General ~ Male BRCA / Breast Cancer
~ Genetics of Breast & Ovarian Cancer

General topics of hereditary/BRCA male breast cancer and other male BRCA-related cancers

Hereditary Male Breast Cancer, BRCA1/2-related Male Cancers and Features, non-BRCA1/2 Male Breast Cancer

List was last updated on Jan 23, 2020 @ 5:21 pm.


    • Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care.
    • Lee SI, Qureshi N, Dutton B, Kai J, Weng S.
    • J Community Genet. 2020 Jan 22. doi: 10.1007/s12687-020-00452-w. [Epub ahead of print]
    • Image-based screening for men at high risk for breast cancer: Benefits and drawbacks.
    • Woods RW, Salkowski LR, Elezaby M, Burnside ES, Strigel RM, Fowler AM.
    • Clin Imaging. 2019 Nov 28;60(1):84-89. doi: 10.1016/j.clinimag.2019.11.005. [Epub ahead of print]
    • Review
    • Hereditary prostate cancer - Primetime for genetic testing?
    • Heidegger I, Tsaur I, Borgmann H, Surcel C, Kretschmer A, Mathieu R, Visschere P, Valerio M, van den Bergh RCN, Ost P, Tilki D, Gandaglia G, Ploussard G; EAU-YAU Prostate Cancer Working Party.
    • Cancer Treat Rev. 2019 Nov 11;81:101927. doi: 10.1016/j.ctrv.2019.101927. [Epub ahead of print]
    • Review
    • "How do we rally around the one who was positive?" Familial uncertainty management in the context of men managing BRCA-related cancer risks.
    • Rauscher EA, Dean M, Campbell-Salome G, Barbour JB.
    • Soc Sci Med. 2019 Oct 11;242:112592. doi: 10.1016/j.socscimed.2019.112592. [Epub ahead of print]
    • Health professional and at-risk BRCA young adult perspectives about information needs: What does Gen Y need to know?
    • Young AL, Butow PN, Tucker KM, Williams R, Healey E, Wakefield CE.
    • J Genet Couns. 2019 Sep 19. doi: 10.1002/jgc4.1167. [Epub ahead of print]
    • The Genetic Education for Men (GEM) Trial: Development of Web-Based Education for Untested Men in BRCA1/2-Positive Families.
    • Peshkin BN, Ladd MK, Isaacs C, Segal H, Jacobs A, Taylor KL, Graves KD, O'Neill SC, Schwartz MD.
    • J Cancer Educ. 2019 Aug 11. doi: 10.1007/s13187-019-01599-y. [Epub ahead of print]
    • Male breast cancer: Specific biological characteristics and survival in a Portuguese cohort.
    • André S, Pereira T, Silva F, Machado P, Vaz F, Aparício M, Silva GL, Pinto AE.
    • Mol Clin Oncol. 2019 Jun;10(6):644-654. doi: 10.3892/mco.2019.1841. Epub 2019 Apr 8.
    • Germline and Somatic Mutations in Prostate Cancer for the Clinician.
    • Cheng HH, Sokolova AO, Schaeffer EM, Small EJ, Higano CS.
    • J Natl Compr Canc Netw. 2019 May 1;17(5):515-521. doi: 10.6004/jnccn.2019.7307.
    • Metachronous Contralateral Male Breast Cancer: Case Report and Literature Review.
    • O'Leary TR, Shriver CD, Wind G.
    • Mil Med. 2019 Apr 2. pii: usz049. doi: 10.1093/milmed/usz049. [Epub ahead of print]
    • Case report, Review
    • Germline genetic testing for inherited prostate cancer in practice: Implications for genetic testing, precision therapy, and cascade testing.
    • Giri VN, Hegarty SE, Hyatt C, O'Leary E, Garcia J, Knudsen KE, Kelly WK, Gomella LG.
    • Prostate. 2019 Mar;79(4):333-339. doi: 10.1002/pros.23739. Epub 2018 Nov 18.
    • Somatic aberrations of BRCA1 gene are associated with ALDH1, EGFR, and tumor progression in prostate cancer.
    • Omari A, Nastały P, Stoupiec S, Bałabas A, Dąbrowska M, Bielińska B, Huss S, Pantel K, Semjonow A, Eltze E, Brandt B, Bednarz-Knoll N.
    • Int J Cancer. 2019 Feb 1;144(3):607-614. doi: 10.1002/ijc.31905. Epub 2018 Oct 22.
    • Male breast cancer: a disease distinct from female breast cancer.
    • Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH, Elias AD, Baskin-Bey ES, Cardoso F.
    • Breast Cancer Res Treat. 2019 Jan;173(1):37-48. doi: 10.1007/s10549-018-4921-9. Epub 2018 Sep 28.
    • Review
    • Germline and Somatic Defects in DNA Repair Pathways in Prostate Cancer.
    • Arce S, Athie A, Pritchard CC, Mateo J.
    • Adv Exp Med Biol. 2019;1210:279-300. doi: 10.1007/978-3-030-32656-2_12.
    • Review, Book chapter
    • Response to "Male Patients With Breast Cancer: Addressing Needs Using an Educational Task Force".
    • Mahon SM.
    • Clin J Oncol Nurs. 2018 Dec 1;22(6):610. doi: 10.1188/18.CJON.610.

    Related:

    Original Research: Male Patients With Breast Cancer: Addressing Needs Using an Educational Task Force. (Clinical Journal of Oncology Nursing)

    • A contemporary review of male breast cancer: current evidence and unanswered questions.
    • Leon-Ferre RA, Giridhar KV, Hieken TJ, Mutter RW, Couch FJ, Jimenez RE, Hawse JR, Boughey JC, Ruddy KJ.
    • Cancer Metastasis Rev. 2018 Dec;37(4):599-614. doi: 10.1007/s10555-018-9761-x.
    • Review
    • [Breast cancer in males, case presentation and literature review.]
    • Fabián-Estrada E, Flores-Rangel GA, Mosiñoz-Montes R, Núñez-Trenado LA, Esparza-García E, Carballido-Barrita CA.
    • Rev Med Inst Mex Seguro Soc. 2018 Nov 30;56(4):424-428.
    • Case report, [Article in Spanish]
    • 9 Myths About Men and Hereditary Cancer.
    • [No author given]
    • My Gene Counsel. 2018 Nov 19.
    • Breast cancer in transgender patients: A systematic review. Part 1: Male to female.
    • Hartley RL, Stone JP, Temple-Oberle C.
    • Eur J Surg Oncol. 2018 Oct;44(10):1455-1462. doi: 10.1016/j.ejso.2018.06.035. Epub 2018 Jul 25.
    • Review
    • Family history of breast or prostate cancer and prostate cancer risk.
    • Barber LE, Gerke T, Markt SC, Peisch SF, Wilson KM, Ahearn TU, Giovannucci EL, Parmigiani G, Mucci LA.
    • Clin Cancer Res. 2018 Aug 6. pii: clincanres.0370.2018. doi: 10.1158/1078-0432.CCR-18-0370. [Epub ahead of print]
    • Male Patients With Breast Cancer: Addressing Needs Using an Educational Task Force.
    • Cutrone JN, Segna AN, Baron RH.
    • Clin J Oncol Nurs. 2018 Aug 1;22(4):415-420. doi: 10.1188/18.CJON.415–420.

    Related:

    Letter, Comment:

    Response to "Male Patients With Breast Cancer: Addressing Needs Using an Educational Task Force".

    • “Second-Class Status?” Insight into Communication Patterns and Common Concerns Among Men with Hereditary Breast and Ovarian Cancer Syndrome.
    • Suttman A, Pilarski R, Agnese DM, Senter L.
    • J Genet Couns. 2018 Aug;27(4):885-893. doi: 10.1007/s10897-018-0214-z. Epub 2018 Feb 5.
    • NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) — Genetic/Familial High-Risk Assessment: Breast and Ovarian
    • Daly MB, Pilarski R, Berry M, Buys SS, Friedman S, Garber JE, Hutton ML, Kauff ND, Khan S, Klein C, Kohlmann W, Kurian A, Laronga C, Litton JK, Madlensky L, Mac JS, Merajver SD, Offit K, Pal T, Peterson HJ, Reiser G, Shannon KM, Thaker P, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Darlow S.
    • NCCN.org. 2018 Jul 11. Version 1.2019.
    • Breast Cancer in Men.
    • Giordano SH.
    • N Engl J Med. 2018 Jun 14;378(24):2311-2320. doi: 10.1056/NEJMra1707939.
    • Review
    • Molecular Subtypes of Prostate Cancer.
    • Arora K, Barbieri CE.
    • Curr Oncol Rep. 2018 Jun 1;20(8):58. doi: 10.1007/s11912-018-0707-9.
    • Review
    • Malignant Abnormalities in Male BRCA Mutation Carriers: Results From a Prospectively Screened Cohort.
    • Mano R, Tamir S, Kedar I, Benjaminov O, Baniel J, Tabachnik T, Margel D.
    • JAMA Oncol. 2018 Jun 1;4(6):872-874. doi: 10.1001/jamaoncol.2018.0271.
    • Prostate Cancer Genomics: Recent Advances and the Prevailing Underrepresentation from Racial and Ethnic Minorities.
    • Tan SH, Petrovics G, Srivastava S.
    • Int J Mol Sci. 2018 Apr 22;19(4). pii: E1255. doi: 10.3390/ijms19041255.
    • Men with a susceptibility to prostate cancer and the role of genetic based screening.
    • Eeles R, Ni Raghallaigh H.
    • Transl Androl Urol. 2018 Feb;7(1):61-69. doi: 10.21037/tau.2017.12.30.
    • Genetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version. Psychosocial Issues in Inherited Breast and Ovarian Cancer Syndromes. Family Effects.
    • PDQ Cancer Genetics Editorial Board.
    • PDQ Cancer Information Summaries [Internet]. Bethesda, MD: National Cancer Institute. Updated 2017 Nov 30. Accessed 2017 Dec 8.
    • The Search for the Missing Heritability of Prostate Cancer.
    • Walsh PC.
    • Eur Urol. 2017 Nov;72(5):657-659. doi: 10.1016/j.eururo.2017.04.003. Epub 2017 Apr 22.
    • Male Breast Cancer: Epidemiology and Risk Factors.
    • Abdelwahab Yousef AJ.
    • Semin Oncol. 2017 Aug;44(4):267-272. doi: 10.1053/j.seminoncol.2017.11.002. Epub 2017 Nov 9.
    • Review
    • Primary Peritoneal Serous Carcinoma in Men: A Rare and Non-BRCA-associated Entity.
    • Neuhausen SL, Shani H, Boker LK, Steele L, Silverman BG, Ottini L, Silvestri V, Laitman Y, Korach J, Perri T, Friedman E.
    • Anticancer Res. 2017 Jun;37(6):3069-3072.
    • BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer.
    • Petrucelli N, Daly MB, Pal T.
    • GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019. 1998 Sep 04 [updated 2016 Dec 15].
    • What Men Should Know About BRCA Variant Testing.
    • Michelle Jacobs
    • Michigan Health. July 22, 2016.
    • Here’s what men need to know about the Angelina Jolie ‘breast-cancer gene’.
    • Laurie McGinley.
    • Washington Post. To Your Health. 2016 May 17.
    • Defective ‘breast cancer’ genes aren’t just dangerous for women. They’re also linked to aggressive cancer in men.
    • Laurie McGinley.
    • Washington Post. To Your Health. 2016 May 15.
    • Male breast cancer is not congruent with the female disease.
    • Fentiman IS.
    • Crit Rev Oncol Hematol. 2016 May;101:119-24. doi: 10.1016/j.critrevonc.2016.02.017. Epub 2016 Feb 27.
    • Genomic profiling of male breast cancer.
    • Burki TK.
    • Lancet Oncol. 2016 Apr;17(4):e141. doi: 10.1016/S1470-2045(16)00179-0. Epub 2016 Mar 18.
    • News
    • Männliches Mammakarzinom: Was ist anders?
    • Niederberger P, Bucher S, Aebi S.
    • Praxis (Bern 1994). 2016 Feb;105(3):147-51. doi: 10.1024/1661-8157/a002250.
    • Review, [Article in German]
    • The Epidemiology of Male Breast Cancer.
    • Ferzoco RM, Ruddy KJ.
    • Curr Oncol Rep. 2016 Jan;18(1):1. doi: 10.1007/s11912-015-0487-4.
    • Review
    • The cancer genetics and pathology of male breast cancer.
    • Deb S, Lakhani SR, Ottini L, Fox SB.
    • Histopathology. 2016 Jan;68(1):110-8. doi: 10.1111/his.12862.
    • [Hereditary Breast and Ovarian Cancer Syndrome].
    • Petráková K, Palácová M, Schneiderová M, Standara M.
    • Klin Onkol. 2015 Winter;29 Suppl 1:14-21.
    • Review, [Article in Czech]
    • Prolonged Survival in a Patient with a Pancreatic Acinar Cell Carcinoma.
    • Ploquin A, Baldini C, Vuagnat P, Makhloufi S, Desauw C, Hebbar M.
    • Case Rep Oncol. 2015 Oct 22;8(3):447-450. doi: 10.1159/000441414.
    • "The BRCA Responder" on Genetic Testing, Family Histories, and Why Counseling Is Key.
    • Kelly Johnson.
    • Oncology Nursing News. 2015 Aug 31.
    • 8 Myths About Men and Hereditary Cancer.
    • [No author given].
    • My Gene Counsel. 2015 Jun 21.
    • Discussion: Men & Hereditary Cancer.
    • Georgia Hurst, Amy Byer Shainman.
    • My Gene Counsel. 2015 Jun 15.
    • Podcast: Yes, Men Can Get Breast Cancer.
    • Ellen T. Matloff.
    • My Gene Counsel. 2015 Jun 8.
    • Tobacco and alcohol in relation to male breast cancer: an analysis of the male breast cancer pooling project consortium.
    • Cook MB, Guénel P, Gapstur SM, van den Brandt PA, Michels KB, Casagrande JT, Cooke R, Van Den Eeden SK, Ewertz M, Falk RT, Gaudet MM, Gkiokas G, Habel LA, Hsing AW, Johnson K, Kolonel LN, La Vecchia C, Lynge E, Lubin JH, McCormack VA, Negri E, Olsson H, Parisi D, Petridou ET, Riboli E, Sesso HD, Swerdlow A, Thomas DB, Willett WC, Brinton LA.
    • Cancer Epidemiol Biomarkers Prev. 2015 Mar;24(3):520-31. doi: 10.1158/1055-9965.EPI-14-1009. Epub 2014 Dec 16.
    • BRCA and Men: Medical Management and Prostate-specific Considerations.
    • Jacquelyn Powers.
    • FORCE. Be Empowered Webinars. 2014 Oct 1.
    • Male breast cancer: a rare disease that might uncover underlying pathways of breast cancer.
    • Ottini L.
    • Nat Rev Cancer. 2014 Oct;14(10):643.
    • Palpable ductal carcinoma in situ of the breast.
    • Downing A, Corsetti R.
    • Ochsner J. 2014 Fall;14(3):438-40.
    • Screening an Asymptomatic Person for Genetic Risk.
    • [No authors listed]
    • N Engl J Med. 2014 Jun 19;370(25):2442-2445.

    Related:

    Comments on NSGC Discussion Forum

    Subject: New England Journal of Medicine article/discussion on Screening an Asymptomatic Person for Genetic R

    • USPSTF, ASCO Issue More Guidance on Genetic Testing Based on Family History.
    • Surabhi Dangi-Garimella.
    • OncLive, 2014 Jun 11.
    • Testing for Familial BRCA1-2 Mutations: Implications for Genetic Counseling and Risk Assessment.
    • Travis T. Sims, Taya J. Fallen, Jeffrey S. Dungan, Lee P. Shulman.
    • Obstetrics & Gynecology. 123(Suppl 1):185S-186S, May 2014. doi: 10.1097/01.AOG.0000447208.37582.d4.
    • Conference abstract
    • Anthropometric and hormonal risk factors for male breast cancer: male breast cancer pooling project results.
    • Brinton LA, Cook MB, McCormack V, Johnson KC, Olsson H, Casagrande JT, Cooke R, Falk RT, Gapstur SM, Gaudet MM, Gaziano JM, Gkiokas G, Guénel P, Henderson BE, Hollenbeck A, Hsing AW, Kolonel LN, Isaacs C, Lubin JH, Michels KB, Negri E, Parisi D, Petridou ET, Pike MC, Riboli E, Sesso HD, Snyder K, Swerdlow AJ; European Rare Cancer Study Group, Trichopoulos D, Ursin G, van den Brandt PA, Van Den Eeden SK, Weiderpass E, Willett WC, Ewertz M, Thomas DB.
    • J Natl Cancer Inst. 2014 Mar 1;106(3):djt465. doi: 10.1093/jnci/djt465. Epub 2014 Feb 19.

    Related:

    Comments from NSGC Discussion Forum Cancer SIG

    Subject: prophylactic mastectomies for male with BRCA1 mutation

    • Risk factors, pathological and phenotypic features of male breast cancer in Greece.
    • Tsoukalas N, Moirogiorgou E, Tolia M, Pistamaltzian N, Bournakis E, Papadimitriou K, Demiri S, Panopoulos C, Koumakis G, Efremidis A; Hellenic Society for the Study of Breast Cancer (HES-BRECA).
    • Anticancer Res. 2014 Mar;34(3):1291-4.
    • BRCA BROTHERHOOD.
    • Amy Byer Shainman @BRCAresponder.
    • The BRCA Responder, 2014 Jan 30.
    • Cancer Risks for Men With BRCA1/2 Mutations.
    • Mahon SM.
    • Oncol Nurs Forum. 2014 Jan 1;41(1):99-101. doi: 10.1188/14.ONF.99-101.
    • Review

    Related:

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: article request

    • Optimizing recruitment to a prostate cancer surveillance program among male BRCA1 mutation carriers: invitation by mail or by telephone.
    • Galor A, Cybulski C, Lubiński J, Narod SA, Gronwald J.
    • Hered Cancer Clin Pract. 2013 Dec 10;11(1):17. doi: 10.1186/1897-4287-11-17.
    • Interest of individuals from BRCA families to participate in research studies focused on male BRCA carriers.
    • Pal T, Vadaparampil S, Kim J, Xu Y, Friedman S, Narod SA, Metcalfe K.
    • Fam Cancer. 2013 Dec;12(4):615-9. doi: 10.1007/s10689-013-9624-0.
    • Male breast cancer: genetics, epigenetics, and ethical aspects.
    • Rizzolo P, Silvestri V, Tommasi S, Pinto R, Danza K, Falchetti M, Gulino M, Frati P, Ottini L.
    • Ann Oncol. 2013 Nov;24 Suppl 8:viii75-viii82. doi: 10.1093/annonc/mdt316.
    • The role of BRCA1 and BRCA2 in prostate cancer.
    • Li D, Kumaraswamy E, Harlan-Williams LM, Jensen RA.
    • Front Biosci (Landmark Ed). 2013 Jun 1;18:1445-59.
    • Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship.
    • Ruddy KJ, Winer EP.
    • Ann Oncol. 2013 Jun;24(6):1434-43. doi: 10.1093/annonc/mdt025. Epub 2013 Feb 20.

    Related:

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: contralateral breast risk for BRCA+ male

    • An international comparison of male and female breast cancer incidence rates.
    • Ly D, Forman D, Ferlay J, Brinton LA, Cook MB.
    • Int J Cancer. 2013 Apr 15;132(8):1918-26. doi: 10.1002/ijc.27841. Epub 2012 Oct 12.
    • Male breast cancer, age and sex chromosome aneuploidy.
    • Jacobs PA, Maloney V, Cooke R, Crolla JA, Ashworth A, Swerdlow AJ.
    • Br J Cancer. 2013 Mar 5;108(4):959-63. doi: 10.1038/bjc.2012.577. Epub 2013 Jan 8.
    • Pathologies of the male breast.
    • Charlot M, Béatrix O, Chateau F, Dubuisson J, Golfier F, Valette PJ, Réty F.
    • Diagn Interv Imaging. 2013 Jan;94(1):26-37. doi: 10.1016/j.diii.2012.10.011. Epub 2012 Dec 5.
    • [Genetic counselling in male carriers of BRCA1 and BRCA2 gene mutations].
    • Plevová P, Hladíková A.
    • Klin Onkol. [2012 Aug;]25 Suppl:S67-73.
    • Association of follicular lymphoma risk with BRCA2 N372H polymorphism in Slovak population.
    • Salagovič J, Klimčáková L, Ilenčíková D, Kafková A.
    • Med Oncol. 2012 Jun;29(2):1173-8. doi: 10.1007/s12032-011-9925-9. Epub 2011 Apr 8.
    • Perspective: not just for women.
    • Speirs V.
    • Nature. 2012 May 30;485(7400):S66. doi: 10.1038/485S66a.
    • News

    Related:

    Letter:

    Tumours: Less lactation may explain cancer rise.

    • Breast cancer in men.
    • Gethins M.
    • J Natl Cancer Inst. 2012 Mar 21;104(6):436-8. doi: 10.1093/jnci/djs172. Epub 2012 Mar 5.