Mutations reported in male breast cancer, of BRCA1/2 and of non-BRCA1/2 genes, other cancers associated with BRCA1/2 mutations in males
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- Association between prostate cancer characteristics and BRCA1/2-associated family cancer history in a Japanese cohort.
- Ishiyama Y, Shimbo M, Iizuka J, Deshpande G, Tanabe K, Hattori K.
- PLoS One. 2020 Dec 22;15(12):e0244149. doi: 10.1371/journal.pone.0244149.
- PMID: 33351846
- PubMed abstract
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- DNA damage repair gene mutation testing and genetic counseling in men with/without prostate cancer: a systematic review.
- Armstrong N, Quek RG, Ryder S, Ross J, Titas Buksnys, Forbes C, Fox KM, Castro E.
- Future Oncol. 2020 Dec 2. doi: 10.2217/fon-2020-0569. Epub ahead of print.
- PMID: 33263430
- PubMed abstract
- Source abstract
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- Genetic Testing Challenges in Oncology: BRCA2-Positive Healthy Young Man Recommended Mastectomy.
- Ray T.
- Precision Oncology News. 2020 Nov 25.
- Press. Case report.
- Free Full Text
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- Case Report: Co-Existence of BRCA2 and PALB2 Germline Mutations in Familial Prostate Cancer With Solitary Lung Metastasis.
- Tang T, Wang LA, Wang P, Tong D, Liu G, Zhang J, Dai N, Zhang Y, Yuan G, Geary K, Zhang D, Liu Q, Jiang J.
- Front Oncol. 2020 Oct 26;10:564694. doi: 10.3389/fonc.2020.564694. PMID: 33194641; PMCID: PMC7649358.
- PMID: 33194641
- PubMed abstract
- Case report
- Free PMC article
- Free Full Text
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- Clinical characteristics and prognostic implications of BRCA-associated tumors in males: a pan-tumor survey.
- Sun P, Li Y, Chao X, Li J, Luo R, Li M, He J.
- BMC Cancer. 2020 Oct 14;20(1):994. doi: 10.1186/s12885-020-07481-1.
- PMID: 33054725
- PubMed abstract
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- Prevalence of comprehensive DNA damage repair gene germline mutations in Chinese prostate cancer patients.
- Wu J, Wei Y, Pan J, Jin S, Gu W, Gan H, Zhu Y, Ye D.
- Int J Cancer. 2020 Oct 2. doi: 10.1002/ijc.33324. Epub ahead of print.
- PMID: 33006389
- PubMed abstract
- Source abstract
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- Impact of mutations in homologous recombination repair genes on treatment outcomes for metastatic castration resistant prostate cancer.
- Carlson AS, Acevedo RI, Lim DM, Gulati R, Gawne A, Sokolova AO, Cheng HH, Nelson PS, Montgomery RB, Yu EY, Schweizer MT.
- PLoS One. 2020 Sep 30;15(9):e0239686. doi: 10.1371/journal.pone.0239686.
- PMID: 32997692
- PubMed abstract
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- Evaluation of a Mainstream Model of Genetic Testing for Men With Prostate Cancer.
- Scheinberg T, Goodwin A, Ip E, Linton A, Mak B, Smith DP, Stockler MR, Strach MC, Tran B, Young AL, Zhang AY, Mahon KL, Horvath LG.
- JCO Oncol Pract. 2020 Sep 24:OP2000399. doi: 10.1200/OP.20.00399. Epub ahead of print.
- PMID: 32970524
- PubMed abstract
- Source abstract
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- Family history of breast cancer in men with non-BRCA male breast cancer: implications for cancer risk counseling.
- Calip GS, Kidd J, Bernhisel R, Cox HC, Saam J, Rauscher GH, Lancaster JM, Hoskins KF.
- Breast Cancer Res Treat. 2020 Sep 11. doi: 10.1007/s10549-020-05922-w. Epub ahead of print.
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- Mutations in ATM, NBN and BRCA2 predispose to aggressive prostate cancer in Poland.
- Wokolorczyk D, Kluzniak W, Huzarski T, Gronwald J, Szymiczek A, Rusak B, Stempa K, Gliniewicz K, Kashyap A, Morawska S, Debniak T, Jakubowska A, Szwiec M, Domagala P, Lubinski J, Narod SA, Akbari MR, Cybulski C, The Polish Hereditary Prostate Cancer Consortium.
- Int J Cancer. 2020 Sep 11. doi: 10.1002/ijc.33272. [Epub ahead of print]
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- Poly (ADP-Ribose) Polymerase Inhibitor Activity in Prostate Cancers Harboring Mutations in DNA Repair Genes: Who Benefits?
- Ganesan S, Garber J.
- JCO Precis Oncol. 2020;4:1034. doi: 10.1200/PO.20.00269. Epub 2020 Sep 9.
- Commentary
- Free Full Text
Original research:
Olaparib for Metastatic Castration-Resistant Prostate Cancer.
- PMID: 32343890
- PubMed abstract
- Source abstract
Study record: Study of Olaparib (Lynparza™) Versus Enzalutamide or Abiraterone Acetate in Men With Metastatic Castration-Resistant Prostate Cancer (PROfound Study). (ClinicalTrials.gov)
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- Identification of novel candidate genes by exome sequencing in Tunisian familial male breast cancer patients.
- Ben Kridis-Rejeb W, Ben Ayed-Guerfali D, Ammous-Boukhris N, Ayadi W, Kifagi C, Charfi S, Saguem I, Sellami-Boudawara T, Daoud J, Khanfir A, Mokdad-Gargouri R.
- Mol Biol Rep. 2020 Sep 8. doi: 10.1007/s11033-020-05703-0. Epub ahead of print.
- PMID: 32901360
- PubMed abstract
- Source abstract
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- Is CHEK2 a moderate-risk breast cancer gene or the younger sister of Li-Fraumeni?
- De Silva DL, Winship I.
- BMJ Case Rep. 2020 Sep 7;13(9):e236435. doi: 10.1136/bcr-2020-236435.
- PMID: 32900738
- PubMed abstract
- Case report
- Free Full Text
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- BRCA Mutations in Prostate Cancer: Prognostic and Predictive Implications.
- Messina C, Cattrini C, Soldato D, Vallome G, Caffo O, Castro E, Olmos D, Boccardo F, Zanardi E.
- J Oncol. 2020 Sep 7;2020:4986365. doi: 10.1155/2020/4986365.
- Review
- Free Full Text
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- Mutations in ATM, NBN and BRCA2 predispose to aggressive prostate cancer in Poland.
- Wokolorczyk D, Kluzniak W, Huzarski T, Gronwald J, Szymiczek A, Rusak B, Stempa K, Gliniewicz K, Kashyap A, Morawska S, Debniak T, Jakubowska A, Szwiec M, Domagala P, Lubinski J, Narod SA, Akbari MR, Cybulski C; Polish Hereditary Prostate Cancer Consortium.
- Int J Cancer. 2020 Sep 1. doi: 10.1002/ijc.33272. Epub ahead of print.
- PMID: 32875559
- PubMed abstract
- Source abstract
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- BRCA2 c.8827C>T pathogenic mutation in a consanguineous Chinese family with hereditary breast cancer.
- Wang J, Qin J, Xi C, Zhang Y.
- Mol Genet Genomic Med. 2020 Sep;8(9):e1411. doi: 10.1002/mgg3.1411. Epub 2020 Jul 20.
- PMID: 32686918
- PubMed abstract
- Source abstract
- Case report
- Free Full Text
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- Male Breast Cancer in Togo: Imaging and Clinicopathological Findings.
- Darre T, Tchaou M, Djiwa T, Simgban P, Amavi AK, N'Timon B, Amadou A, Bombonne M, Sama B, Amégbor K, Napo-Koura G.
- Int J Breast Cancer. 2020 Aug 31;2020:3056067. doi: 10.1155/2020/3056067.
- PMID: 32934847
- PubMed abstract
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- Imaging-based prostate cancer screening among BRCA mutation carriers-results from the first round of screening.
- Segal N, Ber Y, Benjaminov O, Tamir S, Yakimov M, Kedar I, Rosenbaum E, Sela S, Ozalvo R, Shavit-Grievink L, Keder D, Baniel J, Margel D.
- Ann Oncol. 2020 Aug 27:S0923-7534(20)39937-3. doi: 10.1016/j.annonc.2020.06.025. Epub ahead of print.
- PMID: 32958357
- PubMed abstract
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- Germline sequencing DNA repair genes in 5,545 men with aggressive and non-aggressive prostate cancer.
- Darst BF, Dadaev T, Saunders E, Sheng X, Wan P, Pooler L, Xia LY, Chanock S, Berndt SI, Gapstur SM, Stevens V, Albanes D, Weinstein SJ, Gnanapragasam V, Giles GG, Nguyen-Dumont T, Milne RL, Pomerantz M, Schmidt JA, Mucci L, Catalona WJ, Hetrickn KN, Doheny KF, MacInnis RJ, Southey MC, Eeles RA, Wiklund F, Kote-Jarai Z, Conti DV, Haiman CA.
- J Natl Cancer Inst. 2020 Aug 27. pii: djaa032. doi: 10.1093/jnci/djaa132. [Epub ahead of print]
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- A Pilot Study on the Whole Exome Sequencing of Prostate Cancer in the Indian Phenotype Reveals Distinct Polymorphisms.
- Gupta A, Shukla N, Nehra M, Gupta S, Malik B, Mishra AK, Vijay M, Batra J, Lohiya NK, Sharma D, Suravajhala P.
- Front Genet. 2020 Aug 25;11:874. doi: 10.3389/fgene.2020.00874.
- PMID: 33193569
- PubMed abstract
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- Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer.
- Schaid DJ, McDonnell SK, FitzGerald LM, DeRycke L, Fogarty Z, Giles GG, MacInnis RJ, Southey MC, Nguyen-Dumont T, Cancel-Tassin G, Cussenot O, Whittemore AS, Sieh W, Ioannidis NM, Hsieh CL, Stanford JL, Schleutker J, Cropp CD, Carpten J, Hoegel J, Eeles R, Kote-Jarai Z, Ackerman MJ, Klein CJ, Mandal D, Cooney KA, Bailey-Wilson JE, Helfand B, Catalona WJ, Wiklund F, Riska S, Bahetti S, Larson MC, Cannon Albright L, Teerlink C, Xu J, Isaacs W, Ostrander EA, Thibodeau SN.
- Eur Urol. 2020 Aug 13:S0302-2838(20)30614-X. doi: 10.1016/j.eururo.2020.07.038. Epub ahead of print.
- PMID: 32800727
- PubMed abstract
- Source abstract
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- Common susceptibility loci for male breast cancer.
- Maguire S, Perraki E, Tomczyk K, Jones ME, Fletcher O, Pugh M, Winter T, Thompson K, Cooke R; kConFab Consortium, Trainer A, James P, Bojesen S, Flyger H, Nevanlinna H, Mattson J, Friedman E, Laitman Y, Palli D, Masala G, Zanna I, Ottini L, Silvestri V, Hollestelle A, Hooning MJ, Novakovic S, Krajc M, Gago-Dominguez M, Castelao JE, Olsson H, Hedenfalk I, Saloustros E, Georgoulias V, Easton DF, Pharoah P, Dunning AM, Bishop DT, Neuhausen SL, Steele L, Ashworth A, Closas MG, Houlston R, Swerdlow A, Orr N.
- J Natl Cancer Inst. 2020 Aug 12:djaa101. doi: 10.1093/jnci/djaa101. Epub ahead of print.
- PMID: 32785646
- PubMed abstract
- Source abstract
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- Male breast cancer risk assessment and screening recommendations in high risk men who undergo genetic counseling and multi-gene panel testing (MGPT).
- Gaddam S, Heller SL, Babb JS, Gao Y.
- Clin Breast Cancer. 2020 Jul 25:S1526-8209(20)30180-4. doi: 10.1016/j.clbc.2020.07.014. Epub ahead of print.
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- Hereditary Predisposition to Prostate Cancer: From Genetics to Clinical Implications.
- Brandão A, Paulo P, Teixeira MR.
- Int J Mol Sci. 2020 Jul 16;21(14):E5036. doi: 10.3390/ijms21145036.
- PMID: 32708810
- PubMed abstract
- Source abstract
- Review
- Free Full Text
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- A Case of Male Breast Cancer Patient with CHEK2*1100delC Mutation.
- Nguyen QD, Tavana A, Saenz Rios F, Posleman Monetto FE, Robinson AS.
- Cureus. 2020 Jul 2;12(7):e8972. doi: 10.7759/cureus.8972.
- PMID: 32766014
- PubMed abstract
- Case report
- Free PMC article
- Free Full Text
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- Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants: Results From the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).
- Silvestri V, Leslie G, Barnes DR; and the CIMBA Group, Agnarsson BA, Aittomäki K, Alducci E, Andrulis IL, Barkardottir RB, Barroso A, Barrowdale D, Benitez J, Bonanni B, Borg A, Buys SS, Caldés T, Caligo MA, Capalbo C, Campbell I, Chung WK, Claes KBM, Colonna SV, Cortesi L, Couch FJ, de la Hoya M, Diez O, Ding YC, Domchek S, Easton DF, Ejlertsen B, Engel C, Evans DG, Feliubadalò L, Foretova L, Fostira F, Géczi L, Gerdes AM, Glendon G, Godwin AK, Goldgar DE, Hahnen E, Hogervorst FBL, Hopper JL, Hulick PJ, Isaacs C, Izquierdo A, James PA, Janavicius R, Jensen UB, John EM, Joseph V, Konstantopoulou I, Kurian AW, Kwong A, Landucci E, Lesueur F, Loud JT, Machackova E, Mai PL, Majidzadeh-A K, Manoukian S, Montagna M, Moserle L, Mulligan AM, Nathanson KL, Nevanlinna H, Ngeow Yuen Ye J, Nikitina-Zake L, Offit K, Olah E, Olopade OI, Osorio A, Papi L, Park SK, Pedersen IS, Perez-Segura P, Petersen AH, Pinto P, Porfirio B, Pujana MA, Radice P, Rantala J, Rashid MU, Rosenzweig B, Rossing M, Santamariña M, Schmutzler RK, Senter L, Simard J, Singer CF, Solano AR, Southey MC, Steele L, Steinsnyder Z, Stoppa-Lyonnet D, Tan YY, Teixeira MR, Teo SH, Terry MB, Thomassen M, Toland AE, Torres-Esquius S, Tung N, van Asperen CJ, Vega A, Viel A, Vierstraete J, Wappenschmidt B, Weitzel JN, Wieme G, Yoon SY, Zorn KK, McGuffog L, Parsons MT, Hamann U, Greene MH, Kirk JA, Neuhausen SL, Rebbeck TR, Tischkowitz M, Chenevix-Trench G, Antoniou AC, Friedman E, Ottini L.
- JAMA Oncol. 2020 Jul 2. doi: 10.1001/jamaoncol.2020.2134. Epub ahead of print.
- PMID: 32614418
- PubMed abstract
- Source abstract
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- Germline Mutations in DNA Repair Genes in Patients With Metastatic Castration-resistant Prostate Cancer.
- Holeckova K, Baluchova K, Hives M, Musak L, Kliment J Sr, Skerenova M.
- In Vivo. 2020 Jul-Aug;34(4):1773-1778. doi: 10.21873/invivo.11971.
- PMID: 32606146
- PubMed abstract
- Source abstract
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- Re: Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness.
- Taneja SS.
- J Urol. 2020 Jun 26:101097JU000000000000117601. doi: 10.1097/JU.0000000000001176.01. Epub ahead of print.
- PMID: 32586171
- PubMed abstract
- Source abstract
Original research:
Association of Genomic Domains in BRCA1 and BRCA2 With Prostate Cancer Risk and Aggressiveness.
- PMID: 31723001
- PubMed abstract
- Source abstract
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- Multiple primary tumors: a case report and review of the literature.
- Zhao Z, Sun K, Yan T, Wei R, Guo W.
- BMC Musculoskelet Disord. 2020 Jun 22;21(1):394. doi: 10.1186/s12891-020-03426-8.
- PMID: 32571290
- PubMed abstract
- Case report
- Free full text
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- Prostate Cancer Risk by BRCA2 Genomic Regions.
- Nyberg T, Frost D, Barrowdale D, Evans DG, Bancroft E, Adlard J, Ahmed M, Barwell J, Brady AF, Brewer C, Cook J, Davidson R, Donaldson A, Eason J, Gregory H, Henderson A, Izatt L, Kennedy MJ, Miller C, Morrison PJ, Murray A, Ong KR, Porteous M, Pottinger C, Rogers MT, Side L, Snape K, Tripathi V, Walker L, Tischkowitz M, Eeles R, Easton DF, Antoniou AC.
- Eur Urol. 2020 Jun 9:S0302-2838(20)30345-6. doi: 10.1016/j.eururo.2020.05.005. Epub ahead of print.
- PMID: 32532514
- PubMed abstract
- Source abstract
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- Diagnosing hereditary cancer predisposition in men with prostate cancer.
- Pritzlaff M, Tian Y, Reineke P, Stuenkel AJ, Allen K, Gutierrez S, Jackson M, Dolinsky JS, LaDuca H, Xu J, Black MH, Helfand BT.
- Genet Med. 2020 May 22. doi: 10.1038/s41436-020-0830-5. Epub ahead of print.
- PMID: 32439974
- PubMed abstract
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- The Impact of Whole Genome Data on Therapeutic Decision-Making in Metastatic Prostate Cancer: A Retrospective Analysis.
- Crumbaker M, Chan EKF, Gong T, Corcoran N, Jaratlerdsiri W, Lyons RJ, Haynes AM, Kulidjian AA, Kalsbeek AMF, Petersen DC, Stricker PD, Jamieson CAM, Croucher PI, Hovens CM, Joshua AM, Hayes VM.
- Cancers (Basel). 2020 May 7;12(5):E1178. doi: 10.3390/cancers12051178.
- PMID: 32392735
- PubMed abstract
- Source abstract
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- Invitae Study Finds Germline Risk Variants in Wide Range of Prostate Cancer Patients.
- Anderson A.
- GenomeWeb. 2020 May 5.
- Research news
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- Male Breast Cancer: Results of the Application of Multigene Panel Testing to an Italian Cohort of Patients.
- Tedaldi G, Tebaldi M, Zampiga V, Cangini I, Pirini F, Ferracci E, Danesi R, Arcangeli V, Ravegnani M, Martinelli G, Falcini F, Ulivi P, Calistri D.
- Diagnostics (Basel). 2020 Apr 30;10(5). pii: E269. doi: 10.3390/diagnostics10050269.
- PMID: 32365798
- PubMed abstract
- Source abstract
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- Olaparib for Metastatic Castration-Resistant Prostate Cancer.
- de Bono J, Mateo J, Fizazi K, Saad F, Shore N, Sandhu S, Chi KN, Sartor O, Agarwal N, Olmos D, Thiery-Vuillemin A, Twardowski P, Mehra N, Goessl C, Kang J, Burgents J, Wu W, Kohlmann A, Adelman CA, Hussain M.
- N Engl J Med. 2020 Apr 28. doi: 10.1056/NEJMoa1911440. [Epub ahead of print]
- PMID: 32343890
- PubMed abstract
- Source abstract
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- Rare germline genetic variants and risk of aggressive prostate cancer.
- Nguyen-Dumont T, MacInnis RJ, Steen JA, Theys D, Tsimiklis H, Hammet F, Mahmoodi M, Pope BJ, Park DJ, Mahmood K, Severi G, Bolton D, Milne RL, Giles GG, Southey MC.
- Int J Cancer. 2020 Apr 27. doi: 10.1002/ijc.33024. [Epub ahead of print]
- PMID: 32338768
- PubMed abstract
- Source abstract
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- Germline and somatic DNA repair gene alterations in prostate cancer.
- Dall'Era MA, McPherson JD, Gao AC, DeVere White RW, Gregg JP, Lara PN Jr.
- Cancer. 2020 Apr 21. doi: 10.1002/cncr.32908. [Epub ahead of print]
- PMID: 32315455
- PubMed abstract
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- Platinum-Based Chemotherapy in Metastatic Prostate Cancer With DNA Repair Gene Alterations.
- Mota JM, Barnett E, Nauseef JT, Nguyen B, Stopsack KH, Wibmer A, Flynn JR, Heller G, Danila DC, Rathkopf D, Slovin S, Kantoff PW, Scher HI, Morris MJ, Schultz N, Solit DB, Abida W.
- JCO Precis Oncol. 2020;4:355. doi: 10.1200/PO.19.00346. Epub 2020 Apr 16.
Press: Prostate Cancer Patients With DNA Damage Repair Mutations May Respond to Platinum Chemo. (Precision Oncology News)
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- Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer.
- André S, P Nunes S, Silva F, Henrique R, Félix A, Jerónimo C.
- Int J Mol Sci. 2020 Apr 14;21(8). pii: E2715. doi: 10.3390/ijms21082715.
- PMID: 32295201
- PubMed abstract
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- BRCA1 and VDR gene polymorphisms are associated with prostate cancer risk in Mexican men.
- Martínez-Nava GA, Gómez R, Burguete-García AI, Vázquez-Salas RA, Ventura-Bahena A, Torres-Sánchez L.
- Mol Carcinog. 2020 Mar 26. doi: 10.1002/mc.23187. [Epub ahead of print]
- PMID: 32219892
- PubMed abstract
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- Prognostic Value of Germline DNA Repair Gene Mutations in De Novo Metastatic and Castration-Sensitive Prostate Cancer.
- Wei Y, Wu J, Gu W, Wang J, Lin G, Qin X, Dai B, Gan H, Ye D, Zhu Y.
- Oncologist. 2020 Mar 19. doi: 10.1634/theoncologist.2019-0495. [Epub ahead of print]
- PMID: 32190957
- PubMed abstract
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- Inherited DNA Repair Gene Mutations in Men with Lethal Prostate Cancer.
- Rantapero T, Wahlfors T, Kähler A, Hultman C, Lindberg J, Tammela TL, Nykter M, Schleutker J, Wiklund F.
- Genes (Basel). 2020 Mar 14;11(3). pii: E314. doi: 10.3390/genes11030314.
- PMID: 32183364
- PubMed abstract
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- Pathogenic Germline DNA Repair Gene and HOXB13 Mutations in Men With Metastatic Prostate Cancer.
- Boyle JL, Hahn AW, Kapron AL, Kohlmann W, Greenberg SE, Parnell TJ, Teerlink CC, Maughan BL, Feng BJ, Cannon-Albright L, Agarwal N, Cooney KA.
- JCO Precis Oncol. 2020;4:139. doi: 10.1200/PO.19.00284. Epub 2020 Mar 4.
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- Molecular Mechanisms of PALB2 Function and Its Role in Breast Cancer Management.
- Wu S, Zhou J, Zhang K, Chen H, Luo M, Lu Y, Sun Y, Chen Y.
- Front Oncol. 2020 Feb 28;10:301. doi: 10.3389/fonc.2020.00301. eCollection 2020.
- PMID: 32185139
- PubMed abstract
- Review
- Free PMC article
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- BRCA and PALB2 mutations in a cohort of male breast cancer with one bilateral case.
- Vietri MT, Caliendo G, D'Elia G, Resse M, Casamassimi A, Minucci PB, Cioffi M, Molinari AM.
- Eur J Med Genet. 2020 Feb 11:103883. doi: 10.1016/j.ejmg.2020.103883. [Epub ahead of print]
- PMID: 32058061
- PubMed abstract
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- Male Breast Cancer: Surgical and Genetic Features and a Multidisciplinary Management Strategy.
- Pellini F, Granuzzo E, Urbani S, Mirandola S, Caldana M, Lombardi D, Fiorio E, Mandarà M, Pollini GP.
- Breast Care (Basel). 2020 Feb;15(1):14-20. doi: 10.1159/000501711. Epub 2019 Sep 13.
- PMID: 32231493
- PubMed abstract
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- Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness.
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See PubMed abstract for multiple related items.
News:
High frequency of gene mutations in metastatic prostate cancer.
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Comment:
Commentary on: "Inherited DNA-repair gene mutations in men with metastatic prostate cancer." Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R, Carreira S, Eeles R, Elemento O, Rubin MA, Robinson D, Lonigro R, Hussain M, Chinnaiyan A, Vinson J, Filipenko J, Garraway L, Taplin ME, AlDubayan S, Han GC, Beightol M, Morrissey C, Nghiem B, Cheng HH, Montgomery B, Walsh T, Casadei S, Berger M, Zhang L, Zehir A, Vijai J, Scher HI, Sawyers C, Schultz N, Kantoff PW, Solit D, Robson M, Van Allen EM, Offit K, de Bono J, Nelson PS. N Engl J Med. 2016 Aug 4;375(5):443-53.
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Comment:
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Letter, Commentary:
Should we Perform Genetic Testing on Men with Metastatic Prostate Cancer?
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Commentary:
Commentary on "Inherited DNA-repair gene mutations in men with metastatic prostate cancer". Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R, Carreira S, Eeles R, Elemento O, Rubin MA, Robinson D, Lonigro R, Hussain M, Chinnaiyan A, Vinson J, Filipenko J, Garraway L, Taplin ME, AlDubayan S, Han GC, Beightol M, Morrissey C, Nghiem B, Cheng HH, Montgomery B, Walsh T, Casadei S, Berger M, Zhang L, Zehir A, Vijai J, Scher HI, Sawyers C, Schultz N, Kantoff PW, Solit D, Robson M, Van Allen EM, Offit K, de Bono J, Nelson PS. N Engl J Med. 2016;375(5):443-53.
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News Release: Testing for inherited mutations could benefit men with advanced prostate cancer. (Fred Hutch)
Press: Genetic testing can help deliver precision medicine to men with advanced prostate cancer. (Science Daily)
Press: Metastatic Prostate Cancer Needs Genetic Testing; Here's Why. (Medscape Oncology)
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Comments on NSGC Discussion Forum Cancer SIG
Subject: Negative for familial PALB2 mutation
Subject: Initial and reflex testing to guide surgical decisions
Comment, Editorial
PALB2 mutations and breast-cancer risk.
- PMID: 25099582
- PubMed abstract
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Letters
Breast-cancer risk in families with mutations in PALB2.
- PMID: 25337757
- PubMed abstract
- Free full text
Letter, Review:
Partner and Localizer of BRCA-2 (PALB-2) Mutation Analysis Is Rapidly Being Adopted into Clinical Practice.
- PMID: 28331669
- PubMed abstract
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Research News: PALB2 and Breast Cancer Risk (FORCE)
Press: New breast cancer gene mutation found to raise risk. (Yahoo! News)
Press: Another Gene Mutation Increases Breast Cancer Risk. (Medscape Oncology)
Press: PALB2 gene dramatically increases breast cancer risk. (PHG Foundation)
Press: Study Shows Third Gene as Indicator for Breast Cancer (NY Times)
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- Novel nonsense mutation of BRCA2 gene in a Moroccan man with familial breast cancer.
- Guaoua S, Ratbi I, Lyahyai J, El Alaoui SC, Laarabi FZ, Sefiani A.
- Afr Health Sci. 2014 Jun;14(2):468-71. doi: 10.4314/ahs.v14i2.25.
- PMID: 25320599
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- Case report
- Free PMC article
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- Association of BRCA2 variants with cardiovascular disease in Saudi Arabia.
- Alanazi M, Reddy NP, Shaik JP, Ajaj SA, Jafari AA, Saeed H, Khan Z, Khan AP.
- Genet Mol Res. 2014 May 16;13(2):3876-84. doi: 10.4238/2014.May.16.13.
- PMID: 24938600
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- Genetic predisposition to breast cancer: The next chapters.
- Boyd J.
- Cancer. 2014 Apr 1;120(7):932-4. doi: 10.1002/cncr.28503. Epub 2014 Jan 10.
- PMID: 24415404
- PubMed abstract
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- Editorial / Commentary
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Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.
- PMID: 24415441
- PubMed abstract
- Free Full Text
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- Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.
- Fernandes PH, Saam J, Peterson J, Hughes E, Kaldate R, Cummings S, Theisen A, Chen S, Trost J, Roa BB.
- Cancer. 2014 Apr 1;120(7):963-7. doi: 10.1002/cncr.28504. Epub 2014 Jan 10.
- PMID: 24415441
- PubMed abstract
- Source abstract
Editorial, Commentary:
Genetic predisposition to breast cancer: The next chapters.
- PMID: 24415404
- PubMed abstract
- Free Full Text
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- Neurofibromatosis type I with breast cancer: not only for women!
- Lakshmaiah KC, Kumar AN, Purohit S, Viveka BK, Rajan KR, Zameer MA, Namitha P, Saini ML, Azim HA Jr, Saini KS.
- Hered Cancer Clin Pract. 2014 Feb 24;12(1):5. doi: 10.1186/1897-4287-12-5.
- PMID: 24565603
- PubMed abstract
- Case report
- Free PMC article
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- Association of low-penetrance alleles with male breast cancer risk and clinicopathological characteristics: results from a multicenter study in Italy.
- Ottini L, Silvestri V, Saieva C, Rizzolo P, Zanna I, Falchetti M, Masala G, Navazio AS, Graziano V, Bianchi S, Manoukian S, Barile M, Peterlongo P, D'Amico C, Varesco L, Tommasi S, Russo A, Giannini G, Cortesi L, Viel A, Montagna M, Radice P, Palli D.
- Breast Cancer Res Treat. 2013 Apr;138(3):861-8. doi: 10.1007/s10549-013-2459-4. Epub 2013 Mar 7.
- PMID: 23468243
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- Portuguese c.156_157insAlu BRCA2 founder mutation: gastrointestinal and tongue neoplasias may be part of the phenotype.
- Moreira MA, Bobrovnitchaia IG, Lima MA, Santos AC, Ramos JP, Souza KR, Peixoto A, Teixeira MR, Vargas FR.
- Fam Cancer. 2012 Dec;11(4):657-60. doi: 10.1007/s10689-012-9551-5.
- PMID: 22829013
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- Genotypic and phenotypic analysis of familial male breast cancer shows under representation of the HER2 and basal subtypes in BRCA-associated carcinomas.
- Deb S, Jene N; Kconfab Investigators, Fox SB.
- BMC Cancer. 2012 Nov 9;12:510. doi: 10.1186/1471-2407-12-510.
- PMID: 23146383
- PubMed abstract
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- Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
- Orr N, Lemnrau A, Cooke R, Fletcher O, Tomczyk K, Jones M, Johnson N, Lord CJ, Mitsopoulos C, Zvelebil M, McDade SS, Buck G, Blancher C; KConFab Consortium, Trainer AH, James PA, Bojesen SE, Bokmand S, Nevanlinna H, Mattson J, Friedman E, Laitman Y, Palli D, Masala G, Zanna I, Ottini L, Giannini G, Hollestelle A, Ouweland AM, Novaković S, Krajc M, Gago-Dominguez M, Castelao JE, Olsson H, Hedenfalk I, Easton DF, Pharoah PD, Dunning AM, Bishop DT, Neuhausen SL, Steele L, Houlston RS, Garcia-Closas M, Ashworth A, Swerdlow AJ.
- Nat Genet. 2012 Sep 23;44(11):1182-4. doi: 10.1038/ng.2417. Epub 2012 Sep 23.
- PMID: 23001122
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News: Genetic link to male breast cancer. (Lancet Oncology)
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- Prevalence of BRCA1 and BRCA2 mutations in non-familial breast cancer patients with high risks in Korea: the Korean Hereditary Breast Cancer (KOHBRA) Study.
- Son BH, Ahn SH, Kim SW, Kang E, Park SK, Lee MH, Noh WC, Kim LS, Jung Y, Kim KS, Noh DY, Moon BI, Suh YJ, Lee JE, Choi DH, Kim SY, Jung SH, Yom CK, Lee H, Yang JH; KOHBRA Research Group and Korean Breast Cancer Society.
- Breast Cancer Res Treat. 2012 Jun;133(3):1143-52. doi: 10.1007/s10549-012-2001-0. Epub 2012 Mar 2.
- PMID: 22382806
- PubMed abstract
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- Prevalence of BRCA1/2 mutations in sporadic breast/ovarian cancer patients and identification of a novel de novo BRCA1 mutation in a patient diagnosed with late onset breast and ovarian cancer: implications for genetic testing.
- De Leeneer K, Coene I, Crombez B, Simkens J, Van den Broecke R, Bols A, Stragier B, Vanhoutte I, De Paepe A, Poppe B, Claes K.
- Breast Cancer Res Treat. 2012 Feb;132(1):87-95. doi: 10.1007/s10549-011-1544-9. Epub 2011 May 7.
- PMID: 21553119
- PubMed abstract
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- Detection of a large rearrangement in PALB2 in Spanish breast cancer families with male breast cancer.
- Blanco A, de la Hoya M, Balmaña J, Ramón y Cajal T, Teulé A, Miramar MD, Esteban E, Infante M, Benítez J, Torres A, Tejada MI, Brunet J, Graña B, Balbín M, Pérez-Segura P, Osorio A, Velasco EA, Chirivella I, Calvo MT, Feliubadaló L, Lasa A, Díez O, Carracedo A, Caldés T, Vega A.
- Breast Cancer Res Treat. 2012 Feb;132(1):307-15. doi: 10.1007/s10549-011-1842-2. Epub 2011 Nov 4.
- PMID: 22052327
- PubMed abstract
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