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    • Nonsurgical Options for Risk Reduction of Contralateral Breast Cancer in BRCA Mutation Carriers With Early-Stage Breast Cancer.
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    • PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients.
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    • Breast Cancer Res. 2022 Oct 21;24(1):69. doi: 10.1186/s13058-022-01567-3.
    • Risk of ipsilateral breast tumor recurrence and contralateral breast cancer in patients with and without TP53 variant in a large series of breast cancer patients.
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    • Points to Consider Regarding De-Escalation Surgery in High-Risk Breast Cancer.
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    • Review
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    • Eligibility, uptake and response to germline genetic testing in women with DCIS.
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    • Influence of germline test results on surgical decision making in women with invasive breast cancer.
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    • Satisfaction and Quality of Life of Healthy and Unilateral Diseased BRCA1/2 Pathogenic Variant Carriers after Risk-Reducing Mastectomy and Reconstruction Using the BREAST-Q Questionnaire.
    • Herold N, Hellmich M, Lichtenheldt F, Ataseven B, Hillebrand V, Wappenschmidt B, Schmutzler RK, Rhiem K.
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    • Timely cancer genetic counseling and testing for young women with breast cancer: impact on surgical decision-making for contralateral risk-reducing mastectomy.
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    • Association Between Genetic Testing for Hereditary Breast Cancer and Contralateral Prophylactic Mastectomy Among Multiethnic Women Diagnosed With Early-Stage Breast Cancer.
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    • Meta-Analysis
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    • Is there an increasing trend of risk-reducing prophylactic mastectomy procedure in preventing breast cancer among women?
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    • Bilateral DIEP flap breast reconstruction with simultaneous unilateral nipple-sparing mastectomy - case report.
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    • Case report
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    Commentary:

    Genetic Testing and De-escalation of Contralateral Prophylactic Mastectomy.

    • Surgical management of BRCA pathogenic variant carriers with breast cancer: a recent literature review and current state of the art.
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    • Review
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    • Clinical practice guideline of BRCA1/2 testing for patients with breast cancer: Chinese Society of Breast Surgery (CSBrS) practice guideline 2021.
    • Xie F, Wang S.
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    • Influencers of the Decision to Undergo Contralateral Prophylactic Mastectomy among Women with Unilateral Breast Cancer.
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    • Review
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    • Contralateral Prophylactic Mastectomy in Patients with Breast Cancer.
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    • The Angelina Jolie effect: Contralateral risk-reducing mastectomy trends in patients at increased risk of breast cancer.
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    • A Retrospective Analysis of the Relationship Between the Result of BRCA1/2 Genetic Testing and Surgical Method Selection in Japan.
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    • Challenges and Considerations on Risk-Reducing Surgery in BRCA1/2 Patients with Advanced Breast Cancer.
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    • Breast reconstruction in patients with BRCA mutation and breast cancer - our approach.
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    • Clinical outcomes of patients after nipple-sparing mastectomy and reconstruction based on the expander/implant technique.
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    • Surg Today. 2020 Nov 13. doi: 10.1007/s00595-020-02175-4. Epub ahead of print.
    • ASO Author Reflections: Contralateral Prophylactic Mastectomy in Breast Cancer Patients with CHEK2 Gene Mutations.
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    • Commentary
    • Germline BRCA Mutation and Clinical Outcomes in Breast Cancer Patients Focusing on Survival and Failure Patterns: A Long-Term Follow-Up Study of Koreans.
    • Kim H, Choi DH, Park W.
    • Medicina (Kaunas). 2020 Oct 1;56(10):E514. doi: 10.3390/medicina56100514.
    • Rapid Genetic Testing for BRCA1 and BRCA2 Mutations at the Time of Breast Cancer Diagnosis: An Observational Study.
    • Metcalfe KA, Eisen A, Poll A, Candib A, McCready D, Cil T, Wright F, Lerner-Ellis J, McCuaig J, Graham T, Sun P, Akbari M, Narod SA.
    • Ann Surg Oncol. 2020 Sep 28. doi: 10.1245/s10434-020-09160-8. Epub ahead of print.
    • Contralateral Risk-Reducing Mastectomy in Breast Cancer Patients Who Undergo Multigene Panel Testing.
    • Murphy BL, Yi M, Arun BK, Gutierrez Barrera AM, Bedrosian I.
    • Ann Surg Oncol. 2020 Jul 27. doi: 10.1245/s10434-020-08889-6. Epub ahead of print.
    • ASTRO Radiation Therapy Summary of the ASCO-ASTRO-SSO Guideline on Management of Hereditary Breast Cancer.
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    • Pract Radiat Oncol. 2020 Jul-Aug;10(4):235-242. doi: 10.1016/j.prro.2020.04.003. Epub 2020 May 21.

    Guideline:

    Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline.

    • Cancer risk management among female BRCA1/2, PALB2, CHEK2, and ATM carriers.
    • Cragun D, Weidner A, Tezak A, Clouse K, Pal T.
    • Breast Cancer Res Treat. 2020 Jul;182(2):421-428. doi: 10.1007/s10549-020-05699-y. Epub 2020 May 22.
    • Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline.
    • Tung NM, Boughey JC, Pierce LJ, Robson ME, Bedrosian I, Dietz JR, Dragun A, Gelpi JB, Hofstatter EW, Isaacs CJ, Jatoi I, Kennedy E, Litton JK, Mayr NA, Qamar RD, Trombetta MG, Harvey BE, Somerfield MR, Zakalik D.
    • J Clin Oncol. 2020 Jun 20;38(18):2080-2106. doi: 10.1200/JCO.20.00299. Epub 2020 Apr 3.

    Summary, Review:

    Management of Hereditary Breast Cancer: ASCO, ASTRO, and SSO Guideline.

    Summary, Review:

    ASTRO Radiation Therapy Summary of the ASCO-ASTRO-SSO Guideline on Management of Hereditary Breast Cancer.

    Commentary, Review:

    Updates on Management of Hereditary Breast Cancer: New Data on PARP Inhibitors Change Recommendations Regarding the Multidisciplinary Care of Breast Cancer Patients with BRCA Mutations.

    • Prediction of contralateral breast cancer: external validation of risk calculators in 20 international cohorts.
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    • Breast Cancer Res Treat. 2020 Apr 11. doi: 10.1007/s10549-020-05611-8. [Epub ahead of print]
    • Differences in physician opinions about controversial issues surrounding contralateral prophylactic mastectomy (CPM): A survey of physicians from accredited breast centers in the United States.
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    • Predictors of contralateral prophylactic mastectomy in genetically high risk newly diagnosed breast cancer patients.
    • Tynan M, Peshkin BN, Isaacs C, Willey S, Valdimarsdottir HB, Nusbaum R, Hooker G, O'Neill SC, Jandorf L, Kelly SP, Heinzmann J, Kelleher S, Poggi E, Schwartz MD.
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    • Giardiello D, Steyerberg EW, Hauptmann M, Adank MA, Akdeniz D, Blomqvist C, Bojesen SE, Bolla MK, Brinkhuis M, Chang-Claude J, Czene K, Devilee P, Dunning AM, Easton DF, Eccles DM, Fasching PA, Figueroa J, Flyger H, García-Closas M, Haeberle L, Haiman CA, Hall P, Hamann U, Hopper JL, Jager A, Jakubowska A, Jung A, Keeman R, Kramer I, Lambrechts D, Le Marchand L, Lindblom A, Lubiński J, Manoochehri M, Mariani L, Nevanlinna H, Oldenburg HSA, Pelders S, Pharoah PDP, Shah M, Siesling S, Smit VTHBM, Southey MC, Tapper WJ, Tollenaar RAEM, van den Broek AJ, van Deurzen CHM, van Leeuwen FE, van Ongeval C, Van't Veer LJ, Wang Q, Wendt C, Westenend PJ, Hooning MJ, Schmidt MK.
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    • Is prophylactic mastectomy justified in women without BRCA mutation?
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    • Review
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    • Case report, review
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    • Medscape. Medscape Oncology. 2019 Jan 17.

    Original research:

    Prospective Study of Psychosocial Outcomes of Having Contralateral Prophylactic Mastectomy Among Women With Nonhereditary Breast Cancer.

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    Press: 'We've Scared Women': The Growth of Prophylactic Mastectomy (Medscape Oncology)

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    • A comparison of patient satisfaction (using the BREAST-Q questionnaire) with bilateral breast reconstruction following risk-reducing or therapeutic mastectomy.
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    • Review
    • 'We've Scared Women': The Growth of Prophylactic Mastectomy.
    • Davenport L.
    • Medscape. Medscape Oncology. 2018 Jul 3.

    Press: 'Taking Back Control': The Growth in Prophylactic Mastectomy (Medscape Oncology)

    • Psychological outcomes and surgical decisions after genetic testing in women newly diagnosed with breast cancer with and without a family history.
    • Meiser B, Quinn VF, Mitchell G, Tucker K, Watts KJ, Rahman B, Peate M, Saunders C, Geelhoed E, Gleeson M, Barlow-Stewart K, Field M, Harris M, Antill YC, Susman R, Bowen MT, Mills L, Kirk J; TFGT Collaborative Group.
    • Eur J Hum Genet. 2018 Jul;26(7):972-983. doi: 10.1038/s41431-017-0057-3. Epub 2018 Mar 30.
    • Contralateral prophylactic mastectomy rate and predictive factors among patients with breast cancer who underwent multigene panel testing for hereditary cancer.
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    • Juliet's story: No reconstruction is a post-mastectomy option.
    • [No author given]
    • FORCE. XRAYS. 2018 May 24.

    Blog post: I felt empowered by choosing not to have a reconstruction. (Breast Cancer Care)

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    • Review, Meta-Analysis

    Summary: Women should be aware of their true risk of developing breast cancer and the limitations of current evidence when considering risk-reducing mastectomy. (Cochrane Library)

    • Cost-effectiveness of different strategies to prevent breast and ovarian cancer in German women with a BRCA 1 or 2 mutation.
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    • Oncologic Safety of Prophylactic Nipple-Sparing Mastectomy in a Population With BRCA Mutations: A Multi-institutional Study.
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    • JAMA Surg. 2018 Feb 1;153(2):123-129. doi: 10.1001/jamasurg.2017.3422.

    Commentary:

    When is a Little Breast Tissue Too Much?: Nipple-Sparing Risk-Reducing Mastectomy in BRCA Carriers.

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    • Review
    • The psycho-social impact of contralateral risk reducing mastectomy (CRRM) on women: a rapid review.
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    • Review
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    • Contralateral Prophylactic Mastectomy.
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    • Psychosocial factors associated with the uptake of contralateral prophylactic mastectomy among BRCA1/2 mutation noncarriers with newly diagnosed breast cancer.
    • Hamilton JG, Genoff MC, Salerno M, Amoroso K, Boyar SR, Sheehan M, Fleischut MH, Siegel B, Arnold AG, Salo-Mullen EE, Hay JL, Offit K, Robson ME.
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    • [Diagnosis and Treatment of HBOC Syndrome by a Breast Surgical Oncologist].
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    • Review, [Article in Japanese]
    • When knowledge of a heritable gene mutation comes out of the blue: treatment-focused genetic testing in women newly diagnosed with breast cancer.
    • Meiser B, Quinn VF, Gleeson M, Kirk J, Tucker KM, Rahman B, Saunders C, Watts KJ, Peate M, Geelhoed E, Barlow-Stewart K, Field M, Harris M, Antill YC, Mitchell G.
    • Eur J Hum Genet. 2016 Nov;24(11):1517-1523. doi: 10.1038/ejhg.2016.69. Epub 2016 Jun 22.
    • Contralateral Prophylactic Mastectomy (CPM) Consensus Statement from the American Society of Breast Surgeons: Data on CPM Outcomes and Risks.
    • Boughey JC, Attai DJ, Chen SL, Cody HS, Dietz JR, Feldman SM, Greenberg CC, Kass RB, Landercasper J, Lemaine V, MacNeill F, Song DH, Staley AC, Wilke LG, Willey SC, Yao KA, Margenthaler JA.
    • Ann Surg Oncol. 2016 Oct;23(10):3100-5. doi: 10.1245/s10434-016-5443-5. Epub 2016 Jul 28.

    Clinical Guideline

    Contralateral Prophylactic Mastectomy Consensus Statement from the American Society of Breast Surgeons: Additional Considerations and a Framework for Shared Decision Making.

    News: Contralateral Prophylactic Mastectomy Discouraged: ASBrS (Medscape Oncology)

    • Impact that Timing of Genetic Mutation Diagnosis has on Surgical Decision Making and Outcome for BRCA1/BRCA2 Mutation Carriers with Breast Cancer.
    • Chiba A, Hoskin TL, Hallberg EJ, Cogswell JA, Heins CN, Couch FJ, Boughey JC.
    • Ann Surg Oncol. 2016 Oct;23(10):3232-8. doi: 10.1245/s10434-016-5328-7. Epub 2016 Jun 23.

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: Impact of Timing of BRCA Testing

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    • Review
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    • Contralateral prophylactic mastectomy rate stable at major Canadian breast cancer center.
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    • Patient Educ Couns. 2016 May;99(5):814-22.
    • Survey of the Deficits in Surgeons' Knowledge of Contralateral Prophylactic Mastectomy.
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    • JAMA Surg. 2016 Apr 1;151(4):391-3. doi: 10.1001/jamasurg.2015.3601.
    • Letter
    • Predicting women's intentions for contralateral prophylactic mastectomy: An application of an extended theory of planned behaviour.
    • Richards I, Tesson S, Porter D, Phillips KA, Rankin N, Musiello T, Marven M, Butow P.
    • Eur J Oncol Nurs. 2016 Apr;21:57-65. doi: 10.1016/j.ejon.2015.12.002. Epub 2016 Feb 2.
    • Is Sentinel Lymph Node Biopsy Necessary in Patients Undergoing Prophylactic Mastectomy? A Systematic Review and Meta-Analysis.
    • Nagaraja V, Edirimanne S, Eslick GD.
    • Breast J. 2016 Mar-Apr;22(2):158-65. doi: 10.1111/tbj.12549. Epub 2016 Jan 8.
    • Meta-Analysis
    • Why Women Are Choosing Bilateral Mastectomy.
    • Jerome-D'Emilia B, Suplee PD, D'Emilia I.
    • Clin J Oncol Nurs. 2015 Dec 1;19(6):764-8. doi: 10.1188/15.CJON.764-768.

    Free full text: Why Women Are Choosing Bilateral Mastectomy (Medscape Oncology)

    • Bilateral Mastectomy for Unilateral Breast Cancer: a Perplexing Trend.
    • Jatoi I.
    • Indian J Surg Oncol. 2015 Dec;6(4):387-9. doi: 10.1007/s13193-015-0450-8. Epub 2015 Aug 1.
    • Review
    • Local Therapy Decision-Making and Contralateral Prophylactic Mastectomy in Young Women with Early-Stage Breast Cancer.
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    • Ann Surg Oncol. 2015 Nov;22(12):3809-15. doi: 10.1245/s10434-015-4572-6. Epub 2015 May 1.
    • Contralateral Prophylactic Mastectomy: Challenging Considerations for the Surgeon.
    • Angelos P, Bedrosian I, Euhus DM, Herrmann VM, Katz SJ, Pusic A.
    • Ann Surg Oncol. 2015 Oct;22(10):3208-12. doi: 10.1245/s10434-015-4758-y. Epub 2015 Aug 11.
    • Negative Genetic Testing Does Not Deter Contralateral Prophylactic Mastectomy in Younger Patients with Greater Family Histories of Breast Cancer.
    • Wang F, Amara D, Peled AW, Sbitany H, Foster RD, Ewing CA, Alvarado M, Esserman LJ.
    • Ann Surg Oncol. 2015 Oct;22(10):3338-45. doi: 10.1245/s10434-015-4745-3. Epub 2015 Jul 28.
    • Treatment Decision Making and Genetic Testing for Breast Cancer: Mainstreaming Mutations.
    • Katz SJ, Kurian AW, Morrow M.
    • JAMA. 2015 Sep 8;314(10):997-998. doi: 10.1001/jama.2015.8088.
    • Editorial / Commentary
    • Timing of risk reducing mastectomy in breast cancer patients carrying a BRCA1/2 mutation: retrospective data from the Dutch HEBON study.
    • Wevers MR, Schmidt MK, Engelhardt EG, Verhoef S, Hooning MJ, Kriege M, Seynaeve C, Collée M, van Asperen CJ, Tollenaar RA, Koppert LB, Witkamp AJ, Rutgers EJ, Aaronson NK, Rookus MA, Ausems MG.
    • Fam Cancer. 2015 Sep;14(3):355-63. doi: 10.1007/s10689-015-9788-x.
    • Redefining Risk and Benefit: Understanding the Decision to Undergo Contralateral Prophylactic Mastectomy.
    • Rendle KA, Halley MC, May SG, Frosch DL.
    • Qual Health Res. 2015 Sep;25(9):1251-9. doi: 10.1177/1049732314557085. Epub 2014 Nov 4.
    • Predictors that Influence Election of Contralateral Prophylactic Mastectomy among Women with Ductal Carcinoma in Situ who are BRCA-Negative.
    • Elsayegh N, Profato J, Barrera AM, Lin H, Kuerer HM, Ardic C, Litton JK, Tripathy D, Arun BK.
    • J Cancer. 2015 May 23;6(7):610-5. doi: 10.7150/jca.11710. eCollection 2015.
    • Predictors for contralateral prophylactic mastectomy in breast cancer patients.
    • Fu Y, Zhuang Z, Dewing M, Apple S, Chang H.
    • Int J Clin Exp Pathol. 2015 Apr 1;8(4):3748-64. eCollection 2015.
    • Prophylactic Mastectomy Among BRCA1/2 Noncarriers with Newly-diagnosed Breast Cancer: Examining Cognitive, Emotional, and Sociodemographic Influences.
    • Hamilton JG, Salerno M, Amoroso K, Sheehan M, Harlan FM, Glogowski E, Siegel B, Arnold AG, Salo-Mullen EE, Hay J, Offit K, Robson ME.
    • Cancer Epidemiol Biomarkers Prev. 2015 Apr;24(4):760. ASPO 39th Annual Meeting Abstracts. doi: 10.1158/1055-9965.EPI-15-0104.
    • Conference abstract
    • Factors Affecting Informed Decision-Making in Women with Increased Breast Cancer Risk or DCIS Pursuing Contralateral Prophylactic Mastectomy.
    • Valente J, Stybio T, Hyde S, Lipscomb J, Gillespie TW.
    • Cancer Epidemiol Biomarkers Prev. 2015 Apr;24(4):761. ASPO 39th Annual Meeting Abstracts. doi: 10.1158/1055-9965.EPI-15-0105.
    • Conference abstract
    • Better contralateral breast cancer risk estimation and alternative options to contralateral prophylactic mastectomy.
    • Davies KR, Cantor SB, Brewster AM.
    • Int J Womens Health. 2015 Feb 4;7:181-7. doi: 10.2147/IJWH.S52380. eCollection 2015.
    • Prophylactic mastectomy: Who needs it, when and why.
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    • Review
    • Rate of contralateral prophylactic mastectomy is influenced by preoperative MRI recommendations.
    • Xia C, Schroeder MC, Weigel RJ, Sugg SL, Thomas A.
    • Ann Surg Oncol. 2014 Dec;21(13):4133-8. doi: 10.1245/s10434-014-3852-x. Epub 2014 Jun 17.
    • Increasing trend of contralateral prophylactic mastectomy: what are the factors behind this phenomenon?
    • Soran A, Kamali Polat A, Johnson R, McGuire KP.
    • Surgeon. 2014 Dec;12(6):316-22. doi: 10.1016/j.surge.2014.02.005. Epub 2014 Mar 29.
    • Review
    • Predictors that influence contralateral prophylactic mastectomy election among women with ductal carcinoma in situ who were evaluated for BRCA genetic testing.
    • Elsayegh N, Kuerer HM, Lin H, Gutierrez Barrera AM, Jackson M, Muse KI, Litton JK, Albarracin C, Afrough A, Hortobagyi GN, Arun BK.
    • Ann Surg Oncol. 2014 Oct;21(11):3466-72. doi: 10.1245/s10434-014-3747-x. Epub 2014 May 6.
    • Contralateral Prophylactic Mastectomy in the American College of Radiology Imaging Network 6667 Trial: Effect of Breast MR Imaging Assessments and Patient Characteristics.
    • Rahbar H, Hanna LG, Gatsonis C, Mahoney MC, Schnall MD, DeMartini WB, Lehman CD.
    • Radiology. 2014 Oct;273(1):53-60. doi: 10.1148/radiol.14132029. Epub 2014 Jun 16.
    • Social and Clinical Determinants of Contralateral Prophylactic Mastectomy.
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    • JAMA Surg. 2014 Jun;149(6):582-9. doi: 10.1001/jamasurg.2013.5689.

    Comment:

    Contralateral Prophylactic Mastectomy: An Opportunity for Shared Decision Making.

    • Bilateral breast cancers.
    • Narod SA.
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    • Review
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    • A rapid genetic counselling and testing in newly diagnosed breast cancer is associated with high rate of risk-reducing mastectomy in BRCA1/2-positive Italian women.
    • Cortesi L, Razzaboni E, Toss A, De Matteis E, Marchi I, Medici V, Tazzioli G, Andreotti A, De Santis G, Pignatti M, Federico M.
    • Ann Oncol. 2014 Jan;25(1):57-63. doi: 10.1093/annonc/mdt422. Epub 2013 Nov 24.

    Viewpoint: Rapid BRCA Testing Informs Choice of Mastectomy. (Medscape Oncology)

    • Review of risk factors for the development of contralateral breast cancer.
    • Lizarraga IM, Sugg SL, Weigel RJ, Scott-Conner CE.
    • Am J Surg. 2013 Nov;206(5):704-8. doi: 10.1016/j.amjsurg.2013.08.002. Epub 2013 Sep 6.
    • Review
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    • Breast. 2013 Oct;22(5):561-8. doi: 10.1016/j.breast.2013.07.045. Epub 2013 Aug 21.
    • Review
    • Perceptions, knowledge, and satisfaction with contralateral prophylactic mastectomy among young women with breast cancer: a cross-sectional survey.
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    • Ann Intern Med. 2013 Sep 17;159(6):373-81. doi: 10.7326/0003-4819-159-6-201309170-00003.

    Editorial, Comment:

    Contralateral prophylactic mastectomy: perceptions versus reality.

    Summary for Patients:

    Do women with breast cancer overestimate their risk for cancer in the unaffected breast?

    News:

    Women With Breast Cancer Who Opt for Contralateral Prophylactic Mastectomy May Overestimate Future Risk.

    News:

    Young women fearing recurrence opt for prophylactic mastectomy.

    • Contralateral prophylactic mastectomy: perceptions versus reality.
    • Portschy PR, Tuttle TM.
    • Ann Intern Med. 2013 Sep 17;159(6):428-9. doi: 10.7326/0003-4819-159-6-201309170-00011.
    • Editorial, Comment

    Perceptions, knowledge, and satisfaction with contralateral prophylactic mastectomy among young women with breast cancer: a cross-sectional survey.

    • Do women with breast cancer overestimate their risk for cancer in the unaffected breast?
    • [No authors listed]
    • Ann Intern Med. 2013 Sep 17;159(6):I-30. doi: 10.7326/0003-4819-159-6-201309170-00001.

    Perceptions, knowledge, and satisfaction with contralateral prophylactic mastectomy among young women with breast cancer: a cross-sectional survey.

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    • Review
    • The contralateral prophylactic mastectomy decision-making process.
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    • Ann Surg Oncol. 2012 Aug;19(8):2600-6. doi: 10.1245/s10434-012-2299-1. Epub 2012 Mar 7.
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