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- Das familiäre Pankreaskarzinomsyndrom [Familial pancreatic cancer syndrome].
- Seifert L, Weitz J.
- Chirurgie (Heidelb). 2023 Feb 17. German. doi: 10.1007/s00104-023-01819-8. Epub ahead of print.
- PMID: 36799964
- PubMed abstract
- Source abstract
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- Utility of Comprehensive Genomic Profiling Tests for Patients with Incurable Pancreatic Cancer in Clinical Practice.
- Yamai T, Ikezawa K, Sugimoto N, Urabe M, Kai Y, Takada R, Nakabori T, Uehara H, Kawamura T, Kunimasa K, Yamamoto S, Wakamatsu T, Hayashi T, Kukita Y, Fujisawa F, Inoue T, Yamaguchi Y, Yamasaki T, Honma K, Ohkawa K.
- Cancers (Basel). 2023 Feb 3;15(3):970. doi: 10.3390/cancers15030970.
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- Characteristics of familial pancreatic cancer families with additional colorectal carcinoma.
- Lehman B, Matthäi E, Gercke N, Denzer UW, Figiel J, Hess T, Slater EP, Bartsch DK.
- Fam Cancer. 2023 Jan 31. doi: 10.1007/s10689-023-00328-1. Epub ahead of print.
- PMID: 36717525
- PubMed abstract
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- Evaluation of inherited germline mutations in cancer susceptibility genes among pancreatic cancer patients: a single-center study.
- Tavano F, Gioffreda D, Fontana A, Palmieri O, Gentile A, Latiano T, Latiano A, Latiano TP, Scaramuzzi M, Maiello E, Bazzocchi F, Perri F.
- Mol Med. 2023 Jan 30;29(1):14. doi: 10.1186/s10020-023-00600-1.
- PMID: 36717774
- PubMed abstract
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- Genetics, Genomics and Emerging Molecular Therapies of Pancreatic Cancer.
- Liu J, Mroczek M, Mach A, Stępień M, Aplas A, Pronobis-Szczylik B, Bukowski S, Mielczarek M, Gajewska E, Topolski P, Król ZJ, Szyda J, Dobosz P.
- Cancers (Basel). 2023 Jan 27;15(3):779. doi: 10.3390/cancers15030779.
- Review
- Free Full Text
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- Risk Assessment and Pancreatic Cancer: Diagnostic Management and Artificial Intelligence.
- Granata V, Fusco R, Setola SV, Galdiero R, Maggialetti N, Silvestro L, De Bellis M, Di Girolamo E, Grazzini G, Chiti G, Brunese MC, Belli A, Patrone R, Palaia R, Avallone A, Petrillo A, Izzo F.
- Cancers (Basel). 2023 Jan 5;15(2):351. doi: 10.3390/cancers15020351.
- Review
- Free Full Text
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- Testing for homologous recombination repair or homologous recombination deficiency for poly (ADP-ribose) polymerase inhibitors: A current perspective.
- Herzog TJ, Vergote I, Gomella LG, Milenkova T, French T, Tonikian R, Poehlein C, Hussain M.
- Eur J Cancer. 2022 Dec 21 [2023 Jan 1];179:136-146. doi: 10.1016/j.ejca.2022.10.021. Epub ahead of print.
- PMID: 36563604
- PubMed abstract
- Review
- Free Full Text
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- Expert consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the determination of biomarkers in pancreatic and biliary tract cancer.
- Vera R, Ibarrola-de Andrés C, Adeva J, Pérez-Rojas J, García-Alfonso P, Rodríguez-Gil Y, Macarulla T, Serrano-Piñol T, Mondéjar R, Madrigal-Rubiales B.
- Rev Esp Patol. 2023 Jan-Mar;56(1):32-44. doi: 10.1016/j.patol.2022.06.004. Epub 2022 Aug 26.
- PMID: 36599598
- PubMed abstract
- Source abstract
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- Pathologic complete response following FOLFIRINOX and olaparib treatment for hepatic metastasized pancreatic ductal adenocarcinoma with a germline BRCA mutation.
- Okada K, Uemura K, Okamoto W, Sumiyoshi T, Shintakuya R, Otsuka H, Serikawa M, Ishii Y, Arihiro K, Takahashi S.
- Clin J Gastroenterol. 2022 Dec 27. doi: 10.1007/s12328-022-01741-2. Epub ahead of print.
- PMID: 36574187
- PubMed abstract
- Source abstract
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- A chance in hopeless cancer: 5-year complete remission after oxaliplatin-based therapy in a patient with BRCA2 mutant metastatic pancreatic cancer.
- Yildirim HC, Ismayilov R, Akyildiz A, Guven DC, Abdurrahimli N, Dizdar O, Yalcin S.
- Anticancer Drugs. 2022 Dec 19. doi: 10.1097/CAD.0000000000001486. Epub ahead of print.
- PMID: 36729128
- PubMed abstract
- Source abstract
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- Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis.
- Lelong M, Raoul JL, Touchefeu Y, Berthelot JM, Arnolfo P, Matysiak-Budnik T, Senellart H.
- Clin Case Rep. 2022 Dec 12;10(12):e6718. doi: 10.1002/ccr3.6718.
- PMID: 36523391
- PubMed abstract
- Source abstract
- Case report
- Free PMC article
- Free Full Text
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- BRCA1/2 Reversion Mutations in Patients Treated with Poly ADP-Ribose Polymerase (PARP) Inhibitors or Platinum Agents.
- Darabi S, Braxton DR, Xiu J, Carneiro BA, Swensen J, Antonarakis ES, Liu SV, McKay RR, Spetzler D, El-Deiry WS, Demeure MJ.
- Medicina (Kaunas). 2022 Dec 10;58(12):1818. doi: 10.3390/medicina58121818.
- PMID: 36557020
- PubMed abstract
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- Second-line therapy in pancreatic ductal adenocarcinoma (PDAC) patients with germline BRCA1-2 pathogenic variants (gBRCA1-2pv).
- Orsi G, Cavaliere A, Tortora G, Lonardi S, Macchini M, Di Marco M, Giordano G, Vasile E, Scartozzi M, Bozzarelli S, Noventa S, Rodriquenz MG, Militello AM, Rapposelli IG, Garajova I, De Lorenzo S, Merelli B, Bittoni A, Salvatore L, Procaccio L, Paratore C, Spallanzani A, Peretti U, Niger M, Giommoni E, Bernardini I, Tamburini E, Bernardino K, Forti L, Valente MM, Cascinu S, Milella M, Reni M.
- Br J Cancer. 2022 Dec 8. doi: 10.1038/s41416-022-02086-w. Epub ahead of print.
- PMID: 36482190
- PubMed abstract
- Source abstract
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- Genetic medicine in companion diagnostics of germline BRCA testing of Japanese pancreatic cancer patients.
- Matsubayashi H, Todaka A, Kawakami T, Hamauchi S, Yokota T, Higashigawa S, Kiyozumi Y, Harada R, Kado N, Nishimura S, Ishiwatari H, Sato J, Niiya F, Ono H, Sugiura T, Sasaki K, Yasui H, Yamazaki K.
- J Hum Genet. 2022 Dec 8. doi: 10.1038/s10038-022-01097-y. Epub ahead of print.
- PMID: 36482120
- PubMed abstract
- Source abstract
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- Germline BRCA2 variants in advanced pancreatic acinar cell carcinoma: A case report and review of literature.
- Lee CL, Holter S, Borgida A, Dodd A, Ramotar S, Grant R, Wasson K, Elimova E, Jang RW, Moore M, Kim TK, Khalili K, Moulton CA, Gallinger S, O'Kane GM, Knox JJ.
- World J Gastroenterol. 2022 Dec 7;28(45):6421-6432. doi: 10.3748/wjg.v28.i45.6421.
- PMID: 36533108
- PubMed abstract
- Source abstract
- Case report
- Free PMC article
- Free Full Text
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- NGS-based targeted gene mutational profiles in Korean patients with pancreatic cancer.
- Jung K, Lee S, Na HY, Kim JW, Lee JC, Hwang JH, Kim JW, Kim J.
- Sci Rep. 2022 Dec 3;12(1):20937. doi: 10.1038/s41598-022-24732-2.
- PMID: 36463295
- PubMed abstract
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- THE IMPACT OF PANCREATIC CANCER SCREENING ON LIFE EXPECTANCY: A SYSTEMATIC REVIEW OF MODELLING STUDIES.
- Koopmann BDM, Omidvari AH, Lansdorp-Vogelaar I, Cahen DL, Bruno MJ, de Kok IMCM.
- Int J Cancer. 2022 Nov 28. doi: 10.1002/ijc.34379. Epub ahead of print.
- PMID: 36444505
- PubMed abstract
- Source abstract
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- Long-term response to olaparib in a patient with metastatic pancreatic cancer associated with hereditary breast and ovarian cancer syndrome.
- Tsuneizumi M, Terada S, Usui T, Yamaguchi K, Hayami R, Matsunuma R.
- Oxf Med Case Reports. 2022 Nov 24;2022(11):omac124. doi: 10.1093/omcr/omac124.
- PMID: 36447463
- PubMed abstract
- Case report
- Free PMC article
- Free Full Text
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- Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies.
- Murciano-Goroff YR, Schram AM, Rosen EY, Won H, Gong Y, Noronha AM, Janjigian YY, Stadler ZK, Chang JC, Yang SR, Mandelker D, Offit K, Berger MF, Donoghue MTA, Bandlamudi C, Drilon A.
- Nat Commun. 2022 Nov 23;13(1):7182. doi: 10.1038/s41467-022-34109-8.
- PMID: 36418296
- PubMed abstract
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- Avelumab Plus Talazoparib in Patients With BRCA1/2- or ATM-Altered Advanced Solid Tumors: Results From JAVELIN BRCA/ATM, an Open-Label, Multicenter, Phase 2b, Tumor-Agnostic Trial.
- Schram AM, Colombo N, Arrowsmith E, Narayan V, Yonemori K, Scambia G, Zelnak A, Bauer TM, Jin N, Ulahannan SV, Colleoni M, Aftimos P, Donoghue MTA, Rosen E, Rudneva VA, Telli ML, Domchek SM, Galsky MD, Hoyle M, Chappey C, Stewart R, Blake-Haskins JA, Yap TA.
- JAMA Oncol. 2022 Nov 17. doi: 10.1001/jamaoncol.2022.5218. Epub ahead of print.
- PMID: 36394867
- PubMed abstract
•• Identifier: NCT03565991: Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors. (ClinicalTrials.gov . Accessed 2022 Nov 19.)
•• Commentary:
Combining PARP Inhibitor With Immunotherapy-Does the Promise of Preclinical Data Translate to Clinic?
- PMID: 36394835
- PubMed abstract
- Source abstract
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- Pancreatic Tumorigenesis: Precursors, Genetic Risk Factors and Screening.
- Badheeb M, Abdelrahim A, Esmail A, Umoru G, Abboud K, Al-Najjar E, Rasheed G, Alkhulaifawin M, Abudayyeh A, Abdelrahim M.
- Curr Oncol. 2022 Nov 15;29(11):8693-8719. doi: 10.3390/curroncol29110686.
- PMID: 36421339
- PubMed abstract
- Review
- Free Full Text
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- Are targeted therapies or immunotherapies effective in metastatic pancreatic adenocarcinoma?
- Rémond MS, Pellat A, Brezault C, Dhooge M, Coriat R.
- ESMO Open. 2022 Nov 15;7(6):100638. doi: 10.1016/j.esmoop.2022.100638. Epub ahead of print.
- PMID: 36399952
- PubMed abstract
- Review
- Free Full Text
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- The Genetics of Pancreatic Cancer
- [No author given]
- My Gene Counsel. Genetic Journal. 2022 Nov 14.
- Blog post
- Free Full Text
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- BRCA2 gene mutation in cancer.
- Xie C, Luo J, He Y, Jiang L, Zhong L, Shi Y.
- Medicine (Baltimore). 2022 Nov 11;101(45):e31705. doi: 10.1097/MD.0000000000031705.
- PMID: 36397405
- PubMed abstract
- Review
- Free Full Text
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- Gene-Level Associations in Patients With and Without Pathogenic Germline Variants in CDKN2A and Pancreatic Cancer.
- Astiazaran-Symonds E, Graham C, Kim J, Tucker MA, Ingvar C, Helgadottir H, Pastorino L, van Doorn R, Sampson JN, Zhu B, Bruno W, Queirolo P, Fornarini G, Sciallero S, Carter B, Hicks B, Hutchinson A, Jones K, Stewart DR, Chanock SJ, Freedman ND, Landi MT, Höiom V, Puig S, Gruis N, Yang XR, Ghiorzo P, Goldstein AM.
- JCO Precis Oncol. 2022 Nov;6:e2200145. doi: 10.1200/PO.22.00145.
- PMID: 36409970
- PubMed abstract
- Source abstract
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- Risk of pancreatic ductal adenocarcinoma associated with carriage of BRCA1 and/or BRCA2 mutation: A systematic review and meta-analysis.
- McGarry JL, Creavin B, Kelly ME, Gallagher TK.
- J Surg Oncol. 2022 Nov;126(6):1028-1037. doi: 10.1002/jso.26994. Epub 2022 Jun 30.
- PMID: 35770919
- PubMed abstract
- Source abstract
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- The Frequency of Germline BRCA and Non-BRCA HR-Gene-Variants in a Cohort of Pancreatic Cancer Patients.
- Baz M, Gondran-Teiller V, Bressac B, Cabaret O, Fievet A, Dimaria M, Goldbarg V, Colas C, Bonnet-Dupeyron MN, Tinat J, Lebrun M, Mari V, Limacher JM, Corsini C, Ginglinger E, Saurin JC, Brahimi A, Rouzier C, Giraud S, Schuster H, Hollebecque A, Boige V, Cauchin E, Malka D, Caron O, Rouleau E.
- Dig Dis Sci. 2022 Oct 31. doi: 10.1007/s10620-022-07733-z. Epub ahead of print.
- PMID: 36315333
- PubMed abstract
- Source abstract
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- BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.
- Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W, Stein Y, Lior C, Kim HS, Bojmar L, Jarnagin WR, Lecomte N, Mayer S, Stok R, Bishara H, Hamodi R, Levy-Lahad E, Golan T, Porco JA Jr, Iacobuzio-Donahue CA, Schultz N, Tuveson DA, Lyden D, Kelsen D, Scherz-Shouval R.
- Nat Commun. 2022 Oct 31;13(1):6513. doi: 10.1038/s41467-022-34081-3.
- PMID: 36316305
- PubMed abstract
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- Platinum-based chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC): summary of evidence and application in clinical practice.
- Reinacher-Schick A, Arnold D, Venerito M, Goekkurt E, Kraeft AL, Seufferlein T.
- Oncol Res Treat. 2022 Oct 28. doi: 10.1159/000527692. Epub ahead of print.
- PMID: 36310006
- PubMed abstract
- Source abstract
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- Mitomycin C in Homologous Recombination Deficient Metastatic Pancreatic Cancer after Disease Progression on Platinum-Based Chemotherapy and Olaparib.
- Botrus G, Roe D, Jameson GS, Serrano Uson Junior PL, Korn RL, Caldwell L, Bargenquast T, Miller M, Borazanci EH.
- Biomedicines. 2022 Oct 26;10(11):2705. doi: 10.3390/biomedicines10112705.
- Case report
- Free Full Text
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- Pancreatic Cancer Screening Appears Safe, Effective for High-Risk Patients.
- Crist C.
- Medscape Oncology. 2022 Oct 26.
- Conference report
- Free Full Text
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- Olaparib as a single agent treatment in pre-treated metastatic pancreatic cancer patient harboring BRCA2 mutation: What could we expect?
- Garajová I, Balsano R, Gelsomino F, Leonardi F.
- Tumori. 2022 Oct 26:3008916221132589. doi: 10.1177/03008916221132589. Epub ahead of print.
- PMID: 36299234
- PubMed abstract
- Source abstract
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- Unusual dMMR Phenotype Locally Advanced Pancreatic Ductal Adenocarcinoma with Germline and Somatic BRCA2 Mutation in a Jehovah Witness Patient.
- Copur MS, Tun SM, Vargas L, Merani S, Wedel W, Duckert R, Horn A, Lintel N, Herold D, Lavudi S.
- Clin Colorectal Cancer. 2022 Oct 23:S1533-0028(22)00106-2. doi: 10.1016/j.clcc.2022.10.002. Epub ahead of print.
- PMID: 36404245
- PubMed abstract
- Source abstract
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- Therapeutic effect and safety of individualized chemotherapy combined with sequential immunotherapy based on BRCA1 mRNA expression level in the treatment of unresectable pancreatic cancer.
- Du J, Zhu L, Sha H, Zou Z, Zhao L, Shen J, Kong W, Qiu Y, Liu B.
- Front Oncol. 2022 Oct 18;12:1015232. doi: 10.3389/fonc.2022.1015232.
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- Germline variants in cancer-predisposing genes in pancreatic cancer patients with a family history of cancer.
- Terashima T, Morizane C, Ushiama M, Shiba S, Takahashi H, Ikeda M, Mizuno N, Tsuji K, Yasui K, Azemoto N, Satake H, Nomura S, Yachida S, Sugano K, Furuse J.
- Jpn J Clin Oncol. 2022 Oct 6;52(10):1105-1114. doi: 10.1093/jjco/hyac110.
- PMID: 36135357
- PubMed abstract
- Source abstract
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- The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival.
- Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Blackford AL, Rustgi AK, Dudley B, Lee LS, Chhoda A, Kwon R, Ginsberg GG, Klein AP, Kamel I, Hruban RH, He J, Shin EJ, Lennon AM, Canto MI, Goggins M.
- J Clin Oncol. 2022 Oct 1;40(28):3257-3266. doi: 10.1200/JCO.22.00298. Epub 2022 Jun 15.
- PMID: 35704792
- PubMed abstract
- Source abstract
Commentary:
Building on More Than 20 Years of Progress in Pancreatic Cancer Surveillance for High-Risk Individuals.
- PMID: 35862875
- PubMed abstract
- Free Full Text
Research news: Screening for pancreatic cancer detects early-stage disease and improves survival. (FORCE XRAY)
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- Talazoparib, a Poly(ADP-ribose) Polymerase Inhibitor, for Metastatic Castration-resistant Prostate Cancer and DNA Damage Response Alterations: TALAPRO-1 Safety Analyses.
- Mehra N, Fizazi K, de Bono JS, Barthélémy P, Dorff T, Stirling A, Machiels JP, Bimbatti D, Kilari D, Dumez H, Buttigliero C, van Oort IM, Castro E, Chen HC, Di Santo N, DeAnnuntis L, Healy CG, Scagliotti GV.
- Oncologist. 2022 Oct 1;27(10):e783-e795. doi: 10.1093/oncolo/oyac172.
- PMID: 36124924
- PubMed abstract
Identifier: NCT03148795: A Study of Talazoparib in Men With DNA Repair Defects and Metastatic Castration-Resistant Prostate Cancer. (ClinicalTrials.gov)
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- Cribado de cáncer de páncreas en la práctica clínica: es el momento de la prevención [Pancreatic cancer screening in a clinical practice setting: it is the moment of Prevention].
- Adán-Merino L, Mora-Soler A, Zaera-De la Fuente C, Garrido-Gallego F, Crivillén-Anguita O, Ponferrada-Diaz Á.
- Rev Gastroenterol Peru. 2022 Oct-Dec;42(4):234-241. Spanish.
- PMID: 36746463
- PubMed abstract
- Source abstract
- [Article in Spanish]
- Free Full Text (PDF)
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- Pancreatic mixed acinar-neuroendocrine carcinoma in a patient with a germline BRCA2 mutation: a case report.
- Ikeda M, Miura S, Kume K, Kikuta K, Hamada S, Takikawa T, Nakagawa K, Unno M, Furukawa T, Masamune A.
- Clin J Gastroenterol. 2022 Oct;15(5):999-1005. doi: 10.1007/s12328-022-01668-8. Epub 2022 Jul 12.
- PMID: 35819745
- PubMed abstract
- Source abstract
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- PARPis and Other Novel, Targeted Therapeutics in Pancreatic Adenocarcinoma.
- Chapin WJ, Reiss KA.
- Hematol Oncol Clin North Am. 2022 Oct;36(5):1019-1032. doi: 10.1016/j.hoc.2022.07.007. Epub 2022 Sep 23.
- PMID: 36154785
- PubMed abstract
- Source abstract
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- Langzeitremission bei einem Patienten mit metastasiertem Adenokarzinom des Pankreas: Aktuelle Therapiemöglichkeiten und neue Therapiealgorithmen mit Hilfe des Molekularen Tumorboards [Long-term response in advanced pancreatic adenocarcinoma - a case report and literature review].
- Cura Daball P, Tröger H, Daum S.
- Z Gastroenterol. 2022 Oct;60(10):1510-1516. German. doi: 10.1055/a-1695-3528. Epub 2021 Dec 14.
- PMID: 34905798
- PubMed abstract
- Source abstract
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- Controversies and Open Questions in Management of Cancer-Free Carriers of Germline Pathogenic Variants in BRCA1/BRCA2.
- Bernstein-Molho R, Friedman E, Evron E.
- Cancers (Basel). 2022 Sep 22;14(19):4592. doi: 10.3390/cancers14194592.
- PMID: 36230512
- PubMed abstract
- Source abstract
- Review
- Free PMC article
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- Pancreatic Adenocarcinoma Management.
- Jiang Y, Sohal DPS.
- JCO Oncol Pract. 2022 Sep 22:OP2200328. doi: 10.1200/OP.22.00328. Epub ahead of print.
- PMID: 36137253
- PubMed abstract
- Source abstract
- Review
- Free Full Text
Commentary:
Pancreatic Adenocarcinoma: An Evolving Yet Unimpressive Treatment Landscape.
- PMID: 36206500
- PubMed abstract
- Free Full Text
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- Contribution of germline PALB2 variants to an unselected and prospectively registered pancreatic cancer patient cohort in Pakistan.
- Muhammad N, Sadaqat R, Naeemi H, Masood I, Hassan U, Ijaz B, Hanif F, Syed AA, Yusuf MA, Rashid MU.
- HPB (Oxford). 2022 Sep 15:S1365-182X(22)01593-3. doi: 10.1016/j.hpb.2022.09.003. Epub ahead of print.
- PMID: 36175305
- PubMed abstract
- Source abstract
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- Clinical Significance of Germline Pathogenic Variants among 51 Cancer Predisposition Genes in an Unselected Cohort of Italian Pancreatic Cancer Patients.
- Puccini A, Ponzano M, Dalmasso B, Vanni I, Gandini A, Puglisi S, Borea R, Cremante M, Bruno W, Andreotti V, Allavena E, Martelli V, Catalano F, Grassi M, Iaia ML, Pirrone C, Pastorino A, Fornarini G, Sciallero S, Ghiorzo P, Pastorino L.
- Cancers (Basel). 2022 Sep 13;14(18):4447. doi: 10.3390/cancers14184447.
- PMID: 36139606
- PubMed abstract
- Source abstract
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- Frequent abnormal pancreas imaging in patients with pathogenic ATM, BRCA1, BRCA2, and PALB2 breast cancer susceptibility variants.
- Lucas AL, Fu Y, Labiner A, DiMaio CJ, Sethi A, Kastrinos F.
- Clin Gastroenterol Hepatol. 2022 Sep 7:S1542-3565(22)00836-9. doi: 10.1016/j.cgh.2022.08.040. Epub ahead of print.
- PMID: 36087707
- PubMed abstract
- Source abstract
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- Therapeutic advances in metastatic pancreatic cancer: a focus on targeted therapies.
- Turpin A, Neuzillet C, Colle E, Dusetti N, Nicolle R, Cros J, de Mestier L, Bachet JB, Hammel P.
- Ther Adv Med Oncol. 2022 Sep 6;14:17588359221118019. doi: 10.1177/17588359221118019.
- PMID: 36090800
- PubMed abstract
- Source abstract
- Review
- Free PMC article
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- Complete response to talazoparib in patient with pancreatic adenocarcinoma harboring somatic PALB2 mutation: A case report and literature review.
- Kachmazov A, Bolotina L, Kornietskaya A, Kuznetsova O, Ivanov M, Fedenko A.
- Front Oncol. 2022 Sep 2;12:953908. doi: 10.3389/fonc.2022.953908.
- PMID: 36119518
- PubMed abstract
- Case report
- Free PMC article
- Free Full Text
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- Integrative characterization of intraductal tubulopapillary neoplasm (ITPN) of the pancreas and associated invasive adenocarcinoma.
- Mafficini A, Simbolo M, Shibata T, Hong SM, Pea A, Brosens LA, Cheng L, Antonello D, Sciammarella C, Cantù C, Mattiolo P, Taormina SV, Malleo G, Marchegiani G, Sereni E, Corbo V, Paolino G, Ciaparrone C, Hiraoka N, Pallaoro D, Jansen C, Milella M, Salvia R, Lawlor RT, Adsay V, Scarpa A, Luchini C.
- Mod Pathol. 2022 Sep 2. doi: 10.1038/s41379-022-01143-2. Epub ahead of print.
- PMID: 36056133
- PubMed abstract
- Case report
- Free Full Text
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- A Randomized Study of Olaparib or Placebo in Patients with Surgically Removed Pancreatic Cancer who have a BRCA1, BRCA2 or PALB2 Mutation (The APOLLO Trial).
- Teke ME, Saif A, Ryan CE, Lux SC, Hernandez JM, Reiss KA.
- Ann Surg Oncol. 2022 Sep;29(9):5375-5376. doi: 10.1245/s10434-022-11917-2. Epub 2022 Jun 6.
- PMID: 35668307
- PubMed abstract
- Source abstract
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- Significance of prostate/pancreatic/skin cancer family history for detecting BRCA2 pathogenic variant careers among patients with breast cancer.
- Minoura Y, Takahashi M, Maeda H, Kuwahara S, Tachikawa H, Yamamoto M, Tomioka N, Watanabe K, Sakurai A.
- Breast Cancer. 2022 Sep;29(5):808-813. doi: 10.1007/s12282-022-01360-2. Epub 2022 May 31.
- PMID: 35641852
- PubMed abstract
- Source abstract
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- Identification of high-risk germline variants for the development of pancreatic cancer: Common characteristics and potential guidance to screening guidelines.
- Bennett C, Suguitan M, Abad J, Chawla A.
- Pancreatology. 2022 Sep;22(6):719-729. doi: 10.1016/j.pan.2022.05.005. Epub 2022 May 27.
- PMID: 35798629
- PubMed abstract
- Source abstract
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- Role of genetic testing in hepatic, pancreatic, and biliary cancers.
- Hewitt DB, Aziz H, Brown ZJ, Pawlik TM.
- Surg Oncol. 2022 Sep;44:101844. doi: 10.1016/j.suronc.2022.101844. Epub 2022 Sep 5.
- PMID: 36116416
- PubMed abstract
- Source abstract
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- Clinico-genomic characterization of ATM and HRD in Pancreas Cancer: Application for Practice.
- Park W, O'Connor CA, Bandlamudi C, Forman D, Chou JF, Umeda S, Reyngold M, Varghese AM, Keane F, Balogun F, Yu KH, Kelsen DP, Crane C, Capanu M, Iacobuzio-Donahue C, O'Reilly EM.
- Clin Cancer Res. 2022 Aug 30:CCR-22-1483. doi: 10.1158/1078-0432.CCR-22-1483. Epub ahead of print.
- PMID: 36040493
- PubMed abstract
- Source abstract
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- Screening for pancreatic cancer detects early-stage disease and improves survival.
- [No author given]
- FORCE. XRAY. 2022 Aug 30.
- Research review
- Free Full Text
Original research:
The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival.
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- Reaching beyond family history as inclusion criteria for pancreatic cancer surveillance in high-risk populations.
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- Association Between Family History and Risk of Pancreatic Cancer in Patients With BRCA1 and BRCA2 Pathogenic Variants.
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- Therapie des metastasierten Pankreaskarzinoms [Treatment of metastatic pancreatic cancer].
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- Impact of comprehensive family history and genetic analysis in the multidisciplinary pancreatic tumor clinic setting.
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- Cancer Med. 2022 Jul 30. doi: 10.1002/cam4.5059. Epub ahead of print.
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- Precision Medicine of Hepatobiliary and Pancreatic Cancers: Focusing on Clinical Trial Outcomes.
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- Cancers (Basel). 2022 Jul 28;14(15):3674. doi: 10.3390/cancers14153674.
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- A Systematic Review and Meta-Analysis on the Prognostic Value of BRCA Mutations, Homologous Recombination Gene Mutations, and Homologous Recombination Deficiencies in Cancer.
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- Overall Survival Results From the POLO Trial: A Phase III Study of Active Maintenance Olaparib Versus Placebo for Germline BRCA-Mutated Metastatic Pancreatic Cancer.
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- Study Confirms BRCA1 and BRCA2 Linked to Seven Cancers.
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- Medscape Oncology. 2022 Jul 12.
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Original research:
Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants.
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- Pancreatic Ductal Carcinoma Risk Associated with Hereditary Cancer-Risk Genes.
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- A Genome-First Approach to Estimate Prevalence of Germline Pathogenic Variants and Risk of Pancreatic Cancer in Select Cancer Susceptibility Genes.
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- Germline Aberrations in Pancreatic Cancer: Implications for Clinical Care.
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- EARS2 significantly coexpresses with PALB2 in breast and pancreatic cancer.
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- Current status of inherited pancreatic cancer.
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- Intraductal Papillary Mucinous Neoplasms in Hereditary Cancer Syndromes.
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- Biomedicines. 2022 Jun 22;10(7):1475. doi: 10.3390/biomedicines10071475.
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- The Great Majority of Homologous Recombination Repair-Deficient Tumors Are Accounted for by Established Causes.
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- ASGE Expands BRCA Screening for Pancreatic Cancer.
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Guideline summary:
ASGE guideline on screening for pancreatic cancer in individuals with genetic susceptibility: summary and recommendations.
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Guideline:
American Society for Gastrointestinal Endoscopy guideline on screening for pancreatic cancer in individuals with genetic susceptibility: methodology and review of evidence.
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- Leptomeningeal disease in BRIP1-mutated pancreatic adenocarcinoma.
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- Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes.
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- Cancer Med. 2022 Jun 6. doi: 10.1002/cam4.4916. Epub ahead of print.
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- Ipilimumab/Nivolumab Therapy in Patients With Metastatic Pancreatic or Biliary Cancer With Homologous Recombination Deficiency Pathogenic Germline Variants.
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- Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants.
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- RAD51B Harbors Germline Mutations Associated With Pancreatic Ductal Adenocarcinoma.
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- Concurrent Germline BRCA1/2 and Mismatch Repair Mutations in Young-Onset Pancreatic and Colorectal Cancer: The Importance of Comprehensive Germline and Somatic Characterization to Inform Therapeutic Options.
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- Homologous Recombination Deficiency in Pancreatic Cancer: Poly (ADP-ribose) Polymerase Inhibition, Checkpoint Inhibition, or a Combination of Both?
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Letter, Reply:
Reply to F. Keane et al.
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Original research:
Exceptional Response to Olaparib and Pembrolizumab for Pancreatic Adenocarcinoma With Germline BRCA1 Mutation and High Tumor Mutation Burden: Case Report and Literature Review.
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- How to improve metastatic pancreatic ductal adenocarcinoma patients' selection: Between clinical trials and the real-world.
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- BRCA-Mutated Pancreatic Cancer: From Discovery to Novel Treatment Paradigms.
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- Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants.
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Press: BRCA Mutations More Strongly Tied to Prostate and Pancreatic Cancer. (Inside Precision Medicine)
Commentary:
Germline Pathogenic Variants in BRCA1 and BRCA2: Malignancies Beyond Female Breast and Ovarian Cancers.
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Comment, Letter:
Do Female BRCA2 Pathogenic Variant Carriers Have an Increased Risk of Lung Cancer?
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Reply, Letter:
Reply to V. Fallet et al.
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- BRCA1 and RAD51C promotor methylation in human resectable pancreatic adenocarcinoma.
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- Clin Res Hepatol Gastroenterol. 2022 May;46(5):101880. doi: 10.1016/j.clinre.2022.101880. Epub 2022 Feb 11.
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- Pancreatic cancer risk to siblings of probands in bilineal cancer settings.
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- Survival Benefit of Pembrolizumab for Patients With Pancreatic Adenocarcinoma: A Case Series.
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- Longitudinal changes of serum protein N-Glycan levels for earlier detection of pancreatic cancer in high-risk individuals.
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- Optimizing Chemotherapy of Pancreatic Acinar Cell Carcinoma: Our Experiences and Pooled Analysis of Literature.
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- Response in BRCA1 mutation carrier with metastatic pancreatic adenocarcinoma treated with FOLFIRINOX.
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- Current Systemic Treatments for the Hereditary Cancer Syndromes: Drug Development in Light of Genomic Defects.
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- Considerations on the identification and management of metastatic prostate cancer patients with DNA repair gene alterations in the Canadian context.
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- Familial pancreatic cancer: who should be considered for genetic testing?
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- Molecular Pathology of Pancreatic Cancer.
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- Platinum-based chemotherapy for pancreatic cancer: impact of mutations in the homologous recombination repair and Fanconi anemia genes.
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- Germline Pathogenic Variants in BRCA1 and BRCA2: Malignancies Beyond Female Breast and Ovarian Cancers.
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Original research:
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- Pancreatic Neuroendocrine Neoplasms: Updates on Genomic Changes in Inherited Tumour Syndromes and Sporadic Tumours Based on WHO Classification.
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- Crit Rev Oncol Hematol. 2022 Mar 3:103648. doi: 10.1016/j.critrevonc.2022.103648. Epub ahead of print.
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- Racial and ethnic variation in multigene panel testing in a cohort of BRCA1/2-negative individuals who had genetic testing in a large urban comprehensive cancer center.
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- Cancer Med. 2022 Mar;11(6):1465-1473. doi: 10.1002/cam4.4541. Epub 2022 Jan 17.
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- Next-generation sequencing of endoscopically obtained tissues from patients with all stages of pancreatic cancer.
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- Cancer Sci. 2022 Mar;113(3):1069-1077. doi: 10.1111/cas.15249. Epub 2022 Jan 10.
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- Epidemiology and geographic distribution of BRCA1-2 and DNA Damage response genes pathogenic variants in pancreatic ductal adenocarcinoma patients.
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- Incidence and Prevalence of Intraductal Papillary Mucinous Neoplasms in Individuals With BRCA1 and BRCA2 Pathogenic Variant.
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- Poly Adenosine Diphosphate-Ribose Polymerase (PARP) Inhibitors in Pancreatic Cancer.
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- Precision Medicine for BRCA/PALB2-Mutated Pancreatic Cancer and Emerging Strategies to Improve Therapeutic Responses to PARP Inhibition.
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- Pancreatic Cancer with Mutation in BRCA1/2, MLH1, and APC Genes: Phenotype Correlation and Detection of a Novel Germline BRCA2 Mutation.
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- Genes (Basel). 2022 Feb 9;13(2):321. doi: 10.3390/genes13020321.
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- Prevalence of Germline Sequence Variations Among Patients With Pancreatic Cancer in China.
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- Clinicopathological Significance of BRCAness in Resectable Pancreatic Ductal Adenocarcinoma and Its Association With Anticancer Drug Sensitivity in Pancreatic Cancer Cells.
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- Pancreas. 2022 Feb 1;51(2):183-189. doi: 10.1097/MPA.0000000000001975.
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- Influence of Cancer Susceptibility Gene Mutations and ABO Blood Group of Pancreatic Cancer Probands on Concomitant Risk to First-Degree Relatives.
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- Cancer Epidemiol Biomarkers Prev. 2022 Feb;31(2):372-381. doi: 10.1158/1055-9965.EPI-21-0745. Epub 2021 Nov 15.
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- Pancreatic Cancer: Current Multimodality Treatment Options and the Future Impact of Molecular Biological Profiling.
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- An Unexpected Tumor Reduction: Treatment with Olaparib Monotherapy in Heavily Pretreated BRCA2 Mutated Metastatic Pancreatic Cancer.
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- BRCA Mutations More Strongly Tied to Prostate and Pancreatic Cancer.
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Original research:
Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants.
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- Exceptional Response to Olaparib and Pembrolizumab for Pancreatic Adenocarcinoma With Germline BRCA1 Mutation and High Tumor Mutation Burden: Case Report and Literature Review.
- Lundy J, McKay O, Croagh D, Ganju V.
- JCO Precis Oncol. 2022 Jan [27];6:e2100437. doi: 10.1200/PO.21.00437.
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Letter, Commentary:
Homologous Recombination Deficiency in Pancreatic Cancer: Poly (ADP-ribose) Polymerase Inhibition, Checkpoint Inhibition, or a Combination of Both?
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Letter, Reply:
Reply to F. Keane et al.
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- Molecular Features and Clinical Management of Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer.
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- Case Report: Effectiveness of Targeted Treatment in a Patient With Pancreatic Cancer Harboring PALB2 Germline Mutation and KRAS Somatic Mutation.
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- Prevalence of pancreaticobiliary cancers in Irish families with pathogenic BRCA1 and BRCA2 variants.
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- Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival.
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- Cancers (Basel). 2021 Mar 31;13(7):1612. doi: 10.3390/cancers13071612. Erratum in: Cancers (Basel). 2021 Jul 22;13(15):3687.
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- Germline Mutations in Other Homologous Recombination Repair-Related Genes Than BRCA1/2: Predictive or Prognostic Factors?
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TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes.
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- Examination of ATM, BRCA1, and BRCA2 promoter methylation in patients with pancreatic cancer.
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- Pancreatology. 2021 Mar 28:S1424-3903(21)00109-5. doi: 10.1016/j.pan.2021.03.015. Epub ahead of print.
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- Solid Pseudopapillary Neoplasm of the Pancreas and Abdominal Desmoid Tumor in a Patient Carrying Two Different BRCA2 Germline Mutations: New Horizons from Tumor Molecular Profiling.
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- The German National Case Collection for Familial Pancreatic Carcinoma (FaPaCa) / Knowledge Gained in 20 Years.
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- Dtsch Arztebl Int. 2021 Mar 5;118(Forthcoming):arztebl.m2021.0004. doi: 10.3238/arztebl.m2021.0004. Epub ahead of print.
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- Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level.
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- Front Oncol. 2021 Mar 5;11:606820. doi: 10.3389/fonc.2021.606820.
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- Diagnostic, Predictive and Prognostic Molecular Biomarkers in Pancreatic Cancer: An Overview for Clinicians.
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- Cancers (Basel). 2021 Mar 3;13(5):1071. doi: 10.3390/cancers13051071
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- Personalizing Medicine With Germline and Somatic Sequencing in Advanced Pancreatic Cancer: Current Treatments and Novel Opportunities.
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- Biologic behavior of resected BRCA-mutated pancreatic cancer: Comparison with sporadic pancreatic cancer and other BRCA-related cancers.
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- Pancreatology. 2021 Feb 14:S1424-3903(21)00057-0. doi: 10.1016/j.pan.2021.02.007. Epub ahead of print.
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- Tumour-Agnostic Therapy for Pancreatic Cancer and Biliary Tract Cancer.
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- Diagnostik und Therapie des Pankreaskarzinoms [Diagnostics and therapy of pancreatic carcinoma].
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- Genomic Features and Classification of Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma.
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- Gastroenterology. 2021 Jan 29:S0016-5085(21)00326-7. doi: 10.1053/j.gastro.2021.01.220. Epub ahead of print.
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- Germline pathogenic variants in the Ataxia Telangiectasia Mutated (ATM) gene are associated with high and moderate risks for multiple cancers.
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- Cancer Prev Res (Phila). 2021 Jan 28:canprevres.0448.2020. doi: 10.1158/1940-6207.CAPR-20-0448. Epub ahead of print.
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- Clinical Significance of Germline Cancer Predisposing Variants in Unselected Patients with Pancreatic Adenocarcinoma.
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- Cancers (Basel). 2021 Jan 8;13(2):E198. doi: 10.3390/cancers13020198.
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- A novel somatic BRCA2 point mutation in a metastatic pancreatic cancer patient: a case report.
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- Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
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- J Natl Compr Canc Netw. 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001.
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- Correlazioni tra carcinoma pancreatico e pregresse neoplasie [Correlations between pancreatic carcinoma and previous neoplasms.].
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- Recenti Prog Med. 2021 Jan;112(1):81-88. Italian. doi: 10.1701/3525.35128.
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- Japanese Regulators Approve Lynparza for Ovarian, Prostate, Pancreatic Cancers.
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- Poly(ADP-ribose) polymerase inhibition in pancreatic cancer.
- Singh HM, Bailey P, Hübschmann D, Berger AK, Neoptolemos J, Jäger D, Siveke J, Springfeld C.
- Genes Chromosomes Cancer. 2020 Dec 20. doi: 10.1002/gcc.22932. Epub ahead of print.
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- Cost-Effectiveness Analysis of Maintenance Olaparib in Patients with Metastatic Pancreatic Cancer and a Germline BRCA1/2 Mutation Based on the POLO Trial.
- Zhan M, Zheng H, Yang Y, He Z, Xu T, Li Q.
- Cancer Manag Res. 2020 Dec 16;12:12919-12926. doi: 10.2147/CMAR.S283169.
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- Effect of Germline Mutations in Homologous Recombination Repair Genes on Overall Survival of Patients with Pancreatic Adenocarcinoma.
- Yadav S, Kasi PM, Bamlet WR, Ho TP, Polley EC, Hu C, Hart SN, Rabe KG, Boddicker NJ, Gnanaolivu RD, Lee KY, Lindstrom TH, Petersen GM, Couch FJ, McWilliams RR.
- Clin Cancer Res. 2020 Dec 15;26(24):6505-6512. doi: 10.1158/1078-0432.CCR-20-1788. Epub 2020 Oct 7.
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- Pancreatic mucinous cystadenocarcinoma in a patient harbouring BRCA1 germline mutation effectively treated with olaparib: A case report.
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- World J Gastrointest Oncol. 2020 Dec 15;12(12):1456-1463. doi: 10.4251/wjgo.v12.i12.1456.
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- Update on the Role of Poly (ADP-Ribose) Polymerase Inhibitors in the DNA Repair-Deficient Pancreatic Cancers: A Narrative Review.
- Kasi A, Al-Jumayli M, Park R, Baranda J, Sun W.
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- Five Italian Families with Two Mutations in BRCA Genes.
- Vietri MT, Caliendo G, D'Elia G, Resse M, Casamassimi A, Minucci PB, Dello Ioio C, Cioffi M, Molinari AM.
- Genes (Basel). 2020 Dec 3;11(12):E1451. doi: 10.3390/genes11121451.
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- Outcomes of endoscopic ultrasound as a one-off pancreatic cancer screening tool for 122 high- and moderate-risk patients.
- Efthymiou M, Chandran S, Zorron Cheng Tao Pu L, Collins A, Rajadurai A, Nikfarjam M, Vaughan R.
- JGH Open. 2020 Oct 17 [eCollection 2020 Dec];4(6):1217-1223. doi: 10.1002/jgh3.12432.
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- BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives.
- Molinaro E, Andrikou K, Casadei-Gardini A, Rovesti G.
- Cancers (Basel). 2020 Nov 12;12(11):E3346. doi: 10.3390/cancers12113346.
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- Pan-cancer landscape of homologous recombination deficiency.
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- Nat Commun. 2020 Nov 4;11(1):5584. doi: 10.1038/s41467-020-19406-4.
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- Molecular characteristics of BRCA1/2 and PALB2 mutations in pancreatic ductal adenocarcinoma.
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- Study: Inherited gene mutations found in pancreatic cancer families in Spain.
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A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants.
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- An evaluation of olaparib for the treatment of pancreatic cancer.
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- Expert Opin Pharmacother. 2020 Oct 23. doi: 10.1080/14656566.2020.1837113. Epub ahead of print.
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- Exome sequencing and characterization of 49,960 individuals in the UK Biobank.
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- Nature. 2020 Oct 21. doi: 10.1038/s41586-020-2853-0. Epub ahead of print.
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- BRCA2 Reversion Mutation Identified by Liquid Biopsy After Durable Response to FOLFIRINOX in BRCA2-Associated Pancreatic Cancer.
- Kondo T, Kanai M, Matsubara J, Quy PN, Fukuyama K, Yamamoto Y, Yamada T, Nishigaki M, Minamiguchi S, Takeda M, Nishio K, Matsumoto S, Muto M.
- Pancreas. 2020 Oct 2. doi: 10.1097/MPA.0000000000001672. Epub ahead of print.
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- Efficacy of platinum-based chemotherapy and prognosis of patients with pancreatic cancer with homologous recombination deficiency: comparative analysis of published clinical studies.
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- Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes.
- Mizukami K, Iwasaki Y, Kawakami E, Hirata M, Kamatani Y, Matsuda K, Endo M, Sugano K, Yoshida T, Murakami Y, Nakagawa H, Spurdle AB, Momozawa Y.
- EBioMedicine. 2020 Sep 24;60:103033. doi: 10.1016/j.ebiom.2020.103033. Epub ahead of print.
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- Beyond BRCA1 and BRCA2: Deleterious Variants in DNA Repair Pathway Genes in Italian Families with Breast/Ovarian and Pancreatic Cancers.
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- PARP inhibition in treatment of pancreatic cancer.
- Hammel P, Zhang C, Matile J, Colle E, Hadj-Naceur I, Gagaille MP, Bouattour M, Cros J, de Mestier L, Lamuraglia M.
- Expert Rev Anticancer Ther. 2020 Sep 16:1-7. doi: 10.1080/14737140.2020.1820330. Epub ahead of print.
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- Nouvelle AMM : olaparib — cancer du pancréas avec mutation germinale de BRCA [New drug approval: Olaparib - pancreatic cancer with BRCA germline mutation].
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- What is the role of PARP inhibitors in pancreatic cancer?
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- Expert Rev Anticancer Ther. 2020 Sep 11:1-6. doi: 10.1080/14737140.2020.1816174. Epub ahead of print.
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- Genetic Counseling for Hereditary Gastric and Pancreatic Cancer in High-Risk Gastrointestinal Cancer Clinics: An Effective Strategy.
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- Cancers (Basel). 2020 Aug 23;12(9):2386. doi: 10.3390/cancers12092386.
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- Whole-exome Sequencing Reveals New Potential Susceptibility Genes for Japanese Familial Pancreatic Cancer.
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- Ann Surg. 2020 Aug 18. doi: 10.1097/SLA.0000000000004213. Epub ahead of print.
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- A new targeted treatment for patients with a germline BRCA mutation: olaparib in pancreatic cancer.
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- BReast CAncer (BRCA) gene mutations as an emerging biomarker for the treatment of gastrointestinal malignancies.
- Premnath N, O'Reilly EM.
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- Retrospective review of outcomes in patients with DNA-damage repair related pancreatic cancer.
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- Excellent Response to Olaparib in a Patient with Metastatic Pancreatic Adenocarcinoma with Germline BRCA1 Mutation after Progression on FOLFIRINOX: Case Report and Literature Review.
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- A Phase I/II Study of Veliparib (ABT-888) in combination with 5-Fluorouracil and Oxaliplatin in Patients with Metastatic Pancreatic Cancer.
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- Maintenance therapies in metastatic pancreatic cancer: present and future with a focus on PARP inhibitors.
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- Synthetic Lethality strategies: Beyond BRCA1/2 mutations in pancreatic cancer.
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- PARP Inhibitor Lynparza Receives EU Approval for Germline BRCA-Mutated Pancreatic Cancer.
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- Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants: Results From the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).
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- Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas harboring KRAS and BRCA mutations: case report and whole exome sequencing analysis.
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- Small Steps in Pancreatic Cancer – Episode 2: Relatives at Risk.
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- The Role of BRCA Testing in Hereditary Pancreatic and Prostate Cancer Families.
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- My Father’s Fight Against the Breast-Cancer Gene.
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Germline Genetic Testing for Pancreatic Ductal Adenocarcinoma at Time of Diagnosis.
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Press: Genetic Testing in Relatives of Pancreatic Cancer Patients? (Medscape Oncology)
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- Phase 1 trial evaluating cisplatin, gemcitabine, and veliparib in 2 patient cohorts: Germline BRCA mutation carriers and wild-type BRCA pancreatic ductal adenocarcinoma.
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Editorial:
Should We Lower Our Threshold for Germline Genetic Assessment in Pancreatic Adenocarcinoma?
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Introductory Journal Article
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Intraductal papillary mucinous neoplasm was associated with pancreatic carcinogenesis, but not with systemic carcinogenesis.
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