Effects of lifestyle factors on ovarian cancer expression/phenotype. Includes physical activity, BMI, diet, smoking, alcohol, reproductive factors, menarche, parity, breastfeeding, oral contraceptive use, shift work, etc. Also includes papers on the effects of environmental exposures on risk in HBOC.
List was last updated on
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- Pathologic Findings at Risk Reducing Surgery in BRCA and Non-BRCA Mutation Carriers: A Single-Center Experience.
- Cassani C, Rossi C, Camnasio CA, Urtis M, Fiandrino G, Grasso M, Zanellini F, Lucioni M, D’Ambrosio G, Di Toro A, Rossi M, Roccio M, Ferrari A, Secondino S, Nappi RE, Arbustini E, Paulli M, Spinillo A, Cesari S.
- Diagnostics (Basel). 2022 Dec 6;12(12):3054. doi: 10.3390/diagnostics12123054.
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- Contraceptives and cancer risks in BRCA1/2 pathogenic variant carriers: a systematic review and meta-analysis.
- van Bommel MHD, IntHout J, Veldmate G, Kets CM, de Hullu JA, van Altena AM, Harmsen MG.
- Hum Reprod Update. 2022 Nov 16:dmac038. doi: 10.1093/humupd/dmac038. Epub ahead of print.
- PMID: 36383189
- PubMed abstract
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- Fertility Counseling in BRCA1/2-Mutated Women with Breast Cancer and Healthy Individuals.
- Kufel-Grabowska J, Podolak A, Maliszewski D, Bartoszkiewicz M, Ramlau R, Lukaszuk K.
- J Clin Med. 2022 Jul 10;11(14):3996. doi: 10.3390/jcm11143996.
- PMID: 35887761
- PubMed abstract
- Source abstract
- Review
- Free PMC article
- Free Full Text
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- Review of the literature on combined oral contraceptives and cancer.
- Kamani M, Akgor U, Gültekin M.
- Ecancermedicalscience. 2022 Jun 23;16:1416. doi: 10.3332/ecancer.2022.1416.
- PMID: 36072240
- PubMed abstract
- Source abstract
- Review
- Free PMC article
- Free Full Text
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- Current and Emerging Methods for Ovarian Cancer Screening and Diagnostics: A Comprehensive Review.
- Liberto JM, Chen SY, Shih IM, Wang TH, Wang TL, Pisanic TR 2nd.
- Cancers (Basel). 2022 Jun 11;14(12):2885. doi: 10.3390/cancers14122885.
- PMID: 35740550
- PubMed abstract
- Source abstract
- Review
- Free PMC article
- Free Full Text
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- Beyond the pill: contraception and the prevention of hereditary ovarian cancer.
- Xia YY, Kotsopoulos J.
- Hered Cancer Clin Pract. 2022 Jun 6;20(1):21. doi: 10.1186/s13053-022-00227-z.
- PMID: 35668475
- PubMed abstract
- Review
- Free PMC article
- Free Full Text
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- Germline BRCA variants, lifestyle and ovarian cancer survival.
- Gersekowski K, Delahunty R, Alsop K, Goode EL, Cunningham JM, Winham SJ, Pharoah P, Song H, Jordan S, Fereday S, DeFazio A, Friedlander M, Obermair A; OPAL Study Group; AOCS Group, Webb PM.>
- Gynecol Oncol. 2022 Jun;165(3):437-445. doi: 10.1016/j.ygyno.2022.03.020. Epub 2022 Apr 7.
- PMID: 35400525
- PubMed abstract
- Source abstract
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- Oral contraceptives and risk of breast cancer and ovarian cancer in women with a BRCA1 or BRCA2 mutation: a meta-analysis of observational studies.
- Park J, Huang D, Chang YJ, Lim MC, Myung SK.
- Carcinogenesis. 2022 Apr 25;43(3):231-242. doi: 10.1093/carcin/bgab107.
- PMID: 34958358
- PubMed abstract
- Meta-Analysis
- Free full text
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- Oral Contraceptive Use in BRCA1 and BRCA2 Mutation Carriers: Absolute Cancer Risks and Benefits.
- Schrijver LH, Mooij TM, Pijpe A, Sonke GS, Mourits MJE, Andrieu N, Antoniou AC, Easton DF, Engel C, Goldgar D, John EM, Kast K, Milne RL, Olsson H, Phillips KA, Terry MB, Hopper JL, van Leeuwen FE, Rookus MA.
- J Natl Cancer Inst. 2022 Apr 11;114(4):540-552. doi: 10.1093/jnci/djac004.
- PMID: 35048954
- PubMed abstract
Commentary:
Oral Contraceptives and BRCA Cancer: A Balancing Act.
- PMID: 35048983
- PubMed abstract
- Free Full Text
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- Contraceptive use and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.
- Xia YY, Gronwald J, Karlan B, Lubinski J, McCuaig JM, Brooks J, Moller P, Eisen A, Sun S, Senter L, Bordeleau L, Neuhausen SL, Singer CF, Tung N, Foulkes WD, Sun P, Narod SA, Kotsopoulos J; Hereditary Ovarian Cancer Clinical Study Group.
- Gynecol Oncol. 2022 Mar;164(3):514-521. doi: 10.1016/j.ygyno.2022.01.014. Epub 2022 Jan 19.
- PMID: 35063280
- PubMed abstract
- Source abstract
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- Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1).
- Berling-Ernst A, Yahiaoui-Doktor M, Kiechle M, Engel C, Lammert J, Grill S, Dukatz R, Rhiem K, Baumann FT, Bischoff SC, Erickson N, Schmidt T, Niederberger U, Siniatchkin M, Halle M.
- Sci Rep. 2022 Feb 21;12(1):2907. doi: 10.1038/s41598-022-06913-1.
- PMID: 35190584
- PubMed abstract
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- Psychosexual Morbidity in Women With Ovarian Cancer: Evaluation by Germline BRCA Gene Mutational Status.
- Logue CA, Pugh J, Foden P, Mahmood RD, Morgan RD, Mitchell C, Hasan J, Clamp AR, Jayson GC.
- Sex Med. 2022 Feb;10(1):100465. doi: 10.1016/j.esxm.2021.100465. Epub 2021 Dec 15.
- PMID: 34922303
- PubMed abstract
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- Healthy lifestyle, genetic risk, and incidence of cancer: A prospective cohort study of 13 cancer types.
- Byrne S, Boyle T, Ahmed M, Lee SH, Benyamin B, Hyppönen E.
- medRxiv. 2021 Dec 7. doi: 10.1101/2021.12.07.21267341. Unpublished preprint.
- Unpublished preprint
- Free Full Text (PDF)
News: Lifestyle Choices Can Influence Genetic Risks for Cancer. (Medscape Oncology)
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- Physical activity and Mediterranean diet as potential modulators of osteoprotegerin and soluble RANKL in gBRCA1/2 mutation carriers: results of the lifestyle intervention pilot study LIBRE-1.
- Neirich L, Yahiaoui-Doktor M, Lammert J, Basrai M, Seethaler B, Berling-Ernst A, Ramser J, Quante AS, Schmidt T, Niederberger U, Rhiem K, Schmutzler R, Engel C, Bischoff SC, Halle M, Kiechle M, Grill S.
- Breast Cancer Res Treat. 2021 Dec;190(3):463-475. doi: 10.1007/s10549-021-06400-7. Epub 2021 Sep 27.
- PMID: 34570303
- PubMed abstract
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- Weight Gain and the Risk of Ovarian Cancer in BRCA1 and BRCA2 Mutation Carriers.
- Kim SJ, Lubinski J, Huzarski T, Møller P, Armel S, Karlan BY, Senter L, Eisen A, Foulkes WD, Singer CF, Tung N, Bordeleau L, Neuhausen SL, Olopade OI, Eng C, Weitzel JN, Fruscio R, Narod SA, Kotsopoulos J.
- Cancer Epidemiol Biomarkers Prev. 2021 Aug 23:cebp.0296.2021. doi: 10.1158/1055-9965.EPI-21-0296. Epub ahead of print.
- PMID: 34426412
- PubMed abstract
- Source abstract
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- The impact of risk reducing bilateral salpingo-oophorectomy on sexual function in BRCA1/2 mutation carriers and women with Lynch syndrome: A systematic review and meta-analysis.
- Kershaw V, Hickey I, Wyld L, Jha S.
- Eur J Obstet Gynecol Reprod Biol. 2021 Aug 8;265:7-17. doi: 10.1016/j.ejogrb.2021.08.001. Epub ahead of print.
- PMID: 34416580
- PubMed abstract
- Source abstract
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- The preventive effect of breastfeeding against ovarian cancer in BRCA1 and BRCA2 mutation carriers: A systematic review and meta-analysis.
- Eoh KJ, Park EY, Chang YJ, Ha HI, Hong J, Huang D, Nam EJ, Lim MC.
- Gynecol Oncol. 2021 Jul 22:S0090-8258(21)00590-4. doi: 10.1016/j.ygyno.2021.07.028. Epub ahead of print.
- PMID: 34304906
- PubMed abstract
- Source abstract
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- Oral contraceptive use and ovarian cancer risk for BRCA1/2 mutation carriers: an international cohort study.
- Schrijver LH, Antoniou AC, Olsson H, Mooij TM, Roos-Blom MJ, Azarang L, Adlard J, Ahmed M, Barrowdale D, Davidson R, Donaldson A, Eeles R, Evans DG, Frost D, Henderson A, Izatt L, Ong KR, Bonadona V, Coupier I, Faivre L, Fricker JP, Gesta P, van Engelen K, Jager A, Menko FH, Mourits MJE, Singer CF, Tan YY, Foretova L, Navratilova M, Schmutzler RK, Ellberg C, Gerdes AM, Caldes T, Simard J, Olah E, Jakubowska A, Rantala J, Osorio A, Hopper JL, Phillips KA, Milne RL, Beth Terry M, Noguès C, Engel C, Kast K, Goldgar DE, van Leeuwen FE, Easton DF, Andrieu N, Rookus MA; Epidemiological Study of Familial Breast Cancer, Gene Etude Prospective Sein Ovaire Sein, Hereditary Breast and Ovarian Cancer Research Group Netherlands, and International BRCA1/2 Carrier Cohort Study.
- Am J Obstet Gynecol. 2021 Jul;225(1):51.e1-51.e17. doi: 10.1016/j.ajog.2021.01.014. Epub 2021 Jan 22.
- PMID: 33493488
- PubMed abstract
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- Risk of epithelial ovarian cancer Type I and II after hysterectomy, salpingectomy and tubal ligation - A nationwide case control study.
- Darelius A, Kristjansdottir B, Dahm-Kähler P, Strandell A.
- Int J Cancer. 2021 Jun 21. doi: 10.1002/ijc.33714. Epub ahead of print.
- PMID: 34152012
- PubMed abstract
- Source abstract
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- An evaluation of memory and attention in BRCA mutation carriers using an online cognitive assessment tool.
- Kotsopoulos J, Kim SJ, Armel S, Bordeleau L, Foulkes WD, McKinnon W, Panchal S, Cohen SA, Sun S, Sun P, McKetton L, Troyer AK, Narod SA.
- Cancer. 2021 Jun 2. doi: 10.1002/cncr.33654. Epub ahead of print.
- PMID: 34077552
- PubMed abstract
- Source abstract
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- Lifestyle Characteristics in Women Carriers of BRCA Mutations: Results From an Italian Trial Cohort.
- Bruno E, Oliverio A, Paradiso A, Daniele A, Tommasi S, Terribile DA, Filippone A, Digennaro M, Pilato B, Danza K, Guarino D, Rossi C, Rossi MM, Venturelli E, Giussani M, Peissel B, Pasanisi P.
- Clin Breast Cancer. 2021 Jun;21(3):e168-e176. doi: 10.1016/j.clbc.2020.11.002. Epub 2020 Nov 10.
- PMID: 33357965
- PubMed abstract
- Source abstract
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- Did Breastfeeding my Daughter Reduce my Ovarian Cancer Risk?
- Haarlander T.
- FORCE. Blog. 2021 May 3.
- Blog post
- Free Full Text
Research news: Study: Breastfeeding may lower risk of ovarian cancer in women with BRCA mutations. (FORCE. XRAY.)
Original research:
Hereditary Ovarian Cancer Clinical Study Group. Breastfeeding and the risk of epithelial ovarian cancer among women with a BRCA1 or BRCA2 mutation.
- PMID: 33010967
- PubMed abstract
- Source abstract
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- Hormone replacement therapy in BRCA mutation carriers and risk of ovarian, endometrial, and breast cancer: a systematic review.
- Huber D, Seitz S, Kast K, Emons G, Ortmann O.
- J Cancer Res Clin Oncol. 2021 Apr 22. doi: 10.1007/s00432-021-03629-z. Epub ahead of print.
- PMID: 33885953
- PubMed abstract
- Review
- Free Full Text
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- Fertility preservation in patients with BRCA mutations or Lynch syndrome.
- Corrado G, Marchetti C, Trozzi R, Scambia G, Fagotti A.
- Int J Gynecol Cancer. 2021 Mar;31(3):332-338. doi: 10.1136/ijgc-2020-002071.
- PMID: 33649002
- PubMed abstract
- Review
- Free Full Text
Letter:
Should we or should we not? Risk reduction bilateral salpingectomy for BRCA mutation carriers.
- PMID: 33990355
- PubMed abstract
- Source abstract
Letter, Reply:
Response to: Should we or should we not? Risk reduction bilateral salpingectomy for BRCA mutation carriers.
- PMID: 33990354
- PubMed abstract
- Source abstract
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- Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle-intervention in germline BRCA1/2 gene mutation carriers.
- Grill S, Yahiaoui-Doktor M, Basrai M, Struck J, Schulte J, Berling-Ernst A, Engel C, Ullrich M, Lammert J, Bischoff SC, Schmidt T, Niederberger U, Chronas D, Rhiem K, Schmutzler R, Halle M, Kiechle M.
- Breast Cancer Res Treat. 2021 Feb 4. doi: 10.1007/s10549-020-06070-x. Epub ahead of print.
- PMID: 33543354
- PubMed abstract
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- Study: Breastfeeding may lower risk of ovarian cancer in women with BRCA mutations.
- [No author given]
- FORCE. XRAY. 2021 Jan 28.
- Research news
- Free Full Text
Original research:
Hereditary Ovarian Cancer Clinical Study Group. Breastfeeding and the risk of epithelial ovarian cancer among women with a BRCA1 or BRCA2 mutation.
- PMID: 33010967
- PubMed abstract
- Source abstract
Blog post: Did Breastfeeding my Daughter Reduce my Ovarian Cancer Risk? (FORCE. Blog.)
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- A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial.
- Bruno E, Oliverio A, Paradiso AV, Daniele A, Tommasi S, Tufaro A, Terribile DA, Magno S, Filippone A, Venturelli E, Morelli D, Baldassari I, Cravana ML, Manoukian S, Pasanisi P.
- Cancers (Basel). 2020 Dec 11;12(12):3732. doi: 10.3390/cancers12123732.
- PMID: 33322597
- PubMed abstract
- Source abstract
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- Breastfeeding and the risk of epithelial ovarian cancer among women with a BRCA1 or BRCA2 mutation.
- Kotsopoulos J, Gronwald J, McCuaig JM, Karlan BY, Eisen A, Tung N, Bordeleau L, Senter L, Eng C, Couch F, Fruscio R, Weitzel JN, Olopade O, Singer CF, Pal T, Foulkes WD, Neuhausen SL, Sun P, Lubinski J, Narod SA; Hereditary Ovarian Cancer Clinical Study Group.
- Gynecol Oncol. 2020 Dec;159(3):820-826. doi: 10.1016/j.ygyno.2020.09.037. Epub 2020 Sep 30.
- PMID: 33010967
- PubMed abstract
- Source abstract
Research news: Study: Breastfeeding may lower risk of ovarian cancer in women with BRCA mutations. (FORCE. XRAY.)
Blog post: Did Breastfeeding my Daughter Reduce my Ovarian Cancer Risk? (FORCE. Blog.)
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- BRCA1/2 Variants and Metabolic Factors: Results From a Cohort of Italian Female Carriers.
- Oliverio A, Bruno E, Colombo M, Paradiso A, Tommasi S, Daniele A, Terribile DA, Magno S, Guarino D, Manoukian S, Peissel B, Radice P, Pasanisi P.
- Cancers (Basel). 2020 Nov 30;12(12):3584. doi: 10.3390/cancers12123584.
- PMID: 33266155
- PubMed abstract
- Source abstract
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- Use of fertility treatments in BRCA1/2 mutation carriers and risk for ovarian and breast cancer: a systematic review.
- Huber D, Seitz S, Kast K, Emons G, Ortmann O.
- Arch Gynecol Obstet. 2020 Jul 27. doi: 10.1007/s00404-020-05690-4. Epub ahead of print.
- PMID: 32719921
- PubMed abstract
- Review
- Free Full Text
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- Diet, weight management, physical activity and Ovarian & Breast Cancer Risk in women with BRCA1/2 pathogenic Germline gene variants: systematic review.
- Coletta AM, Peterson SK, Gatus LA, Krause KJ, Schembre SM, Gilchrist SC, Arun B, You YN, Rodriguez-Bigas MA, Strong LL, Lu KH, Basen-Engquist K.
- Hered Cancer Clin Pract. 2020 Mar 7;18:5. doi: 10.1186/s13053-020-0137-1. eCollection 2020.
- PMID: 32165993
- PubMed abstract
- Review
- Free PMC article
- Free Full Text
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- Use of oral contraceptives in BRCA mutation carriers and risk for ovarian and breast cancer: a systematic review.
- Huber D, Seitz S, Kast K, Emons G, Ortmann O.
- Arch Gynecol Obstet. 2020 Mar 5. doi: 10.1007/s00404-020-05458-w. [Epub ahead of print]
- PMID: 32140806
- PubMed abstract
- Source abstract
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- MUTATIONS OF GENES BRCA1 AND BRCA2 IN WOMEN WITH OVARIAN CANCER EXPOSED TO FACTORS OF CHORNOBYL NUCLEAR ACCIDENT.
- Rybchenko LA, Poluben LO, Bychkova GM, Stephanovych GV, Klymenko SV.
- Probl Radiac Med Radiobiol. 2019 Dec;24:455-464. doi: 10.33145/2304-8336-2019-24-455-464.
- PMID: 31841487
- PubMed abstract
- Source abstract
- [Article in Ukranian, English]
- Free Full Text (PDF)
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- Reproductive and hormonal considerations in women at increased risk for hereditary gynecologic cancers: Society of Gynecologic Oncology and American Society for Reproductive Medicine Evidence-Based Review.
- Chen LM, Blank SV, Burton E, Glass K, Penick E, Woodard T.
- Fertil Steril. 2019 Oct 3. pii: S0015-0282(19)31982-X. doi: 10.1016/j.fertnstert.2019.07.1349. [Epub ahead of print]
- PMID: 31606136
- PubMed abstract
- Source abstract
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- Reproductive and Hormonal Considerations in Women at Increased Risk for Hereditary Gynecologic Cancers: Society of Gynecologic Oncology and American Society for Reproductive Medicine Evidence-Based Review.
- Chen LM, Blank SV, Burton E, Glass K, Penick E, Woodard T.
- Gynecol Oncol. 2019 Aug 22. pii: S0090-8258(19)31333-2. doi: 10.1016/j.ygyno.2019.06.017. [Epub ahead of print]
- PMID: 31606283
- PubMed abstract
- Source abstract
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- Combined hormonal contraceptives in BRCA gene mutation carriers: why not?
- Grandi G, Sammarini M, Chiara Del Savio M, Toss A, Facchinetti F.
- Eur J Contracept Reprod Health Care. 2019 Jul 30:1-3. doi: 10.1080/13625187.2019.1647335. [Epub ahead of print]
- PMID: 31361161
- PubMed abstract
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- Olaparib in germline-mutated metastatic breast cancer: implications of the OlympiAD trial.
- Armstrong AC, Clay V.
- Future Oncol. 2019 Jul 15. doi: 10.2217/fon-2018-0067. [Epub ahead of print]
- PMID: 31304797
- PubMed abstract
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- Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers.
- Qian F, Rookus MA, Leslie G, Risch HA, Greene MH, Aalfs CM, Adank MA, Adlard J, Agnarsson BA, Ahmed M, Aittomäki K, Andrulis IL, Arnold N, Arun BK, Ausems MGEM, Azzollini J, Barrowdale D, Barwell J, Benitez J, Białkowska K, Bonadona V, Borde J, Borg A, Bradbury AR, Brunet J, Buys SS, Caldés T, Caligo MA, Campbell I, Carter J, Chiquette J, Chung WK, Claes KBM, Collée JM, Collonge-Rame MA, Couch FJ, Daly MB, Delnatte C, Diez O, Domchek SM, Dorfling CM, Eason J, Easton DF, Eeles R, Engel C, Evans DG, Faivre L, Feliubadaló L, Foretova L, Friedman E, Frost D, Ganz PA, Garber J, Garcia-Barberan V, Gehrig A, Glendon G, Godwin AK, Gómez Garcia EB, Hamann U, Hauke J, Hopper JL, Hulick PJ, Imyanitov EN, Isaacs C, Izatt L, Jakubowska A, Janavicius R, John EM, Karlan BY, Kets CM, Laitman Y, Lázaro C, Leroux D, Lester J, Lesueur F, Loud JT, Lubiński J, Łukomska A, McGuffog L, Mebirouk N, Meijers-Heijboer HEJ, Meindl A, Miller A, Montagna M, Mooij TM, Mouret-Fourme E, Nathanson KL, Nehoray B, Neuhausen SL, Nevanlinna H, Nielsen FC, Offit K, Olah E, Ong KR, Oosterwijk JC, Ottini L, Parsons MT, Peterlongo P, Pfeiler G, Pradhan N, Radice P, Ramus SJ, Rantala J, Rennert G, Robson M, Rodriguez GC, Salani R, Scheuner MT, Schmutzler RK, Shah PD, Side LE, Simard J, Singer CF, Steinemann D, Stoppa-Lyonnet D, Tan YY, Teixeira MR, Terry MB, Thomassen M, Tischkowitz M, Tognazzo S, Toland AE, Tung N, van Asperen CJ, van Engelen K, van Rensburg EJ, Venat-Bouvet L, Vierstraete J, Wagner G, Walker L, Weitzel JN, Yannoukakos D; KConFab Investigators; HEBON Investigators; GEMO Study Collaborators; EMBRACE Collaborators, Antoniou AC, Goldgar DE, Olopade OI, Chenevix-Trench G, Rebbeck TR, Huo D; CIMBA.
- Br J Cancer. 2019 Jun 19. doi: 10.1038/s41416-019-0492-8. [Epub ahead of print]
- PMID: 31213659
- PubMed abstract
- Source abstract
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- [Additional non-contraceptive effects of contraception: CNGOF Contraception Guidelines].
- Amat L, Bulach A, Leclercq M, Mesrine S, Scheffler F, Sperandeo D, Scheffler M.
- Gynecol Obstet Fertil Senol. 2018 Dec;46(12):883-888. doi: 10.1016/j.gofs.2018.10.013. Epub 2018 Nov 7.
- PMID: 30414725
- PubMed abstract
- Source abstract
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- The association between smoking and cancer incidence in BRCA1 and BRCA2 mutation carriers.
- Ko KP, Kim SJ, Huzarski T, Gronwald J, Lubinski J, Lynch HT, Armel S, Park SK, Karlan B, Singer CF, Neuhausen SL, Narod SA, Kotsopoulos J; Hereditary Breast Cancer Clinical Study Group.
- Int J Cancer. 2018 Jun 1;142(11):2263-2272. doi: 10.1002/ijc.31257. Epub 2018 Jan 25.
- PMID: 29330845
- PubMed abstract
- Source abstract
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- Difference in Risk of Breast and Ovarian Cancer According to Putative Functional Domain Regions in Korean BRCA1/2 Mutation Carriers.
- Park JS, Lee ST, Han JW, Kim TI, Nam EJ, Park HS.
- Clin Breast Cancer. 2018 Feb 20. pii: S1526-8209(17)30785-1. doi: 10.1016/j.clbc.2018.02.007. [Epub ahead of print]
- PMID: 29673794
- PubMed abstract
- Source abstract
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- Self-compassion, physical fitness and climacteric symptoms in oophorectomized BRCA1/2 mutation carriers.
- Arts-de Jong M, van Westerop LL, Hoogerbrugge N, Massuger LF, Maas AH, van Beek MH, de Hullu JA.
- Maturitas. 2018 Feb;108:13-17. doi: 10.1016/j.maturitas.2017.11.002. Epub 2017 Nov 3.
- PMID: 29290209
- PubMed abstract
- Source abstract
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- Smoking and physical inactivity increase cancer prevalence in BRCA-1 and BRCA-2 mutation carriers: results from a retrospective observational analysis.
- Grill S, Yahiaoui-Doktor M, Dukatz R, Lammert J, Ullrich M, Engel C, Pfeifer K, Basrai M, Siniatchkin M, Schmidt T, Weisser B, Rhiem K, Ditsch N, Schmutzler R, Bischoff SC, Halle M, Kiechle M.
- Arch Gynecol Obstet. 2017 Dec;296(6):1135-1144. doi: 10.1007/s00404-017-4546-y. Epub 2017 Oct 3.
- PMID: 28975393
- PubMed abstract
- Source abstract
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- Genetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version. Introduction. Risk Factors for Ovarian Cancer.
- PDQ Cancer Genetics Editorial Board.
- PDQ Cancer Information Summaries [Internet]. Bethesda, MD: National Cancer Institute. Updated 2017 Nov 30. Accessed 2017 Dec 8.
- PMID: 26389210
- PubMed abstract
- Section link
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- A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.
- Tan SLW, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, Constantinou S, Renaudin X, Lee M, Aebersold R, Venkitaraman AR.
- Cell. 2017 Jun 1;169(6):1105-1118.e15. doi: 10.1016/j.cell.2017.05.010.
- PMID: 28575672
- PubMed abstract
- Source abstract
Preview, Research news:
Aldehydes Pose a Threat to BRCA2 Mutation Carriers.
- PMID: 28575676
- PubMed abstract
- Source abstract
Research news:
Aldehydes Promote BRCA2 Haploinsufficiency and Genomic Instability.
- PMID: 28600463
- PubMed abstract
- Source abstract
Research report, Commentary:
Thwarting endogenous stress: BRCA protects against aldehyde toxicity.
- PMID: 28835508
- PubMed abstract
- Free Full Text
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- [Reflections on treatments for infertility and the possible occurrence of ovarian carcinomas.]
- Ferranti G, Prosperi Porta R, La Rosa VL, Vitale SG, Laganà AS.
- Recenti Prog Med. 2017 Mar;108(3):136-140. doi: 10.1701/2656.27236.
- PMID: 28398407
- PubMed abstract
- Source abstract
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- BRCA2: a grown-up cancer susceptibility gene.
- Foulkes WD, Sugano K.
- Endocr Relat Cancer. 2016 Oct;23(10):E1-E3.
- PMID: 27650115
- PubMed abstract
- Source abstract
- Introductory article, Editorial
- Free Full Text
Review:
BRCA2 functions: from DNA repair to replication fork stabilization.
- PMID: 27530658
- PubMed abstract
- Free Full Text
Review:
Defects in homologous recombination repair behind the human diseases: FA and HBOC.
- PMID: 27550963
- PubMed abstract
- Free Full Text
Review:
Synthetic lethality: the road to novel therapies for breast cancer.
- PMID: 27528623
- PubMed abstract
- Free Full Text
Review:
Pancreatic ductal adenocarcinoma in BRCA2 mutation carriers.
- PMID: 27511924
- PubMed abstract
- Free Full Text
Review:
Modifiers of breast and ovarian cancer risks for BRCA1 and BRCA2 mutation carriers.
- PMID: 27528622
- PubMed abstract
- Free Full Text
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- Modifiers of breast and ovarian cancer risks for BRCA1 and BRCA2 mutation carriers.
- Milne RL, Antoniou A.
- Endocr Relat Cancer. 2016 Oct;23(10):T69-T84. Epub 2016 Aug 15.
- PMID: 27528622
- PubMed abstract
- Source abstract
- Review
- Free Full Text
Introductory article, Editorial:
BRCA2: a grown-up cancer susceptibility gene.
- PMID: 27650115
- PubMed abstract
- Free Full Text
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- Effects of lifestyle intervention in BRCA1/2 mutation carriers on nutrition, BMI, and physical fitness (LIBRE study): study protocol for a randomized controlled trial.
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Comments on NSGC Discussion Forum Cancer SIG
Subject: chemoprevetion for ovarian cancer
News: Study Identifies Modifiers of Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. (The ASCO Post)
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