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    • Cancers (Basel). 2023 Feb 20;15(4):1346. doi: 10.3390/cancers15041346.
    • Validation of a breast cancer risk prediction model based on the key risk factors: family history, mammographic density and polygenic risk.
    • Allman R, Mu Y, Dite GS, Spaeth E, Hopper JL, Rosner BA.
    • Breast Cancer Res Treat. 2023 Feb 7. doi: 10.1007/s10549-022-06834-7. Epub ahead of print.
    • Oncogenetic pedigrees: Relation between design and ability to predict mutation.
    • Kwiatkowski F, Serlet L, Stos A.
    • Biosystems. 2023 Feb 4:104841. doi: 10.1016/j.biosystems.2023.104841. Epub ahead of print.
    • Inference on the Genetic Architecture of Breast Cancer Risk.
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    • Cancer Epidemiol Biomarkers Prev. 2023 Jan 18:EPI-22-1073. doi: 10.1158/1055-9965.EPI-22-1073. Epub ahead of print.
    • Myriad Genetics Generates More Data on its PRS's Ability to Identify Who Will Develop Breast Cancer.
    • Ray F.
    • Precision Oncology News. 2022 Dec 12.
    • Use of Breast Cancer Risk Factors to Identify Risk-Adapted Starting Age of Screening in China.
    • Zheng Y, Dong X, Li J, Qin C, Xu Y, Wang F, Cao W, Xia C, Yu Y, Zhao L, Wu Z, Luo Z, Chen W, Li N, He J.
    • JAMA Netw Open. 2022 Nov 1;5(11):e2241441. doi: 10.1001/jamanetworkopen.2022.41441.

    Related:

    •• Commentary:

    Risk-Based Approaches to Breast Cancer Screening in China.

    • Methylation of promoter region of BRCA1 gene versus pathogenic variants of gene: risk factor or clinical marker of breast cancer.
    • Lobanova O, Medvedieva N, Fishchuk L, Dubitska O, Cheshuk V, Vereshchako R, Zakhartseva L, Rossokha Z, Gorovenko N.
    • Breast Cancer Res Treat. 2022 Oct 25. doi: 10.1007/s10549-022-06774-2. Epub ahead of print.
    • Breast cancer incidence among women with a family history of breast cancer by relative's age at diagnosis.
    • Durham DD, Abraham LA, Roberts MC, Khan CP, Smith RA, Kerlikowske K, Miglioretti DL.
    • Cancer. 2022 Oct 19. doi: 10.1002/cncr.34365. Epub ahead of print.

    Related:

    •• Commentary:

    What if the age at which a woman started regular mammographic screening depended on her risk, not age?

    •• Press release: Study finds earlier mammograms for women with family history of breast cancer may not be needed. (UC Davis Health | News)

    •• Research news: Earlier mammograms for women with family history of breast cancer may not be needed. (ScienceDaily)

    •• Research news: Earlier Mammograms Based on Family Breast Cancer History May Not Be Necessary. (Inside Precision Medicine)

    • Association of Treatment Response with Clinicopathological Characteristics in Female Breast Cancer Patients: Genomic Insights for Future Implementation of Personalized Medicine in Egypt.
    • Nakhla S, Elhameed AA, Ali IM, Elnaggar M, Hassan R, Yousef M, Adel K, Saleh W, Gaber M, Kotze MJ, El-Sharkawy RM.
    • Front Genet. 2022 Oct 12;12:990669. doi: 10.3389/fgene.2022.990669.
    • Segregation analysis of 17,425 population-based breast cancer families: Evidence for genetic susceptibility and risk prediction.
    • Li S, MacInnis RJ, Lee A, Nguyen-Dumont T, Dorling L, Carvalho S, Dite GS, Shah M, Luccarini C, Wang Q, Milne RL, Jenkins MA, Giles GG, Dunning AM, Pharoah PDP, Southey MC, Easton DF, Hopper JL, Antoniou AC.
    • Am J Hum Genet. 2022 Oct 6;109(10):1777-1788. doi: 10.1016/j.ajhg.2022.09.006.

    Related:

    Research news: Breast Cancer Risk Contributors, Remaining Gaps Found With Familial Analyses. (GenomeWeb)

    • Family history of breast cancer, mammographic breast density and breast cancer risk: Findings from a cohort study of Korean women.
    • Mai Tran TX, Kim S, Song H, Park B.
    • Breast. 2022 Oct;65:180-186. doi: 10.1016/j.breast.2022.08.008. Epub 2022 Aug 23.
    • Enhancing the BOADICEA cancer risk prediction model to incorporate new data on RAD51C, RAD51D, BARD1 updates to tumour pathology and cancer incidence.
    • Lee A, Mavaddat N, Cunningham A, Carver T, Ficorella L, Archer S, Walter FM, Tischkowitz M, Roberts J, Usher-Smith J, Simard J, Schmidt MK, Devilee P, Zadnik V, Jürgens H, Mouret-Fourme E, De Pauw A, Rookus M, Mooij TM, Pharoah PP, Easton DF, Antoniou AC.
    • J Med Genet. 2022 Sep 26:jmedgenet-2022-108471. doi: 10.1136/jmedgenet-2022-108471. Epub ahead of print.
    • Prospective validation of the BOADICEA multifactorial breast cancer risk prediction model in a large prospective cohort study.
    • Yang X, Eriksson M, Czene K, Lee A, Leslie G, Lush M, Wang J, Dennis J, Dorling L, Carvalho S, Mavaddat N, Simard J, Schmidt MK, Easton DF, Hall P, Antoniou AC.
    • J Med Genet. 2022 Sep 26:jmg-2022-108806. doi: 10.1136/jmg-2022-108806. Epub ahead of print.
    • Clinical applicability of the Polygenic Risk Score for breast cancer risk prediction in familial cases.
    • Lakeman IMM, Rodríguez-Girondo MDM, Lee A, Celosse N, Braspenning ME, van Engelen K, van de Beek I, van der Hout AH, Gómez García EB, Mensenkamp AR, Ausems MGEM, Hooning MJ, Adank MA, Hollestelle A, Schmidt MK, van Asperen CJ, Devilee P.
    • J Med Genet. 2022 Sep 22:jmedgenet-2022-108502. doi: 10.1136/jmg-2022-108502. Epub ahead of print.

    Related:

    Research news: Polygenic Risk Scores Could Refine Breast Cancer Screening Recommendations. (Precision Oncology News)

    • Association between fertility treatments and breast cancer risk in women with a family history or BRCA mutations: a systematic review and meta-analysis.
    • Liu X, Yue J, Pervaiz R, Zhang H, Wang L.
    • Front Endocrinol (Lausanne). 2022 Sep 13;13:986477. doi: 10.3389/fendo.2022.986477.

    Related:

    Review registration number: CRD42021281336: The incidence of breast cancer in high risk population after fertility treatment: a systematic review and meta-analysis. (PROSPERO register)

    • Association between epidemiological and clinico-pathological features of breast cancer with prognosis, family history, Ki-67 proliferation index and survival in Tunisian breast cancer patients.
    • Mighri N, Mejri N, Boujemaa M, Berrazega Y, Rachdi H, El Benna H, Labidi S, Benna F, Boubaker S, Boussen H, Abdelhak S, Hamdi Y.
    • PLoS One. 2022 Sep 12;17(9):e0269732. doi: 10.1371/journal.pone.0269732.
    • Ethnic predisposition, risk factors and breast cancer presentation; a 10-year data. Single centered prospective cohort study from Karachi.
    • Sultan N, Memon SA, Mooghal M, Wali S, Khan W, Tahseen H, Khan M, Monis D.
    • Ann Med Surg (Lond). 2022 Sep 9;82:104612. doi: 10.1016/j.amsu.2022.104612.
    • CDH1 (E-cadherin) Gene Methylation in Human Breast Cancer: Critical Appraisal of a Long and Twisted Story.
    • Bücker L, Lehmann U.
    • Cancers (Basel). 2022 Sep 8;14(18):4377. doi: 10.3390/cancers14184377.
    • Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade Serous Ovarian Cancer.
    • Lønning PE, Nikolaienko O, Pan K, Kurian AW, Eikesdal HP, Pettinger M, Anderson GL, Prentice RL, Chlebowski RT, Knappskog S.
    • JAMA Oncol. 2022 Sep 8. doi: 10.1001/jamaoncol.2022.3846. Epub ahead of print.
    • Significance of prostate/pancreatic/skin cancer family history for detecting BRCA2 pathogenic variant careers among patients with breast cancer.
    • Minoura Y, Takahashi M, Maeda H, Kuwahara S, Tachikawa H, Yamamoto M, Tomioka N, Watanabe K, Sakurai A.
    • Breast Cancer. 2022 Sep;29(5):808-813. doi: 10.1007/s12282-022-01360-2. Epub 2022 May 31.
    • Background Parenchymal Enhancement at Postoperative Surveillance Breast MRI: Association with Future Second Breast Cancer Risk.
    • Lee SH, Jang MJ, Yoen H, Lee Y, Kim YS, Park AR, Ha SM, Kim SY, Chang JM, Cho N, Moon WK.
    • Radiology. 2022 Aug 30:220440. doi: 10.1148/radiol.220440. Epub ahead of print.

    Related:

    Commentary:

    Background Parenchymal Enhancement at Breast MRI: More Is Not Better.

    • Homologous Recombination Deficiency Scar: Mutations and Beyond—Implications for Precision Oncology.
    • van der Wiel AMA, Schuitmaker L, Cong Y, Theys J, Van Hoeck A, Vens C, Lambin P, Yaromina A, Dubois LJ.
    • Cancers (Basel). 2022 Aug 27;14(17):4157. doi: 10.3390/cancers14174157.
    • Fibroblast testing can inform medical management in individuals with mosaic variants detected on hereditary cancer panels.
    • Sutcliffe EG, Mester JL, Susswein LR, Roberts ME, Marshall ML, Hruska KS.
    • Cancer Genet. 2022 Aug;266-267:86-89. doi: 10.1016/j.cancergen.2022.07.004. Epub 2022 Jul 28.
    • The Great Majority of Homologous Recombination Repair-Deficient Tumors Are Accounted for by Established Causes.
    • Štancl P, Hamel N, Sigel KM, Foulkes WD, Karlic R, Polak P.
    • Front Genet. 2022 Jun 17;13:852159. doi: 10.3389/fgene.2022.852159.
    • Ethical, legal, and sociocultural challenges of genomic research in Jordan: a mixed methods study in patients with breast cancer with Jordanian-Palestinian heritage.
    • Al-Omari A, Al-Hussaini M, Zahran F, Abdel-Razeq H.
    • Lancet. 2022 Jun;399 Suppl 1:S26. doi: 10.1016/S0140-6736(22)01161-8.
    • Molecular phenotypes and clinical characterization of familial hereditary breast cancer among half and full sisters.
    • Xu Y, He J, Qian C, Yang C.
    • BMC Womens Health. 2022 May 2;22(1):145. doi: 10.1186/s12905-022-01732-y.
    • Association of Genetic Ancestry and Molecular Signatures with Cancer Survival Disparities: A Pan-Cancer Analysis.
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    • Cancer Res. 2022 Apr 1;82(7):1222-1233. doi: 10.1158/0008-5472.CAN-21-2105.
    • Importance of multigene panel test in patients with consanguineous marriage and family history of breast cancer.
    • Ozmen V, Caglayan AO, Yararbas K, Ordu C, Aktepe F, Ozmen T, Ilgun AS, Soybir G, Alco G, Tsaousis GN, Papadopoulou E, Agiannitopoulos K, Pepe G, Kampouri S, Nasioulas G, Sezgin E, Soran A.
    • Oncol Lett. 2022 Apr;23(4):118. doi: 10.3892/ol.2022.13238. Epub 2022 Feb 9.
    • Familial Aspects of Mammographic Density Measures Associated with Breast Cancer Risk.
    • Nguyen TL, Li S, Dowty JG, Dite GS, Ye Z, Nguyen-Dumont T, Trinh HN, Evans CF, Tan M, Sung J, Jenkins MA, Giles GG, Southey MC, Hopper JL.
    • Cancers (Basel). 2022 Mar 14;14(6):1483. doi: 10.3390/cancers14061483.
    • Risk of Second Malignant Neoplasm in Familial Non-Medullary Thyroid Cancer Patients.
    • Capezzone M, Sagnella A, Cantara S, Fralassi N, Maino F, Forleo R, Brilli L, Pilli T, Cartocci A, Castagna MG.
    • Front Endocrinol (Lausanne). 2022 Mar 4;13:845954. doi: 10.3389/fendo.2022.845954.
    • Weight is More Informative than Body Mass Index for Predicting Postmenopausal Breast Cancer Risk: Prospective Family Study Cohort (ProF-SC).
    • Ye Z, Li S, Dite GS, Nguyen TL, MacInnis RJ, Andrulis IL, Buys SS, Daly MB, John EM, Kurian AW, Genkinger JM, Chung WK, Phillips KA, Thorne H, Winship IM, Milne RL, Dugué PA, Southey MC, Giles GG, Terry MB, Hopper JL.
    • Cancer Prev Res (Phila). 2022 Mar 1;15(3):185-191. doi: 0.1158/1940-6207.CAPR-21-0164.
    • Predictive and prognostic significance of BRCAness in HER2-negative breast cancer.
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    • Breast Cancer. 2022 Mar;29(2):368-376. doi: 10.1007/s12282-021-01319-9. Epub 2022 Jan 5.
    • Epidemiologic evidence of exposure to polycyclic aromatic hydrocarbons and breast cancer: A systematic review and meta-analysis.
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    • Meta-Analysis
    • Breast and prostate cancer risk: The interplay of polygenic risk, rare pathogenic germline variants, and family history.
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    • Mutations in exon region of BRCA1-related RING domain 1 gene and risk of breast cancer.
    • Wu J, Aini A, Ma B.
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    • Family History of Breast Cancer and Mammographic Breast Density in Premenopausal Women.
    • Han Y, Moore JX, Colditz GA, Toriola AT.
    • JAMA Netw Open. 2022 Feb 1;5(2):e2148983. doi: 10.1001/jamanetworkopen.2021.48983.

    Related:

    Research news: Breast Density Linked to Familial Breast Cancer Risk. (Medscape)

    • The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples.
    • Barrett JE, Herzog C, Jones A, Leavy OC, Evans I, Knapp S, Reisel D, Nazarenko T, Kim YN, Franchi D, Ryan A, Franks J, Bjørge L, Zikan M, Cibula D, Harbeck N, Colombo N, Dudbridge F, Jones L, Sundström K, Dillner J, Rådestad AF, Gemzell-Danielsson K, Pashayan N, Widschwendter M.
    • Nat Commun. 2022 Feb 1;13(1):449. doi: 10.1038/s41467-021-27918-w.

    Related:

    Press: Methylation Signatures Within Cervical Cells Capture Ovarian, Breast Cancer Risk. (GenomeWeb)

    • Air Pollution and Breast Cancer: An Examination of Modification By Underlying Familial Breast Cancer Risk.
    • Niehoff NM, Terry MB, Bookwalter DB, Kaufman JD, O'Brien KM, Sandler DP, White AJ.
    • Cancer Epidemiol Biomarkers Prev. 2022 Feb;31(2):422-429. doi: 10.1158/1055-9965.EPI-21-1140. Epub 2021 Dec 14.
    • [SCREENING WOMEN AT HIGH RISK FOR BREAST CANCER - BRCA AND BEYOND].
    • Hermann N, Westergard S, McCready DR.
    • Harefuah. 2022 Feb;161(2):95-100. Hebrew.
    • [Article in Hebrew]
    • Non-BRCA Early-Onset Breast Cancer in Young Women.
    • Gao Y, Samreen N, Heller SL.
    • Radiographics. 2022 Jan-Feb;42(1):5-22. doi: 10.1148/rg.210109.
    • Review

    Related:

    Commentary:

    Invited Commentary: The Challenges of Early-Onset Breast Cancer.

    • Association of Family Cancer History With Pathogenic Variants in Specific Breast Cancer Susceptibility Genes.
    • Kurian AW, Abrahamse P, Ward KC, Hamilton AS, Deapen D, Berek JS, Hoang L, Yussuf A, Dolinsky J, Brown K, Slavin T, Hofer TP, Katz SJ.
    • JCO Precis Oncol. 2021 Dec 22;5:PO.21.00261. doi: 10.1200/PO.21.00261.
    • Epidemiology of Ductal Carcinoma In Situ.
    • Iatrakis G, Zervoudis S.
    • Chirurgia (Bucur). 2021 Dec;116(500):S15-S21. doi: 10.21614/chirurgia.116.5.suppl.S15.
    • Somatic mosaics in hereditary tumor predisposition syndromes.
    • Steinke-Lange V, de Putter R, Holinski-Feder E, Claes KB.
    • Eur J Med Genet. 2021 Dec;64(12):104360. doi: 10.1016/j.ejmg.2021.104360. Epub 2021 Oct 13.
    • Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk.
    • Kehm RD, MacInnis RJ, John EM, Liao Y, Kurian AW, Genkinger JM, Knight JA, Colonna SV, Chung WK, Milne R, Zeinomar N, Dite GS, Southey MC, Giles GG, McLachlan SA, Whitaker KD, Friedlander ML, Weideman PC, Glendon G, Nesci S; kConFab Investigators, Phillips KA, Andrulis IL, Buys SS, Daly MB, Hopper JL, Terry MB.
    • JNCI Cancer Spectr. 2021 Dec;5(6):pkab090. doi: 10.1093/jncics/pkab090.
    • Epigenetic Dysregulation of KCNK9 Imprinting and Triple-Negative Breast Cancer.
    • Skaar DA, Dietze EC, Alva-Ornelas JA, Ann D, Schones DE, Hyslop T, Sistrunk C, Zalles C, Ambrose A, Kennedy K, Idassi O, Miranda Carboni G, Gould MN, Jirtle RL, Seewaldt VL.
    • Cancers (Basel). 2021 Nov 30;13(23):6031. doi: 10.3390/cancers13236031.
    • Characteristics of Germline Non-BRCA Mutation Status of High-Risk Breast Cancer Patients in China and Correlation with High-Risk Factors and Multigene Testing Suggestions.
    • Su Y, Yao Q, Xu Y, Yu C, Zhang J, Wang Q, Li J, Shi D, Yu B, Zeng Y, Zhu X, Bai Q, Zhou X.
    • Front Genet. 2021 Nov 30;12:674094. doi: 10.3389/fgene.2021.674094.
    • Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study.
    • Zheng G, Sundquist J, Sundquist K, Ji J.
    • BMC Cancer. 2021 Nov 12;21(1):1210. doi: 10.1186/s12885-021-08925-y.
    • Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009-2020.
    • Baranska A, Blaszczuk A, Kanadys W, Malm M, Drop K, Polz-Dacewicz M.
    • Cancers (Basel). 2021 Nov 12;13(22):5654. doi: 10.3390/cancers13225654.
    • Detection of hypermethylation BRCA1/2 gene promoter in breast tumours among Moroccan women.
    • Saif I, Bouziyane A, Benhessou M, Karroumi ME, Ennaji MM.
    • Mol Biol Rep. 2021 Nov;48(11):7147-7152. doi: 10.1007/s11033-021-06705-2. Epub 2021 Sep 30.
    • Commentary: Mismatch Repair Deficiency and Microsatellite Instability in Triple-Negative Breast Cancer: A Retrospective Study of 440 Patients.
    • Venetis K, Fusco N, Sajjadi E.
    • Front Oncol. 2021 Sep 29;11:735476. doi: 10.3389/fonc.2021.735476.

    Related:

    Original research:

    Mismatch Repair Deficiency and Microsatellite Instability in Triple-Negative Breast Cancer: A Retrospective Study of 440 Patients.

    • Retrospective Analysis of Clinicopathological Features and Familial Cancer History of Synchronous Bilateral Breast Cancer.
    • Huang KL, Liu YL, Hsu YY, Kuo WL.
    • Healthcare (Basel). 2021 Sep 13;9(9):1203. doi: 10.3390/healthcare9091203.
    • Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility.
    • Wen W, Chen Z, Bao J, Long Q, Shu XO, Zheng W, Guo X.
    • Nat Commun. 2021 Sep 13;12(1):5318. doi: 10.1038/s41467-021-25670-9.
    • Germline Genetic Testing for Women With Breast Cancer: Shifting the Paradigm From Whom to Test to Whom NOT to Test.
    • Tung N, Desai N.
    • J Clin Oncol. 2021 Sep 7:JCO2101761. doi: 10.1200/JCO.21.01761. Epub ahead of print.

    Related:

    Original research:

    Risk of Late-Onset Breast Cancer in Genetically Predisposed Women.

    Original research:

    Evaluation of Germline Genetic Testing Criteria in a Hospital-Based Series of Women With Breast Cancer.

    • Biological Role and Clinical Implications of microRNAs in BRCA Mutation Carriers.
    • Tommasi C, Pellegrino B, Boggiani D, Sikokis A, Michiara M, Uliana V, Bortesi B, Bonatti F, Mozzoni P, Pinelli S, Squadrilli A, Viani MV, Cassi D, Maglietta G, Meleti M, Musolino A.
    • Front Oncol. 2021 Sep 6;11:700853. doi: 10.3389/fonc.2021.700853.
    • Body mass index and type 2 diabetes and breast cancer survival: a Mendelian randomization study.
    • Liu YS, Wu PE, Chou WC, Vikram R, Chen WT, Yang SL, Bolla MK, Wang Q, Dennis J, Chan TL, Choi JY, Hou MF, Ito H, Kang D, Kim SW, Kwong A, Matsuo K, Park SK, Shu XO, Zheng W, Dunning AM, Easton DF, Shen CY.
    • Am J Cancer Res. 2021 Aug 15;11(8):3921-3934.
    • Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation.
    • Ribeiro Guerra M, Coignard J, Eon-Marchais S, Dondon MG, Le Gal D, Beauvallet J, Mebirouk N, Belotti M, Caron O, Gauthier-Villars M, Coupier I, Buecher B, Lortholary A, Fricker JP, Gesta P, Noguès C, Faivre L, Berthet P, Luporsi E, Delnatte C, Bonadona V, Maugard CM, Pujol P, Lasset C, Longy M, Bignon YJ, Adenis-Lavignasse C, Venat-Bouvet L, Dreyfus H, Gladieff L, Mortemousque I, Audebert-Bellanger S, Soubrier F, Giraud S, Lejeune-Dumoulin S, Limacher JM, Chiesa J, Fajac A, Floquet A, Eisinger F, Tinat J, Fert-Ferrer S, Colas C, Frebourg T, Damiola F, Barjhoux L, Cavaciuti E, Mazoyer S, Tardivon A, Lesueur F, Stoppa-Lyonnet D, Andrieu N.
    • Breast Cancer Res. 2021 Aug 3;23(1):79. doi: 10.1186/s13058-021-01456-1.
    • Risk of Late-Onset Breast Cancer in Genetically Predisposed Women.
    • Boddicker NJ, Hu C, Weitzel JN, Kraft P, Nathanson KL, Goldgar DE, Na J, Huang H, Gnanaolivu RD, Larson N, Yussuf A, Yao S, Vachon CM, Trentham-Dietz A, Teras L, Taylor JA, Scott CE, Sandler DP, Pesaran T, Patel AV, Palmer JR, Ong IM, Olson JE, O'Brien K, Neuhausen S, Martinez E, Ma H, Lindstrom S, Le Marchand L, Kooperberg C, Karam R, Hunter DJ, Hodge JM, Haiman C, Gaudet MM, Gao C, LaDuca H, Lacey JV, Dolinsky JS, Chao E, Carter BD, Burnside ES, Bertrand KA, Bernstein L, Auer PW, Ambrosone C, Yadav S, Hart SN, Polley EC, Domchek SM, Couch FJ.
    • J Clin Oncol. 2021 Jul 22:JCO2100531. doi: 10.1200/JCO.21.00531. Epub ahead of print.

    Related:

    Commentary, Research report:

    Germline Genetic Testing for Women With Breast Cancer: Shifting the Paradigm From Whom to Test to Whom NOT to Test.

    Press: Older Women with Breast Cancer May Benefit from Genetic Testing (Clinical OMICs)

    • No Association of Early-Onset Breast or Ovarian Cancer with Early-Onset Cancer in Relatives in BRCA1 or BRCA2 Mutation Families.
    • Imbert-Bouteille M, Corsini C, Picot MC, Mizrahy L, Akouete S, Huguet H, Thomas F, Geneviève D, Taourel P, Ychou M, Galibert V, Rideau C, Baudry K, Kogut Kubiak T, Coupier I, Hobeika R, Macary Y, Toledano A, Solassol J, Maalouf A, Daures JP, Pujol P.
    • Genes (Basel). 2021 Jul 20;12(7):1100. doi: 10.3390/genes12071100.
    • A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients.
    • Wendt C, Muranen TA, Mielikäinen L, Thutkawkorapin J, Blomqvist C, Jiao X, Ehrencrona H, Tham E, Arver B, Melin B, Kuchinskaya E, Stenmark Askmalm M, Paulsson-Karlsson Y, Einbeigi Z, von Wachenfeldt Väppling A, Kalso E, Tasmuth T, Kallioniemi A, Aittomäki K, Nevanlinna H, Borg Å, Lindblom A.
    • Sci Rep. 2021 Jul 20;11(1):14763. doi: 10.1038/s41598-021-93926-x.
    • Genomic Risk Prediction for Breast Cancer in Older Women.
    • Lacaze P, Bakshi A, Riaz M, Orchard SG, Tiller J, Neumann JT, Carr PR, Joshi AD, Cao Y, Warner ET, Manning A, Nguyen-Dumont T, Southey MC, Milne RL, Ford L, Sebra R, Schadt E, Gately L, Gibbs P, Thompson BA, Macrae FA, James P, Winship I, McLean C, Zalcberg JR, Woods RL, Chan AT, Murray AM, McNeil JJ.
    • Cancers (Basel). 2021 Jul 14;13(14):3533. doi: 10.3390/cancers13143533.
    • Clinical and pathological features and risk factors for primary breast cancer patients.
    • Lei YY, Bai S, Chen QQ, Luo XJ, Li DM.
    • World J Clin Cases. 2021 Jul 6;9(19):5046-5053. doi: 10.12998/wjcc.v9.i19.5046.
    • Soluble interleukin-2 receptor as a predictive and prognostic marker for patients with familial breast cancer.
    • Gonda K, Horita S, Maejima Y, Takenoshita S, Shimomura K.
    • Sci Prog. 2021 Jul-Sep;104(3):368504211039590. doi: 10.1177/00368504211039590.
    • Impact of breast cancer risk factors on clinically relevant prognostic biomarkers for primary breast cancer.
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    • Breast Cancer Res Treat. 2021 Jun 29. doi: 10.1007/s10549-021-06294-5. Epub ahead of print.
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    Related:

    Commentary, Presentation:

    Discussion on: Breast cancer risk assessment in patients who test negative for a hereditary cancer syndrome.

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    • Polygenic background modifies penetrance of monogenic variants conferring risk for coronary artery disease, breast cancer, or colorectal cancer.
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    Related:

    Press: Polygenic Modifiers of Pathogenic Genes May Refine Disease Risk Prediction. (GenomeWeb)

    • Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC).
    • Zeinomar N, Knight JA, Genkinger JM, Phillips KA, Daly MB, Milne RL, Dite GS, Kehm RD, Liao Y, Southey MC, Chung WK, Giles GG, McLachlan SA, Friedlander ML, Weideman PC, Glendon G, Nesci S; kConFab Investigators, Andrulis IL, Buys SS, John EM, MacInnis RJ, Hopper JL, Terry MB.
    • Breast Cancer Res. 2019 Nov 28;21(1):128. doi: 10.1186/s13058-019-1213-1.
    • Synergistic Effect Between Full-Term Pregnancy/Breastfeeding And Familial Susceptibility On Breast Cancer Risk.
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    • Cancer Manag Res. 2019 Nov 15;11:9743-9748. doi: 10.2147/CMAR.S231426. eCollection 2019.
    • Risk-Adapted Starting Age of Screening for Relatives of Patients With Breast Cancer.
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    Related:

    Editorial:

    Toward Risk-Stratified Breast Cancer Screening: Considerations for Changes in Screening Guidelines.

    Editorial:

    Breast cancer screening programs: does one risk fit all?

    Letter, Comment:

    Determining the Appropriate Risk-Adapted Screening Age for Familial Breast Cancer.

    Letter, Reply:

    Determining the Appropriate Risk-Adapted Screening Age for Familial Breast Cancer-Reply.

    • DNA methylation-based biological age, genome-wide average DNA methylation, and conventional breast cancer risk factors.
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    • Interval Breast Cancer Risk Associations with Breast Density, Family History, and Breast Tissue Ageing.
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    Related:

    Editorial:

    Polygenic risk scores for breast cancer risk prediction: Lessons learned and future opportunities.

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    Women's occupational exposure to polycyclic aromatic hydrocarbons and risk of breast cancer.

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    Cancer incidence in familial Mediterranean fever patients: a retrospective analysis from central Anatolia.

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    Letter, Commentary:

    A closer look at familial Mediterranean fever cases in a large breast cancer dataset.

    • Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study.
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    • Nat Commun. 2019 Jan 25;10(1):431. doi: 10.1038/s41467-018-08054-4.
    • Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas.
    • Hoffman J, Fejerman L, Hu D, Huntsman S, Li M, John EM, Torres-Mejia G, Kushi L, Ding YC, Weitzel J, Neuhausen SL, Lott P; COLUMBUS Consortium, Echeverry M, Carvajal-Carmona L, Burchard E, Eng C, Long J, Zheng W, Olopade O, Huo D, Haiman C, Ziv E.
    • Breast Cancer Res. 2019 Jan 14;21(1):3. doi: 10.1186/s13058-018-1085-9.
    • Constitutive BRCA1 Promoter Hypermethylation Can Be a Predisposing Event in Isolated Early-Onset Breast Cancer.
    • Azzollini J, Pesenti C, Pizzamiglio S, Fontana L, Guarino C, Peissel B, Plebani M, Tabano S, Sirchia SM, Colapietro P, Villa R, Paolini B, Verderio P, Miozzo M, Manoukian S.
    • Cancers (Basel). 2019 Jan 9;11(1). pii: E58. doi: 10.3390/cancers11010058.
    • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.
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    • Am J Hum Genet. 2019 Jan 3;104(1):21-34. doi: 10.1016/j.ajhg.2018.11.002. Epub 2018 Dec 13.
    • The association between non-breast and ovary cancers and BRCA mutation in first- and second-degree relatives of high-risk breast cancer patients: a large-scale study of Koreans.
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    • Hered Cancer Clin Pract. 2019 Jan 3;17:1. doi: 10.1186/s13053-018-0103-3. eCollection 2019.
    • Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies.
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    • Ann Intern Med. 2019 Jan 1;170(1):22-30. doi: 10.7326/M18-1323. Epub 2018 Dec 11.

    Related:

    Editorial, Comment:

    Learning From Temporal Relationships: Childbirth and Breast Cancer Risk.

    Research news: Breast cancer risk increases modestly after childbirth. (FORCE. XRAYS.)

    • Relationship between Background Parenchymal Enhancement on High-risk Screening MRI and Future Breast Cancer Risk.
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    • Adult Physical Activity and Breast Cancer Risk in Women with a Family History of Breast Cancer.
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    • Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):51-58. doi: 10.1158/1055-9965.EPI-18-0674. Epub 2018 Oct 17.
    • Second primary cancer after female breast cancer: Familial risks and cause of death.
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    • Cancer Med. 2019 Jan;8(1):400-407. doi: 10.1002/cam4.1899. Epub 2018 Nov 26.
    • Final Results of the Prospective FH02 Mammographic Surveillance Study of Women Aged 35-39 at Increased Familial Risk of Breast Cancer.
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    • EClinicalMedicine. 2019 Jan;7:39-46. doi: 10.1016/j.eclinm.2019.01.005.
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    • Women's occupational exposure to polycyclic aromatic hydrocarbons and risk of breast cancer.
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    Related:

    Letter, Comment:

    Response to Lee et al 2019: Essential to frame study implications within the context of prior findings from enriched cohorts for underlying familial risk of breast cancer.

    • Family History of Breast Cancer Associated with Breast Cancer in Survivors of Hodgkin Lymphoma.
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    • Int J Cancer Clin Res. 2019;6(1). pii: 107. doi: 10.23937/2378-3419/1410107. Epub 2019 Feb 25.
    • Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects.
    • Meijer TG, Verkaik NS, Sieuwerts AM, van Riet J, Naipal KAT, van Deurzen CHM, den Bakker MA, Sleddens HFBM, Dubbink HJ, den Toom TD, Dinjens WNM, Lips E, Nederlof PM, Smid M, van de Werken HJG, Kanaar R, Martens JWM, Jager A, van Gent DC.
    • Clin Cancer Res. 2018 Dec 15;24(24):6277-6287. doi: 10.1158/1078-0432.CCR-18-0063. Epub 2018 Aug 23.
    • A Linkage Between Thyroid and Breast Cancer: A Common Etiology?
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    • CYP2D6 phenotype, tamoxifen, and risk of contralateral breast cancer in the WECARE Study.
    • Brooks JD, Comen EA, Reiner AS, Orlow I, Leong SF, Liang X, Mellemkjær L, Knight JA, Lynch CF, John EM, Bernstein L, Woods M, Doody DR; WECARE Study collaborative group, Malone KE, Bernstein JL.
    • Breast Cancer Res. 2018 Dec 10;20(1):149. doi: 10.1186/s13058-018-1083-y.
    • Genome-wide DNA methylation assessment of 'BRCA1-like' early-onset breast cancer: Data from the Australian Breast Cancer Family Registry.
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    • Exp Mol Pathol. 2018 Dec;105(3):404-410. doi: 10.1016/j.yexmp.2018.11.006. Epub 2018 Nov 10.
    • Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC).
    • Hopper JL, Dite GS, MacInnis RJ, Liao Y, Zeinomar N, Knight JA, Southey MC, Milne RL, Chung WK, Giles GG, Genkinger JM, McLachlan SA, Friedlander ML, Antoniou AC, Weideman PC, Glendon G, Nesci S; kConFab Investigators, Andrulis IL, Buys SS, Daly MB, John EM, Phillips KA, Terry MB.
    • Breast Cancer Res. 2018 Nov 3;20(1):132. doi: 10.1186/s13058-018-1056-1.
    • Differential Burden of Rare and Common Variants on Tumor Characteristics, Survival, and Mode of Detection in Breast Cancer.
    • Li J, Ugalde-Morales E, Wen WX, Decker B, Eriksson M, Torstensson A, Christensen HN, Dunning AM, Allen J, Luccarini C, Pooley KA, Simard J, Dorling L, Easton DF, Teo SH, Hall P, Czene K.
    • Cancer Res. 2018 Nov 1;78(21):6329-6338. doi: 10.1158/0008-5472.CAN-18-1018.
    • Physical Activity, Global DNA Methylation, and Breast Cancer Risk: A Systematic Literature Review and Meta-analysis.
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    • Review
    • The Importance of Distinguishing Sporadic Cancers from Those Related to Cancer Predisposing Germline Mutations.
    • Sorscher S.
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    • Case report
    • BRCA1/BRCA2 Mutations Shaped by Ancient Consanguinity Practice in Southern Mediterranean Populations
    • Belaiba F, Medimegh I, Bidet Y, Boussetta S, Baroudi O, Mezlini A, Bignon YJ, Benammar El gaaied A.
    • Asian Pac J Cancer Prev. 2018 Oct 26;19(10):2963-2972.
    • BRCA1 methylation in newborns: genetic disposition, maternal transfer, environmental influence, or by chance only?
    • Lønning PE, Knappskog S.
    • Clin Epigenetics. 2018 Oct 22;10(1):128. doi: 10.1186/s13148-018-0566-0.

    Related:

    Original research:

    Methylation of BRCA1 and MGMT genes in white blood cells are transmitted from mothers to daughters.

    • Evaluation of the BRCAness phenotype and its correlations with clinicopathologic features in triple-negative breast cancers.
    • Tian T, Shan L, Yang W, Zhou X, Shui R.
    • Hum Pathol. 2018 Oct 16. pii: S0046-8177(18)30390-3. doi: 10.1016/j.humpath.2018.10.004. [Epub ahead of print]
    • BRCAness Combined With a Family History of Cancer Is Associated With a Poor Prognosis for Breast Cancer Patients With a High Risk of BRCA Mutations.
    • Mori H, Kubo M, Kai M, Velasquez VV, Kurata K, Yamada M, Okido M, Kuroki S, Oda Y, Nakamura M.
    • Clin Breast Cancer. 2018 Oct;18(5):e1217-e1227. doi: 10.1016/j.clbc.2018.05.008. Epub 2018 Jun 2.
    • BRCA1 Promoter Methylation and Clinicopathological Characteristics in Sporadic Breast Cancer Patients in Indonesia.
    • Harahap WA, Sudji IR, Nindrea RD.
    • Asian Pac J Cancer Prev. 2018 Sep 26;19(9):2643-2649.
    • Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation-negative early-onset and high-risk breast cancer patients.
    • Böck J, Appenzeller S, Haertle L, Schneider T, Gehrig A, Schröder J, Rost S, Wolf B, Bartram CR, Sutter C, Haaf T.
    • Int J Cancer. 2018 Sep 15;143(6):1416-1425. doi: 10.1002/ijc.31526. Epub 2018 Apr 25.
    • Meta-Analysis of BRCA1 Polymorphisms and Breast Cancer Susceptibility.
    • Soudeh GF, Ali D, Sepideh F.
    • Klin Onkol. 2018 Fall;31(5):330-338. doi: 10.14735/amko2018330.
    • Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.
    • Khera AV, Chaffin M, Aragam KG, Haas ME, Roselli C, Choi SH, Natarajan P, Lander ES, Lubitz SA, Ellinor PT, Kathiresan S.
    • Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13.

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    • Family history of breast or prostate cancer and prostate cancer risk.
    • Barber LE, Gerke T, Markt SC, Peisch SF, Wilson KM, Ahearn TU, Giovannucci EL, Parmigiani G, Mucci LA.
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    • Effect of exercise on metabolic syndrome in black women by family history and predicted risk of breast cancer: The FIERCE Study.
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    • Methylation Profiles of BRCA1, RASSF1A and GSTP1 in Vietnamese Women with Breast Cancer.
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    • Methylation of BRCA1 and MGMT genes in white blood cells are transmitted from mothers to daughters.
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    • Clin Epigenetics. 2018 Jul 26;10(1):99. doi: 10.1186/s13148-018-0529-5.

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    • Breast cancer in an 18-year-old female: A fatal case report and literature review.
    • Jóźwik M, Posmyk R, Jóźwik M, Semczuk A, Gogiel-Shields M, Kuś-Słowińska M, Garbowicz M, Klukowski M, Wojciechowicz J.
    • Cancer Biol Ther. 2018 Jul 3;19(7):543-548. doi: 10.1080/15384047.2017.1416931.
    • Vitamin D Receptor Gene Polymorphism: Association with Susceptibility to Early-Onset Breast Cancer in Iranian, BRCA1/2-Mutation Carrier and non-carrier Patients.
    • Shahabi A, Alipour M, Safiri H, Tavakol P, Alizadeh M, Milad Hashemi S, Shahabi M, Halimi M.
    • Pathol Oncol Res. 2018 Jul;24(3):601-607. doi: 10.1007/s12253-017-0281-8. Epub 2017 Aug 6.
    • Promoter hypermethylation of p16, BRCA1 and RASSF1A genes in triple-negative breast cancer patients from Serbia.
    • Kozomara Z, Supic G, Krivokuca A, Magic Z, Dzodic R, Milovanovic Z, Brankovic-Magic M.
    • J BUON. 2018 May-Jun;23(3):684-691.
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    • J Cancer Res Clin Oncol. 2018 May;144(5):865-874. doi: 10.1007/s00432-018-2609-5. Epub 2018 Feb 17.
    • Association of BRCA1 Promoter Methylation with Breast Cancer in Asia: A Meta- Analysis.
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    • Asian Pac J Cancer Prev. 2018 Apr 25;19(4):885-889.
    • Common genetic variation and novel loci associated with volumetric mammographic density.
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    • Breast Cancer Res. 2018 Apr 17;20(1):30. doi: 10.1186/s13058-018-0954-6.
    • Full in-frame exon 3 skipping of BRCA2 confers high risk of breast and/or ovarian cancer.
    • Caputo SM, Léone M, Damiola F, Ehlen A, Carreira A, Gaidrat P, Martins A, Brandão RD, Peixoto A, Vega A, Houdayer C, Delnatte C, Bronner M, Muller D, Castera L, Guillaud-Bataille M, Søkilde I, Uhrhammer N, Demontety S, Tubeuf H, Castelain G; French COVAR group collaborators, Jensen UB, Petitalot A, Krieger S, Lefol C, Moncoutier V, Boutry-Kryza N, Nielsen HR, Sinilnikova O, Stoppa-Lyonnet D, Spurdle AB, Teixeira MR, Coulet F, Thomassen M, Rouleau E.
    • Oncotarget. 2018 Apr 3;9(25):17334-17348. doi: 10.18632/oncotarget.24671. eCollection 2018 Apr 3.
    • Family History and Breast Cancer Risk Among Older Women in the Breast Cancer Surveillance Consortium Cohort.
    • Braithwaite D, Miglioretti DL, Zhu W, Demb J, Trentham-Dietz A, Sprague B, Tice JA, Onega T, Henderson LM, Buist DSM, Ziv E, Walter LC, Kerlikowske K; Breast Cancer Surveillance Consortium.
    • JAMA Intern Med. 2018 Apr 1;178(4):494-501. doi: 10.1001/jamainternmed.2017.8642.

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    • Common Genetic Variation and Breast Cancer Risk-Past, Present, and Future.
    • Lilyquist J, Ruddy KJ, Vachon CM, Couch FJ.
    • Cancer Epidemiol Biomarkers Prev. 2018 Apr;27(4):380-394. doi: 10.1158/1055-9965.EPI-17-1144. Epub 2018 Jan 30.
    • Assessing the effectiveness of NICE criteria for stratifying breast cancer risk in a UK cohort.
    • Littlejohn LA, Gibbs J, Jordan LB, Miedzybrodzka ZH, Bell C, Goudie D, Dunlop J, Berg JN.
    • Eur J Hum Genet. 2018 Apr;26(4):599-603. doi: 10.1038/s41431-017-0072-4. Epub 2018 Jan 15.
    • A Germline Mutation in the BRCA1 3’UTR Variant Predicts Susceptibility to Breast Cancer in a Saudi Arabian Population.
    • Mir R, Javid J, Al Balawi IA, Alkharsah KR, Hadi MA, Rahman MA, Hamoud E, Al Alawi Y, Al Zahrani ABM, Abu-Duhier FM.
    • Asian Pac J Cancer Prev. 2018 Mar 27;19(3):859-866.
    • Impact of homologous recombination deficiency biomarkers on outcomes in patients with triple-negative breast cancer treated with adjuvant doxorubicin and cyclophosphamide (SWOG S9313).
    • Sharma P, Barlow WE, Godwin AK, Pathak H, Isakova K, Williams D, Timms KM, Hartman AR, Wenstrup RJ, Linden HM, Tripathy D, Hortobagyi GN, Hayes DF.
    • Ann Oncol. 2018 Mar 1;29(3):654-660. doi: 10.1093/annonc/mdx821.
    • Breast Cancer is Common in Women With Ovarian Malignant Mixed Mullerian Tumors.
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    • Am J Clin Oncol. 2018 Mar;41(3):286-288. doi: 10.1097/COC.0000000000000266.
    • Family History and Risk of Second Primary Breast Cancer after In Situ Breast Carcinoma.
    • Baglia ML, Tang MC, Malone KE, Porter P, Li CI.
    • Cancer Epidemiol Biomarkers Prev. 2018 Mar;27(3):315-320. doi: 10.1158/1055-9965.EPI-17-0837. Epub 2018 Jan 16.
    • A20 Constitutional methylation of BRCA1 gene in breast cancer.
    • Prajzendanc K, Kaczmarek K, Łukomska A, Sukiennicki G, Szwiec M, Huzarski T, Wojdacz TK, Lubiński J, Jakubowska A.
    • Hered Cancer Clin Pract. 2018 Feb 28;16(Suppl 1):A20. Meeting abstracts from Clinical Genetics of Cancer 2017; Szczecin, Poland. 21-22 September 2017. doi: 10.1186/s13053-018-0087-z.
    • Conference abstract
    • Evaluation of three polygenic risk score models for the prediction of breast cancer risk in Singapore Chinese.
    • Chan CHT, Munusamy P, Loke SY, Koh GL, Yang AZY, Law HY, Yoon CS, Wong CY, Yong WS, Wong NS, Ng RCH, Ong KW, Madhukumar P, Oey CL, Ho GH, Tan PH, Tan MH, Ang P, Yap Y, Lee ASG.
    • Oncotarget. 2018 Jan 31;9(16):12796-12804. doi: 10.18632/oncotarget.24374. eCollection 2018 Feb 27.
    • Promoter Methylation of BRCA1, DAPK1 and RASSF1A is Associated with Increased Mortality among Indian Women with Breast Cancer.
    • Yadav P, Masroor M, Nandi K, Kaza RCM, Jain SK, Khurana N, Saxena A.
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    • Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?
    • Nguyen-Dumont T, Teo ZL, Hammet F, Roberge A, Mahmoodi M, Tsimiklis H, Park DJ, Pope BJ, Lonie A, Kapuscinski MK, Mahmood K; ABCFR, Goldgar DE, Giles GG, Winship I, Hopper JL, Southey MC.
    • BMC Cancer. 2018 Feb 8;18(1):165. doi: 10.1186/s12885-018-4028-z.
    • Breast cancer risk factors and mammographic density among high-risk women in urban China.
    • Sung H, Ren J, Li J, Pfeiffer RM, Wang Y, Guida JL, Fang Y, Shi J, Zhang K, Li N, Wang S, Wei L, Hu N, Gierach GL, Dai M, Yang XR, He J.
    • NPJ Breast Cancer. 2018 Feb 6;4:3. doi: 10.1038/s41523-018-0055-9. eCollection 2018.
    • Combined Hormonal Contraceptive Use and Risk of Breast Cancer in a Population of Women With a Family History.
    • Grandi G, Toss A, Cagnacci A, Marcheselli L, Pavesi S, Facchinetti F, Cascinu S, Cortesi L.
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    • Inherited factors contribute to an inverse association between preeclampsia and breast cancer.
    • Yang H, He W, Eriksson M, Li J, Holowko N, Chiesa F, Hall P, Czene K.
    • Breast Cancer Res. 2018 Jan 23;20(1):6. doi: 10.1186/s13058-017-0930-6.
    • Double Heterozygosity for BRCA1 Pathogenic Variant and BRCA2 Polymorphic Stop Codon K3326X: A Case Report in a Southern Italian Family.
    • Palmirotta R, Lovero D, Stucci LS, Silvestris E, Quaresmini D, Cardascia A, Silvestris F.
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    • Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population.
    • Chen FY, Wang H, Li , Hu XL, Dai , Wang SM, Yan GJ, Jiang PL, Hu YP, Huang J, Tang LL.
    • Technol Cancer Res Treat. 2018 Jan 1;17:1533033818819841. doi: 10.1177/1533033818819841.
    • Predictive value of BRCA1/2 mRNA expression for response to neoadjuvant chemotherapy in BRCA-negative breast cancers.
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    • Breast Cancer Disparities: How Can We Leverage Genomics to Improve Outcomes?
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    • Review
    • Breast cancer family history and allele-specific DNA methylation in the legacy girls study.
    • Wu HC, Do C, Andrulis IL, John EM, Daly MB, Buys SS, Chung WK, Knight JA, Bradbury AR, Keegan THM, Schwartz L, Krupska I, Miller RL, Santella RM, Tycko B, Terry MB.
    • Epigenetics. 2018;13(3):240-250. doi: 10.1080/15592294.2018.1435243. Epub 2018 Apr 2.
    • BRCA1 Promoter Methylation and Expression - Associations with ER+, PR+ and HER2+ Subtypes of Breast Carcinoma.
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    • Asian Pac J Cancer Prev. 2017 Dec 29;18(12):3293-3299.
    • Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas.
    • Huo D, Hu H, Rhie SK, Gamazon ER, Cherniack AD, Liu J, Yoshimatsu TF, Pitt JJ, Hoadley KA, Troester M, Ru Y, Lichtenberg T, Sturtz LA, Shelley CS, Benz CC, Mills GB, Laird PW, Shriver CD, Perou CM, Olopade OI.
    • JAMA Oncol. 2017 Dec 1;3(12):1654-1662. doi: 10.1001/jamaoncol.2017.0595.

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    Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening.

    Letter, Reply:

    Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening-Reply.

    • Familial associations of male breast cancer with other cancers.
    • Zheng G, Yu H, Hemminki A, Försti A, Sundquist K, Hemminki K.
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    • Biology and Etiology of Young-Onset Breast Cancers among Premenopausal African American Women: Results from the AMBER Consortium.
    • Chollet-Hinton L, Olshan AF, Nichols HB, Anders CK, Lund JL, Allott EH, Bethea TN, Hong CC, Cohen SM, Khoury T, Zirpoli GR, Borges VF, Rosenberg LA, Bandera EV, Ambrosone CB, Palmer JR, Troester MA.
    • Cancer Epidemiol Biomarkers Prev. 2017 Dec;26(12):1722-1729. doi: 10.1158/1055-9965.EPI-17-0450. Epub 2017 Sep 13.
    • Emerging Trends in Family History of Breast Cancer and Associated Risk.
    • Shiyanbola OO, Arao RF, Miglioretti DL, Sprague BL, Hampton JM, Stout NK, Kerlikowske K, Braithwaite D, Buist DSM, Egan KM, Newcomb PA, Trentham-Dietz A.
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    • Synchronous Breast Cancer and Gallbladder Diseases-A Chromosomal Analysis: A Pilot Study at a Tertiary Care Centre.
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    • Diseases potentially related to Flammer syndrome.
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    • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
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    • Nat Genet. 2017 Dec;49(12):1767-1778. doi: 10.1038/ng.3785. Epub 2017 Oct 23.

    Related:

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    • Møller P, Hovig E.
    • Hered Cancer Clin Pract. 2017 Nov 13;15:20. doi: 10.1186/s13053-017-0080-y. eCollection 2017.

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    Retraction Note to: The BRCA2 variant c.68-7 T > A is associated with breast cancer.

    • Association analysis identifies 65 new breast cancer risk loci.
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    Related:

    Press: More Breast Cancer Risk Gene Variants Discovered. (Medscape/WebMD)

    Press: Global Breast Cancer Study Reveals 72 New Mutations. (OncoTherapy Network)

    Research News: No new high-risk breast cancer genes here. (FORCE)

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    Genetics: BRCA-mutant breast/ovarian cancer revealed.

    Press: Breast and ovarian cancers: Large study improves estimates of genetic risk. (Medical News Today)

    Press: Most Precise Estimates Ever of Cancer Risks With BRCA. (Medscape)

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    • Cancer Incidence in First- and Second-Degree Relatives of BRCA1 and BRCA2 Mutation Carriers.
    • Streff H, Profato J, Ye Y, Nebgen D, Peterson SK, Singletary C, Arun BK, Litton JK.
    • Oncologist. 2016 Jul;21(7):869-74. doi: 10.1634/theoncologist.2015-0354. Epub 2016 Jun 15.
    • Second Primary Cancers After Primary Breast Cancer Diagnosis in Israeli Women, 1992 to 2006.
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    • Common genetic susceptibility to DCIS and invasive ductal carcinoma.
    • Sopik V, Narod SA.
    • Breast Cancer Res. 2016 Jun 10;18(1):60. doi: 10.1186/s13058-016-0719-z.

    Related:

    Genetic predisposition to ductal carcinoma in situ of the breast.

    • Pyrosequencing quantified methylation level of BRCA1 promoter as prognostic factor for survival in breast cancer patient.
    • Cai FF, Chen S, Wang MH, Lin XY, Zhang L, Zhang JX, Wang LX, Yang J, Ding JH, Pan X, Shao ZM, Biskup E.
    • Oncotarget. 2016 May 10;7(19):27499-510. doi: 10.18632/oncotarget.8355.
    • The LEGACY Girls Study: Growth and Development in the Context of Breast Cancer Family History.
    • John EM, Terry MB, Keegan TH, Bradbury AR, Knight JA, Chung WK, Frost CJ, Lilge L, Patrick-Miller L, Schwartz LA, Whittemore AS, Buys SS, Daly MB, Andrulis IL.
    • Epidemiology. 2016 May;27(3):438-48. doi: 10.1097/EDE.0000000000000456.
    • Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer.
    • Jobsen JJ, van der Palen J, Brinkhuis M, Ong F, Struikmans H.
    • Acta Oncol. 2016 Apr;55(4):449-54. doi: 10.3109/0284186X.2015.1074281. Epub 2015 Sep 23.
    • Increased ID4 expression, accompanied by mutant p53 accumulation and loss of BRCA1/2 proteins in triple-negative breast cancer, adversely affects survival.
    • Thike AA, Tan PH, Ikeda M, Iqbal J.
    • Histopathology. 2016 Apr;68(5):702-12. doi: 10.1111/his.12801. Epub 2015 Nov 2.
    • Identification and frequency of the rs12516 and rs8176318 BRCA1 gene polymorphisms among different populations.
    • Yang F, Chen F, Xu J, Guan X.
    • Oncol Lett. 2016 Apr;11(4):2481-2486. Epub 2016 Feb 19.
    • [Relationship of clinicopathological features and chemotherapeutic outcomes in women with BRCA1 and BRCA2 mutation-negative familial breast cancer].
    • Zhang J, Sun J, Ouyang T, Li JF, Wang TF, Fan ZQ, Fan T, Lin BY, Xie YT.
    • Zhonghua Zhong Liu Za Zhi. 2016 Mar 23;38(3):185-9. doi: 10.3760/cma.j.issn.0253-3766.2016.03.005.
    • Patients with a High Polygenic Risk of Breast Cancer do not have An Increased Risk of Radiotherapy Toxicity.
    • Dorling L, Barnett GC, Michailidou K, Coles CE, Burnet NG, Yarnold J, Elliott RM, Dunning AM, Pharoah PD, West CM.
    • Clin Cancer Res. 2016 Mar 15;22(6):1413-20. doi: 10.1158/1078-0432.CCR-15-1080. Epub 2015 Oct 28.
    • Genetic evaluation of BRCA1 associated a complex genes with triple-negative breast cancer susceptibility in Chinese women.
    • Ling H, Li S, Wu Y, Zheng YZ, Qiao F, Yao L, Cao ZG, Ye FG, Wu J, Hu X, Wang B, Shao ZM.
    • Oncotarget. 2016 Mar 1;7(9):9759-72. doi: 10.18632/oncotarget.7112.
    • Genetic predisposition to ductal carcinoma in situ of the breast.
    • Petridis C, Brook MN, Shah V, Kohut K, Gorman P, Caneppele M, Levi D, Papouli E, Orr N, Cox A, Cross SS, Dos-Santos-Silva I, Peto J, Swerdlow A, Schoemaker MJ, Bolla MK, Wang Q, Dennis J, Michailidou K, Benitez J, González-Neira A, Tessier DC, Vincent D, Li J, Figueroa J, Kristensen V, Borresen-Dale AL, Soucy P, Simard J, Milne RL, Giles GG, Margolin S, Lindblom A, Brüning T, Brauch H, Southey MC, Hopper JL, Dörk T, Bogdanova NV, Kabisch M, Hamann U, Schmutzler RK, Meindl A, Brenner H, Arndt V, Winqvist R, Pylkäs K, Fasching PA, Beckmann MW, Lubinski J, Jakubowska A, Mulligan AM, Andrulis IL, Tollenaar RA, Devilee P, Le Marchand L, Haiman CA, Mannermaa A, Kosma VM, Radice P, Peterlongo P, Marme F, Burwinkel B, van Deurzen CH, Hollestelle A, Miller N, Kerin MJ, Lambrechts D, Floris G, Wesseling J, Flyger H, Bojesen SE, Yao S, Ambrosone CB, Chenevix-Trench G, Truong T, Guénel P, Rudolph A, Chang-Claude J, Nevanlinna H, Blomqvist C, Czene K, Brand JS, Olson JE, Couch FJ, Dunning AM, Hall P, Easton DF, Pharoah PD, Pinder SE, Schmidt MK, Tomlinson I, Roylance R, García-Closas M, Sawyer EJ.
    • Breast Cancer Res. 2016 Feb 17;18(1):22. doi: 10.1186/s13058-016-0675-7.

    Related:

    Letter

    Common genetic susceptibility to DCIS and invasive ductal carcinoma.

    • Triple-Negative versus Non-Triple-Negative Breast Cancers in High-Risk Women: Phenotype Features and Survival from the HIBCRIT-1 MRI-Including Screening Study.
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    • Clin Cancer Res. 2016 Feb 15;22(4):895-904. doi: 10.1158/1078-0432.CCR-15-0459. Epub 2015 Oct 26.
    • The Breast-Thyroid Cancer Link: A Systematic Review and Meta-analysis.
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    • Cancer Epidemiol Biomarkers Prev. 2016 Feb;25(2):231-8. doi: 10.1158/1055-9965.EPI-15-0833.
    • Meta-Analysis, Review
    • Associations of Breast Cancer Risk Prediction Tools With Tumor Characteristics and Metastasis.
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    • miR-146a and miR-638 in BRCA1-deficient triple negative breast cancer tumors, as potential biomarkers for improved overall survival.
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    • Association of polymorphisms with a family history of cancer and the presence of germline mutations in the BRCA1/BRCA2 genes.
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    • Hered Cancer Clin Pract. 2016 Jan 13;14:2. doi: 10.1186/s13053-015-0042-1. eCollection 2016.
    • Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.
    • Li J, Meeks H, Feng BJ, Healey S, Thorne H, Makunin I, Ellis J; kConFab Investigators, Campbell I, Southey M, Mitchell G, Clouston D, Kirk J, Goldgar D, Chenevix-Trench G.
    • J Med Genet. 2016 Jan;53(1):34-42. doi: 10.1136/jmedgenet-2015-103452. Epub 2015 Nov 3.
    • [Germline mutations of TP53 gene among Chinese families with high risk for breast cancer].
    • Yang X, Hu Z, Wu J, Liu G, Di G, Chen C, Hou Y, Huang X, Liu Z, Shen Z, Shao Z.
    • Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Dec 10;32(6):761-5. doi: 10.3760/cma.j.issn.1003-9406.2015.06.001.
    • [Article in Chinese]
    • Association of BRCA1 promoter methylation with sporadic breast cancers: Evidence from 40 studies.
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    • Mol Oncol. 2015 Oct;9(8):1528-38. doi: 10.1016/j.molonc.2015.04.011. Epub 2015 May 7.
    • Patients Tested at a Laboratory for Hereditary Cancer Syndromes Show an Overlap for Multiple Syndromes in Their Personal and Familial Cancer Histories.
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    • Oncology. [2015 Oct;]89(5):288-93. doi: 10.1159/000437307. Epub 2015 Aug 28.
    • CCR 20th Anniversary Commentary: Triple-Negative Breast Cancer in 2015-Still in the Ballpark.
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    • Clin Cancer Res. 2015 Sep 1;21(17):3813-4. doi: 10.1158/1078-0432.CCR-14-3122.

    Related:

    Triple-negative breast cancer: clinical features and patterns of recurrence.

    • Heterozygous germline mutations in NBS1 among Korean patients with high-risk breast cancer negative for BRCA1/2 mutation.
    • Kim H, Cho DY, Choi DH, Jung GH, Shin I, Park W, Huh SJ, Kim SW, Park SK, Lee JW, Nam SJ, Lee JE, Gil WH, Kim SW.
    • Fam Cancer. 2015 Sep;14(3):365-71. doi: 10.1007/s10689-015-9789-9.
    • Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.
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    • Gastroenterology. 2015 Sep;149(3):604-613.e20. doi: 10.1053/j.gastro.2015.05.006. Epub 2015 May 14.

    Related:

    Editorial

    Next Generation Multigene Panel Testing: The Next Step for Identification of Hereditary Colorectal Cancer Syndromes?

    • Fibroadenoma with an unexpected lobular carcinoma in situ: A case report and review of the literature.
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    • Personal or first-degree family breast cancer history: which has higher impact on tumor detection and tumor size in breast cancer.
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    • A case-control study to assess the impact of mammographic density on breast cancer risk in women aged 40-49 at intermediate familial risk.
    • Assi V, Massat NJ, Thomas S, MacKay J, Warwick J, Kataoka M, Warsi I, Brentnall A, Warren R, Duffy SW.
    • Int J Cancer. 2015 May 15;136(10):2378-87. doi: 10.1002/ijc.29275. Epub 2014 Nov 22.
    • Family history and risk of pregnancy-associated breast cancer (PABC).
    • Johansson AL, Andersson TM, Hsieh CC, Cnattingius S, Dickman PW, Lambe M.
    • Breast Cancer Res Treat. 2015 May;151(1):209-17. doi: 10.1007/s10549-015-3369-4. Epub 2015 Apr 19.
    • Patterns of changing cancer risks with time since diagnosis of a sibling.
    • Lee M, Czene K, Rebora P, Reilly M.
    • Int J Cancer. 2015 Apr 15;136(8):1948-56. doi: 10.1002/ijc.29239. Epub 2014 Oct 10.
    • Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid cancer.
    • Ni Y, Seballos S, Ganapathi S, Gurin D, Fletcher B, Ngeow J, Nagy R, Kloos RT, Ringel MD, LaFramboise T, Eng C.
    • Endocr Relat Cancer. 2015 Apr;22(2):121-30. doi: 10.1530/ERC-14-0537.
    • Close-familial prostate cancer might increase risk of breast cancer.
    • [No author given]
    • Nurs Stand. 2015 Mar 18;29(29):14. doi: 10.7748/ns.29.29.14.s15.
    • News
    • Clinical and molecular characteristics of triple-negative breast cancer patients in Northern Israel: single center experience.
    • Asleh-Aburaya K, Fried G.
    • Springerplus. 2015 Mar 15;4:132. doi: 10.1186/s40064-015-0900-3. eCollection 2015.
    • Familial Risks and Estrogen Receptor-Positive Breast Cancer in Hong Kong Chinese Women.
    • Tse LA, Li M, Chan WC, Kwok CH, Leung SL, Wu C, Yu IT, Yu WC, Lao X, Wang X, Wong CK, Lee PM, Wang F, Yang XR.
    • PLoS One. 2015 Mar 10;10(3):e0120741. doi: 10.1371/journal.pone.0120741.
    • Sister chromatid exchange: A possible approach to characterize familial breast cancer patients.
    • De Pascalis I, Pilato B, Mazzotta A, Dell'Endice TS, Rubini V, Simone G, Paradiso A, Aiello V, Mangia A.
    • Oncol Rep. 2015 Feb;33(2):930-4. doi: 10.3892/or.2014.3628. Epub 2014 Nov 26.
    • Consanguinity Protecting Effect Against Breast Cancer among Tunisian Women: Analysis of BRCA1 Haplotypes.
    • Medimegh I, Troudi W, Omrane I, Ayari H, Uhrhummer N, Majoul H, Benayed F, Mezlini A, Bignon YJ, Sibille C, Elgaaied AB.
    • Asian Pac J Cancer Prev. 2015;16(9):4051-5.
    • Breast cancer in female survivors of Wilms tumor: A report from the National Wilms Tumor late effects study.
    • Lange JM, Takashima JR, Peterson SM, Kalapurakal JA, Green DM, Breslow NE.
    • Cancer. 2014 Dec 1;120(23):3722-3730. doi: 10.1002/cncr.28908. Epub 2014 Oct 27.

    Related:

    Editorial:

    Breast cancer in Wilms tumor survivors: New insights into primary and secondary prevention.

    Letter, Comment:

    Wilms tumor and breast cancer.

    Letter, Reply:

    Wilms tumor and breast cancer.

    • Clinicopathologic characteristics of breast cancer in BRCA-carriers and non-carriers in women 35 years of age or less.
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    • Clinicopathological features of young patients (<35 years of age) with breast cancer in a Japanese Breast Cancer Society supported study.
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    • Case Report
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    • Impact of familial risk and mammography screening on prognostic indicators of breast disease among women from the Ontario site of the Breast Cancer Family Registry.
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    • Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.
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    • Comparison of breast cancers diagnosed in screening patients in their 40s with and without family history of breast cancer in a community outpatient facility.
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    • Prevalence of breast cancer in thyroid diseases: results of a cross-sectional study of 3,921 patients.
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    • Determinants of genetic counseling uptake and its impact on breast cancer outcome: a population-based study.
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    • A Novel Splice Site Mutation in the Noncoding Region of BRCA2: Implications for Fanconi Anemia and Familial Breast Cancer Diagnostics.
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    • Review
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    • Is multiple SNP testing in BRCA2 and BRCA1 female carriers ready for use in clinical practice? Results from a large Genetic Centre in the UK.
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    • Clin Genet. 2013 Jul;84(1):37-42. doi: 10.1111/cge.12035. Epub 2012 Nov 20.
    • Parental origin of mutation and the risk of breast cancer in a prospective study of women with a BRCA1 or BRCA2 mutation.
    • Senst N, Llacuachaqui M, Lubinski J, Lynch H, Armel S, Neuhausen S, Ghadirian P, Sun P, Narod S; Hereditary Breast Cancer Study Group.
    • Clin Genet. 2013 Jul;84(1):43-6. doi: 10.1111/cge.12037. Epub 2012 Nov 7.
    • Association of BRCA1 promoter methylation with rs11655505 (c.2265C>T) variants and decreased gene expression in sporadic breast cancer.
    • Hasan TN, Leena Grace B, Shafi G, Syed R.
    • Clin Transl Oncol. 2013 Jul;15(7):555-62. doi: 10.1007/s12094-012-0968-y. Epub 2012 Dec 21.
    • Breast cancer in women aged 25 years and younger.
    • Dimitrakakis C, Tsigginou A, Zagouri F, Marinopoulos S, Sergentanis TN, Keramopoulos A, Liakou P, Zografos GC, Papadimitriou CA, Dimopoulos MA, Antsaklis A.
    • Obstet Gynecol. 2013 Jun;121(6):1235-40. doi: 10.1097/AOG.0b013e318291ef9a.
    • Mammographic density and breast cancer: a comparison of related and unrelated controls in the Breast Cancer Family Registry.
    • Linton L, Martin LJ, Li Q, Huszti E, Minkin S, John EM, Rommens J, Paterson AD, Boyd NF.
    • Breast Cancer Res. 2013 May 25;15(3):R43. doi: 10.1186/bcr3430.
    • Serum microRNA expression as an early marker for breast cancer risk in prospectively collected samples from the Sister Study cohort.
    • Godfrey AC, Xu Z, Weinberg CR, Getts RC, Wade PA, DeRoo LA, Sandler DP, Taylor JA.
    • Breast Cancer Res. 2013 May 24;15(3):R42. doi: 10.1186/bcr3428.
    • Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation.
    • Rinella ES, Shao Y, Yackowski L, Pramanik S, Oratz R, Schnabel F, Guha S, Leduc C, Campbell CL, Klugman SD, Terry MB, Senie RT, Andrulis IL, Daly M, John EM, Roses D, Chung WK, Ostrer H.
    • Hum Genet. 2013 May;132(5):523-36. doi: 10.1007/s00439-013-1269-4. Epub 2013 Jan 25.
    • Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers.
    • Gilam A, Edry L, Mamluk-Morag E, Bar-Ilan D, Avivi C, Golan D, Laitman Y, Barshack I, Friedman E, Shomron N.
    • Breast Cancer Res Treat. 2013 Apr;138(3):753-60. doi: 10.1007/s10549-013-2502-5. Epub 2013 Apr 3.
    • Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer.
    • Wang J, Scholtens D, Holko M, Ivancic D, Lee O, Hu H, Chatterton RT Jr, Sullivan ME, Hansen N, Bethke K, Zalles CM, Khan SA.
    • Cancer Prev Res (Phila). 2013 Apr;6(4):321-30. doi: 10.1158/1940-6207.CAPR-12-0304. Epub 2013 Mar 19.

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    Press: Breast cancer gene test could allow preventive treatment. (The Telegraph)

    • Methylation of BRCA1 promoter region is associated with unfavorable prognosis in women with early-stage breast cancer.
    • Hsu NC, Huang YF, Yokoyama KK, Chu PY, Chen FM, Hou MF.
    • PLoS One. 2013;8(2):e56256. doi: 10.1371/journal.pone.0056256. Epub 2013 Feb 6.
    • Risk of Asynchronous Contralateral Breast Cancer in Noncarriers of BRCA1 and BRCA2 Mutations With a Family History of Breast Cancer: A Report From the Women's Environmental Cancer and Radiation Epidemiology Study.
    • Reiner AS, John EM, Brooks JD, Lynch CF, Bernstein L, Mellemkjær L, Malone KE, Knight JA, Capanu M, Teraoka SN, Concannon P, Liang X, Figueiredo JC, Smith SA, Stovall M, Pike MC, Haile RW, Thomas DC, Begg CB, Bernstein JL.
    • J Clin Oncol. 2013 Feb 1;31(4):433-9. doi: 10.1200/JCO.2012.43.2013. Epub 2012 Dec 26.

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    Comments on NSGC Discussion Forum Cancer SIG

    Subject: justification for MRI?

    Subject: Estimating risk of a SECOND breast cancer and breast MRI

    Subject: MRI in patients who are BRCA negative, high risk, have cancer

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    • Germline DNA copy number aberrations identified as potential prognostic factors for breast cancer recurrence.
    • Sapkota Y, Ghosh S, Lai R, Coe BP, Cass CE, Yasui Y, Mackey JR, Damaraju S.
    • PLoS One. 2013;8(1):e53850. doi: 10.1371/journal.pone.0053850. Epub 2013 Jan 16.

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    • Low level of consanguinity in moroccan families at high risk of breast cancer.
    • Elalaoui SC, Jaouad IC, Laarabi FZ, Elgueddari Bel K.
    • Asian Pac J Cancer Prev. 2013;14(2):723-6.
    • Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts.
    • Zienolddiny S, Haugen A, Lie JA, Kjuus H, Anmarkrud KH, Kjærheim K.
    • Breast Cancer Res. 2013;15(4):R53.
    • Multifocal Breast Cancer in Young Women with Prolonged Contact between Their Breasts and Their Cellular Phones.
    • West JG, Kapoor NS, Liao SY, Chen JW, Bailey L, Nagourney RA.
    • Case Rep Med. 2013;2013:354682. doi: 10.1155/2013/354682. Epub 2013 Sep 18.
    • A role for common genomic variants in the assessment of familial breast cancer.
    • Sawyer S, Mitchell G, McKinley J, Chenevix-Trench G, Beesley J, Chen XQ, Bowtell D, Trainer AH, Harris M, Lindeman GJ, James PA.
    • J Clin Oncol. 2012 Dec 10;30(35):4330-6. doi: 10.1200/JCO.2012.41.7469. Epub 2012 Oct 29.

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    Comment, Editorial:

    Evaluating breast cancer risk with genome-wide association studies: is this approach patient ready?

    Press: Evaluating Breast Cancer Risk With Genome-Wide Association Studies: Is This Approach Patient Ready? (Journal of Clinical Oncology)

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    • Varghese JS, Smith PL, Folkerd E, Brown J, Leyland J, Audley T, Warren RM, Dowsett M, Easton DF, Thompson DJ.
    • Cancer Epidemiol Biomarkers Prev. 2012 Dec;21(12):2167-75. doi: 10.1158/1055-9965.EPI-12-0789. Epub 2012 Oct 16.
    • Estrogen receptor, progesterone receptor, and HER2-neu expression in first primary breast cancers and risk of second primary contralateral breast cancer.
    • Saltzman BS, Malone KE, McDougall JA, Daling JR, Li CI.
    • Breast Cancer Res Treat. 2012 Oct;135(3):849-55. doi: 10.1007/s10549-012-2183-5. Epub 2012 Aug 19.
    • BRCA1-methylated sporadic breast cancers are BRCA-like in showing a basal phenotype and absence of ER expression.
    • Bal A, Verma S, Joshi K, Singla A, Thakur R, Arora S, Singh G.
    • Virchows Arch. 2012 Sep;461(3):305-12. doi: 10.1007/s00428-012-1286-z. Epub 2012 Jul 21.
    • Tumour morphology of early-onset breast cancers predicts breast cancer risk for first-degree relatives: the Australian Breast Cancer Family Registry.
    • Dite GS, Makalic E, Schmidt DF, Giles GG, Hopper JL, Southey MC.
    • Breast Cancer Res. 2012 Aug 28;14(4):R122. doi: 10.1186/bcr3248.
    • Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study.
    • Kotsopoulos J, Sukiennicki G, Muszyńska M, Gackowski D, Kąklewski K, Durda K, Jaworska K, Huzarski T, Gronwald J, Byrski T, Ashuryk O, Dębniak T, Tołoczko-Grabarek A, Stawicka M, Godlewski D, Oliński R, Jakubowska A, Narod SA, Lubinski J.
    • Cancer Causes Control. 2012 Jul;23(7):1065-74. doi: 10.1007/s10552-012-9975-0. Epub 2012 May 11.
    • Young women with family history of breast cancer and their risk factors for benign breast disease.
    • Berkey CS, Tamimi RM, Rosner B, Frazier AL, Colditz GA.
    • Cancer. 2012 Jun 1;118(11):2796-803. doi: 10.1002/cncr.26519. Epub 2011 Nov 14.

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    • Family history and risk of breast cancer: nurses' health study.
    • Colditz GA, Kaphingst KA, Hankinson SE, Rosner B.
    • Breast Cancer Res Treat. 2012 Jun;133(3):1097-104. doi: 10.1007/s10549-012-1985-9. Epub 2012 Feb 19.
    • BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls.
    • Bosviel R, Garcia S, Lavediaux G, Michard E, Dravers M, Kwiatkowski F, Bignon YJ, Bernard-Gallon DJ.
    • Cancer Epidemiol. 2012 Jun;36(3):e177-82. doi: 10.1016/j.canep.2012.02.001. Epub 2012 Mar 7.
    • Risk factors for breast cancer for women aged 40 to 49 years: a systematic review and meta-analysis.
    • Nelson HD, Zakher B, Cantor A, Fu R, Griffin J, O'Meara ES, Buist DS, Kerlikowske K, van Ravesteyn NT, Trentham-Dietz A, Mandelblatt JS, Miglioretti DL.
    • Ann Intern Med. 2012 May 1;156(9):635-48. doi: 10.7326/0003-4819-156-9-201205010-00006.

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    Comment, Editorial:

    Risk-based mammography screening: an effort to maximize the benefits and minimize the harms.

    News:

    Studies support risk-based mammography screening.

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    • Brennan K, Garcia-Closas M, Orr N, Fletcher O, Jones M, Ashworth A, Swerdlow A, Thorne H; KConFab Investigators, Riboli E, Vineis P, Dorronsoro M, Clavel-Chapelon F, Panico S, Onland-Moret NC, Trichopoulos D, Kaaks R, Khaw KT, Brown R, Flanagan JM.
    • Cancer Res. 2012 May 1;72(9):2304-13. Epub 2012 Feb 28.

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    News: Epigenetic test could inform breast cancer risk prediction. (PHG Foundation)

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    • Verkooijen HM, Hartman M, Usel M, Benhamou S, Neyroud-Caspar I, Czene K, Vlastos G, Chappuis PO, Bouchardy C, Rapiti E.
    • Int J Cancer. 2012 May 1;130(9):2103-10. doi: 10.1002/ijc.26206. Epub 2011 Nov 17.
    • Routine testing for PALB2 mutations in familial pancreatic cancer families and breast cancer families with pancreatic cancer is not indicated.
    • Harinck F, Kluijt I, van Mil SE, Waisfisz Q, van Os TA, Aalfs CM, Wagner A, Olderode-Berends M, Sijmons RH, Kuipers EJ, Poley JW, Fockens P, Bruno MJ.
    • Eur J Hum Genet. 2012 May;20(5):577-9. doi: 10.1038/ejhg.2011.226. Epub 2011 Dec 14.
    • Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study.
    • Wang LE, Han CH, Xiong P, Bondy ML, Yu TK, Brewster AM, Shete S, Arun BK, Buchholz TA, Wei Q.
    • Breast Cancer Res Treat. 2012 Apr;132(3):1147-55. doi: 10.1007/s10549-011-1940-1. Epub 2012 Jan 5.
    • Increased risk for distant metastasis in patients with familial early-stage breast cancer and high EZH2 expression.
    • Alford SH, Toy K, Merajver SD, Kleer CG.
    • Breast Cancer Res Treat. 2012 Apr;132(2):429-37. doi: 10.1007/s10549-011-1591-2. Epub 2011 May 26.
    • Risk of breast cancer in families of multiple affected women and men.
    • Bevier M, Sundquist K, Hemminki K.
    • Breast Cancer Res Treat. 2012 Apr;132(2):723-8. doi: 10.1007/s10549-011-1915-2. Epub 2011 Dec 17.

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    Comments from NSGC Discussion Forum Cancer SIG

    Subject: Relative risks for male breast cancer

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    • Ben Gacem R, Hachana M, Ziadi S, Amara K, Ksia F, Mokni M, Trimeche M.
    • Cancer Epidemiol. 2012 Apr;36(2):190-7. doi: 10.1016/j.canep.2011.09.001. Epub 2011 Oct 5.
    • Breast cancer risk factors in Queensland women attending population-based mammography screening.
    • Protani M, Page A, Taylor R, Glazebrook R, Lahmann PH, Branch E, Muller J.
    • Maturitas. 2012 Mar;71(3):279-86. doi: 10.1016/j.maturitas.2011.12.008. Epub 2012 Jan 4.
    • Appendectomy and cancer risk in Jewish BRCA1 and BRCA2 mutation carriers.
    • Bernholtz S, Jakobson-Setton A, Korach J, Ben Baruch G, Laitman Y, Friedman E.
    • Breast Cancer Res Treat. 2012 Feb;131(3):981-5. doi: 10.1007/s10549-011-1807-5. Epub 2011 Oct 9.
    • Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer.
    • Collins LC, Marotti JD, Gelber S, Cole K, Ruddy K, Kereakoglow S, Brachtel EF, Schapira L, Come SE, Winer EP, Partridge AH.
    • Breast Cancer Res Treat. 2012 Feb;131(3):1061-6. doi: 10.1007/s10549-011-1872-9. Epub 2011 Nov 13.
    • Are genetic and environmental components of variance in mammographic density measures that predict breast cancer risk independent of within-twin pair differences in body mass index?
    • Dite GS, Stone J, Chiarelli AM, Giles GG, English DR, Cawson JC, Hopper JL.
    • Breast Cancer Res Treat. 2012 Jan;131(2):553-9. doi: 10.1007/s10549-011-1739-0. Epub 2011 Aug 27.