Fertility Preservation in HBOC
~ Genetics of Breast & Ovarian Cancer

List was last updated on Nov 25, 2019 @ 10:34 am.


    • Counseling young women with early breast cancer on fertility preservation.
    • Ter Welle-Butalid MEE, Vriens IJHI, Derhaag JGJ, Leter EME, de Die-Smulders CEC, Smidt MM, van Golde RJTR, Tjan-Heijnen VCGV.
    • J Assist Reprod Genet. 2019 Nov 23. doi: 10.1007/s10815-019-01615-6. [Epub ahead of print]
    • Contraception options for patients with known hereditary risk for ovarian cancer.
    • Joy KM.
    • JAAPA. 2019 Nov;32(11):37-41. doi: 10.1097/01.JAA.0000586384.47435.31.
    • Review
    • Reproductive and hormonal considerations in women at increased risk for hereditary gynecologic cancers: Society of Gynecologic Oncology and American Society for Reproductive Medicine Evidence-Based Review.
    • Chen LM, Blank SV, Burton E, Glass K, Penick E, Woodard T.
    • Fertil Steril. 2019 Oct 3. pii: S0015-0282(19)31982-X. doi: 10.1016/j.fertnstert.2019.07.1349. [Epub ahead of print]
    • Review
    • Is it safe for BRCA mutation carriers to become pregnant following breast cancer?
    • [No author given]
    • FORCE. XRAYS. 2019 Sep 4.
    • Reproductive and Hormonal Considerations in Women at Increased Risk for Hereditary Gynecologic Cancers: Society of Gynecologic Oncology and American Society for Reproductive Medicine Evidence-Based Review.
    • Chen LM, Blank SV, Burton E, Glass K, Penick E, Woodard T.
    • Gynecol Oncol. 2019 Aug 22. pii: S0090-8258(19)31333-2. doi: 10.1016/j.ygyno.2019.06.017. [Epub ahead of print]
    • Review
    • Management of ovarian cancer risk in women with BRCA1/2 pathogenic variants.
    • Walker M, Jacobson M, Sobel M.
    • CMAJ. 2019 Aug 12;191(32):E886-E893. doi: 10.1503/cmaj.190281.
    • BRCA2 deficiency is a potential driver for human primary ovarian insufficiency.
    • Miao Y, Wang P, Xie B, Yang M, Li S, Cui Z, Fan Y, Li M, Xiong B.
    • Cell Death Dis. 2019 Jun 17;10(7):474. doi: 10.1038/s41419-019-1720-0.
    • Online decision support for persons having a genetic predisposition to cancer and their partners during reproductive decision-making.
    • Reumkens K, Tummers MHE, Gietel-Habets JJG, van Kuijk SMJ, Aalfs CM, van Asperen CJ, Ausems MGEM, Collée M, Dommering CJ, Kets CM, van der Kolk LE, Oosterwijk JC, Tjan-Heijnen VCG, van der Weijden T1, de Die-Smulders CEM, van Osch LADM.
    • J Genet Couns. 2019 Jun;28(3):533-542. doi: 10.1002/jgc4.1056. Epub 2018 Dec 21.
    • Time from referral to ovarian tissue cryopreservation in a cohort of Danish women.
    • Kristensen SG, Pors SE, Poulsen LC, Andersen ST, Wakimoto Y, Yding Andersen C.
    • Acta Obstet Gynecol Scand. 2019 May;98(5):616-624. doi: 10.1111/aogs.13575. Epub 2019 Mar 7.
    • Association of BRCA Mutations and Anti-müllerian Hormone Level in Young Breast Cancer Patients.
    • Son KA, Lee DY, Choi D.
    • Front Endocrinol (Lausanne). 2019 Apr 11;10:235. doi: 10.3389/fendo.2019.00235. eCollection 2019.
    • Exploring the preferences of involved health professionals regarding the implementation of an online decision aid to support couples during reproductive decision-making in hereditary cancer: a mixed methods approach.
    • Reumkens K, de Die-Smulders CEM, van Osch LADM.
    • Fam Cancer. 2019 Apr;18(2):285-291. doi: 10.1007/s10689-019-00119-7.
    • BRCA1/2 gene mutations do not affect the capacity of oocytes from breast cancer candidates for fertility preservation to mature in vitro.
    • Grynberg M, Dagher Hayeck B, Papanikolaou EG, Sifer C, Sermondade N, Sonigo C.
    • Hum Reprod. 2019 Feb 1;34(2):374-379. doi: 10.1093/humrep/dey358.
    • Knowledge, attitudes and practice of physicians towards fertility and pregnancy-related issues in youngBRCA-mutated breast cancer patients.
    • Lambertini M, Di Maio M, Poggio F, Pagani O, Curigliano G, Mastro LD, Paluch-Shimon S, Loibl S, Partridge AH, Azim HA Jr, Peccatori FA, Demeestere I.
    • Reprod Biomed Online. 2019 Jan 10. pii: S1472-6483(19)30011-2. doi: 10.1016/j.rbmo.2018.11.031. [Epub ahead of print]
    • Improving outcomes for young women with breast cancer: fertility and childbearing issues.
    • [No author given]
    • FORCE. XRAYS. 2019 Jan 7.

    ClinicalTrials.gov: Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer (POSITIVE) (NIH. ClinicalTrials.gov.)

    • The development of an online decision aid to support persons having a genetic predisposition to cancer and their partners during reproductive decision-making: a usability and pilot study.
    • Reumkens K, Tummers MHE, Gietel-Habets JJG, van Kuijk SMJ, Aalfs CM, van Asperen CJ, Ausems MGEM, Collée M, Dommering CJ, Kets CM, van der Kolk LE, Oosterwijk JC, Tjan-Heijnen VCG, van der Weijden T, de Die-Smulders CEM, van Osch LADM.
    • Fam Cancer. 2019 Jan;18(1):137-146. doi: 10.1007/s10689-018-0092-4.
    • Fertility preservation in ovarian tumours.
    • Tomao F, Di Pinto A, Sassu CM, Di Donato V, Muzii L, Petrella MC, Peccatori FA, Panici PB, Bardhi E.
    • Ecancermedicalscience. 2018 Dec 6;12:885. doi: 10.3332/ecancer.2018.885. eCollection 2018.
    • No. 366-Gynaecologic Management of Hereditary Breast and Ovarian Cancer.
    • Jacobson M, Bernardini M, Sobel ML, Kim RH, McCuaig J, Allen L.
    • J Obstet Gynaecol Can. 2018 Nov;40(11):1497-1510. doi: 10.1016/j.jogc.2018.05.046.
    • Guidelines

    [Article in French]:

    No 366 - Prise en charge gynécologique du cancer du sein et de l'ovaire héréditaire.

    • Determinants of fertility issues experienced by young women diagnosed with breast or gynaecological cancer - a quantitative, cross-cultural study.
    • Sobota A, Ozakinci G.
    • BMC Cancer. 2018 Sep 6;18(1):874. doi: 10.1186/s12885-018-4766-y.
    • Pregnancy and Ovarian Stimulation in the Patients with Breast Cancer.
    • Lukáš D, David P, Jaromír M.
    • Klin Onkol. 2018 Fall;31(5):325-329. doi: 10.14735/amko2018325.
    • Support needs of couples with hereditary breast and ovarian cancer during reproductive decision-making.
    • Gietel-Habets JJG, de Die-Smulders CEM, Derks-Smeets IAP, Tibben A, Tjan-Heijnen VCG, van Golde R, Gomez-Garcia E, van Osch LADM.
    • Psychooncology. 2018 Jul;27(7):1795-1801. doi: 10.1002/pon.4729. Epub 2018 May 4.
    • Fertility preservation in women harboring deleterious BRCA mutations: ready for prime time?
    • Peccatori FA, Mangili G, Bergamini A, Filippi F, Martinelli F, Ferrari F, Noli S, Rabaiotti E, Candiani M, Somigliana E.
    • Hum Reprod. 2018 Feb 1;33(2):181-187. doi: 10.1093/humrep/dex356.
    • Fertility preservation in BRCA-mutated women: when and how?
    • Grynberg M, Raad J, Comtet M, Vinolas C, Cédrin-Durnerin I, Sonigo C.
    • Future Oncol. 2018 Feb;14(5):483-490. doi: 10.2217/fon-2017-0415. Epub 2018 Jan 12.
    • Review
    • Reproductive potential and performance of fertility preservation strategies in BRCA-mutated breast cancer patients.
    • Lambertini M, Goldrat O, Ferreira AR, Dechene J, Azim HA Jr, Desir J, Delbaere A, t'Kint de Roodenbeke MD, de Azambuja E, Ignatiadis M, Demeestere I.
    • Ann Oncol. 2018 Jan 1;29(1):237-243. doi: 10.1093/annonc/mdx639.

    Introductory article:

    BRCA 1 and 2 mutation status: the elephant in the room during oncofertility counseling for young breast cancer patients.

    Introductory article: BRCA 1 and 2 Mutation Status: The Elephant in the Room During Oncofertility Counseling for Young Breast Cancer Patients. (Medscape, Free full text)

    • BRCA mutations and reproduction.
    • Daum H, Peretz T, Laufer N.
    • Fertil Steril. 2018 Jan;109(1):33-38. doi: 10.1016/j.fertnstert.2017.12.004.
    • Review
    • Ovarian Stimulation in Patients With Cancer: Impact of Letrozole and BRCA Mutations on Fertility Preservation Cycle Outcomes.
    • Turan V, Bedoschi G, Emirdar V, Moy F, Oktay K.
    • Reprod Sci. 2018 Jan;25(1):26-32. doi: 10.1177/1933719117728800. Epub 2017 Sep 6.
    • Genetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version. Clinical Management of Carriers of BRCA Pathogenic Variants. Reproductive Considerations in Carriers of BRCA Pathogenic Variants.
    • PDQ Cancer Genetics Editorial Board.
    • PDQ Cancer Information Summaries [Internet]. Bethesda, MD: National Cancer Institute. Updated 2017 Nov 30. Accessed 2017 Dec 8.
    • Preferences for breast cancer risk reduction among BRCA1/BRCA2 mutation carriers: a discrete-choice experiment.
    • Liede A, Mansfield CA, Metcalfe KA, Price MA; Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Snyder C, Lynch HT, Friedman S, Amelio J, Posner J, Narod SA, Lindeman GJ, Evans DG.
    • Breast Cancer Res Treat. 2017 Sep;165(2):433-444. doi: 10.1007/s10549-017-4332-3. Epub 2017 Jun 17.
    • Fertility and pregnancy issues in BRCA-mutated breast cancer patients.
    • Lambertini M, Goldrat O, Toss A, Azim HA Jr, Peccatori FA, Ignatiadis M, Del Mastro L, Demeestere I.
    • Cancer Treat Rev. 2017 Sep;59:61-70. doi: 10.1016/j.ctrv.2017.07.001. Epub 2017 Jul 14.
    • Review
    • Ex vivo retrieval and cryopreservation of oocytes from oophorectomized specimens for fertility preservation in a BRCA1 mutation carrier with ovarian cancer.
    • Pereira N, Hubschmann AG, Lekovich JP, Schattman GL, Rosenwaks Z.
    • Fertil Steril. 2017 Aug;108(2):357-360. doi: 10.1016/j.fertnstert.2017.05.025. Epub 2017 Jun 16.
    • Case report
    • Oncofertility for women with gynecologic malignancies.
    • Chan JL, Wang ET.
    • Gynecol Oncol. 2017 Mar;144(3):631-636. doi: 10.1016/j.ygyno.2016.12.013. Epub 2016 Dec 21.
    • Review
    • [Reflections on treatments for infertility and the possible occurrence of ovarian carcinomas.]
    • Ferranti G, Prosperi Porta R, La Rosa VL, Vitale SG, Laganà AS.
    • Recenti Prog Med. 2017 Mar;108(3):136-140. doi: 10.1701/2656.27236.
    • Commentary, [Article in Italian]
    • Ovarian Function Suppression in Premenopausal Women with Early-Stage Breast Cancer.
    • Lambertini M, Del Mastro L, Viglietti G, Pondé NF, Solinas C, de Azambuja E.
    • Curr Treat Options Oncol. 2017 Jan;18(1):4. doi: 10.1007/s11864-017-0442-8.
    • Review
    • Potential implications on female fertility and reproductive lifespan in BRCA germline mutation women.
    • de la Noval BD.
    • Arch Gynecol Obstet. 2016 Nov;294(5):1099-1103. Epub 2016 Aug 25.
    • Letter
    • Fertility preservation in BRCA mutation carriers.
    • Revelli A, Salvagno F, Delle Piane L, Casano S, Evangelista F, Pittatore G, Razzano A, Marchino GL, Gennarelli G, Benedetto C.
    • Minerva Ginecol. 2016 Oct;68(5):587-601. Epub 2016 Mar 10.
    • Review

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: Article request

    • Young adult female cancer survivors' unmet information needs and reproductive concerns contribute to decisional conflict regarding posttreatment fertility preservation.
    • Benedict C, Thom B, N Friedman D, Diotallevi D, M Pottenger E, J Raghunathan N, Kelvin JF.
    • Cancer. 2016 Jul 1;122(13):2101-9. doi: 10.1002/cncr.29917. Epub 2016 May 23.

    Press: Young Female Cancer Survivors Not Clear on Infertility Risks. (Medscape/Reuters)

    • Women's Health Issues for BRCA Mutation Carriers.
    • Sabatini ME, Ellisen LW.
    • Am Soc Clin Oncol Educ Book. 2016 May;(36):14-17. doi: 10.1200/EDBK_100001.
    • Exploring Your Family Planning Options Through Assisted Reproduction as a Cancer Previvor or Survivor.
    • Matthew Lederman
    • FORCE. Be Empowered Webinars. 2016 Apr 25.
    • Long-Term Safety of Letrozole and Gonadotropin Stimulation for Fertility Preservation in Women With Breast Cancer.
    • Kim J, Turan V, Oktay K.
    • J Clin Endocrinol Metab. 2016 Apr;101(4):1364-71. doi: 10.1210/jc.2015-3878. Epub 2016 Jan 11.
    • Women's Health Issues for BRCA Mutation Carriers.
    • Sabatini ME, Ellisen LW.
    • Am Soc Clin Oncol Educ Book. 2016;35:14-17. doi: 10.14694/EDBK_100001.

    Comments from NSGC Discussion Forum Cancer SIG

    Subject: hormonal birth control with ATM mutations?

    • [Assisted Reproduction and Preimplantation Genetic Diagnosis in Patients Susceptible to Breast Cancer].
    • Veselá K, Kocur T, Horák J, Horňák M, Oráčová E, Hromadová L, Veselý J, Trávník P.
    • Klin Onkol. 2015 Winter;29 Suppl 1:93-9.
    • Review, [Article in Czech]
    • [Should a systematic fertility preservation be proposed to healthy women carrying a BRCA1/2 mutation?].
    • Sénéchal C, Rousset-Jablonski C.
    • Gynecol Obstet Fertil. 2015 Dec;43(12):800-5. doi: 10.1016/j.gyobfe.2015.09.012. Epub 2015 Oct 18.
    • [Article in French]
    • Breast cancer and fertility: an update.
    • Ronn R, Holzer H.
    • Curr Opin Support Palliat Care. 2015 Sep;9(3):285-93. doi: 10.1097/SPC.0000000000000164.
    • Review
    • IVF for fertility preservation in breast cancer patients--efficacy and safety issues.
    • Shapira M, Raanani H, Meirow D.
    • J Assist Reprod Genet. 2015 Aug;32(8):1171-8. doi: 10.1007/s10815-015-0519-x. Epub 2015 Jul 1.
    • Review
    • Fertility preservation and breast cancer: a review.
    • de Pedro M, Otero B, Martín B.
    • Ecancermedicalscience. 2015 Feb 3;9:503. doi: 10.3332/ecancer.2015.503. eCollection 2015.
    • Update on fertility preservation in young women undergoing breast cancer and ovarian cancer therapy.
    • Lambertini M, Ginsburg ES, Partridge AH.
    • Curr Opin Obstet Gynecol. 2015 Feb;27(1):98-107. doi: 10.1097/GCO.0000000000000138.
    • Review
    • A Pilot Study of BRCA Mutation Carriers' Knowledge About the Clinical Impact of Prophylactic-oophorectomy and Views on Fertility Consultation: A Single-Center Pilot Study.
    • Kim J, Skrzynia C, Mersereau JE.
    • J Genet Couns. 2015 Feb;24(1):149-57. doi: 10.1007/s10897-014-9747-y. Epub 2014 Aug 15.
    • Serous adenocarcinoma of the ovary diagnosed during ultrasound evaluation for fertility preservation.
    • Hachem HE, Poulain M, Höher M, Fanchin R, Frydman R, Grynberg M.
    • Future Oncol. 2014 Oct;10(12):1907-12. doi: 10.2217/fon.14.82.
    • Case report
    • Fertility Preservation and Pregnancy in Women With and Without BRCA Mutation-Positive Breast Cancer.
    • Rodriguez-Wallberg KA, Oktay K.
    • Oncologist. [2012 Nov;]17(11):1409-17. doi: 10.1634/theoncologist.2012-0236. Epub 2012 Sep 24.
    • Pregnancy and Fertility for Previvors and Survivors.
    • Jennifer Litton.
    • FORCE. Be Empowered Webinars. 2012 Jun 19.