Primarily chemotherapy and PARP inhibitor therapy, but includes all treatment modalities except surgery and radiation.
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- Sacituzumab govitecan and radiotherapy in metastatic, triple-negative, and BRCA-mutant breast cancer patient with active brain metastases: A case report.
- di Mauro P, Schivardi G, Pedersini R, Laini L, Esposito A, Amoroso V, Laganà M, Grisanti S, Cosentini D, Berruti A.
- Front Oncol. 2023 Feb 20;13:1139372. doi: 10.3389/fonc.2023.1139372.
- Case report
- Free Full Text
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- Clinical Utility of Genomic Tests Evaluating Homologous Recombination Repair Deficiency (HRD) for Treatment Decisions in Early and Metastatic Breast Cancer.
- Galland L, Roussot N, Desmoulins I, Mayeur D, Kaderbhai C, Ilie S, Hennequin A, Reda M, Albuisson J, Arnould L, Boidot R, Truntzer C, Ghiringhelli F, Ladoire S.
- Cancers (Basel). 2023 Feb 17;15(4):1299. doi: 10.3390/cancers15041299.
- Review
- Free Full Text
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- OlympiAD extended follow-up for overall survival and safety: olaparib versus chemotherapy treatment of physician’s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer.
- Robson ME, Im SA, Senkus E, Xu B, Domchek SM, Masuda N, Delaloge S, Tung N, Armstrong A, Dymond M, Fielding A, Allen A, Conte P.
- Eur J Cancer. 2023 Feb 14. doi: 10.1016/j.ejca.2023.01.031. Epub ahead of print.
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- PARP inhibitor-related hemorrhages:What does the real-world study say?
- Wang S, Guo M, Fan P, Jin Z.
- Front Oncol. 2023 Feb 14;13:1070343. doi: 10.3389/fonc.2023.1070343.
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- Targeting Breast Cancer: An Overlook on Current Strategies.
- Iacopetta D, Ceramella J, Baldino N, Sinicropi MS, Catalano A.
- Int J Mol Sci. 2023 Feb 11;24(4):3643. doi: 10.3390/ijms24043643.
- Review
- Free Full Text
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- Radiotherapy, PARP Inhibition, and Immune-Checkpoint Blockade: A Triad to Overcome the Double-Edged Effects of Each Single Player.
- Rosado MM, Pioli C.
- Cancers (Basel). 2023 Feb 8;15(4):1093. doi: 10.3390/cancers15041093.
- Review
- Free Full Text
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- 2022 : nouvelles pratiques thérapeutiques en oncologie mammaire [2022: New therapeutic practices in breast oncology].
- Deluche E, Verret B.
- Bull Cancer. 2023 Feb 7:S0007-4551(23)00036-X. French. doi: 10.1016/j.bulcan.2023.01.002. Epub ahead of print.
- PMID: 36759216
- PubMed abstract
- Source abstract
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- Homologous recombination deficiency prediction using low-pass whole genome sequencing in breast cancer.
- Liu Y, Li Y, Zhang MZ, Chen D, Leng Y, Wang J, Han BW, Wang J.
- Cancer Genet. 2023 Feb 4;272-273:35-40. doi: 10.1016/j.cancergen.2023.02.001. Epub ahead of print.
- PMID: 36758499
- PubMed abstract
- Source abstract
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- Systemic Therapy for Hereditary Breast Cancers.
- Harvey-Jones EJ, Lord CJ, Tutt ANJ.
- Hematol Oncol Clin North Am. 2023 Feb;37(1):203-224. doi: 10.1016/j.hoc.2022.08.018.
- PMID: 36435611
- PubMed abstract
- Review
- Free Full Text
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- A phase 1 dose-escalation study of the poly(ADP-ribose) polymerase inhibitor senaparib in Australian patients with advanced solid tumors.
- Gao B, Voskoboynik M, Cooper A, Wilkinson K, Hoon S, Hsieh CY, Cai S, Tian YE, Bao J, Ma N, Wang C, Zhang M, Li B, Guo M, Zhou R, Wang X, Xu C, de Souza P.
- Cancer. 2023 Jan 31. doi: 10.1002/cncr.34662. Epub ahead of print.
- PMID: 36718624
- PubMed abstract
- Source abstract
•• Identifier: NCT03507543: The Safety and Pharmacokinetics of IMP4297 in Patients With Advanced Solid Tumors. (ClinicalTrials.gov . Accessed 2023 Jan 31.)
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- Efficacy of Olaparib in Treatment-Refractory, Metastatic Breast Cancer with Uncommon Somatic BRCA Mutations Detected in Circulating Tumor DNA.
- Yoon JK, Ahn J, Kim S, Kim HP, Kang JK, Bang D, Lim Y, Kim TY.
- Cancer Res Treat. 2023 Jan 31. doi: 10.4143/crt.2022.1529. Epub ahead of print.
- PMID: 36731462
- PubMed abstract
- Source abstract
- Case report
- Free Full Text (PDF)
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- Risk of seizures in a population of women with BRCA-positive metastatic breast cancer from an electronic health record database in the United States.
- Liede A, Sebby W, Miriyala AKR, Potluri R, Mazumder D, Ghosh A, Papademetriou E, Kilpatrick R, Tyczynski JE.
- BMC Cancer. 2023 Jan 24;23(1):78. doi: 10.1186/s12885-023-10554-6.
- PMID: 36690978
- PubMed abstract
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- Efficacy and safety of treatment regimens for metastatic, locally advanced, or recurrent breast cancer patients with breast cancer susceptibility genes 1 or 2 mutations: a network meta-analysis.
- Zhu Y, Li Y, Liu W, Zhou R, Tse SL, Wang Y, Li W.
- Front Oncol. 2023 Jan 24;13:1080297. doi: 10.3389/fonc.2023.1080297.
- Meta-Analysis
- Free Full Text
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- Genetic Testing Challenges in Oncology: Patient With Pending Bill Has BRCA1 Result Withheld.
- Ray T.
- Precision Oncology News. 2023 Jan 23.
- Case report
- Free Full Text
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- Discrimination between Complete versus Non-Complete Pathologic Response to Neoadjuvant Therapy Using Ultrasensitive Mutation Analysis: A Proof-of-Concept Study in BRCA1-Driven Breast Cancer Patients.
- Sokolenko AP, Moiseyenko FV, Iyevleva AG, Ivantsov AO, Dolmatov GD, Shelekhova KV, Gulo EV, Topal AX, Artemieva EV, Abduloeva NH, Rysev NA, Barsova DA, Levchenko NV,, Volkov NM, Egorenkov VV, Moiseyenko VM, Imyanitov EN.
- Int J Mol Sci. 2023 Jan 18;24(3):1870. doi: 10.3390/ijms24031870.
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- Novel Agents in the Adjuvant Setting: PARP Inhibitors.
- Geyer C, Krop IE.
- OncLive. OncLive NewsNetwork. 2023 Jan 18.
- Video
- Free video
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- The Role of PARP Inhibitors in Non-BRCA Mutated Breast Cancer.
- Ballinger TJ.
- Medscape Oncology. Decision Point. 2023 Jan 13.
- Review
- Free Full Text
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- Klinisch relevante molekularpathologische Diagnostik beim Mammakarzinom [Clinically relevant molecular pathological diagnostics in breast cancer].
- Rodepeter FR, Teply-Szymanski J, Romey M, Grass A, Erber R, Lebeau A, Mack EKM, Tarawneh TS, Gremke N, Boekhoff J, Wündisch T, Wagner U, Jank P, Denkert C.
- Pathologie (Heidelb). 2023 Jan 11. German. doi: 10.1007/s00292-022-01175-0. Epub ahead of print.
- PMID: 36629894
- PubMed abstract
- Source abstract
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- Real-world safety and effectiveness of maintenance niraparib for platinum-sensitive recurrent ovarian cancer: A GEICO retrospective observational study within the Spanish Expanded-Access Programme.
- Cueva JF, Palacio I, Churruca C, Herrero A, Pardo B, Constenla M, Santaballa A, Manso L, Estévez P, Maximiano C, Legerén M, Marquina G, de Juan A, Quindós M, Sánchez L, Barquin A, Fernández I, Martín C, Juárez A, Martín T, García Y, Yubero A, Gallego A, Martínez Bueno A, Guerra E, González-Martín A.
- Eur J Cancer. 2023 Jan 9. doi: 10.1016/j.ejca.2022.12.023. Epub ahead of print.
•• Identifier: NCT04546373: Niraparib as Maintenance Therapy in Patients With Platinum Sensitive Recurrent Ovarian Cancer. (ClinicalTrials.gov . Accessed 2023 Jan 9.)
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- Ideaya to Launch PARG Inhibitor Trial in Homologous Recombination Repair-Deficient Cancers.
- [No author given]
- Precision Oncology News. 2023 Jan 9.
- News
- Free Full Text
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- High-dose chemotherapy with stem cell rescue to treat stage III homologous deficient breast cancer: factors influencing clinical implementation.
- Verbeek JGE, de Jong VMT, Wijnja HM, Jager A, Linn SC, Retèl VP, van Harten WH.
- BMC Cancer. 2023 Jan 7;23(1):26. doi: 10.1186/s12885-022-10412-x.
- PMID: 36611165
- PubMed abstract
- Guideline
- Free Full Text
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- Clinical application of PARP inhibitors in ovarian cancer: from molecular mechanisms to the current status.
- Wu Y, Xu S, Cheng S, Yang J, Wang Y.
- J Ovarian Res. 2023 Jan 7;16(1):6. doi: 10.1186/s13048-023-01094-5.
- PMID: 36611214
- PubMed abstract
- Review
- Free Full Text
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- Targeting the DNA damage response for cancer therapy.
- Curtin NJ.
- Biochem Soc Trans. 2023 Jan 6:BST20220681. doi: 10.1042/BST20220681. Epub ahead of print.
- PMID: 36606678
- PubMed abstract
- Review
- Free Full Text
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- Optimizing choices and sequences in the diagnostic-therapeutic landscape of advanced triple-negative breast cancer: An Italian consensus paper and critical review.
- Miglietta F, Fabi A, Generali D, Dieci MV, Arpino G, Bianchini G, Cinieri S, Conte PF, Curigliano G, De Laurentis M, Del Mastro L, De Placido S, Gennari A, Puglisi F, Zambelli A, Perrone F, Guarneri V.
- Cancer Treat Rev. 2023 Jan 6;114:102511. doi: 10.1016/j.ctrv.2023.102511. Epub ahead of print.
- PMID: 36638600
- PubMed abstract
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- Cisplatin with veliparib or placebo in metastatic triple-negative breast cancer and BRCA mutation-associated breast cancer (S1416): a randomised, double-blind, placebo-controlled, phase 2 trial.
- Rodler E, Sharma P, Barlow WE, Gralow JR, Puhalla SL, Anders CK, Goldstein L, Tripathy D, Brown-Glaberman UA, Huynh TT, Szyarto CS, Godwin AK, Pathak HB, Swisher EM, Radke MR, Timms KM, Lew DL, Miao J, Pusztai L, Hayes DF, Hortobagyi GN.
- Lancet Oncol. 2023 Jan 6:S1470-2045(22)00739-2. doi: 10.1016/S1470-2045(22)00739-2. Epub ahead of print.
- PMID: 36623515
- PubMed abstract
- Source abstract
•• Identifier: NCT02595905: Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases. (ClinicalTrials.gov . Accessed 2023 Jan 7.)
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- Breast Cancer Advances in 2022 Showcase a Shifting Landscape.
- Sparano JA.
- OncLive. 2023 Jan 6.
- Commentary
- Free Full Text
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- Novel combination treatment of CDK 4/6 inhibitors with PARP inhibitors in triple negative breast cancer cells.
- Guney Eskiler G, Ozman Z, Haciefendi A, Cansaran-Duman D.
- Naunyn Schmiedebergs Arch Pharmacol. 2023 Jan 4. doi: 10.1007/s00210-022-02375-4. Epub ahead of print.
- PMID: 36598514
- PubMed abstract
- Source abstract
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- Testing for homologous recombination repair or homologous recombination deficiency for poly (ADP-ribose) polymerase inhibitors: A current perspective.
- Herzog TJ, Vergote I, Gomella LG, Milenkova T, French T, Tonikian R, Poehlein C, Hussain M.
- Eur J Cancer. 2022 Dec 21 [2023 Jan 1];179:136-146. doi: 10.1016/j.ejca.2022.10.021. Epub ahead of print.
- PMID: 36563604
- PubMed abstract
- Review
- Free Full Text
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- Homologous Recombination Repair Gene Mutations to Predict Olaparib Plus Bevacizumab Efficacy in the First-Line Ovarian Cancer PAOLA-1/ENGOT-ov25 Trial.
- Pujade-Lauraine E, Brown J, Barnicle A, Wessen J, Lao-Sirieix P, Criscione SW, du Bois A, Lorusso D, Romero I, Petru E, Yoshida H, Vergote I, Colombo N, Hietanen S, Provansal M, Schmalfeldt B, Pignata S, Martín Lorente C, Berton D, Runnebaum IB, Ray-Coquard I.
- JCO Precis Oncol. 2023 Jan;7:e2200258. doi: 10.1200/PO.22.00258.
- PMID: 36716415
- PubMed abstract
•• Identifier: NCT02477644: Platine, Avastin and OLAparib in 1st Line (PAOLA-1). (ClinicalTrials.gov . Accessed 2023 Jan 30.)
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- Impact of Homologous Recombination Deficiency on Outcomes in Patients With Triple-Negative Breast Cancer Treated With Carboplatin-Based Neoadjuvant Chemotherapy: Secondary Analysis of the NeoCART Randomized Clinical Trial.
- Zhang L, Wu Z, Li J, Zhu D, Yang L, Shao Y, Lin Y, Liu Z, Cao Y, Zhang G, Shang S, Zhang Y, Wang K.
- JCO Precis Oncol. 2023 Jan;7:e2200337. doi: 10.1200/PO.22.00337.
- PMID: 36652665
- PubMed abstract
- Source abstract
•• Identifier: NCT03154749: DCb (Docetaxel/Carboplatin) Versus EC-D (Epirubicin/Cyclophosphamide Followed by Docetaxe) as Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer. (ClinicalTrials.gov . Accessed 2023 Jan 18.)
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- Effectiveness of Secondary Risk-Reducing Strategies in Patients With Unilateral Breast Cancer With Pathogenic Variants of BRCA1 and BRCA2 Subjected to Breast-Conserving Surgery: Evidence-Based Simulation Study.
- Maksimenko J, Rodrigues PP, Nakazawa-Miklaševiča M, Pinto D, Miklaševičs E, Trofimovičs G, Gardovskis J, Cardoso F, Cardoso MJ.
- JMIR Form Res. 2022 Dec 29;6(12):e37144. doi: 10.2196/37144.
- PMID: 36580360
- PubMed abstract
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- Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer.
- Perez-Villatoro F, Oikkonen J, Casado J, Chernenko A, Gulhan DC, Tumiati M, Li Y, Lavikka K, Hietanen S, Hynninen J, Haltia UM, Tyrmi JS, Laivuori H, Konstantinopoulos PA, Hautaniemi S, Kauppi L, Färkkilä A.
- NPJ Precis Oncol. 2022 Dec 29;6(1):96. doi: 10.1038/s41698-022-00339-8.
- PMID: 36581696
- PubMed abstract
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- All HER2-negative breast cancer patients need gBRCA testing: cost-effectiveness and clinical benefits.
- Wu HL, Luo ZY, He ZL, Gong Y, Mo M, Ming WK, Liu GY.
- Br J Cancer. 2022 Dec 23. doi: 10.1038/s41416-022-02111-y. Epub ahead of print.
- PMID: 36564566
- PubMed abstract
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- Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-negative advanced breast cancer from the United States, Europe, and Israel.
- Mahtani R, Niyazov A, Arondekar B, Lewis K, Rider A, Massey L, Lux MP.
- BMC Cancer. 2022 Dec 22;22(1):1343. doi: 10.1186/s12885-022-10325-9.
- PMID: 36550413
- PubMed abstract
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- Determination of BRCAness Phenotype in Breast Tumors for the Appointment of Neoadjuvant Chemotherapy Based on Platinum and Taxanes.
- Mihajlovich Tsyganov MM, Ibragimova MK, Garbukov EY, Bragina OD, Karchevskaya AA, Usynin EA, Litvyakov NV.
- Int J Mol Sci. 2022 Dec 22;24(1):207. doi: 10.3390/ijms24010207.
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- Cost-effectiveness of PARP inhibitors in malignancies: A systematic review.
- Ding H, He C, Tong Y, Fang Q, Mi X, Chen L, Xin W, Fang L.
- PLoS One. 2022 Dec 15;17(12):e0279286. doi: 10.1371/journal.pone.0279286.
- PMID: 36520958
- PubMed abstract
- Review
- Free Full Text
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- Ideaya Biosciences Files IND With FDA for PARG Inhibitor.
- [No author goven]
- Precision Oncology News. 2022 Dec 12.
- News
- Free Full Text
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- BRCA1/2 Reversion Mutations in Patients Treated with Poly ADP-Ribose Polymerase (PARP) Inhibitors or Platinum Agents.
- Darabi S, Braxton DR, Xiu J, Carneiro BA, Swensen J, Antonarakis ES, Liu SV, McKay RR, Spetzler D, El-Deiry WS, Demeure MJ.
- Medicina (Kaunas). 2022 Dec 10;58(12):1818. doi: 10.3390/medicina58121818.
- PMID: 36557020
- PubMed abstract
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- Neoadjuvant Olaparib Combo Fails to Surpass Carboplatin/Paclitaxel in HER2– Early Breast Cancer.
- Lovely B.
- OncLive. 2022 Dec 9.
- Conference report
- Free Full Text
•• Identifier: NCT02789332: Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency (GeparOla). (ClinicalTrials.gov . Accessed 2022 Dec 10.)
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- Sociodemographic, Clinical, and Variation Outcomes for Breast Cancer and Breast Cancer-Related Mutations in a Ten-Year Cohort From Neiva, Huila, Colombia.
- Olaya J, Sanjuan J, Torres-Lopez D, Olaya L, Gutierrez-Vargas M, Olaya G, Olaya JD.
- Cureus. 2022 Dec 6;14(12):e32257. doi: 10.7759/cureus.32257.
- PMID: 36620844
- PubMed abstract
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- Pamiparib in patients with locally advanced or metastatic HER2-negative breast cancer with germline BRCA mutations: a phase II study.
- Xu B, Sun T, Shi Y, Cui J, Yin Y, Ouyang Q, Liu Q, Zhang Q, Chen Y, Wang S, Wang X, Tong Z, Zhong Y, Wang J, Yan M, Yan X, Wang C, Feng J, Wang X, Hu G, Cheng Y, Ge R, Zhu Z, Zhang W, Shao Z.
- Breast Cancer Res Treat. 2022 Dec 2. doi: 10.1007/s10549-022-06785-z. Epub ahead of print.
- PMID: 36459284
- PubMed abstract
•• Identifier: NCT03575065: Efficacy and Safety of BGB-290 in the Treatment of Metastatic HER2-Negative Breast Cancer Patients With BRCA Mutation in China. (ClinicalTrials.gov . Accessed 2022 Dec 2.)
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- The potential of PARP inhibitors in targeted cancer therapy and immunotherapy.
- Hunia J, Gawalski K, Szredzka A, Suskiewicz MJ, Nowis D.
- Front Mol Biosci. 2022 Dec 1;9:1073797. doi: 10.3389/fmolb.2022.1073797.
- PMID: 36533080
- PubMed abstract
- Review
- Free PMC article
- Free Full Text
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- Predictive factors for relapse in triple-negative breast cancer patients without pathological complete response after neoadjuvant chemotherapy.
- Toss A, Venturelli M, Civallero M, Piombino C, Domati F, Ficarra G, Combi F, Cabitza E, Caggia F, Barbieri E, Barbolini M, Moscetti L, Omarini C, Piacentini F, Tazzioli G, Dominici M, Cortesi L.
- Front Oncol. 2022 Dec 1;12:1016295. doi: 10.3389/fonc.2022.1016295.
- PMID: 36531080
- PubMed abstract
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- Cost-effectiveness of talazoparib for patients with locally advanced or metastasized breast cancer in Germany.
- Schwarz F, Arefian H, Hartmann M, Runnebaum I.
- PLoS One. 2022 Dec 1;17(12):e0278460. doi: 10.1371/journal.pone.0278460.
- PMID: 36454738
- PubMed abstract
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- Adolescent triple-negative breast cancer with germline pathogenic variants in both BRCA1 and TP53 genes: A case report.
- Chen D, Zhang C, Yuan M, Zhang Y, Liu Q, Wan D.
- Front Oncol. 2022 Nov 28;12:970641. doi: 10.3389/fonc.2022.970641.
- Case report
- Free Full Text
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- A review of the cost-effectiveness of genetic testing for germline variants in familial cancer.
- Teppala S, Hodgkinson B, Hayes S, Scuffham P, Tuffaha H.
- J Med Econ. 2022 Nov 25:1-38. doi: 10.1080/13696998.2022.2152233. Epub ahead of print.
- PMID: 36426964
- PubMed abstract
- Review
- Free Full Text
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- Pre-Existing and Acquired Resistance to PARP Inhibitor-Induced Synthetic Lethality.
- Viet Le B, Podszywalow-Bartnicka P, Piwocka K, Skorski T.
- Cancers (Basel). 2022 Nov 24;14(23):5795. doi: 10.3390/cancers14235795.
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- Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies.
- Murciano-Goroff YR, Schram AM, Rosen EY, Won H, Gong Y, Noronha AM, Janjigian YY, Stadler ZK, Chang JC, Yang SR, Mandelker D, Offit K, Berger MF, Donoghue MTA, Bandlamudi C, Drilon A.
- Nat Commun. 2022 Nov 23;13(1):7182. doi: 10.1038/s41467-022-34109-8.
- PMID: 36418296
- PubMed abstract
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- Poly-ADP-ribose polymerase (PARP) inhibitors and ovarian function.
- Li J, Li Q, Zhang L, Zhang S, Dai Y.
- Biomed Pharmacother. 2022 Nov 18;157:114028. doi: 10.1016/j.biopha.2022.114028. Epub ahead of print.
- PMID: 36410122
- PubMed abstract
- Review
- Free Full Text
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- Molecular intrinsic subtypes, genomic, and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancers.
- Ballot E, Galland L, Mananet H, Boidot R, Arnould L, Desmoulins I, Mayeur D, Kaderbhai C, Ilie S, Hennequin A, Bergeron A, Derangère V, Ghiringhelli F, Truntzer C, Ladoire S.
- Breast Cancer Res. 2022 Nov 18;24(1):80. doi: 10.1186/s13058-022-01572-6.
- PMID: 36401316
- PubMed abstract
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- Impact of totally implanted venous access port placement on body image in women with breast cancer.
- Pizzuti G, Cassani C, Bottazzi A, Ruggieri A, Della Valle A, Dionigi F, Anghelone CAP, Sgarella A, Ferrari A.
- J Vasc Access. 2022 Nov 18:11297298221136330. doi: 10.1177/11297298221136330. Epub ahead of print.
- PMID: 36401349
- PubMed abstract
- Case report
- Free Full Text
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- Avelumab Plus Talazoparib in Patients With BRCA1/2- or ATM-Altered Advanced Solid Tumors: Results From JAVELIN BRCA/ATM, an Open-Label, Multicenter, Phase 2b, Tumor-Agnostic Trial.
- Schram AM, Colombo N, Arrowsmith E, Narayan V, Yonemori K, Scambia G, Zelnak A, Bauer TM, Jin N, Ulahannan SV, Colleoni M, Aftimos P, Donoghue MTA, Rosen E, Rudneva VA, Telli ML, Domchek SM, Galsky MD, Hoyle M, Chappey C, Stewart R, Blake-Haskins JA, Yap TA.
- JAMA Oncol. 2022 Nov 17. doi: 10.1001/jamaoncol.2022.5218. Epub ahead of print.
- PMID: 36394867
- PubMed abstract
•• Identifier: NCT03565991: Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors. (ClinicalTrials.gov . Accessed 2022 Nov 19.)
•• Commentary:
Combining PARP Inhibitor With Immunotherapy-Does the Promise of Preclinical Data Translate to Clinic?
- PMID: 36394835
- PubMed abstract
- Source abstract
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- BMN673 Is a PARP Inhibitor with Unique Radiosensitizing Properties: Mechanisms and Potential in Radiation Therapy.
- Soni A, Lin X, Mladenov E, Mladenova V, Stuschke M, Iliakis G.
- Cancers (Basel). 2022 Nov 16;14(22):5619. doi: 10.3390/cancers14225619.
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- Role of PARP Inhibitors in Cancer Immunotherapy: Potential Friends to Immune Activating Molecules and Foes to Immune Checkpoints.
- Franzese O, Graziani G.
- Cancers (Basel). 2022 Nov 16;14(22):5633. doi: 10.3390/cancers14225633.
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- Dose Adjustment of Poly (ADP-Ribose) Polymerase Inhibitors in Patients with Hepatic or Renal Impairment.
- Zhao D, Long X, Wang J.
- Drug Des Devel Ther. 2022 Nov 14;16:3947-3955. doi: 10.2147/DDDT.S387920.
- PMID: 36405648
- PubMed abstract
- Review
- Free PMC article
- Free Full Text
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- Development of a novel BRCAness score that predicts response to PARP inhibitors.
- Oshi M, Gandhi S, Wu R, Asaoka M, Yan L, Yamada A, Yamamoto S, Narui K, Chishima T, Ishikawa T, Endo I, Takabe K.
- Biomark Res. 2022 Nov 12;10(1):80. doi: 10.1186/s40364-022-00427-8.
- PMID: 36371386
- PubMed abstract
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- Differences in Durability of PARP Inhibition by Clinically Approved PARP Inhibitors: Implications for Combinations and Scheduling.
- Smith HL, Willmore E, Mukhopadhyay A, Drew Y, Curtin NJ.
- Cancers (Basel). 2022 Nov 12;14(22):5559. doi: 10.3390/cancers14225559.
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- Study Suggests a PARP Inhibitors Has Wider Cancer Applications.
- [No author given]
- Inside Precision Medicine. Topics. Oncology. 2022 Nov 9.
- Research news
- Free Full Text
•• Original research:
A phase II study of talazoparib monotherapy in patients with wild-type BRCA1 and BRCA2 with a mutation in other homologous recombination genes.
- PMID: 36253484
- PubMed abstract
- Free Full Text
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- Targeted Therapy and Immunotherapy for Heterogeneous Breast Cancer.
- Sun X, Liu K, Lu S, He W, Du Z.
- Cancers (Basel). 2022 Nov 6;14(21):5456. doi: 10.3390/cancers14215456.
- PMID: 36358874
- PubMed abstract
- Source abstract
- Review
- Free Full Text
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- Detection of microsatellite instability high (MSI-H) status by targeted plasma-based genotyping in metastatic breast cancer.
- Vidula N, Lipman A, Kato S, Weipert C, Hesler K, Azzi G, Elkhanany A, Juric D, Rodriguez E, Faulkner C, Makhlouf P, Price K, O'Shaughnessy J, Bardia A.
- NPJ Breast Cancer. 2022 Nov 4;8(1):117. doi: 10.1038/s41523-022-00490-2.
- PMID: 36333333
- PubMed abstract
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- Exquisitely Platinum-Sensitive Triple-Negative Breast Cancer, Time for BRCA Methylation Testing?
- Tan TJ, Fink JL, Tay TK, Jaradi B, Stone N, Waring P, Koo KM, Tan PH, Tan DS, Dent RA.
- JCO Precis Oncol. [2022 Nov 3];6:e2200309. doi: 10.1200/PO.22.00309.
- PMID: 36331241
- PubMed abstract
- Source abstract
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- Sequential Olaparib, Adavosertib Administration Overcomes Concurrent Use Toxicity Problems.
- [No author given]
- Inside Precision Medicine. Topics. Oncology. 2022 Nov 2.
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- Emerging strategies: PARP inhibitors in combination with immune checkpoint blockade in BRCA1 and BRCA2 mutation-associated and triple-negative breast cancer.
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- Local treatment in patients with hereditary breast cancer: decision-making process in low-, moderate-, high-penetrance pathogenic germline mutation carriers.
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- Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance.
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- Loss of Heterozygosity of BRCA1/2 as a Predictive Marker for Talazoparib Response.
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- Genomic Scar Score: A robust model predicting homologous recombination deficiency based on genomic instability.
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- PARP-inhibitors for BRCA1/2-related advanced HER2-negative breast cancer: A meta-analysis and GRADE recommendations by the Italian Association of Medical Oncology.
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- Concurrent Olaparib and Radiotherapy in Patients With Triple-Negative Breast Cancer: The Phase 1 Olaparib and Radiation Therapy for Triple-Negative Breast Cancer Trial.
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- JAMA Oncol. 2022 Oct 27. doi: 10.1001/jamaoncol.2022.5074. Epub ahead of print.
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- PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination.
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- Deciding on the best pharmacotherapy for advanced triple-negative breast cancer: expert guidance.
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- RAD6 inhibition enhances paclitaxel sensitivity of triple negative breast cancer cells by aggravating mitotic spindle damage.
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- Real-world study of patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-Negative advanced breast cancer: Patient demographics, treatment patterns, adverse events, and physician-reported satisfaction in the United States, Europe, and Israel.
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- Germline Genetic Testing in Breast Cancer: Systemic Therapy Implications.
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- The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment.
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- Efficacy of platinum-based and non-platinum-based drugs on triple-negative breast cancer: meta-analysis.
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- Association of Treatment Response with Clinicopathological Characteristics in Female Breast Cancer Patients: Genomic Insights for Future Implementation of Personalized Medicine in Egypt.
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- Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high risk, early breast cancer.
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- Ann Oncol. 2022 Oct 10:S0923-7534(22)04165-5. doi: 10.1016/j.annonc.2022.09.159. Epub ahead of print.
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- The Evolving Field of Biomarker Testing in Solid Tumors - Episode 14: Targeted Therapy in Metastatic Breast Cancer for Patients with BRCA Mutations.
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- OncLive. Peer Exchange. 2022 Oct 10.
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- Outcomes of patients with HER2-negative metastatic breast cancer after platinum- and non-platinum-based first-line chemotherapy among patients with and without pathogenic germline BRCA1/2 mutations.
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- Br J Cancer. 2022 Oct 7. doi: 10.1038/s41416-022-02003-1. Epub ahead of print.
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- Emerging Targeted Therapies for Early Breast Cancer.
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- Drugs. 2022 Oct 7. doi: 10.1007/s40265-022-01781-5. Epub ahead of print.
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- CXCR4 inhibitor, AMD3100, down-regulates PARP1 expression and Synergizes with olaparib causing severe DNA damage in BRCA-proficient triple-negative breast cancer.
- Xie XF, Wu NQ, Wu JF, Zhang GL, Guo JF, Chen XL, Du CW.
- Cancer Lett. 2022 Oct 6:215944. doi: 10.1016/j.canlet.2022.215944. Epub ahead of print.
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- Patient-associated risk factors for severe anemia in patients with advanced ovarian or breast cancer receiving olaparib monotherapy: A multicenter retrospective study.
- Tashiro R, Kawazoe H, Mamishin K, Seto K, Udagawa R, Saito Y, Hashimoto H, Shimoi T, Yonemori K, Yonemura M, Terakado H, Kawasaki T, Furukawa T, Nakamura T.
- Front Oncol. 2022 Oct 4;12:898150. doi: 10.3389/fonc.2022.898150.
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- Combined inhibition of PARP and EZH2 for cancer treatment: Current status, opportunities, and challenges.
- Zhang X, Huo X, Guo H, Xue L.
- Front Pharmacol. 2022 Oct 3;13:965244. doi: 10.3389/fphar.2022.965244.
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- A First-in-Class Clinical G-Quadruplex-Targeting Drug. The Bench-to-Bedside Translation of the Fluoroquinolone QQ58 to CX-5461 (Pidnarulex).
- Xu H, Hurley LH.
- Bioorg Med Chem Lett. 2022 Oct 1:129016. doi: 10.1016/j.bmcl.2022.129016. Epub ahead of print.
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Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies.
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•• Identifier: NCT04890613: Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation. (ClinicalTrials.gov)
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- Comparison of Clinical, Pathological, and Prognostic Features in BRCA Mutant and Wild-Type Male Breast Cancer Patients.
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- Eur J Breast Health. 2022 Oct 1;18(4):323-328. doi: 10.4274/ejbh.galenos.2022.2022-5-2.
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- Updates on Management of Hereditary Breast Cancer: New Data on PARP Inhibitors Change Recommendations Regarding the Multidisciplinary Care of Breast Cancer Patients with BRCA Mutations.
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•• Guideline:
Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline.
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Management of Hereditary Breast Cancer: ASCO, ASTRO, and SSO Guideline.
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•• Guideline:
Adjuvant PARP Inhibitors in Patients With High-Risk Early-Stage HER2-Negative Breast Cancer and Germline BRCA Mutations: ASCO Hereditary Breast Cancer Guideline Rapid Recommendation Update.
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- Targeted therapy for breast cancer: An overview of drug classes and outcomes.
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- Biochem Pharmacol. 2022 Oct;204:115209. doi: 10.1016/j.bcp.2022.115209. Epub 2022 Aug 14.
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- Moderate penetrance genes complicate genetic testing for breast cancer diagnosis: ATM, CHEK2, BARD1 and RAD51D.
- Graffeo R, Rana HQ, Conforti F, Bonanni B, Cardoso MJ, Paluch-Shimon S, Pagani O, Goldhirsch A, Partridge AH, Lambertini M, Garber JE.
- Breast. 2022 Oct;65:32-40. doi: 10.1016/j.breast.2022.06.003. Epub 2022 Jun 18.
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- Prognostic significance of germline BRCA mutations in patients with HER2-POSITIVE breast cancer.
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- Breast. 2022 Oct;65:145-150. doi: 10.1016/j.breast.2022.07.012. Epub 2022 Jul 31.
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- Discovery and validation of a transcriptional signature identifying homologous recombination-deficient breast, endometrial and ovarian cancers.
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- Lurbinectedin, a selective inhibitor of oncogenic transcription, in patients with pretreated germline BRCA1/2 metastatic breast cancer: results from a phase II basket study.
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- ESMO Open. 2022 Oct;7(5):100571. doi: 10.1016/j.esmoop.2022.100571. Epub 2022 Aug 28.
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•• Identifier: NCT02454972: Clinical Trial of Lurbinectedin (PM01183) in Selected Advanced Solid Tumors. (ClinicalTrials.gov)
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- Exposure-Response Model With Time-Varying Predictors to Estimate the Effects of Veliparib in Combination With Carboplatin/Paclitaxel and as Monotherapy: Veliparib Phase 3 Study in BRCA-Mutated Advanced Breast Cancer (BROCADE3) Trial.
- Stodtmann S, Eckert D, Joshi R, Nuthalapati S, Ratajczak CK, Menon R, Mensing S, Xiong H.
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- State of the Biomarker Science in Ovarian Cancer: A National Cancer Institute Clinical Trials Planning Meeting Report.
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- A phase II study of talazoparib monotherapy in patients with wild-type BRCA1 and BRCA2 with a mutation in other homologous recombination genes.
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•• Research news: Study Suggests a PARP Inhibitors Has Wider Cancer Applications. (Inside Precision Medicine)
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- Genomics to select treatment for patients with metastatic breast cancer.
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- Intrathecal Methotrexate Toxicity Resulting in Brain Death due to Generalized Cerebral Edema Case Report.
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- Multiple Bayesian network meta-analyses to establish therapeutic algorithms for metastatic triple negative breast cancer.
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- Alterations in Homologous Recombination-Related Genes and Distinct Platinum Response in Metastatic Triple-Negative Breast Cancers: A Subgroup Analysis of the ProfiLER-01 Trial.
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- Precision medicine in the real-world setting. Clinical activity of talazoparib in a woman with hormone receptor-positive HER2-negative metastatic breast cancer with pathogenic mutation in somatic BRCA2.
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- Ecancermedicalscience. 2022 Sep 26;16:1448. doi: 10.3332/ecancer.2022.1448.
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- BRCA Mutation Status in Triple-Negative Breast Cancer Patients Treated with Neoadjuvant Chemotherapy: A Pivotal Role for Treatment Decision-Making.
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- Cancers (Basel). 2022 Sep 21;14(19):4571. doi: 10.3390/cancers14194571.
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- PD-L1-Positive High-Grade Triple-Negative Breast Cancer Patients Respond Better to Standard Neoadjuvant Treatment-A Retrospective Study of PD-L1 Expression in Relation to Different Clinicopathological Parameters.
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- TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-?B activation.
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- Biomarkers for Systemic Therapy in Metastatic Breast Cancer: ASCO Guideline Update.
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- The Evolving Field of Biomarker Testing in Solid Tumors - Episode 10: Discussing Biomarker Testing with Patients
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- Tumor Immune Microenvironment Changes by Multiplex Immunofluorescence Staining in a Pilot Study of Neoadjuvant Talazoparib for Early-Stage Breast Cancer Patients with a Hereditary BRCA Mutation.
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- BAP1-defficient breast cancer in a patient with BAP1 cancer syndrome.
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- Prevalent versus incident breast cancers: benefits of clinical and radiological monitoring in women with pathogenic BRCA1/2 variants.
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- Breast cancer in a teenage girl with BRCA mutation: A case report from a low middle-income country.
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- PARP Inhibition and Beyond in BRCA-Associated Breast Cancer in Women: A State-Of-The-Art Summary of Preclinical Research on Risk Reduction and Clinical Benefits.
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- Comprehensive Analysis of Adverse Events Induced by PARP Inhibitors Using JADER and Time to Onset.
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- Updated Neoadjuvant Treatment Landscape for Early Triple Negative Breast Cancer: Immunotherapy, Potential Predictive Biomarkers, and Novel Agents.
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- A Real-World Multicentre Retrospective Study of Low-Dose Apatinib for Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer.
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- Comparative Efficacy and safety of new targeted therapies and immunotherapies for metastatic triple negative breast cancer: a network meta-analysis.
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- PLX038: a long-acting topoisomerase I inhibitor with robust anti-tumor activity in ATM deficient tumors and potent synergy with PARP inhibitors.
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- Mol Cancer Ther. 2022 Aug 23:MCT-22-0217. doi: 10.1158/1535-7163.MCT-22-0217. Epub ahead of print.
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- Optimal Choice of Neoadjuvant Chemotherapy for HER2-Negative Breast Cancer: Clinical Insights.
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- Triple negative breast cancer: approved treatment options and their mechanisms of action.
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- Comparison between talazoparib and conventional chemotherapy in the treatment of HER2-positive breast cancer patients: A retrospective study.
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- Merck, AstraZeneca Net European Approval for Adjuvant Lynparza in BRCA-Mutated Early Breast Cancer.
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- Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Breast Cancer Patients.
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- Current and future diagnostic and treatment strategies for patients with invasive lobular breast cancer.
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- Ann Oncol. 2022 Aug;33(8):769-785. doi: 10.1016/j.annonc.2022.05.006. Epub 2022 May 21.
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- A commentary on the discrepancy between blood and tumour BRCA testing: An open question.
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- Nat Cancer. 2022 Aug;3(8):927-931. doi: 10.1038/s43018-022-00400-2. Epub 2022 Jul 4. Erratum in: Nat Cancer. 2022 Aug 5.
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Identifier: NCT03329937: Study Evaluating the Antitumor Activity and Safety of Niraparib as Neoadjuvant Treatment in Participants With Breast Cancer. (ClinicalTrials.gov)
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- The increasing importance of pathology in modern clinical trial conduct: OlympiA as a case in point.
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- Efficacy and safety of talazoparib in Japanese patients with germline BRCA-mutated locally advanced or metastatic breast cancer: results of the phase 1 dose-expansion study.
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- Breast Cancer. 2022 Jul 30. doi: 10.1007/s12282-022-01390-w. Epub ahead of print.
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Identifier: NCT03343054: A Phase 1 Study Of Talazoparib, PARP Inhibitor, In Japanese Patients With Advanced Solid Tumors. (ClinicalTrials.gov)
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- PARP Inhibitors: Clinical Limitations and Recent Attempts to Overcome Them.
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- Satisfaction and Quality of Life of Healthy and Unilateral Diseased BRCA1/2 Pathogenic Variant Carriers after Risk-Reducing Mastectomy and Reconstruction Using the BREAST-Q Questionnaire.
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- High grade acinic cell carcinoma of the breast with clear cytoplasm mimics clear cell carcinoma in a BRCA1 mutation carrier: a case report and review of the literature on the molecular analysis.
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- Management Strategies of Breast Cancer Patients with BRCA1 and BRCA2 Pathogenic Germline Variants.
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- Prognostic Value of Stromal Tumor-Infiltrating Lymphocytes in Young, Node-Negative, Triple-Negative Breast Cancer Patients Who Did Not Receive (neo)Adjuvant Systemic Therapy.
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- A Systematic Review and Meta-Analysis on the Prognostic Value of BRCA Mutations, Homologous Recombination Gene Mutations, and Homologous Recombination Deficiencies in Cancer.
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- Cost-Effectiveness of Poly ADP-Ribose Polymerase Inhibitors in Cancer Treatment: A Systematic Review.
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- Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer.
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- Triple-Negative Breast Cancer: A Review of Current Curative Intent Therapies.
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- AZD5305 More Tolerable than Earlier PARP Agents.
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- New Adjuvant Treatment for High-Risk Early Breast Cancer.
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- A Phase II Trial to Evaluate the Efficacy of Bortezomib and Liposomal Doxorubicin in Patients With BRCA Wild-type Platinum-resistant Recurrent Ovarian Cancer (KGOG 3044/EBLIN).
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- Survival of BRCA1/BRCA2-associated pT1 breast cancer patients, a cohort study.
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- Breast Cancer Res Treat. 2022 Jul;194(1):159-170. doi: 10.1007/s10549-022-06608-1. Epub 2022 May 4.
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- Durable Disease-free Survival in a Patient with Metastatic Triple-negative Breast Cancer Treated with Olaparib Monotherapy.
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- Analysis of the Clinical Advancements for BRCA-Related Malignancies Highlights the Lack of Treatment Evidence for BRCA-Positive Male Breast Cancer.
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- Clinical Application of Next-Generation Sequencing in Patients With Breast Cancer: Real-World Data.
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- Breast Cancer with Low Recurrence Score on Oncotype DX©: Interplay Between Early Recurrence, Lobular Histology and BRCA Mutation.
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- Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-182-5p as a potential expression signature of BRCAness.
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- Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer.
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- Homologous Recombination Deficiency in Ovarian, Breast, Colorectal, Pancreatic, Non-Small Cell Lung and Prostate Cancers, and the Mechanisms of Resistance to PARP Inhibitors.
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- The Homologous Recombination Deficiency Scar in Advanced Cancer: Agnostic Targeting of Damaged DNA Repair.
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- Insights into the Possible Molecular Mechanisms of Resistance to PARP Inhibitors.
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- Update Breast Cancer 2022 Part 1 - Early Stage Breast Cancer.
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- Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status.
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- High chromosome instability identified by low-pass whole-genome sequencing assay is associated with TP53 copy loss and worse prognosis in BRCA1 germline mutation breast cancer.
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- Recent Advances in Enhancing the Therapeutic Index of PARP Inhibitors in Breast Cancer.
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- BRCA testing and outcomes in women with breast cancer.
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- The role of novel poly (ADP-ribose) inhibitors in the treatment of locally advanced and metastatic Her-2/neu negative breast cancer with inherited germline BRCA1/2 mutations. A review of the literature.
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- Tumor-Infiltrating Lymphocyctes in Triple-Negative Breast Cancer: Update for 2020.
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- Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy.
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- Neoadjuvant paclitaxel/olaparib in comparison to paclitaxel/carboplatinum in patients with HER2-negative breast cancer and homologous recombination deficiency (GeparOLA study).
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- BRCA1 and BRCA2 associated breast cancer and the roles of current modelling systems in drug discovery.
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- Pamiparib dose escalation in Chinese patients with non-mucinous high-grade ovarian cancer or advanced triple-negative breast cancer.
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- Efficacy of cancer vaccines in selected gynaecological breast and ovarian cancers: A 20-year systematic review and meta-analysis.
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- [Effects of Olaparib, a PARP-1 Inhibitor, on Triple Negative Breast Cancer Cells with a BRCA1 Mutation].
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- Prognostic and predictive parameters in breast pathology: a pathologist's primer.
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- PARP inhibitor resistance and TP53 mutations in patients treated with olaparib for BRCA-mutated cancer: Four case reports.
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- Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.
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- Integrating PARP inhibitors into the management of breast cancer: where are we?
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- Phase II study of eribulin in combination with gemcitabine for the treatment of patients with locally advanced or metastatic triple negative breast cancer (ERIGE trial). Clinical and pharmacogenetic results on behalf of the Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC).
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- Immunosuppressive Macrophages Limit PARP Inhibitor Efficacy in TNBC.
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- Surgical Treatment after Neoadjuvant Systemic Therapy in Young Women with Breast Cancer: Results from a Prospective Cohort Study.
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- TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes.
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- DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition.
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- Germline TP53 Testing in Breast Cancers: Why, When and How?
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- Gilead's Trodelvy Benefits TNBC Patients Regardless of Trop-2 Expression, BRCA1/2 Status.
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- Impact of BRCA Mutation Status on Tumor Infiltrating Lymphocytes (TILs), Response to Treatment, and Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy.
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- Differential immunomodulatory Effect of PARP Inhibition in BRCA1 deficient and competent tumor cells.
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- Editorial: Hereditary Breast and Ovarian Cancer: Current Concepts of Prevention and Treatment.
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- Dextran-modified Quercetin-Cu(II)/hyaluronic acid nanomedicine with natural poly(ADP-ribose) polymerase inhibitor and dual targeting for programmed synthetic lethal therapy in triple-negative breast cancer.
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- Biomarkers in Her2- Positive Disease.
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- Novel therapies for triple-negative breast cancer.
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- [A Case of Ipsilateral Breast Tumor Recurrence(IBTR)after Breast-Conserving Surgery Which Successfully Resected after Chemotherapy Using Carboplatin plus Gemcitabine].
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- Triple-negative breast cancer therapy: Current and future perspectives (Review).
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- Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1).
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- A Review of Natural Therapies Potentially Relevant in Triple Negative Breast Cancer Aimed at Targeting Cancer Cell Vulnerabilities.
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- Comparative efficacy, safety, and acceptability of single-agent poly (ADP-ribose) polymerase (PARP) inhibitors in BRCA-mutated HER2-negative metastatic or advanced breast cancer: a network meta-analysis.
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- New Perspectives for Resistance to PARP Inhibitors in Triple-Negative Breast Cancer.
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- Olaparib Monotherapy as Primary Treatment in Unselected Triple Negative Breast Cancer.
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- Nanoparticle Formulations of Poly (ADP-ribose) Polymerase Inhibitors for Cancer Therapy.
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- Clinical Challenges in the Management of Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: A Literature Review.
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- A review of current progress in triple-negative breast cancer therapy.
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- Germline BRCA-mutated metastatic breast cancer with positive hormone receptor.
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Original research:
Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study.
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- Platinum-Based Neoadjuvant Chemotherapy for Breast Cancer With BRCA Mutations: A Meta-Analysis.
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- BRCA1 Mutations in Cancer: Coordinating Deficiencies in Homologous Recombination with Tumorigenesis.
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- Survival benefits of PARP inhibitors in advanced breast cancer: a mirage?
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Talazoparib versus chemotherapy in patients with germline BRCA1/2-mutated HER2-negative advanced breast cancer: final overall survival results from the EMBRACA trial.
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- Talazoparib versus chemotherapy in patients with germline BRCA1/2-mutated HER2-negative advanced breast cancer: final overall survival results from the EMBRACA trial.
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Editorial:
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- Update Breast Cancer 2020 Part 4 - Advanced Breast Cancer.
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- BARD1 and Breast Cancer: The Possibility of Creating Screening Tests and New Preventive and Therapeutic Pathways for Predisposed Women.
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- Ideaya Biosciences, Broad Institute Partner on Synthetic Lethality-Based Cancer Drug Discovery.
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- PARP Inhibitors in Cancer Diagnosis and Therapy.
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- Surgical and Systemic Treatment of Hereditary Breast Cancer: A Mini-Review With a Focus on BRCA1 and BRCA2 Mutations.
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- Repurposing denosumab in breast cancer beyond prevention of skeletal related events: could nonclinical data be translated into clinical practice?
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- Novel Agents for Metastatic Triple-Negative Breast Cancer: Finding the Positive in the Negative.
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- The DNA damaging revolution.
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- Identifying germline APOBEC3B deletion and immune phenotype in Korean patients with operable breast cancer.
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- Was ist neu bei der Diagnostik und Therapie des Mammakarzinoms? – Aktuelle Standards in der Behandlung von Brustkrebs [Breast cancer - state of the art - Short overview of the current standard of treatment].
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