Treatment for HBOC- or BRCA1/2 mutation-related pancreatic cancer
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- Utility of Comprehensive Genomic Profiling Tests for Patients with Incurable Pancreatic Cancer in Clinical Practice.
- Yamai T, Ikezawa K, Sugimoto N, Urabe M, Kai Y, Takada R, Nakabori T, Uehara H, Kawamura T, Kunimasa K, Yamamoto S, Wakamatsu T, Hayashi T, Kukita Y, Fujisawa F, Inoue T, Yamaguchi Y, Yamasaki T, Honma K, Ohkawa K.
- Cancers (Basel). 2023 Feb 3;15(3):970. doi: 10.3390/cancers15030970.
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- Dr. King on Delays in Access to Germline Testing in Pancreatic Cancer.
- King D.
- OncLive. OncLive TV. 2023 Jan 31.
- Conference report
- Free video
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- Genetics, Genomics and Emerging Molecular Therapies of Pancreatic Cancer.
- Liu J, Mroczek M, Mach A, Stępień M, Aplas A, Pronobis-Szczylik B, Bukowski S, Mielczarek M, Gajewska E, Topolski P, Król ZJ, Szyda J, Dobosz P.
- Cancers (Basel). 2023 Jan 27;15(3):779. doi: 10.3390/cancers15030779.
- Review
- Free Full Text
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- Implementation of a multi modal best practice bundle to improve genetic testing referral for pancreatic cancer patients. [2022 CGA-IGC Annual Meeting: The collaborative group of the Americas on Inherited Gastrointestinal Cancer November 11–13, 2022.]
- Blazey M, Lee T, Hendershot A, Bartell N, Marino D.
- Fam Cancer. [P-20: Research Categories» Delivery of Care and Alternative Models.] 2023 Jan 23. doi: 10.1007/s10689-022-00324-x. Epub ahead of print.
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- Identification of a large intra-exonic deletion in BRCA2 exon 18 in a pancreatic ductal adenocarcinoma.
- Debbabi I, Vacher S, Neuzillet C, Cros J, Revillon F, Petitalot A, Turpin A, Antonio S, Girard E, Dupain C, Kamal M, Hammel P, Bièche I, Masliah-Planchon J, Caputo SM.
- Ther Adv Med Oncol. 2023 Jan 18;15:17588359221146132. doi: 10.1177/17588359221146132.
- PMID: 36700131
- PubMed abstract
- Case report
- Free PMC article
- Free Full Text
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- Testing for homologous recombination repair or homologous recombination deficiency for poly (ADP-ribose) polymerase inhibitors: A current perspective.
- Herzog TJ, Vergote I, Gomella LG, Milenkova T, French T, Tonikian R, Poehlein C, Hussain M.
- Eur J Cancer. 2022 Dec 21 [2023 Jan 1];179:136-146. doi: 10.1016/j.ejca.2022.10.021. Epub ahead of print.
- PMID: 36563604
- PubMed abstract
- Review
- Free Full Text
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- Expert consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the determination of biomarkers in pancreatic and biliary tract cancer.
- Vera R, Ibarrola-de Andrés C, Adeva J, Pérez-Rojas J, García-Alfonso P, Rodríguez-Gil Y, Macarulla T, Serrano-Piñol T, Mondéjar R, Madrigal-Rubiales B.
- Rev Esp Patol. 2023 Jan-Mar;56(1):32-44. doi: 10.1016/j.patol.2022.06.004. Epub 2022 Aug 26.
- PMID: 36599598
- PubMed abstract
- Source abstract
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- Outcomes of Universal Point-of-Care Genetic Testing in Diverse Patients With Pancreatic Ductal Adenocarcinoma.
- Drogan CM, Kindler HL, Gao G, Kupfer SS.
- JCO Precis Oncol. 2023 Jan;7:e2200196. doi: 10.1200/PO.22.00196.
- PMID: 36689696
- PubMed abstract
- Source abstract
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- Pathologic complete response following FOLFIRINOX and olaparib treatment for hepatic metastasized pancreatic ductal adenocarcinoma with a germline BRCA mutation.
- Okada K, Uemura K, Okamoto W, Sumiyoshi T, Shintakuya R, Otsuka H, Serikawa M, Ishii Y, Arihiro K, Takahashi S.
- Clin J Gastroenterol. 2022 Dec 27. doi: 10.1007/s12328-022-01741-2. Epub ahead of print.
- PMID: 36574187
- PubMed abstract
- Source abstract
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- A chance in hopeless cancer: 5-year complete remission after oxaliplatin-based therapy in a patient with BRCA2 mutant metastatic pancreatic cancer.
- Yildirim HC, Ismayilov R, Akyildiz A, Guven DC, Abdurrahimli N, Dizdar O, Yalcin S.
- Anticancer Drugs. 2022 Dec 19. doi: 10.1097/CAD.0000000000001486. Epub ahead of print.
- PMID: 36729128
- PubMed abstract
- Source abstract
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- Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma.
- Huffman BM, Ellis H, Jordan AC, Freed-Pastor WA, Perez K, Rubinson DA, Sethi N, Singh H, Surana R, Wolpin BM, Aguirre AJ, Cleary JM.
- Cancers (Basel). 2022 Dec 16;14(24):6223. doi: 10.3390/cancers14246223.
- Review
- Free Full Text
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- Cost-effectiveness of PARP inhibitors in malignancies: A systematic review.
- Ding H, He C, Tong Y, Fang Q, Mi X, Chen L, Xin W, Fang L.
- PLoS One. 2022 Dec 15;17(12):e0279286. doi: 10.1371/journal.pone.0279286.
- PMID: 36520958
- PubMed abstract
- Review
- Free Full Text
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- Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis.
- Lelong M, Raoul JL, Touchefeu Y, Berthelot JM, Arnolfo P, Matysiak-Budnik T, Senellart H.
- Clin Case Rep. 2022 Dec 12;10(12):e6718. doi: 10.1002/ccr3.6718.
- PMID: 36523391
- PubMed abstract
- Source abstract
- Case report
- Free PMC article
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- BRCA1/2 Reversion Mutations in Patients Treated with Poly ADP-Ribose Polymerase (PARP) Inhibitors or Platinum Agents.
- Darabi S, Braxton DR, Xiu J, Carneiro BA, Swensen J, Antonarakis ES, Liu SV, McKay RR, Spetzler D, El-Deiry WS, Demeure MJ.
- Medicina (Kaunas). 2022 Dec 10;58(12):1818. doi: 10.3390/medicina58121818.
- PMID: 36557020
- PubMed abstract
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- Second-line therapy in pancreatic ductal adenocarcinoma (PDAC) patients with germline BRCA1-2 pathogenic variants (gBRCA1-2pv).
- Orsi G, Cavaliere A, Tortora G, Lonardi S, Macchini M, Di Marco M, Giordano G, Vasile E, Scartozzi M, Bozzarelli S, Noventa S, Rodriquenz MG, Militello AM, Rapposelli IG, Garajova I, De Lorenzo S, Merelli B, Bittoni A, Salvatore L, Procaccio L, Paratore C, Spallanzani A, Peretti U, Niger M, Giommoni E, Bernardini I, Tamburini E, Bernardino K, Forti L, Valente MM, Cascinu S, Milella M, Reni M.
- Br J Cancer. 2022 Dec 8. doi: 10.1038/s41416-022-02086-w. Epub ahead of print.
- PMID: 36482190
- PubMed abstract
- Source abstract
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- Genetic medicine in companion diagnostics of germline BRCA testing of Japanese pancreatic cancer patients.
- Matsubayashi H, Todaka A, Kawakami T, Hamauchi S, Yokota T, Higashigawa S, Kiyozumi Y, Harada R, Kado N, Nishimura S, Ishiwatari H, Sato J, Niiya F, Ono H, Sugiura T, Sasaki K, Yasui H, Yamazaki K.
- J Hum Genet. 2022 Dec 8. doi: 10.1038/s10038-022-01097-y. Epub ahead of print.
- PMID: 36482120
- PubMed abstract
- Source abstract
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- Germline BRCA2 variants in advanced pancreatic acinar cell carcinoma: A case report and review of literature.
- Lee CL, Holter S, Borgida A, Dodd A, Ramotar S, Grant R, Wasson K, Elimova E, Jang RW, Moore M, Kim TK, Khalili K, Moulton CA, Gallinger S, O'Kane GM, Knox JJ.
- World J Gastroenterol. 2022 Dec 7;28(45):6421-6432. doi: 10.3748/wjg.v28.i45.6421.
- PMID: 36533108
- PubMed abstract
- Source abstract
- Case report
- Free PMC article
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- NGS-based targeted gene mutational profiles in Korean patients with pancreatic cancer.
- Jung K, Lee S, Na HY, Kim JW, Lee JC, Hwang JH, Kim JW, Kim J.
- Sci Rep. 2022 Dec 3;12(1):20937. doi: 10.1038/s41598-022-24732-2.
- PMID: 36463295
- PubMed abstract
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- Long-term response to olaparib in a patient with metastatic pancreatic cancer associated with hereditary breast and ovarian cancer syndrome.
- Tsuneizumi M, Terada S, Usui T, Yamaguchi K, Hayami R, Matsunuma R.
- Oxf Med Case Reports. 2022 Nov 24;2022(11):omac124. doi: 10.1093/omcr/omac124.
- PMID: 36447463
- PubMed abstract
- Case report
- Free PMC article
- Free Full Text
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- Pharmacotherapeutic options for pancreatic ductal adenocarcinoma.
- Sardar M, Recio-Boiles A, Mody K, Karime C, Chandana SR, Mahadevan D, Starr J, Jones J, Borad M, Babiker H.
- Expert Opin Pharmacother. 2022 Nov 17. doi: 10.1080/14656566.2022.2149322. Epub ahead of print.
- PMID: 36394449
- PubMed abstract
- Source abstract
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- Avelumab Plus Talazoparib in Patients With BRCA1/2- or ATM-Altered Advanced Solid Tumors: Results From JAVELIN BRCA/ATM, an Open-Label, Multicenter, Phase 2b, Tumor-Agnostic Trial.
- Schram AM, Colombo N, Arrowsmith E, Narayan V, Yonemori K, Scambia G, Zelnak A, Bauer TM, Jin N, Ulahannan SV, Colleoni M, Aftimos P, Donoghue MTA, Rosen E, Rudneva VA, Telli ML, Domchek SM, Galsky MD, Hoyle M, Chappey C, Stewart R, Blake-Haskins JA, Yap TA.
- JAMA Oncol. 2022 Nov 17. doi: 10.1001/jamaoncol.2022.5218. Epub ahead of print.
- PMID: 36394867
- PubMed abstract
•• Identifier: NCT03565991: Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors. (ClinicalTrials.gov . Accessed 2022 Nov 19.)
•• Commentary:
Combining PARP Inhibitor With Immunotherapy-Does the Promise of Preclinical Data Translate to Clinic?
- PMID: 36394835
- PubMed abstract
- Source abstract
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- Are targeted therapies or immunotherapies effective in metastatic pancreatic adenocarcinoma?
- Rémond MS, Pellat A, Brezault C, Dhooge M, Coriat R.
- ESMO Open. 2022 Nov 15;7(6):100638. doi: 10.1016/j.esmoop.2022.100638. Epub ahead of print.
- PMID: 36399952
- PubMed abstract
- Review
- Free Full Text
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- The Evolving Landscape of Pancreatic Cancer.
- Krishnan M.
- JCO Oncol Pract. 2022 Nov 10:OP2200636. doi: 10.1200/OP.22.00636. Epub ahead of print.
- PMID: 36354334
- PubMed abstract
- Source abstract
- Commentary
- Free Full Text
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- Expert consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the determination of biomarkers in pancreatic and biliary tract cancer.
- Vera R, Ibarrola-de-Andrés C, Adeva J, Pérez-Rojas J, García-Alfonso P, Rodríguez-Gil Y, Macarulla T, Serrano-Piñol T, Mondéjar R, Madrigal-Rubiales B.
- Clin Transl Oncol. 2022 Nov;24(11):2107-2119. doi: 10.1007/s12094-022-02873-0. Epub 2022 Aug 25.
- PMID: 36008616
- PubMed abstract
- Guideline
- Free PMC article
- Free Full Text
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- Platinum-based chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC): summary of evidence and application in clinical practice.
- Reinacher-Schick A, Arnold D, Venerito M, Goekkurt E, Kraeft AL, Seufferlein T.
- Oncol Res Treat. 2022 Oct 28. doi: 10.1159/000527692. Epub ahead of print.
- PMID: 36310006
- PubMed abstract
- Source abstract
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- Mitomycin C in Homologous Recombination Deficient Metastatic Pancreatic Cancer after Disease Progression on Platinum-Based Chemotherapy and Olaparib.
- Botrus G, Roe D, Jameson GS, Serrano Uson Junior PL, Korn RL, Caldwell L, Bargenquast T, Miller M, Borazanci EH.
- Biomedicines. 2022 Oct 26;10(11):2705. doi: 10.3390/biomedicines10112705.
- Case report
- Free Full Text
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- TRAIL Receptor Targeting Agents Potentiate PARP Inhibitor Efficacy in Pancreatic Cancer Independently of BRCA2 Mutation Status.
- Khaled NB, Hammer K, Ye L, Alnatsha A, Widholz SA, Piseddu I, Sirtl S, Schneider J, Munker S, Mahajan UM, Montero JJ, Griger J, Mayerle J, Reiter FP, De Toni EN.
- Cancers (Basel). 2022 Oct 26;14(21):5240. doi: 10.3390/cancers14215240.
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- Olaparib as a single agent treatment in pre-treated metastatic pancreatic cancer patient harboring BRCA2 mutation: What could we expect?
- Garajová I, Balsano R, Gelsomino F, Leonardi F.
- Tumori. 2022 Oct 26:3008916221132589. doi: 10.1177/03008916221132589. Epub ahead of print.
- PMID: 36299234
- PubMed abstract
- Source abstract
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- Unusual dMMR Phenotype Locally Advanced Pancreatic Ductal Adenocarcinoma with Germline and Somatic BRCA2 Mutation in a Jehovah Witness Patient.
- Copur MS, Tun SM, Vargas L, Merani S, Wedel W, Duckert R, Horn A, Lintel N, Herold D, Lavudi S.
- Clin Colorectal Cancer. 2022 Oct 23:S1533-0028(22)00106-2. doi: 10.1016/j.clcc.2022.10.002. Epub ahead of print.
- PMID: 36404245
- PubMed abstract
- Source abstract
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- Therapeutic effect and safety of individualized chemotherapy combined with sequential immunotherapy based on BRCA1 mRNA expression level in the treatment of unresectable pancreatic cancer.
- Du J, Zhu L, Sha H, Zou Z, Zhao L, Shen J, Kong W, Qiu Y, Liu B.
- Front Oncol. 2022 Oct 18;12:1015232. doi: 10.3389/fonc.2022.1015232.
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- Germline variants in cancer-predisposing genes in pancreatic cancer patients with a family history of cancer.
- Terashima T, Morizane C, Ushiama M, Shiba S, Takahashi H, Ikeda M, Mizuno N, Tsuji K, Yasui K, Azemoto N, Satake H, Nomura S, Yachida S, Sugano K, Furuse J.
- Jpn J Clin Oncol. 2022 Oct 6;52(10):1105-1114. doi: 10.1093/jjco/hyac110.
- PMID: 36135357
- PubMed abstract
- Source abstract
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- Talazoparib, a Poly(ADP-ribose) Polymerase Inhibitor, for Metastatic Castration-resistant Prostate Cancer and DNA Damage Response Alterations: TALAPRO-1 Safety Analyses.
- Mehra N, Fizazi K, de Bono JS, Barthélémy P, Dorff T, Stirling A, Machiels JP, Bimbatti D, Kilari D, Dumez H, Buttigliero C, van Oort IM, Castro E, Chen HC, Di Santo N, DeAnnuntis L, Healy CG, Scagliotti GV.
- Oncologist. 2022 Oct 1;27(10):e783-e795. doi: 10.1093/oncolo/oyac172.
- PMID: 36124924
- PubMed abstract
Identifier: NCT03148795: A Study of Talazoparib in Men With DNA Repair Defects and Metastatic Castration-Resistant Prostate Cancer. (ClinicalTrials.gov)
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- PARPis and Other Novel, Targeted Therapeutics in Pancreatic Adenocarcinoma.
- Chapin WJ, Reiss KA.
- Hematol Oncol Clin North Am. 2022 Oct;36(5):1019-1032. doi: 10.1016/j.hoc.2022.07.007. Epub 2022 Sep 23.
- PMID: 36154785
- PubMed abstract
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- Langzeitremission bei einem Patienten mit metastasiertem Adenokarzinom des Pankreas: Aktuelle Therapiemöglichkeiten und neue Therapiealgorithmen mit Hilfe des Molekularen Tumorboards [Long-term response in advanced pancreatic adenocarcinoma - a case report and literature review].
- Cura Daball P, Tröger H, Daum S.
- Z Gastroenterol. 2022 Oct;60(10):1510-1516. German. doi: 10.1055/a-1695-3528. Epub 2021 Dec 14.
- PMID: 34905798
- PubMed abstract
- Source abstract
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- Methylation Analyses Reveal Promoter Hypermethylation as a Rare Cause of "Second Hit" in Germline BRCA1-Associated Pancreatic Ductal Adenocarcinoma.
- Zheng-Lin B, Rainone M, Varghese AM, Yu KH, Park W, Berger M, Mehine M, Chou J, Capanu M, Mandelker D, Stadler ZK, Birsoy O, Jairam S, Yang C, Li Y, Wong D, Benhamida JK, Ladanyi M, Zhang L, O'Reilly EM.
- Mol Diagn Ther. 2022 Sep 30. doi: 10.1007/s40291-022-00614-1. Epub ahead of print.
- PMID: 36178671
- PubMed abstract
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- Pancreatic Adenocarcinoma Management.
- Jiang Y, Sohal DPS.
- JCO Oncol Pract. 2022 Sep 22:OP2200328. doi: 10.1200/OP.22.00328. Epub ahead of print.
- PMID: 36137253
- PubMed abstract
- Source abstract
- Review
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Commentary:
Pancreatic Adenocarcinoma: An Evolving Yet Unimpressive Treatment Landscape.
- PMID: 36206500
- PubMed abstract
- Free Full Text
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- Niraparib-induced STAT3 inhibition increases its antitumor effects.
- Yu HE, Rodriguez-Rodriguez L, Zhao Q, Kohut A, Li YJ, Martincuks A, Austria T, Zhang C, Santiago NL, Borrero RM, Phan XT, Melstrom L.
- Front Oncol. 2022 Sep 21;12:966492. doi: 10.3389/fonc.2022.966492.
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- Multiple Perspectives Reveal the Role of DNA Damage Repair Genes in the Molecular Classification and Prognosis of Pancreatic Adenocarcinoma.
- Li Y, Zhang K, Peng L, Chen L, Gao H, Chen H.
- Int J Mol Sci. 2022 Sep 6;23(18):10231. doi: 10.3390/ijms231810231.
- PMID: 36142142
- PubMed abstract
- Source abstract
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- Therapeutic advances in metastatic pancreatic cancer: a focus on targeted therapies.
- Turpin A, Neuzillet C, Colle E, Dusetti N, Nicolle R, Cros J, de Mestier L, Bachet JB, Hammel P.
- Ther Adv Med Oncol. 2022 Sep 6;14:17588359221118019. doi: 10.1177/17588359221118019.
- PMID: 36090800
- PubMed abstract
- Source abstract
- Review
- Free PMC article
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- Complete response to talazoparib in patient with pancreatic adenocarcinoma harboring somatic PALB2 mutation: A case report and literature review.
- Kachmazov A, Bolotina L, Kornietskaya A, Kuznetsova O, Ivanov M, Fedenko A.
- Front Oncol. 2022 Sep 2;12:953908. doi: 10.3389/fonc.2022.953908.
- PMID: 36119518
- PubMed abstract
- Case report
- Free PMC article
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- A Randomized Study of Olaparib or Placebo in Patients with Surgically Removed Pancreatic Cancer who have a BRCA1, BRCA2 or PALB2 Mutation (The APOLLO Trial).
- Teke ME, Saif A, Ryan CE, Lux SC, Hernandez JM, Reiss KA.
- Ann Surg Oncol. 2022 Sep;29(9):5375-5376. doi: 10.1245/s10434-022-11917-2. Epub 2022 Jun 6.
- PMID: 35668307
- PubMed abstract
- Source abstract
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- Imaging PARP with [18F]rucaparib in pancreatic cancer models.
- Chan CY, Chen Z, Destro G, Veal M, Lau D, O'Neill E, Dias G, Mosley M, Kersemans V, Guibbal F, Gouverneur V, Cornelissen B.
- Eur J Nucl Med Mol Imaging. 2022 Sep;49(11):3668-3678. doi: 10.1007/s00259-022-05835-4. Epub 2022 May 26.
- PMID: 35614267
- PubMed abstract
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- Role of genetic testing in hepatic, pancreatic, and biliary cancers.
- Hewitt DB, Aziz H, Brown ZJ, Pawlik TM.
- Surg Oncol. 2022 Sep;44:101844. doi: 10.1016/j.suronc.2022.101844. Epub 2022 Sep 5.
- PMID: 36116416
- PubMed abstract
- Source abstract
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- Clinico-genomic characterization of ATM and HRD in Pancreas Cancer: Application for Practice.
- Park W, O'Connor CA, Bandlamudi C, Forman D, Chou JF, Umeda S, Reyngold M, Varghese AM, Keane F, Balogun F, Yu KH, Kelsen DP, Crane C, Capanu M, Iacobuzio-Donahue C, O'Reilly EM.
- Clin Cancer Res. 2022 Aug 30:CCR-22-1483. doi: 10.1158/1078-0432.CCR-22-1483. Epub ahead of print.
- PMID: 36040493
- PubMed abstract
- Source abstract
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- Current Screening Strategies for Pancreatic Cancer.
- Vanek P, Urban O, Zoundjiekpon V, Falt P.
- Biomedicines. 2022 Aug 23;10(9):2056. doi: 10.3390/biomedicines10092056.
- PMID: 36140157
- PubMed abstract
- Source abstract
- Review
- Free PMC article
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- Moving the Needle on Precision Medicine in Pancreatic Cancer.
- O'Kane GM, Lowery MA.
- J Clin Oncol. 2022 Aug 20;40(24):2693-2705. doi: 10.1200/JCO.21.02514. Epub 2022 Jul 15.
- PMID: 35839440
- PubMed abstract
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- Therapie des metastasierten Pankreaskarzinoms [Treatment of metastatic pancreatic cancer].
- Heinemann V, Boeck S, Westphalen CB.
- Inn Med (Heidelb). 2022 Aug;63(8):851-862. German. doi: 10.1007/s00108-022-01334-8. Epub 2022 Jul 6.
- PMID: 35925070
- PubMed abstract
- Source abstract
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- Precision Medicine of Hepatobiliary and Pancreatic Cancers: Focusing on Clinical Trial Outcomes.
- Tsumura T, Doi K, Marusawa H.
- Cancers (Basel). 2022 Jul 28;14(15):3674. doi: 10.3390/cancers14153674.
- PMID: 35954337
- PubMed abstract
- Source abstract
- Review
- Free PMC article
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- A Systematic Review and Meta-Analysis on the Prognostic Value of BRCA Mutations, Homologous Recombination Gene Mutations, and Homologous Recombination Deficiencies in Cancer.
- Shao C, Chang MS, Lam FC, Marley AR, Tang H, Song Y, Miller C, Brown M, Wan I, Han J, Adeboyeje G.
- J Oncol. 2022 Jul 20;2022:5830475. doi: 10.1155/2022/5830475.
- PMID: 35909902
- PubMed abstract
- Review
- Free PMC article
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- Overall Survival Results From the POLO Trial: A Phase III Study of Active Maintenance Olaparib Versus Placebo for Germline BRCA-Mutated Metastatic Pancreatic Cancer.
- Kindler HL, Hammel P, Reni M, Van Cutsem E, Macarulla T, Hall MJ, Park JO, Hochhauser D, Arnold D, Oh DY, Reinacher-Schick A, Tortora G, Algül H, O'Reilly EM, Bordia S, McGuinness D, Cui K, Locker GY, Golan T.
- J Clin Oncol. 2022 Jul 14:JCO2101604. doi: 10.1200/JCO.21.01604. Epub ahead of print.
- PMID: 35834777
- PubMed abstract
- Source abstract
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- Cost-Effectiveness of Poly ADP-Ribose Polymerase Inhibitors in Cancer Treatment: A Systematic Review.
- Chan VKY, Yang R, Wong ICK, Li X.
- Front Pharmacol. 2022 Jul 11;13:891149. doi: 10.3389/fphar.2022.891149.
- PMID: 35899114
- PubMed abstract
- Review
- Free PMC article
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- AZD5305 More Tolerable than Earlier PARP Agents.
- [No author given]
- Cancer Discov. 2022 Jul 6;12(7):1602. doi: 10.1158/2159-8290.CD-NB2022-0039.
- PMID: 35616497
- PubMed abstract
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- Germline Aberrations in Pancreatic Cancer: Implications for Clinical Care.
- Casolino R, Corbo V, Beer P, Hwang CI, Paiella S, Silvestri V, Ottini L, Biankin AV.
- Cancers (Basel). 2022 Jun 30;14(13):3239. doi: 10.3390/cancers14133239.
- PMID: 35805011
- PubMed abstract
- Source abstract
- Review
- Free PMC article
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- Mainstreaming germline genetic testing for patients with pancreatic cancer increases uptake.
- Ramsey ML, Tomlinson J, Pearlman R, Abushahin L, Aeilts A, Chen HZ, Chen Y, Compton A, Elkhatib R, Geiger L, Hays J, Jeter J, Jin N, Malalur P, Roychowdhury S, Ruple J, Prebish J, Stanich PP, Hampel H.
- Fam Cancer. 2022 Jun 17. doi: 10.1007/s10689-022-00300-5. Epub ahead of print.
- PMID: 35713757
- PubMed abstract
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- The Homologous Recombination Deficiency Scar in Advanced Cancer: Agnostic Targeting of Damaged DNA Repair.
- Pacheco-Barcia V, Muñoz A, Castro E, Ballesteros AI, Marquina G, González-Díaz I, Colomer R, Romero-Laorden N.
- Cancers (Basel). 2022 Jun 15;14(12):2950. doi: 10.3390/cancers14122950.
- PMID: 35740616
- PubMed abstract
- Source abstract
- Review
- Free PMC article
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- Leptomeningeal disease in BRIP1-mutated pancreatic adenocarcinoma.
- Yim E, Leung D.
- BMJ Case Rep. 2022 Jun 8;15(6):e249837. doi: 10.1136/bcr-2022-249837.
- PMID: 35675963
- PubMed abstract
- Source abstract
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- Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes.
- Gu L, Mehta PP, Rao D, Rotemberg V, Capanu M, Chou J, Lin S, Sigel CS, Busam KJ, Boyce L, Gordon A, O'Reilly EM.
- Cancer Med. 2022 Jun 6. doi: 10.1002/cam4.4916. Epub ahead of print.
- PMID: 35666021
- PubMed abstract
- Source abstract
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- Ipilimumab/Nivolumab Therapy in Patients With Metastatic Pancreatic or Biliary Cancer With Homologous Recombination Deficiency Pathogenic Germline Variants.
- Terrero G, Datta J, Dennison J, Sussman DA, Lohse I, Merchant NB, Hosein PJ.
- JAMA Oncol. 2022 Jun 1;8(6):1-3. doi: 10.1001/jamaoncol.2022.0611.
- PMID: 35446342
- PubMed abstract
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- Implementation of preventive and predictive BRCA testing in patients with breast, ovarian, pancreatic, and prostate cancer: a position paper of Italian Scientific Societies.
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See PubMed abstract for multiple related items.
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Research news: Results from the POLO trial: Olaparib may delay cancer progression in metastatic pancreatic cancer patients with BRCA mutations. (FORCE. XRAYS.)
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