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- Clinical Contrubution of Next-Generation Sequencing Multi- Gene Panel Testing for BRCA Negative High Risk Breast Cancer Patients.
- Solmaz AE, Yeniay L, Gökmen E, Zekioglu O, Haydaroglu A, Bilgen I, Özkinay F, Onay H.
- Clin Breast Cancer. 2021 Apr 12:S1526-8209(21)00070-7. doi: 10.1016/j.clbc.2021.04.002. Epub ahead of print.
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- Thai patients who fulfilled NCCN criteria for breast/ovarian cancer genetic assessment demonstrated high prevalence of germline mutations in cancer susceptibility genes: implication to Asian population testing.
- Lertwilaiwittaya P, Roothumnong E, Nakthong P, Dungort P, Meesamarnpong C, Tansa-Nga W, Pongsuktavorn K, Wiboonthanasarn S, Tititumjariya W, Thongnoppakhun W, Chanprasert S, Limwongse C, Pithukpakorn M.
- Breast Cancer Res Treat. 2021 Mar 1. doi: 10.1007/s10549-021-06152-4. Epub ahead of print.
- PMID: 33649982
- PubMed abstract
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- Update: variable implementation of the 2018 UKCGG/UKGTN guidelines for breast cancer gene panel tests offered by UK genetics services.
- Wedderburn S, Archer S, Tischkowitz M, Hanson H, on behalf of UKCGG.
- J Med Genet. 2021 Feb 10:jmedgenet-2020-107529. doi: 10.1136/jmedgenet-2020-107529. Epub ahead of print.
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- Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report.
- Papez J, Starha J, Zerhau P, Pavlovska D, Jezova M, Jurencak T, Slaba K, Sterba M, Kerekes A, Merta T, Haluskova T, Palova H, Slaby O, Sterba J, Jabandziev P.
- Genes (Basel). 2021 Feb 3;12(2):220. doi: 10.3390/genes12020220.
- PMID: 33546375
- PubMed abstract
- Source abstract
- Case report
- Free Full Text
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- A Population-Based Study of Genes Previously Implicated in Breast Cancer.
- Hu C, Hart SN, Gnanaolivu R, Huang H, Lee KY, Na J, Gao C, Lilyquist J, Yadav S, Boddicker NJ, Samara R, Klebba J, Ambrosone CB, Anton-Culver H, Auer P, Bandera EV, Bernstein L, Bertrand KA, Burnside ES, Carter BD, Eliassen H, Gapstur SM, Gaudet M, Haiman C, Hodge JM, Hunter DJ, Jacobs EJ, John EM, Kooperberg C, Kurian AW, Le Marchand L, Lindstroem S, Lindstrom T, Ma H, Neuhausen S, Newcomb PA, O'Brien KM, Olson JE, Ong IM, Pal T, Palmer JR, Patel AV, Reid S, Rosenberg L, Sandler DP, Scott C, Tamimi R, Taylor JA, Trentham-Dietz A, Vachon CM, Weinberg C, Yao S, Ziogas A, Weitzel JN, Goldgar DE, Domchek SM, Nathanson KL, Kraft P, Polley EC, Couch FJ.
- N Engl J Med. 2021 Jan 20. doi: 10.1056/NEJMoa2005936. Epub ahead of print.
- PMID: 33471974
- PubMed abstract
- Source abstract
Editorial:
Which Genes for Hereditary Breast Cancer?
- PMID: 33471975
- PubMed abstract
- Source abstract
Press: Breast Cancer Risk Gene Associations Refined in Large-Scale Studies. (Precision Oncology News)
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- Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women.
- Breast Cancer Association Consortium, Dorling L, Carvalho S, Allen J, González-Neira A, Luccarini C, Wahlström C, Pooley KA, Parsons MT, Fortuno C, Wang Q, Bolla MK, Dennis J, Keeman R, Alonso MR, Álvarez N, Herraez B, Fernandez V, Núñez-Torres R, Osorio A, Valcich J, Li M, Törngren T, Harrington PA, Baynes C, Conroy DM, Decker B, Fachal L, Mavaddat N, Ahearn T, Aittomäki K, Antonenkova NN, Arnold N, Arveux P, Ausems MGEM, Auvinen P, Becher H, Beckmann MW, Behrens S, Bermisheva M, Bialkowska K, Blomqvist C, Bogdanova NV, Bogdanova-Markov N, Bojesen SE, Bonanni B, Børresen-Dale AL, Brauch H, Bremer M, Briceno I, Brüning T, Burwinkel B, Cameron DA, Camp NJ, Campbell A, Carracedo A, Castelao JE, Cessna MH, Chanock SJ, Christiansen H, Collée JM, Cordina-Duverger E, Cornelissen S, Czene K, Dörk T, Ekici AB, Engel C, Eriksson M, Fasching PA, Figueroa J, Flyger H, Försti A, Gabrielson M, Gago-Dominguez M, Georgoulias V, Gil F, Giles GG, Glendon G, Garcia EBG, Alnæs GIG, Guénel P, Hadjisavvas A, Haeberle L, Hahnen E, Hall P, Hamann U, Harkness EF, Hartikainen JM, Hartman M, He W, Heemskerk-Gerritsen BAM, Hillemanns P, Hogervorst FBL, Hollestelle A, Ho WK, Hooning MJ, Howell A, Humphreys K, Idris F, Jakubowska A, Jung A, Kapoor PM, Kerin MJ, Khusnutdinova E, Kim SW, Ko YD, Kosma VM, Kristensen VN, Kyriacou K, Lakeman IMM, Lee JW, Lee MH, Li J, Lindblom A, Lo WY, Loizidou MA, Lophatananon A, Lubinski J, MacInnis RJ, Madsen MJ, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Martinez ME, Maurer T, Mavroudis D, McLean C, Meindl A, Mensenkamp AR, Michailidou K, Miller N, Mohd Taib NA, Muir K, Mulligan AM, Nevanlinna H, Newman WG, Nordestgaard BG, Ng PS, Oosterwijk JC, Park SK, Park-Simon TW, Perez JIA, Peterlongo P, Porteous DJ, Prajzendanc K, Prokofyeva D, Radice P, Rashid MU, Rhenius V, Rookus MA, Rüdiger T, Saloustros E, Sawyer EJ, Schmutzler RK, Schneeweiss A, Schürmann P, Shah M, Sohn C, Southey MC, Surowy H, Suvanto M, Thanasitthichai S, Tomlinson I, Torres D, Truong T, Tzardi M, Valova Y, van Asperen CJ, Van Dam RM, van den Ouweland AMW, van der Kolk LE, van Veen EM, Wendt C, Williams JA, Yang XR, Yoon SY, Zamora MP, Evans DG, de la Hoya M, Simard J, Antoniou AC, Borg Å, Andrulis IL, Chang-Claude J, García-Closas M, Chenevix-Trench G, Milne RL, Pharoah PDP, Schmidt MK, Spurdle AB, Vreeswijk MPG, Benitez J, Dunning AM, Kvist A, Teo SH, Devilee P, Easton DF.
- N Engl J Med. 2021 Jan 20. doi: 10.1056/NEJMoa1913948. Epub ahead of print.
- PMID: 33471991
- PubMed abstract
- Source abstract
Editorial:
Which Genes for Hereditary Breast Cancer?
- PMID: 33471975
- PubMed abstract
- Source abstract
Press: Breast Cancer Risk Gene Associations Refined in Large-Scale Studies. (Precision Oncology News)
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- Two tSNPs in BRIP1 are associated with breast cancer during TDT analysis.
- Li X, Li Z, Yang M, Luo Y, Hu L, Xiao Z, Huang A, Huang J.
- Mol Genet Genomic Med. 2021 Jan 5:e1578. doi: 10.1002/mgg3.1578. Epub ahead of print.
- PMID: 33403820
- PubMed abstract
- Source abstract
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- Mutational Landscape for Indian Hereditary Breast and Ovarian Cancer cohort suggests need for identifying population specific genes and biomarkers for screening.
- Shaad M, Patel K, Bhargava PA, Shah FD, Badgujar NV, Tarapara BV, Patel PS, Shaikh I, Shah K, Patel A, Pandya S, Vora H, Joshi CG, Joshi M.
- Front Oncol. 2020 Dec 2;10:568786. doi: 10.3389/fonc.2020.568786.
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- Current practices on genetic testing in ovarian cancer.
- Fostira F, Papadimitriou M, Papadimitriou C.
- Ann Transl Med. 2020 Dec;8(24):1703. doi: 10.21037/atm-20-1422.
- PMID: 33490215
- PubMed abstract
- Review
- Free PMC article
- Free Full Text
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- Multiple cancer susceptible genes sequencing in BRCA-negative breast cancer with high hereditary risk.
- Lang GT, Shi JX, Huang L, Cao AY, Zhang CH, Song CG, Zhuang ZG, Hu X, Huang W, Shao ZM.
- Ann Transl Med. 2020 Nov;8(21):1417. doi: 10.21037/atm-20-2999.
- PMID: 33313162
- PubMed abstract
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- Rare Germline Genetic Variants and the Risks of Epithelial Ovarian Cancer.
- Pavanello M, Chan IHY, Ariff A, Pharoah PDP, Gayther SA, Ramus SJ.
- Cancers (Basel). 2020 Oct 19;12(10):E3046. doi: 10.3390/cancers12103046.
- Review
- Free Full Text (PDF)
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- Inhibition of poly(ADP-ribose) polymerase induces synthetic lethality in BRIP1 deficient ovarian epithelial cells.
- Ciccone MA, Adams CL, Bowen C, Thakur T, Ricker C, Culver JO, Maoz A, Melas M, Idos GE, Jeyasekharan AD, Matsuo K, Roman LD, Gruber SB, McDonnell KJ.
- Gynecol Oncol. 2020 Oct 5:S0090-8258(20)33950-0. doi: 10.1016/j.ygyno.2020.09.040. Epub ahead of print.
- PMID: 33032822
- PubMed abstract
- Source abstract
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- Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
- Pietragalla A, Arcieri M, Marchetti C, Scambia G, Fagotti A.
- Int J Gynecol Cancer. 2020 Sep 6:ijgc-2020-001556. doi: 10.1136/ijgc-2020-001556. Epub ahead of print.
- PMID: 32895312
- PubMed abstract
- Source abstract
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- Heritable susceptibility to breast cancer among African American women in the Detroit Research on Cancer Survivors Study.
- Purrington KS, Raychaudhuri S, Simon MS, Clark J, Ratliff V, Dyson G, Craig DB, Boerner JL, Beebe-Dimmer JL, Schwartz AG.
- Cancer Epidemiol Biomarkers Prev. 2020 Aug 31:cebp.0564.2020. doi: 10.1158/1055-9965.EPI-20-0564. Epub ahead of print.
- PMID: 32868316
- PubMed abstract
- Source abstract
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- Pathogenic germline variants in patients with features of hereditary renal cell carcinoma: evidence for further locus heterogeneity.
- Smith PS, West H, Whitworth J, Castle B, Sansbury FH, Warren AY, Woodward ER, Tischkowitz M, Maher ER.
- Genes Chromosomes Cancer. 2020 Aug 23. doi: 10.1002/gcc.22893. Epub ahead of print.
- PMID: 32830346
- PubMed abstract
- Source abstract
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- Morphological and molecular heterogeneity of epithelial ovarian cancer: Therapeutic implications.
- Romero I, Leskelä S, Mies BP, Velasco AP, Palacios J.
- EJC Suppl. 2020 Aug 22;15:1-15. doi: 10.1016/j.ejcsup.2020.02.001.
- PMID: 33240438
- PubMed abstract
- Review
- Free PMC article
- Free Full Text
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- Risk for breast cancer and management of unaffected individuals with non-BRCA hereditary breast cancer.
- Wood ME, McKinnon W, Garber J.
- Breast J. 2020 Aug 2. doi: 10.1111/tbj.13969. Epub ahead of print.
- PMID: 32741080
- PubMed abstract
- Source abstract
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- Comparison of Patient Susceptibility Genes Across Breast Cancer: Implications for Prognosis and Therapeutic Outcomes.
- Peleg Hasson S, Menes T, Sonnenblick A.
- Pharmgenomics Pers Med. 2020 Jul 27;13:227-238. doi: 10.2147/PGPM.S233485.
- PMID: 32801835
- PubMed abstract
- Source abstract
- Review
- Free PMC article
- Free Full Text
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- Secondary Prevention in Hereditary Breast and/or Ovarian Cancer Syndromes Other Than BRCA.
- Piombino C, Cortesi L, Lambertini M, Punie K, Grandi G, Angela Toss A.
- J Oncol. 2020 Jul 14;2020:6384190. doi: 10.1155/2020/6384190.
- Review
- Free Full Text
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- New germline mutations in non-BRCA genes among breast cancer women of Mongoloid origin.
- Gervas P, Molokov A, Schegoleva A, Kiselev A, Babyshkina N, Pisareva L, Tyukalov Y, Choynzonov E, Cherdyntseva N.
- Mol Biol Rep. 2020 Jun 29. doi: 10.1007/s11033-020-05612-2. Epub ahead of print.
- PMID: 32601921
- PubMed abstract
- Source abstract
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- DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome.
- Tomasova K, Cumova A, Seborova K, Horak J, Koucka K, Vodickova L, Vaclavikova R, Vodicka P.
- Cancers (Basel). 2020 Jun 28;12(7):E1713. doi: 10.3390/cancers12071713.
- PMID: 32605254
- PubMed abstract
- Source abstract
- Review
- Free Full Text
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- Biomarkers in Triple-Negative Breast Cancer: State-of-the-Art and Future Perspectives.
- Cocco S, Piezzo M, Calabrese A, Cianniello D, Caputo R, Lauro VD, Fusco G, Gioia GD, Licenziato M, Laurentiis M.
- Int J Mol Sci. 2020 Jun 27;21(13):E4579. doi: 10.3390/ijms21134579.
- PMID: 32605126
- PubMed abstract
- Source abstract
- Review
- Free Full Text
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- A comprehensive custom panel evaluation for routine hereditary cancer testing: improving the yield of germline mutation detection.
- Velázquez C, Lastra E, Avila Cobos F, Abella L, de la Cruz V, Hernando BA, Hernández L, Martínez N, Infante M, Durán M.
- J Transl Med. 2020 Jun 10;18(1):232. doi: 10.1186/s12967-020-02391-z.
- PMID: 32522261
- PubMed abstract
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- Frequency of heterozygous germline pathogenic variants in genes for Fanconi anemia in patients with non-BRCA1/BRCA2 breast cancer: a meta-analysis.
- Alter BP, Best AF.
- Breast Cancer Res Treat. 2020 Jun 2. doi: 10.1007/s10549-020-05710-6. Epub ahead of print.
- PMID: 32488392
- PubMed abstract
- Source abstract
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- Identifying Patients With Pancreatic Cancer Likely to Respond.
- Harrison P.
- Medscape. 2020 Jun 2.
- Research news
- Free Full Text
Original research:
Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection.
- PMID: 32444418
- PubMed abstract
- Source abstract
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- Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study.
- Abida W, Campbell D, Patnaik A, Shapiro JD, Sautois B, Vogelzang NJ, Voog EG, Bryce AH, McDermott R, Ricci F, Rowe J, Zhang J, Piulats JM, Fizazi K, Merseburger AS, Higano CS, Krieger LE, Ryan CJ, Feng FY, Simmons AD, Loehr A, Despain D, Dowson M, Green F, Watkins SP, Golsorkhi T, Chowdhury S.
- Clin Cancer Res. 2020 Jun 1;26(11):2487-2496. doi: 10.1158/1078-0432.CCR-20-0394. Epub 2020 Feb 21.
- PMID: 32086346
- PubMed abstract
- Source abstract
Research review:
Honing in on PARPi Response in Prostate Cancer: from HR Pathway to Gene-by-Gene Granularity.
- PMID: 32234758
- PubMed abstract
- Source abstract
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- The contribution of hereditary cancer-related germline mutations to lung cancer susceptibility.
- Liu M, Liu X, Suo P, Gong Y, Qu B, Peng X, Xiao W, Li Y, Chen Y, Zeng Z, Lu Y, Huang T, Zhao Y, Liu M, Li L, Chen Y, Zhou Y, Liu G, Yao J, Chen S, Song L.
- Transl Lung Cancer Res. 2020 Jun;9(3):646-658. doi: 10.21037/tlcr-19-403.
- PMID: 32676327
- PubMed abstract
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- Ancestry-specific predisposing germline variants in cancer.
- Oak N, Cherniack AD, Mashl RJ; TCGA Analysis Network, Hirsch FR, Ding L, Beroukhim R, Gümüs ZH, Plon SE, Huang KL.
- Genome Med. 2020 May 29;12(1):51. doi: 10.1186/s13073-020-00744-3.
- PMID: 32471518
- PubMed abstract
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- Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection.
- Park W, Chen J, Chou JF, Varghese AM, Yu KH, Wong W, Capanu M, Balachandran V, McIntyre CA, El Dika I, Khalil DN, Harding JJ, Ghalehsari N, McKinnell Z, Chalasani SB, Makarov V, Selenica P, Pei X, Lecomte N, Kelsen DP, Abou-Alfa GK, Robson ME, Zhang L, Berger MF, Schultz N, Chan TA, Powell SN, Reis-Filho JS, Iacobuzio-Donahue CA, Riaz N, O'Reilly EM.
- Clin Cancer Res. 2020 May 22. doi: 10.1158/1078-0432.CCR-20-0418. Epub ahead of print.
- PMID: 32444418
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- Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention.
- Gaba F, Blyuss O, Liu X, Goyal S, Lahoti N, Chandrasekaran D, Kurzer M, Kalsi J, Sanderson S, Lanceley A, Ahmed M, Side L, Gentry-Maharaj A, Wallis Y, Wallace A, Waller J, Luccarini C, Yang X, Dennis J, Dunning A, Lee A, Antoniou AC, Legood R, Menon U, Jacobs I, Manchanda R.
- Cancers (Basel). 2020 May 15;12(5):E1241. doi: 10.3390/cancers12051241.
- PMID: 32429029
- PubMed abstract
- Source abstract
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- BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases.
- Suszynska M, Ratajska M, Kozlowski P.
- J Ovarian Res. 2020 May 2;13(1):50. doi: 10.1186/s13048-020-00654-3.
- PMID: 32359370
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- Meta-Analysis
- Free Full Text
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- Development and validation of next generation sequencing based 35-gene hereditary cancer panel.
- Chan W, Lee M, Yeo ZX, Ying D, Grimaldi KA, Pickering C, Yang MMS, Sundaram SK, Tzang LCH.
- Hered Cancer Clin Pract. 2020 Apr 28;18:9. doi: 10.1186/s13053-020-00141-2. eCollection 2020.
- PMID: 32368312
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- Primary fallopian tube carcinoma (PFTC) in a BRIP-1 mutation carrier: the first case report.
- Grandi G, Caroli M, Alboni C, Cortesi L, Toss A, Barbieri E, Botticelli L, Facchinetti F.
- Fam Cancer. 2020 Apr 24. doi: 10.1007/s10689-020-00179-0. [Epub ahead of print]
- PMID: 32328861
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- Evaluation of pathogenetic mutations in breast cancer predisposition genes in population-based studies conducted among Chinese women.
- Zeng C, Guo X, Wen W, Shi J, Long J, Cai Q, Shu XO, Xiang Y, Zheng W.
- Breast Cancer Res Treat. 2020 Apr 21. doi: 10.1007/s10549-020-05643-0. [Epub ahead of print]
- PMID: 32318955
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- Multigene Panel Germline Testing of 1333 Czech Patients with Ovarian Cancer.
- Lhotova K, Stolarova L, Zemankova P, Vocka M, Janatova M, Borecka M, Cerna M, Jelinkova S, Kral J, Volkova Z, Urbanova M, Kleiblova P, Machackova E, Foretova L, Hazova J, Vasickova P, Lhota F, Koudova M, Cerna L, Tavandzis S, Indrakova J, Hruskova L, Kosarova M, Vrtel R, Stranecky V, Kmoch S, Zikan M, Macurek L, Kleibl Z, Soukupova J.
- Cancers (Basel). 2020 Apr 13;12(4). pii: E956. doi: 10.3390/cancers12040956.
- PMID: 32295079
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- [Hereditary breast carcinomas pathologist's perspective].
- Vincent-Salomon A, Bataillon G, Djerroudi L.
- Ann Pathol. 2020 Mar 30. pii: S0242-6498(20)30059-6. doi: 10.1016/j.annpat.2020.02.023. [Epub ahead of print]
- PMID: 32241645
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- Landscape of BRIP1 molecular lesions in gastrointestinal cancers from published genomic studies.
- Voutsadakis IA.
- World J Gastroenterol. 2020 Mar 21;26(11):1197-1207. doi: 10.3748/wjg.v26.i11.1197.
- PMID: 32231423
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- Comparison of BRCA versus non-BRCA germline mutations and associated somatic mutation profiles in patients with unselected breast cancer.
- Chen B, Zhang G, Li X, Ren C, Wang Y, Li K, Mok H, Cao L, Wen L, Jia M, Li C, Guo L, Wei G, Lin J, Li Y, Zhang Y, Han-Zhang H, Liu J, Lizaso A, Liao N.
- Aging (Albany NY). 2020 Feb 24;12(4):3140-3155. doi: 10.18632/aging.102783. Epub 2020 Feb 24.
- PMID: 32091409
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- Genetic testing for epithelial ovarian cancer.
- Amin N, Chaabouni N, George A.
- Best Pract Res Clin Obstet Gynaecol. 2020 Jan 16. pii: S1521-6934(20)30017-1. doi: 10.1016/j.bpobgyn.2020.01.005. [Epub ahead of print]
- PMID: 32122773
- PubMed abstract
- Review
- Free full text
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- Characterization of splice-altering mutations in inherited predisposition to cancer.
- Casadei S, Gulsuner S, Shirts BH, Mandell JB, Kortbawi HM, Norquist BS, Swisher EM, Lee MK, Goldberg Y, O'Connor R, Tan Z, Pritchard CC, King MC, Walsh T.
- Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 201915608. doi: 10.1073/pnas.1915608116. [Epub ahead of print]
- PMID: 31843900
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Comments from NSGC Cancer SIG Discussion Forum
Subject: cBROCA Technology for Detecting Cancer Gene Splicing Variants Published in PNAS
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- Rare BRIP1 missense alleles confer risk for ovarian and breast cancer.
- Moyer CL, Ivanovich J, Gillespie JL, Doberstein R, Radke MR, Richardson ME, Kaufmann SH, Swisher EM, Goodfellow PJ.
- Cancer Res. 2019 Dec 10. pii: canres.1991.2019. doi: 10.1158/0008-5472.CAN-19-1991. [Epub ahead of print]
- PMID: 31822495
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- Analysis of polymorphisms in genes associated with the FA/BRCA pathway in three patients with multiple primary malignant neoplasms.
- Wang L, Wang H, Wang T, Liu J, Chen W, Wang Y, Chen C, Zhu H, Dai P.
- Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1101-1112. doi: 10.1080/21691401.2019.1575846.
- PMID: 30942098
- PubMed abstract
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- Retesting of women who are negative for a BRCA1 and BRCA2 mutation using a 20-gene panel.
- Lerner-Ellis J, Sopik V, Wong A, Lázaro C, Narod SA, Charames GS.
- J Med Genet. 2019 Nov 29. pii: jmedgenet-2019-106403. doi: 10.1136/jmedgenet-2019-106403. [Epub ahead of print]
- PMID: 31784482
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- Identification of germline pathogenic variants in DNA damage repair genes by a next-generation sequencing multigene panel in BRCAX patients.
- Rodríguez-Balada M, Roig B, Melé M, Albacar C, Serrano S, Salvat M, Querol M, Borràs J, Martorell L, Gumà J.
- Clin Biochem. 2019 Nov 28. pii: S0009-9120(19)30856-2. doi: 10.1016/j.clinbiochem.2019.11.014. [Epub ahead of print]
- PMID: 31786208
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- Clinical utility of hereditary cancer panel testing: Impact of PALB2, ATM, CHEK2, NBN, BRIP1, RAD51C, and RAD51D results on patient management and adherence to provider recommendations.
- Vysotskaia V, Kaseniit KE, Bucheit L, Ready K, Price K, Johansen Taber K.
- Cancer. 2019 Nov 4. doi: 10.1002/cncr.32572. [Epub ahead of print]
- PMID: 31682005
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- Landscape of Germline Mutations in DNA Repair Genes for Breast Cancer in Latin America: Opportunities for PARP-Like Inhibitors and Immunotherapy.
- Urbina-Jara LK, Rojas-Martinez A, Martinez-Ledesma E, Aguilar D, Villarreal-Garza C, Ortiz-Lopez R.
- Genes (Basel). 2019 Oct 10;10(10). pii: E786. doi: 10.3390/genes10100786.
- PMID: 31658756
- PubMed abstract
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- Review
- Free Full Text
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- Older breast cancer survivors may harbor hereditary cancer predisposition pathogenic variants and are at risk for clonal hematopoiesis.
- Slavin TP, Sun CL, Chavarri-Guerra Y, Sedrak MS, Katheria V, Castillo D, Herzog J, Dale W, Hurria A, Weitzel JN.
- J Geriatr Oncol. 2019 Sep 28. pii: S1879-4068(19)30174-2. doi: 10.1016/j.jgo.2019.09.004. [Epub ahead of print]
- PMID: 31575519
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- Pathogenic Germline Variants in Patients With Metastatic Breast Cancer.
- Stuttgen K, Croessmann S, Fetting J, Stearns V, Nunes R, Connolly RM, Park BH.
- JAMA Oncol. 2019 Aug 29. doi: 10.1001/jamaoncol.2019.3116. [Epub ahead of print]
- PMID: 31465090
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Press: Hereditary Cancer Risk Variants Found in Significant Subset of Metastatic Breast Cancer Patients. (GenomeWeb)
Research news: Inherited Mutations In Metastatic Breast Cancer Patients. (FORCE. XRAYS.)
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- Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
- Weitzel JN, Neuhausen SL, Adamson A, Tao S, Ricker C, Maoz A, Rosenblatt M, Nehoray B, Sand S, Steele L, Unzeitig G, Feldman N, Blanco AM, Hu D, Huntsman S, Castillo D, Haiman C, Slavin T, Ziv E.
- Cancer. 2019 Jun 17. doi: 10.1002/cncr.32083. [Epub ahead of print]
- PMID: 31206626
- PubMed abstract
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Editorial:
Genetic testing for breast cancer in the Hispanic community.
- PMID: 31206622
- PubMed abstract
- Source abstract
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- The Spectrum of Mutations Predisposing to Familial Breast Cancer in Poland.
- Cybulski C, Kluźniak W, Huzarski T, Wokołorczyk D, Kashyap A, Rusak B, Stempa K, Gronwald J, Szymiczek A, Bagherzadeh M, Jakubowska A, Dębniak T, Lener M, Rudnicka H, Szwiec M, Jarkiewicz-Tretyn J, Stawicka M, Domagała P, Narod SA, Lubiński J, Akbari MR; Polish Hereditary Breast Cancer Consortium.
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Comments on NSGC Discussion Forum Cancer SIG
Subject: BRIP1 Mutation
Subject: Register for the November Cancer SIG Journal Club
Subject: searching for BRIP1 article
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Comments on NSGC Discussion Forum Cancer SIG
Subject: RAD50 Positive Letter
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- Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
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- Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.
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Comments on NSGC Discussion Forum Cancer SIG
Subject: PALB2 and Ovarian Cancer
Comment, Letter
DNA repair mutations and outcomes in ovarian cancer--letter.
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DNA repair mutations and outcomes in ovarian cancer--response.
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