• Points to Consider Regarding De-Escalation Surgery in High-Risk Breast Cancer.
    • Corso G, Magnoni F, Veronesi P.
    • Ann Surg Oncol. 2022 Sep 15. doi: 10.1245/s10434-022-12542-9. Epub ahead of print.
    • Review
    • Surgery and prophylactic surgery in hereditary breast cancer.
    • Morrow M.
    • Breast. 2022 Mar;62 Suppl 1:S63-S66. doi: 10.1016/j.breast.2021.12.010. Epub 2021 Dec 13.
    • Pregnancy induced hyperplasia of residual breast tissue following risk reducing contralateral mastectomy - simply interesting or a clinically important observation.
    • Pitiyarachchi O, Phillips KA, Friedlander M.
    • Cancer Treat Res Commun. 2022 Jan 1;30:100504. doi: 10.1016/j.ctarc.2021.100504. Epub ahead of print.
    • ASO Visual Abstract: How Protective are Nipple-Sparing Prophylactic Mastectomies in BRCA1 and BRCA2 Mutation Carriers?
    • Garstka M, Henriquez A, Kelly BN, Webster A, Khubchandani JA, Hughes K, Nguyen A, Oseni T, Specht M, Coopey SB, Gadd MA, Smith BL.
    • Ann Surg Oncol. 2021 Dec;28(Suppl 3):594-595. doi: 10.1245/s10434-021-10583-0.
    • Contralateral risk-reducing local therapy in breast cancer patients with BRCA1/2 mutations: systemic review and meta-analysis.
    • Jia Z, Li J, Zhang Y, Wang X, Xing J, Xing Z, Huang X, Liu G, Zhang M, Feng K, Wu J, Wang W, Wang J, Liu J, Wang X.
    • Cancer Cell Int. 2021 Sep 25;21(1):512. doi: 10.1186/s12935-021-02194-2.
    • Management of patients with BRCA mutation from the point of view of a breast surgeon.
    • Riis ML.
    • Ann Med Surg (Lond). 2021 Apr 16;65:102311. doi: 10.1016/j.amsu.2021.102311.
    • Contralateral prophylactic mastectomy: A narrative review of the evidence and acceptability.
    • Scheepens JCC, van 't Veer L, Esserman L, Belkora J, Mukhtar RA.
    • Breast. 2021 Apr;56:61-69. doi: 10.1016/j.breast.2021.02.003. Epub 2021 Feb 10.
    • Post-mastectomy surveillance of BRCA1/BRCA2 mutation carriers: Outcomes from a specialized clinic for high-risk breast cancer patients.
    • Kanana N, Ben David MA, Nissan N, Yagil Y, Shalmon A, Halshtok O, Gotlieb M, Faermann R, Klang E, Samoocha D, Yassin M, Davidson T, Zippel D, Madorsky Feldman D, Friedman E, Kaidar-Person O, Sklair Levy M.
    • Breast J. 2021 Feb 11. doi: 10.1111/tbj.14190. Epub ahead of print.
    • Contralateral breast cancer and tumor recurrence in BRCA1/2 carriers and non-carriers at a high risk of hereditary breast cancer after bilateral mastectomy.
    • Allué Cabañuz M, Domingo Bretón M, Chóliz Ezquerro J, Arribas Del Amo MD, Güemes Sánchez AT.
    • Cir Esp. 2020 Jun 3:S0009-739X(20)30115-9. English, Spanish. doi: 10.1016/j.ciresp.2020.04.008. Epub ahead of print.
    • [Article in English, Spanish.]
    • Contralateral Prophylactic Mastectomy in Women with Unilateral Breast Cancer Who Are Genetic Carriers, Have a Strong Family History or Are just Young at Presentation.
    • Teoh V, Tasoulis MK, Gui G.
    • Cancers (Basel). 2020 Jan 6;12(1). pii: E140. doi: 10.3390/cancers12010140.
    • Residual glandular tissue (RGT) in BRCA1/2 germline mutation carriers with unilateral and bilateral prophylactic mastectomies.
    • Grinstein O, Krug B, Hellmic M, Siedek F, Malter W, Burke C, Schmutzler R, Maintz D, Rhiem K.
    • Surg Oncol. 2019 Jun;29:126-133. doi: 10.1016/j.suronc.2019.04.009. Epub 2019 May 3.
    • Surgery for BRCA, TP53 and PALB2: a literature review.
    • Song CV, Teo SH, Taib NA, Yip CH.
    • Ecancermedicalscience. 2018 Aug 29;12:863. doi: 10.3332/ecancer.2018.863. eCollection 2018.
    • Risk-reducing mastectomy for the prevention of primary breast cancer.
    • Carbine NE, Lostumbo L, Wallace J, Ko H.
    • Cochrane Database Syst Rev. 2018 Apr 5;4:CD002748. doi: 10.1002/14651858.CD002748.pub4.
    • Review, Meta-Analysis

    Summary: Women should be aware of their true risk of developing breast cancer and the limitations of current evidence when considering risk-reducing mastectomy. (Cochrane Library)

    • Oncologic Safety of Prophylactic Nipple-Sparing Mastectomy in a Population With BRCA Mutations: A Multi-institutional Study.
    • Jakub JW, Peled AW, Gray RJ, Greenup RA, Kiluk JV, Sacchini V, McLaughlin SA, Tchou JC, Vierkant RA, Degnim AC, Willey S.
    • JAMA Surg. 2018 Feb 1;153(2):123-129. doi: 10.1001/jamasurg.2017.3422.


    When is a Little Breast Tissue Too Much?: Nipple-Sparing Risk-Reducing Mastectomy in BRCA Carriers.

    • Outcomes of contralateral prophylactic mastectomy in relation to familial history: a decision analysis (BRCR-D-16-00033).
    • Davies KR, Brewster AM, Bedrosian I, Parker PA, Crosby MA, Peterson SK, Shen Y, Volk RJ, Cantor SB.
    • Breast Cancer Res. 2016 Sep 20;18(1):93. doi: 10.1186/s13058-016-0752-y.
    • Effectiveness of Prophylactic Surgeries in BRCA1 or BRCA2 Mutation Carriers: A Meta-analysis and Systematic Review.
    • Li X, You R, Wang X, Liu C, Xu Z, Zhou J, Yu B, Xu T, Cai H, Zou Q.
    • Clin Cancer Res. 2016 Aug 1;22(15):3971-81. doi: 10.1158/1078-0432.CCR-15-1465. Epub 2016 Mar 15.
    • Contralateral prophylactic mastectomy: current perspectives.
    • Yao K, Sisco M, Bedrosian I.
    • Int J Womens Health. 2016 Jun 22;8:213-23. doi: 10.2147/IJWH.S82816. eCollection 2016.
    • More Proof: Nipple-Sparing Mastectomy Safe for BRCA Carriers.
    • Nick Mulcahy.
    • Medscape Medical News. Conference News. 17th Annual Meeting of the American Society of Breast Surgeons. 2016 Apr 21.
    • Improved overall survival after contralateral risk-reducing mastectomy in BRCA1/2 mutation carriers with a history of unilateral breast cancer: A prospective analysis.
    • A M Heemskerk-Gerritsen B, Rookus MA, Aalfs CM, Ausems MG, Collée JM, Jansen L, Kets CM, Keymeulen KB, Koppert LB, Meijers-Heijboer HE, Mooij TM, Tollenaar RA, Vasen HF, Hebon, Hooning MJ, Seynaeve C.
    • Int J Cancer. 2015 Feb 15;136(3):668-677. doi: 10.1002/ijc.29032. Epub 2014 Jul 8.
    • Better contralateral breast cancer risk estimation and alternative options to contralateral prophylactic mastectomy.
    • Davies KR, Cantor SB, Brewster AM.
    • Int J Womens Health. 2015 Feb 4;7:181-7. doi: 10.2147/IJWH.S52380. eCollection 2015.
    • Contralateral prophylactic mastectomy after unilateral breast cancer: a systematic review and meta-analysis.
    • Fayanju OM, Stoll CR, Fowler S, Colditz GA, Margenthaler JA.
    • Ann Surg. 2014 Dec;260(6):1000-10. doi: 10.1097/SLA.0000000000000769.
    • Contralateral prophylactic mastectomy and its association with reduced mortality: evidence for selection bias.
    • Jatoi I, Parsons HM.
    • Breast Cancer Res Treat. 2014 Nov;148(2):389-96. doi: 10.1007/s10549-014-3160-y. Epub 2014 Oct 10.
    • Threshold for genetic testing in women with breast cancer needs to be determined.
    • Basu NN, Barr L, Evans DG, Ross GL.
    • BMJ. 2014 Mar 6;348:g1863. doi: 10.1136/bmj.g1863.
    • Letter

    Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis.

    • Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis.
    • Metcalfe K, Gershman S, Ghadirian P, Lynch HT, Snyder C, Tung N, Kim-Sing C, Eisen A, Foulkes WD, Rosen B, Sun P, Narod SA.
    • BMJ. 2014 Feb 11;348:g226. doi: 10.1136/bmj.g226.

    Comment, Editorial:

    Contralateral mastectomy for women with hereditary breast cancer.

    Letter, Comment:

    Threshold for genetic testing in women with breast cancer needs to be determined.

    Research News:

    Women with BRCA mutation have better survival rates after double mastectomy.

    Press: Bilateral Mastectomy Ups Survival in BRCA Carriers. (Medscape/Reuters)

    • Improved long-term survival with contralateral prophylactic mastectomy among young women.
    • Zeichner SB, Zeichner SB, Ruiz AL, Markward NJ, Rodriguez E.
    • Asian Pac J Cancer Prev. 2014;15(3):1155-62.
    • Review of risk factors for the development of contralateral breast cancer.
    • Lizarraga IM, Sugg SL, Weigel RJ, Scott-Conner CE.
    • Am J Surg. 2013 Nov;206(5):704-8. doi: 10.1016/j.amjsurg.2013.08.002. Epub 2013 Sep 6.
    • Review
    • Contralateral mastectomy improves survival in women with BRCA1/2-associated breast cancer.
    • Evans DG, Ingham SL, Baildam A, Ross GL, Lalloo F, Buchan I, Howell A.
    • Breast Cancer Res Treat. 2013 Jul;140(1):135-42. doi: 10.1007/s10549-013-2583-1. Epub 2013 Jun 20.
    • Contralateral prophylactic mastectomy: clinical and pathological features from a prospective database.
    • Barry PN, Johnson RR, Harkenrider MM, Freeman AB, Kruse B, Wilson MR, Pan J, Dragun AE.
    • Am J Med Sci. 2012 Dec;344(6):452-6. doi: 10.1097/MAJ.0b013e31824a82ce.
    • Association between contralateral prophylactic mastectomy and breast cancer outcomes by hormone receptor status.
    • Brewster AM, Bedrosian I, Parker PA, Dong W, Peterson SK, Cantor SB, Crosby M, Shen Y.
    • Cancer. 2012 Nov 15;118(22):5637-43. doi: 10.1002/cncr.27574. Epub 2012 Apr 19.