consultation on psychological well-being, body image, and intimacy following bilateral prophylactic mastectomy: A qualitative analysis.
    • Glassey R, Hardcastle SJ, O'Connor M, Ives A; kConFab Investigators, Saunders C.
    • Psychooncology. 2018 Feb;27(2):633-639. doi: 10.1002/pon.4558. Epub 2017 Oct 16.
    • Quality-of-life implications of risk-reducing cancer surgery.
    • Altman AM, Hui JYC, Tuttle TM.
    • Br J Surg. 2018 Jan;105(2):e121-e130. doi: 10.1002/bjs.10725.
    • Heightened perception of breast cancer risk in young women at risk of familial breast cancer.
    • Glassey R, O'Connor M, Ives A, Saunders C; kConFab Investigators, O'Sullivan S, Hardcastle SJ.
    • Fam Cancer. 2018 Jan;17(1):15-22. doi: 10.1007/s10689-017-0001-2.
    • Genetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version. Psychosocial Issues in Inherited Breast and Ovarian Cancer Syndromes. Psychosocial Outcome Studies.
    • PDQ Cancer Genetics Editorial Board.
    • PDQ Cancer Information Summaries [Internet]. Bethesda, MD: National Cancer Institute. Updated 2017 Nov 30. Accessed 2017 Dec 8.
    • [Satisfaction and overall quality of life in BRCA positive women after prophylactic surgeries].
    • Šašková P, Pavlišta D, Dostálek L.
    • Rozhl Chir. 2017 Fall;96(8):328-333.
    • Review, [Article in Czech]
    • "The Absence Doubled?" Photo-Poetic Narratives of Prophylactic Mastectomy.
    • Bolaki S.
    • Lit Med. [2017 Spring;]35(1):1-26. doi: 10.1353/lm.2017.0000.
    • Commentary
    • Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes.
    • Razdan SN, Patel V, Jewell S, McCarthy CM.
    • Qual Life Res. 2016 Jun;25(6):1409-21. doi: 10.1007/s11136-015-1181-6. Epub 2015 Nov 14.
    • Risk-reducing, conservative mastectomy-analysis of surgical outcome and quality of life in 272 implant-based reconstructions using TiLoop(®) Bra versus autologous corial flaps.
    • Rezai M, Strauß S, Kimmig R, Kern P.
    • Gland Surg. 2016 Feb;5(1):1-8. doi: 10.3978/j.issn.2227-684X.2015.07.03.
    • Risk-reducing mastectomy for BRCA gene mutation carriers.
    • Euhus DM.
    • Ann Surg Oncol. 2015 Sep;22(9):2807-9. doi: 10.1245/s10434-015-4537-9. Epub 2015 Mar 28.
    • Editorial
    • Long-term outcomes of risk-reducing surgery in unaffected women at increased familial risk of breast and/or ovarian cancer.
    • Heiniger L, Butow PN, Coll J, Bullen T, Wilson J, Baylock B, Meiser B, Price MA.
    • Fam Cancer. 2015 Mar;14(1):105-15. doi: 10.1007/s10689-014-9759-7.
    • [Prophylactic surgery in patients mutated BRCA or high risk: Retrospective study of 61 patients in the ICO].
    • Oger AS, Classe JM, Ingster O, Morin-Meschin ME, Sauterey B, Lorimier G, Wernert R, Paillocher N, Raro P.
    • Ann Chir Plast Esthet. 2015 Feb;60(1):19-25. doi: 10.1016/j.anplas.2014.10.001. Epub 2014 Nov 18.
    • [Article in French]
    • Long-term satisfaction and quality of life following risk reducing surgery in BRCA1/2 mutation carriers.
    • Hooker GW, King L, Vanhusen L, Graves K, Peshkin BN, Isaacs C, Taylor KL, Poggi E, Schwartz MD.
    • Hered Cancer Clin Pract. 2014 Apr 2;12(1):9. doi: 10.1186/1897-4287-12-9.
    • Risk reducing mastectomy, breast reconstruction and patient satisfaction in Norwegian BRCA1/2 mutation carriers.
    • Hagen AI, Mæhle L, Vedå N, Vetti HH, Stormorken A, Ludvigsen T, Guntvedt B, Isern AE, Schlichting E, Kleppe G, Bofin A, Gullestad HP, Møller P.
    • Breast. 2014 Feb;23(1):38-43. doi: 10.1016/j.breast.2013.10.002. Epub 2013 Nov 5.
    • Before Angelina: Portraits of Breast Cancer Previvors and Survivors.
    • [No author given]
    • Yale Cancer Genetic Counseling. 2013 Nov 1.
    • Body image issues after bilateral prophylactic mastectomy with breast reconstruction in healthy women at risk for hereditary breast cancer.
    • Gopie JP, Mureau MA, Seynaeve C, Ter Kuile MM, Menke-Pluymers MB, Timman R, Tibben A.
    • Fam Cancer. 2013 Sep;12(3):479-87. doi: 10.1007/s10689-012-9588-5.
    • Body Image and Sexuality After Surgery, Cancer and/or Treatment, for Survivors and Previvors.
    • Sharon Bober
    • FORCE. Be Empowered Webinars. 2013 Aug 28.
    • [The effect of prophylactic mastectomy with recontruction on quality of life in BRCA positive women].
    • Spurná Z, Dražan L, Foretová L, Dvorská L.
    • Klin Onkol. [2012 Aug;]25 Suppl:S74-7.
    • [Article in Czech]
    • Body image and psychological distress after prophylactic mastectomy and breast reconstruction in genetically predisposed women: a prospective long-term follow-up study.
    • den Heijer M, Seynaeve C, Timman R, Duivenvoorden HJ, Vanheusden K, Tilanus-Linthorst M, Menke-Pluijmers MB, Tibben A.
    • Eur J Cancer. 2012 Jun;48(9):1263-8. doi: 10.1016/j.ejca.2011.10.020. Epub 2011 Nov 19.
    • Looking different, feeling different: women's reactions to risk-reducing breast and ovarian surgery.
    • Hallowell N, Baylock B, Heiniger L, Butow PN, Patel D, Meiser B, Saunders C; kConFab Psychosocial Group on behalf of the kConFab Investigators, Price MA.
    • Fam Cancer. 2012 Jun;11(2):215-24. doi: 10.1007/s10689-011-9504-4.