Obstetrician Gynecologists ~ Healthcare Providers and Genetic Services
~ Genetics of Breast & Ovarian Cancer

Healthcare Providers' Education, Knowledge, Opinions, Preferences, Roles in Provision of/Referral to Genetic Services for HBOC. Also includes reviews, education papers, and other papers that are focused on or specifically written for the given provider group.

List was last updated on Nov 26, 2019 @ 7:51 am.


    • Hereditary Cancer Syndromes and Risk Assessment: ACOG COMMITTEE OPINION SUMMARY, Number 793.
    • [No authors listed]
    • Obstet Gynecol. 2019 Dec;134(6):1366-1367. doi: 10.1097/AOG.0000000000003563.
    • Hereditary Cancer Syndromes and Risk Assessment: ACOG COMMITTEE OPINION, Number 793.
    • [No authors listed]
    • Obstet Gynecol. 2019 Dec;134(6):e143-e149. doi: 10.1097/AOG.0000000000003562.
    • Knowledge and opinions regarding BRCA1 and BRCA2 genetic testing among primary care physicians.
    • Dekanek EW, Thull DL, Massart M, Grubs RE, Rajkovic A, Mai PL.
    • J Genet Couns. 2019 Nov 14. doi: 10.1002/jgc4.1189. [Epub ahead of print]
    • Menopausal hormone therapy for BRCA-mutation carriers: attitudes of Israeli healthcare providers before and after a brief educational intervention.
    • Perri T, Farhadian Y, Friedman E, Korach J.
    • Menopause. 2019 Nov 4. doi: 10.1097/GME.0000000000001432. [Epub ahead of print]
    • Survey of primary care physicians’ views about breast and ovarian cancer screening for true BRCA1/2 non-carriers.
    • Pelletier S, Larouche G. Chiquette J, El Haffaf Z, Foulkes WD, Hamet P, Simard J, Dorval M.
    • J Community Genet. 2019 Oct 28. doi: 10.1007/s12687-019-00438-3. [Epub ahead of print]
    • Health Care Provider Adherence to Surgical Guidelines for Risk-Reducing Salpingo-Oophorectomy.
    • Wilhite AM, Oestreich MC, Olson M, Bedell SM, Westenberg D, Bangdiwala A, Ikramuddin S, Sanchez-Avila M, Madoff RD, Khalifa MA, Erickson BK.
    • Obstet Gynecol. 2019 Sep;134(3):520-526. doi: 10.1097/AOG.0000000000003421.
    • Evaluation of a Clinical Decision Support System for the Prescription of Genetic Tests in the Gynecological Cancer Risk.
    • Moreno-Conde J, Alvarez-Romero C, Suárez-Mejías C, Martínez-Maestre MÁ, Silvan-Alfaro JM, Parra-Calderón CL.
    • Stud Health Technol Inform. 2019 Aug 21;264:704-708. doi: 10.3233/SHTI190314.
    • Practical Cancer Genetics and Genomics in Women's Health.
    • Modesitt S, Pederson HJ, Adkins RT.
    • Clin Obstet Gynecol. 2019 Jul 11. doi: 10.1097/GRF.0000000000000480. [Epub ahead of print]
    • Review
    • The first Japanese nationwide multicenter study of BRCA mutation testing in ovarian cancer: CHARacterizing the cross-sectionaL approach to Ovarian cancer geneTic TEsting of BRCA (CHARLOTTE).
    • Enomoto T, Aoki D, Hattori K, Jinushi M, Kigawa J, Takeshima N, Tsuda H, Watanabe Y, Yoshihara K, Sugiyama T.
    • Int J Gynecol Cancer. 2019 Jul;29(6):1043-1049. doi: 10.1136/ijgc-2019-000384.
    • How Safe Is Hormone Replacement Therapy After Risk-Reducing Salpingo-oophorectomy in Women With BRCA Mutations?
    • Markman M.
    • Medscape Oncology. 2019 Jun 14.

    Original research:

    Hormone replacement therapy after risk reducing salpingo-oophorectomy in patients with BRCA1 or BRCA2 mutations; a systematic review of risks and benefits.

    • Challenges in Managing Patients with Hereditary Cancer at Gynecological Services.
    • Ueda M, Tsubamoto H, Kashima-Morii M, Torii Y, Kamihigashi M, Wakimoto Y, Nakagomi N, Hashimoto-Tamaoki T, Sawai H, Shibahara H.
    • Obstet Gynecol Int. 2019 May 27;2019:4365754. doi: 10.1155/2019/4365754. eCollection 2019.
    • Universal tumor DNA BRCA1/2 testing of ovarian cancer: prescreening PARPi treatment and genetic predisposition.
    • Vos JR, Fakkert IE, de Hullu JA, van Altena AM, Sie AS, Ouchene H, Willems RW, Nagtegaal ID, Jongmans MCJ, Mensenkamp AR, Woldringh GH, Bulten J, Leter EM, Kets CM, Simons M, Ligtenberg MJL, Hoogerbrugge N.
    • J Natl Cancer Inst. 2019 May 11. pii: djz080. doi: 10.1093/jnci/djz080. [Epub ahead of print]

    Letter, Comment:

    RE: Universal tumor DNA BRCA1/2 testing of ovarian cancer: prescreening PARPi treatment and genetic predisposition.

    • Risk factors for sexual dysfunction in BRCA mutation carriers after risk-reducing salpingo-oophorectomy.
    • Chan JL, Senapati S, Johnson LNC, DiGiovanni L, Voong C, Butts SF, Domchek SM.
    • Menopause. 2019 Feb;26(2):132-139. doi: 10.1097/GME.0000000000001176.
    • Understanding and Practices of Gynaecologists Related to Breast Cancer Screening, Detection, Treatment and Common Breast Diseases: A Study from India.
    • Singh GN, Agarwal A, Jain V, Kumar P.
    • World J Surg. 2019 Jan;43(1):183-191. doi: 10.1007/s00268-018-4740-5.
    • No. 366-Gynaecologic Management of Hereditary Breast and Ovarian Cancer.
    • Jacobson M, Bernardini M, Sobel ML, Kim RH, McCuaig J, Allen L.
    • J Obstet Gynaecol Can. 2018 Nov;40(11):1497-1510. doi: 10.1016/j.jogc.2018.05.046.
    • Guidelines

    [Article in French]:

    No 366 - Prise en charge gynécologique du cancer du sein et de l'ovaire héréditaire.

    • Hereditary Cancer Risk Assessment and Genetic Testing in the Community-Practice Setting.
    • DeFrancesco MS, Waldman RN, Pearlstone MM, Karanik D, Bernhisel R, Logan J, Alico L, Adkins RT.
    • Obstet Gynecol. 2018 Nov;132(5):1121-1129. doi: 10.1097/AOG.0000000000002916.
    • Involvement and Influence of Healthcare Providers, Family Members, and Other Mutation Carriers in the Cancer Risk Management Decision-Making Process of BRCA1 and BRCA2 Mutation Carriers.
    • Puski A, Hovick S, Senter L, Toland AE4.
    • J Genet Couns. 2018 Sep;27(5):1291-1301. doi: 10.1007/s10897-018-0254-4. Epub 2018 Mar 29.
    • Study protocol: a cluster randomized controlled trial of web-based decision support tools for increasing BRCA1/2 genetic counseling referral in primary care.
    • Silverman TB, Vanegas A, Marte A, Mata J, Sin M, Ramirez JCR, Tsai WY, Crew KD, Kukafka R.
    • BMC Health Serv Res. 2018 Aug 13;18(1):633. doi: 10.1186/s12913-018-3442-x.
    • Effects of Cancer Genetic Panel Testing on at-Risk Individuals.
    • Frost AS, Toaff M, Biagi T, Stark E, McHenry A, Kaltman R.
    • Obstet Gynecol. 2018 Jun;131(6):1103-1110. doi: 10.1097/AOG.0000000000002531.
    • Hereditary Cancer Genetic Testing in Community-Based Obstetrics and Gynecology Settings.
    • Obstet Gynecol. 2018 May;131(5):119s. doi: 10.1097/01.AOG.0000533506.01865.a1.
    • Risk Screening for Hereditary Cancer During Obstetrical Care: Barriers to Testing and Health Disparities.
    • Lua LL, Jackson D, Foggia M, Rosenbaum A.
    • Obstet Gynecol. 2018 May;131(5):148s. doi: 10.1097/01.AOG.0000533083.79347.8c.
    • Hereditary Cancers in Gynecology: What Physicians Should Know About Genetic Testing, Screening, and Risk Reduction.
    • Ring KL, Modesitt SC.
    • Obstet Gynecol Clin North Am. 2018 Mar;45(1):155-173. doi: 10.1016/j.ogc.2017.10.011.
    • Review
    • Surgical Findings and Outcomes in Premenopausal Breast Cancer Patients Undergoing Oophorectomy: A Multicenter Review From the Society of Gynecologic Surgeons Fellows Pelvic Research Network.
    • Harvey LFB, Abramson VG, Alvarez J, DeStephano C, Hur HC, Lee K, Mattingly P, Park B, Piszczek C, Seifi F, Stuparich M, Yunker A.
    • J Minim Invasive Gynecol. 2018 Jan;25(1):111-115. doi: 10.1016/j.jmig.2017.08.643. Epub 2017 Aug 15.
    • ACOG Committee Opinion No. 727: Cascade Testing: Testing Women for Known Hereditary Genetic Mutations Associated With Cancer.
    • [No authors listed]
    • Obstet Gynecol. 2018 Jan;131(1):e31-e34. doi: 10.1097/AOG.0000000000002457.

    Summary:

    ACOG Committee Opinion No. 727 Summary: Cascade Testing: Testing Women For Known Hereditary Genetic Mutations Associated With Cancer.

    Press: 'Cascade Testing' Important for Hereditary Gynecologic Cancers: ACOG (Medscape/Reuters)

    • "Best practices in risk reducing bilateral salpingo-oophorectomy: the influence of surgical specialty".
    • Malacarne DR, Boyd LR, Long Y, Blank SV.
    • World J Surg Oncol. 2017 Dec 11;15(1):218. doi: 10.1186/s12957-017-1282-5.
    • Current and future role of genetic screening in gynecologic malignancies.
    • Ring KL, Garcia C, Thomas MH, Modesitt SC.
    • Am J Obstet Gynecol. 2017 Nov;217(5):512-521. doi: 10.1016/j.ajog.2017.04.011. Epub 2017 Apr 12.
    • Hereditary gynaecologic cancers in Nepal: a proposed model of care to serve high risk populations in developing countries.
    • Pokharel HP, Hacker NF, Andrews L.
    • Hered Cancer Clin Pract. 2017 Sep 18;15:12. doi: 10.1186/s13053-017-0072-y. eCollection 2017.
    • Practice Bulletin No 182: Hereditary Breast and Ovarian Cancer Syndrome.
    • Committee on Practice Bulletins–Gynecology, Committee on Genetics, Society of Gynecologic Oncology.
    • Obstet Gynecol. 2017 Sep;130(3):e110-e126. doi: 10.1097/AOG.0000000000002296.
    • Guidelines

    Summary:

    Practice Bulletin No. 182 Summary: Hereditary Breast and Ovarian Cancer Syndrome.

    • Committee Opinion No. 716: The Role of the Obstetrician-Gynecologist in the Early Detection of Epithelial Ovarian Cancer in Women at Average Risk.
    • Committee on Gynecologic Practice, Society of Gynecologic Oncology.
    • Obstet Gynecol. 2017 Sep;130(3):e146-e149. doi: 10.1097/AOG.0000000000002299.

    Summary:

    Committee Opinion No. 716 Summary: The Role of the Obstetrician-Gynecologist in the Early Detection of Epithelial Ovarian Cancer in Women at Average Risk.

    • Validation of a scale for assessing attitudes towards outcomes of genetic cancer testing among primary care providers and breast specialists.
    • Bouhnik AD, N'Diaye K, Evans DG, Harris H, Tibben A, van Asperen C, Schmidtke J, Nippert I, Mancini J, Julian-Reynier C.
    • PLoS One. 2017 Jun 1;12(6):e0178447. doi: 10.1371/journal.pone.0178447. eCollection 2017.
    • Familial breast cancer: Genetic counseling over time, including patients´ expectations and initiators considering the Angelina Jolie effect.
    • Evers C, Fischer C, Dikow N, Schott S.
    • PLoS One. 2017 May 25;12(5):e0177893. doi: 10.1371/journal.pone.0177893. eCollection 2017.
    • Physicians' Perspectives and Practice Patterns Toward Opportunistic Salpingectomy in High- and Low-Risk Women.
    • Jones NL, Schulkin J, Urban RR, Wright JD, Burke WM, Hou JY, McElwain CA, Tergas AI.
    • Cancer Invest. 2017 Jan 2;35(1):51-61. doi: 10.1080/07357907.2016.1242597. Epub 2016 Dec 28.
    • Breast Cancer: Genetics and Risk Assessment.
    • Tejada-Bergés T.
    • Clin Obstet Gynecol. 2016 Dec;59(4):673-687.
    • Want A BRCA Test? Some Insurers Require Genetic Counseling First.
    • Michelle Andrews
    • NPR. Shots. 2016 Sep 14.
    • Insurers May Insist On Counseling Before Genetic Tests For Breast Cancer.
    • Michelle Andrews
    • Kaiser Health News. 2016 Sep 13.
    • [Current surgical practice of prophylactic and opportunistic salpingectomy in France].
    • Chene G, de Rochambeau B, Le Bail-Carval K, Beaufils E, Chabert P, Mellier G, Lamblin G.
    • Gynecol Obstet Fertil. 2016 Jul-Aug;44(7-8):377-84. doi: 10.1016/j.gyobfe.2016.05.003. Epub 2016 Jun 27.
    • [Article in French]
    • Genetic testing for hereditary cancer predisposition: BRCA1/2, Lynch syndrome, and beyond.
    • Hall MJ, Obeid EI, Schwartz , Mantia-Smaldone G, Forman AD, Daly MB.
    • Gynecol Oncol. 2016 Mar;140(3):565-74. doi: 10.1016/j.ygyno.2016.01.019. Epub 2016 Jan 23.
    • Review
    • [Hereditary Breast and Ovarian Cancer--From the Gynecological Viewpoint].
    • Ohsumi S.
    • Gan To Kagaku Ryoho. 2016 Feb;43(2):189-92.
    • [Article in Japanese]
    • ACOG Objects to Insurers' Genetic Counseling Requirements for BRCA Testing.
    • [No author given]
    • GenomeWeb. 2015 Dec 18.
    • Genetic Testing for BRCA Mutations Today and Tomorrow-About the ABOUT Study.
    • Narod S.
    • JAMA Oncol. 2015 Dec 1;1(9):1225-1226. doi: 10.1001/jamaoncol.2015.3269.
    • Comment

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: Dr. Narod's commentary on pre-test genetic counseling

    Utilization and Outcomes of BRCA Genetic Testing and Counseling in a National Commercially Insured Population: The ABOUT Study.

    • Utilization and Outcomes of BRCA Genetic Testing and Counseling in a National Commercially Insured Population: The ABOUT Study.
    • Armstrong J, Toscano M, Kotchko N, Friedman S, Schwartz MD, Virgo KS, Lynch K, Andrews JE, Aguado Loi CX, Bauer JE, Casares C, Bourquardez Clark E, Kondoff MR, Molina AD, Abdollahian M, Walker G, Sutphen R.
    • JAMA Oncol. 2015 Dec 1;1(9):1251-1260. doi: 10.1001/jamaoncol.2015.3048.

    Blog post: Rates of Genetic Testing on the Rise While Utilization of Genetic Counseling Plummets (My Gene Counsel)

    Press: Most Women Get No Counseling After BRCA Testing (Medscape Oncology)

    Press: Study of Aetna-Insured Finds Lack of Pre-BRCA Test Counseling Despite Guidelines (GenomeWeb)

    Press: BRCA Testing, Genetic Counseling Utilization in the Community Setting (OncoTherapy Network)

    Press: Too Few Women Get Counseling Before Breast Cancer Gene Test: Study (MedlinePlus)

    Press: Too Few Get Counseling Before BRCA Gene Test (WEbMD / HealthDay News)

    • Risk reducing salpingectomy and delayed oophorectomy in high risk women: views of cancer geneticists, genetic counsellors and gynaecological oncologists in the UK.
    • Chandrasekaran D, Menon U, Evans G, Crawford R, Saridogan E, Jacobs C, Tischkowitz M, Brockbank E, Kalsi J, Jurkovic D, Manchanda R.
    • Fam Cancer. 2015 Dec;14(4):521-30. doi: 10.1007/s10689-015-9823-y.

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: Article request

    • A Rare Case of BRCA2-Associated Breast Cancer in Pregnancy.
    • Leidhin CN, Heeney A, Connolly C, Swan N, Foster A, Geraghty J.
    • Ir Med J. 2015 Jul-Aug;108(7):217-8.
    • Look Before You Leap: Genomic Screening in Obstetrics and Gynecology.
    • Adams MC, Berg JS, Pearlman MD, Vora NL.
    • Obstet Gynecol. 2015 Jun;125(6):1299-1305.
    • Editorial / Commentary
    • Committee opinion no. 634: Hereditary cancer syndromes and risk assessment.
    • [No authors listed]
    • Obstet Gynecol. 2015 Jun;125(6):1538-43. doi: 10.1097/01.AOG.0000466373.71146.51.

    Press: ACOG Issues Guidelines for Hereditary Cancer Screening. (Medscape Oncology)

    • [Recommendation for genetic testing in patients suffering from gynecological malignancy].
    • Zikán M.
    • Ceska Gynekol. 2015 Spring;80(2):97-103.
    • Review, [Article in Czech]
    • Hereditary breast/ovarian cancer syndrome: a primer for obstetricians/gynecologists.
    • Meaney-Delman D, Bellcross CA.
    • Obstet Gynecol Clin North Am. 2013 Sep;40(3):475-512. doi: 10.1016/j.ogc.2013.05.009. Epub 2013 Jul 30.
    • Review
    • Opportunistic and interventional salpingectomy in women at risk: a strategy for preventing pelvic serous cancer (PSC).
    • Kamran MW, Vaughan D, Crosby D, Wahab NA, Saadeh FA, Gleeson N.
    • Eur J Obstet Gynecol Reprod Biol. 2013 Aug;170(1):251-4. doi: 10.1016/j.ejogrb.2013.06.030. Epub 2013 Jul 21.
    • Risk-reducing salpingectomy in Canada: a survey of obstetrician-gynaecologists.
    • Reade CJ, Finlayson S, McAlpine J, Tone AA, Fung-Kee-Fung M, Ferguson SE.
    • J Obstet Gynaecol Can. 2013 Jul;35(7):627-34.
    • Hereditary gynecologic cancers: risk assessment, counseling, testing and management.
    • Ballinger LL.
    • Obstet Gynecol Clin North Am. 2012 Jun;39(2):165-81. doi: 10.1016/j.ogc.2012.02.006.
    • Review