• Das familiäre Pankreaskarzinomsyndrom [Familial pancreatic cancer syndrome].
    • Seifert L, Weitz J.
    • Chirurgie (Heidelb). 2023 Feb 17. German. doi: 10.1007/s00104-023-01819-8. Epub ahead of print.
    • Review. [Article in German]
    • Socioeconomic Factors Are Associated With Disparities in Germline Testing in Pancreatic Cancer.
    • King D, Scott R.
    • OncLive. 2023 Feb 5.
    • Risk Assessment and Pancreatic Cancer: Diagnostic Management and Artificial Intelligence.
    • Granata V, Fusco R, Setola SV, Galdiero R, Maggialetti N, Silvestro L, De Bellis M, Di Girolamo E, Grazzini G, Chiti G, Brunese MC, Belli A, Patrone R, Palaia R, Avallone A, Petrillo A, Izzo F.
    • Cancers (Basel). 2023 Jan 5;15(2):351. doi: 10.3390/cancers15020351.
    • Expert consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the determination of biomarkers in pancreatic and biliary tract cancer.
    • Vera R, Ibarrola-de Andrés C, Adeva J, Pérez-Rojas J, García-Alfonso P, Rodríguez-Gil Y, Macarulla T, Serrano-Piñol T, Mondéjar R, Madrigal-Rubiales B.
    • Rev Esp Patol. 2023 Jan-Mar;56(1):32-44. doi: 10.1016/j.patol.2022.06.004. Epub 2022 Aug 26.
    • Review
    • THE IMPACT OF PANCREATIC CANCER SCREENING ON LIFE EXPECTANCY: A SYSTEMATIC REVIEW OF MODELLING STUDIES.
    • Koopmann BDM, Omidvari AH, Lansdorp-Vogelaar I, Cahen DL, Bruno MJ, de Kok IMCM.
    • Int J Cancer. 2022 Nov 28. doi: 10.1002/ijc.34379. Epub ahead of print.
    • Review
    • Pancreatic Tumorigenesis: Precursors, Genetic Risk Factors and Screening.
    • Badheeb M, Abdelrahim A, Esmail A, Umoru G, Abboud K, Al-Najjar E, Rasheed G, Alkhulaifawin M, Abudayyeh A, Abdelrahim M.
    • Curr Oncol. 2022 Nov 15;29(11):8693-8719. doi: 10.3390/curroncol29110686.
    • Pancreatic Cancer Screening Appears Safe, Effective for High-Risk Patients.
    • Crist C.
    • Medscape Oncology. 2022 Oct 26.
    • Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline.
    • Sessa C, Balmaña J, Bober SL, Cardoso MJ, Colombo N, Curigliano G, Domchek SM, Evans DG, Fischerova D, Harbeck N, Kuhl C, Lemley B, Levy-Lahad E, Lambertini M, Ledermann JA, Loibl S, Phillips KA, Shimon P; ESMO Guidelines Committee.
    • Ann Oncol. 2022 Oct 19:S0923-7534(22)04193-X. doi: 10.1016/j.annonc.2022.10.004. Epub ahead of print.
    • The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival.
    • Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Blackford AL, Rustgi AK, Dudley B, Lee LS, Chhoda A, Kwon R, Ginsberg GG, Klein AP, Kamel I, Hruban RH, He J, Shin EJ, Lennon AM, Canto MI, Goggins M.
    • J Clin Oncol. 2022 Oct 1;40(28):3257-3266. doi: 10.1200/JCO.22.00298. Epub 2022 Jun 15.

    Commentary:

    Building on More Than 20 Years of Progress in Pancreatic Cancer Surveillance for High-Risk Individuals.

    Research news: Screening for pancreatic cancer detects early-stage disease and improves survival. (FORCE XRAY)

    • Cribado de cáncer de páncreas en la práctica clínica: es el momento de la prevención [Pancreatic cancer screening in a clinical practice setting: it is the moment of Prevention].
    • Adán-Merino L, Mora-Soler A, Zaera-De la Fuente C, Garrido-Gallego F, Crivillén-Anguita O, Ponferrada-Diaz Á.
    • Rev Gastroenterol Peru. 2022 Oct-Dec;42(4):234-241. Spanish.
    • Controversies and Open Questions in Management of Cancer-Free Carriers of Germline Pathogenic Variants in BRCA1/BRCA2.
    • Bernstein-Molho R, Friedman E, Evron E.
    • Cancers (Basel). 2022 Sep 22;14(19):4592. doi: 10.3390/cancers14194592.
    • Frequent abnormal pancreas imaging in patients with pathogenic ATM, BRCA1, BRCA2, and PALB2 breast cancer susceptibility variants.
    • Lucas AL, Fu Y, Labiner A, DiMaio CJ, Sethi A, Kastrinos F.
    • Clin Gastroenterol Hepatol. 2022 Sep 7:S1542-3565(22)00836-9. doi: 10.1016/j.cgh.2022.08.040. Epub ahead of print.
    • Survey
    • Identification of high-risk germline variants for the development of pancreatic cancer: Common characteristics and potential guidance to screening guidelines.
    • Bennett C, Suguitan M, Abad J, Chawla A.
    • Pancreatology. 2022 Sep;22(6):719-729. doi: 10.1016/j.pan.2022.05.005. Epub 2022 May 27.
    • Review
    • Genetic testing to guide screening for pancreatic ductal adenocarcinoma: Results of a microsimulation model.
    • Peters MLB, Eckel A, Lietz A, Seguin C, Mueller P, Hur C, Pandharipande PV.
    • Pancreatology. 2022 Sep;22(6):760-769. doi: 10.1016/j.pan.2022.05.003. Epub 2022 May 31.
    • Screening for pancreatic cancer detects early-stage disease and improves survival.
    • [No author given]
    • FORCE. XRAY. 2022 Aug 30.

    Original research:

    The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival.

    • Reaching beyond family history as inclusion criteria for pancreatic cancer surveillance in high-risk populations.
    • Wang L, Domchek SM, Kochman ML, Katona BW.
    • Genes Cancer. 2022 Aug 29;13:49-51. doi: 10.18632/genesandcancer.223.
    • Current Screening Strategies for Pancreatic Cancer.
    • Vanek P, Urban O, Zoundjiekpon V, Falt P.
    • Biomedicines. 2022 Aug 23;10(9):2056. doi: 10.3390/biomedicines10092056.
    • Association Between Family History and Risk of Pancreatic Cancer in Patients With BRCA1 and BRCA2 Pathogenic Variants.
    • Shah I, Silva-Santisteban A, Germansky KA, Kandasamy C, Mlabasati J, Huang DC, Wadhwa V, Bilal M, Sawhney MS.
    • Pancreas. 2022 Aug 1;51(7):733-738. doi: 10.1097/MPA.0000000000002104.
    • Impact of comprehensive family history and genetic analysis in the multidisciplinary pancreatic tumor clinic setting.
    • Everett JN, Dettwyler SA, Jing X, Stender C, Schmitter M, Baptiste A, Chun J, Kawaler EA, Khanna LG, Gross SA, Gonda TA, Beri N, Oberstein PE, Simeone DM.
    • Cancer Med. 2022 Jul 30. doi: 10.1002/cam4.5059. Epub ahead of print.
    • Germline Aberrations in Pancreatic Cancer: Implications for Clinical Care.
    • Casolino R, Corbo V, Beer P, Hwang CI, Paiella S, Silvestri V, Ottini L, Biankin AV.
    • Cancers (Basel). 2022 Jun 30;14(13):3239. doi: 10.3390/cancers14133239.
    • Current status of inherited pancreatic cancer.
    • Olakowski M, Buldak L.
    • Hered Cancer Clin Pract. 2022 Jun 27;20(1):26. doi: 10.1186/s13053-022-00224-2.
    • Intraductal Papillary Mucinous Neoplasms in Hereditary Cancer Syndromes.
    • Ardeshna DR, Rangwani S, Cao T, Pawlik TM, Stanich PP, Krishna SG.
    • Biomedicines. 2022 Jun 22;10(7):1475. doi: 10.3390/biomedicines10071475.
    • ASGE Expands BRCA Screening for Pancreatic Cancer.
    • [No author given]
    • Inside Precision Medicine. Topics. Oncology. 2022 Jun 9.

    Guideline summary:

    ASGE guideline on screening for pancreatic cancer in individuals with genetic susceptibility: summary and recommendations.

    Guideline:

    American Society for Gastrointestinal Endoscopy guideline on screening for pancreatic cancer in individuals with genetic susceptibility: methodology and review of evidence.

    • ASGE guideline on screening for pancreatic cancer in individuals with genetic susceptibility: summary and recommendations.
    • Sawhney MS, Calderwood AH, Thosani NC, Rebbeck TR, Wani S, Canto MI, Fishman DS, Golan T, Hidalgo M, Kwon RS, Riegert-Johnson DL, Sahani DV, Stoffel EM, Vollmer CM Jr, Qumseya BJ; Prepared by: ASGE STANDARDS OF PRACTICE COMMITTEE.
    • Gastrointest Endosc. 2022 May;95(5):817-826. doi: 10.1016/j.gie.2021.12.001. Epub 2022 Feb 16.

    Guideline:

    American Society for Gastrointestinal Endoscopy guideline on screening for pancreatic cancer in individuals with genetic susceptibility: methodology and review of evidence.

    Video: 2022 May Author Interview-Bashar Qumseya, Mandeep S. Sawhney, and Audrey H. Calderwood. (Author Interview Series / YouTube)

    News: ASGE Expands BRCA Screening for Pancreatic Cancer. (Inside Precision Medicine)

    • Longitudinal changes of serum protein N-Glycan levels for earlier detection of pancreatic cancer in high-risk individuals.
    • Levink IJM, Klatte DCF, Hanna-Sawires RG, Vreeker GCM, Ibrahim IS, van der Burgt YEM, Overbeek KA, Koopmann BDM, Cahen DL, Fuhler GM, Wuhrer M, Bonsing BA, Tollenaar RAEM, Vleggaar FP, Vasen HFA, van Leerdam ME, Bruno MJ, Mesker WE.
    • Pancreatology. 2022 May;22(4):497-506. doi: 10.1016/j.pan.2022.03.021. Epub 2022 Apr 4.
    • Molecular Features and Clinical Management of Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer.
    • Kasuga A, Okamoto T, Udagawa S, Mori C, Mie T, Furukawa T, Yamada Y, Takeda T, Matsuyama M, Sasaki T, Ozaka M, Ueki A, Sasahira N.
    • Int J Mol Sci. 2022 Jan 21;23(3):1205. doi: 10.3390/ijms23031205.
    • Association of BRCA Mutations and Pancreatic Cancer: Review of Literature and Meta-analysis.
    • Chandan S, Deliwala SS, Facciorusso A, Mohan BP, Ramai D, Kochhar GS.
    • Pancreas. 2022 Jan 1;51(1):e8-e10. doi: 10.1097/MPA.0000000000001956.
    • Meta-Analysis
    • Familial Predisposition and Genetic Risk Factors Associated with Pancreatic Cancer.
    • Rustgi SD, Hilfrank KJ, Kastrinos F.
    • Gastrointest Endosc Clin N Am. 2022 Jan;32(1):1-12. doi: 10.1016/j.giec.2021.09.001.
    • Review
    • Pancreatic Cancer Surveillance and Novel Strategies for Screening.
    • Dudley B, Brand RE.
    • Gastrointest Endosc Clin N Am. 2022 Jan;32(1):13-25. doi: 10.1016/j.giec.2021.08.008.
    • Review
    • Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study.
    • Furniss CS, Yurgelun MB, Ukaegbu C, Constantinou PE, Lafferty CC, Talcove-Berko ER, Schwartz AN, Stopfer JE, Underhill-Blazey M, Kenner B, Nelson SH, Okumura S, Law S, Zhou AY, Coffin TB, Rodriguez NJ, Uno H, Ocean AJ, McAllister F, Lowy AM, Lippman SM, Klein AP, Madlensky L, Petersen GM, Garber JE, Goggins MG, Maitra A, Syngal S.
    • Cancer Prev Res (Phila). 2021 Nov;14(11):1021-1032. doi: 10.1158/1940-6207.CAPR-20-0642. Epub 2021 Oct 8.
    • Hereditary pancreatic cancer.
    • Abe K, Kitago M, Kitagawa Y, Hirasawa A.
    • Int J Clin Oncol. 2021 Sep 2. doi: 10.1007/s10147-021-02015-6. Epub ahead of print.
    • EUS-based pancreatic cancer surveillance in BRCA1/BRCA2/PALB2/ATM carriers without a family history of pancreatic cancer.
    • Katona BW, Long JM, Ahmad NA, Attalla S, Bradbury AR, Carpenter EL, Clark DF, Constantino G, Das KK, Domchek SM, Dudzik C, Ebrahimzadeh J, Ginsberg GG, Heiman J, Kochman ML, Maxwell KN, McKenna DB, Powers J, Shah PD, Wangensteen KJ, Rustgi AK.
    • Cancer Prev Res (Phila). 2021 Aug 2:canprevres.0161.2021. doi: 10.1158/1940-6207.CAPR-21-0161. Epub ahead of print.
    • Cancer surveillance awareness and practice among families at increased risk for pancreatic adenocarcinoma.
    • Everett JN, Burgos G, Chun J, Baptiste A, Khanna LG, Oberstein PE, Simeone DM.
    • Cancer. 2021 Jul 1;127(13):2271-2278. doi: 10.1002/cncr.33500. Epub 2021 Mar 15.
    • Biologic behavior of resected BRCA-mutated pancreatic cancer: Comparison with sporadic pancreatic cancer and other BRCA-related cancers.
    • Kim SH, Kang CM.
    • Ann Hepatobiliary Pancreat Surg. 2021 Jun 30;25(Suppl 1):S149. doi: 10.14701/ahbps.BP-PP-1-2.
    • Pancreas in Hereditary Syndromes: Cross-sectional Imaging Spectrum.
    • Katabathina VS, Buddha S, Rajebi H, Shah JN, Morani AC, Lubner MG, Dasyam A, Nazarullah A, Menias CO, Prasad SR.
    • Radiographics. 2021 Jun 18:200164. doi: 10.1148/rg.2021200164. Epub ahead of print.
    • Combined modality therapy including cytoreductive surgery and heated intraperitoneal chemotherapy for synchronous low volume peritoneal carcinomatosis from adenocarcinoma of the tail of pancreas in a BRCA-2 carrier resulting in long-term disease-free survival: A case report.
    • Hoefer RA, Obiora C, Azab B, Harden EA, Kessler JF.
    • Int J Surg Case Rep. 2021 Jun;83:106047. doi: 10.1016/j.ijscr.2021.106047. Epub 2021 May 29.
    • Genetic Variants in Patients With a Family History of Pancreatic Cancer: Impact of Multigene Panel Testing.
    • Zhu H, Welinsky S, Soper ER, Brown KL, Abul-Husn NS, Lucas AL.
    • Pancreas. 2021 Apr 1;50(4):602-606. doi: 10.1097/MPA.0000000000001804.
    • Biologic behavior of resected BRCA-mutated pancreatic cancer: Comparison with sporadic pancreatic cancer and other BRCA-related cancers.
    • Kim SH, Hwang HK, Lee WJ, Kang CM.
    • Pancreatology. 2021 Feb 14:S1424-3903(21)00057-0. doi: 10.1016/j.pan.2021.02.007. Epub ahead of print.
    • Germline pathogenic variants in the Ataxia Telangiectasia Mutated (ATM) gene are associated with high and moderate risks for multiple cancers.
    • Hall MJ, Bernhisel R, Hughes E, Larson K, Rosenthal ET, Singh NA, Lancaster JM, Kurian AW.
    • Cancer Prev Res (Phila). 2021 Jan 28:canprevres.0448.2020. doi: 10.1158/1940-6207.CAPR-20-0448. Epub ahead of print.
    • Predictive Factors for Pancreatic Cancer and Its Early Detection Using Special Pancreatic Ultrasonography in High-Risk Individuals.
    • Fukuda J, Ikezawa K, Nakao M, Okagaki S, Ashida R, Ioka T, Takada R, Yamai T, Fukutake N, Uehara H, Nagata S, Takahashi H, Tabuchi T, Tanaka S, Ohkawa K, Katayama K.
    • Cancers (Basel). 2021 Jan 28;13(3):502. doi: 10.3390/cancers13030502.
    • Outcomes of endoscopic ultrasound as a one-off pancreatic cancer screening tool for 122 high- and moderate-risk patients.
    • Efthymiou M, Chandran S, Zorron Cheng Tao Pu L, Collins A, Rajadurai A, Nikfarjam M, Vaughan R.
    • JGH Open. 2020 Oct 17 [eCollection 2020 Dec];4(6):1217-1223. doi: 10.1002/jgh3.12432.
    • Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants: Results From the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).
    • Silvestri V, Leslie G, Barnes DR; and the CIMBA Group, Agnarsson BA, Aittomäki K, Alducci E, Andrulis IL, Barkardottir RB, Barroso A, Barrowdale D, Benitez J, Bonanni B, Borg A, Buys SS, Caldés T, Caligo MA, Capalbo C, Campbell I, Chung WK, Claes KBM, Colonna SV, Cortesi L, Couch FJ, de la Hoya M, Diez O, Ding YC, Domchek S, Easton DF, Ejlertsen B, Engel C, Evans DG, Feliubadalò L, Foretova L, Fostira F, Géczi L, Gerdes AM, Glendon G, Godwin AK, Goldgar DE, Hahnen E, Hogervorst FBL, Hopper JL, Hulick PJ, Isaacs C, Izquierdo A, James PA, Janavicius R, Jensen UB, John EM, Joseph V, Konstantopoulou I, Kurian AW, Kwong A, Landucci E, Lesueur F, Loud JT, Machackova E, Mai PL, Majidzadeh-A K, Manoukian S, Montagna M, Moserle L, Mulligan AM, Nathanson KL, Nevanlinna H, Ngeow Yuen Ye J, Nikitina-Zake L, Offit K, Olah E, Olopade OI, Osorio A, Papi L, Park SK, Pedersen IS, Perez-Segura P, Petersen AH, Pinto P, Porfirio B, Pujana MA, Radice P, Rantala J, Rashid MU, Rosenzweig B, Rossing M, Santamariña M, Schmutzler RK, Senter L, Simard J, Singer CF, Solano AR, Southey MC, Steele L, Steinsnyder Z, Stoppa-Lyonnet D, Tan YY, Teixeira MR, Teo SH, Terry MB, Thomassen M, Toland AE, Torres-Esquius S, Tung N, van Asperen CJ, Vega A, Viel A, Vierstraete J, Wappenschmidt B, Weitzel JN, Wieme G, Yoon SY, Zorn KK, McGuffog L, Parsons MT, Hamann U, Greene MH, Kirk JA, Neuhausen SL, Rebbeck TR, Tischkowitz M, Chenevix-Trench G, Antoniou AC, Friedman E, Ottini L.
    • JAMA Oncol. 2020 Jul 2. doi: 10.1001/jamaoncol.2020.2134. Epub ahead of print.
    • Small Steps in Pancreatic Cancer – Episode 2: Relatives at Risk.
    • McAllister F, Maitra A, Burton M, McGuire M..
    • Medscape. 2020 Jun 25.
    • Cancer Surveillance in Healthy Carriers of Germline Pathogenic Variants in BRCA1/2: A Review of Secondary Prevention Guidelines.
    • Dullens B, de Putter R, Lambertini M, Toss A, Han S, Van Nieuwenhuysen E, Van Gorp T, Vanderstichele A, Van Ongeval C, Keupers M, Prevos R, Celis V, Dekervel J, Everaerts W, Wildiers H, Nevelsteen I, Neven P, Timmerman D, Smeets A, Denayer E, Van Buggenhout G, Legius E, Punie K.
    • J Oncol. 2020 Jun 20;2020:9873954. doi: 10.1155/2020/9873954.
    • AGA Clinical Practice Update on Pancreas Cancer Screening in High Risk Individuals: Expert Review.
    • Aslanian HR, Lee JH, Canto MI.
    • Gastroenterology. 2020 May 13:S0016-5085(20)30657-0. doi: 10.1053/j.gastro.2020.03.088. Epub ahead of print.
    • Review, Practice Guideline
    • AGA Clinical Practice Update on Colorectal and Pancreatic Cancer Risk and Screening in BRCA1 and BRCA2 carriers: Commentary.
    • Kupfer SS, Gupta S, Weitzel JN, Samadder J.
    • Gastroenterology. 2020 Apr 23. pii: S0016-5085(20)30562-X. doi: 10.1053/j.gastro.2020.03.086. [Epub ahead of print]
    • NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020.
    • Daly MB, Pilarski R, Yurgelun MB, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Garber JE, Goggins M, Hutton ML, Khan S, Klein C, Kohlmann W, Kurian AW, Laronga C, Litton JK, Mak JS, Menendez CS, Merajver SD, Norquist BS, Offit K, Pal T, Pederson HJ, Reiser G, Shannon KM, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Dwyer MA, Darlow SD.
    • J Natl Compr Canc Netw. 2020 Apr;18(4):380-391. doi: 10.6004/jnccn.2020.0017.

    Continuing Education course: NCCN Guidelines® Insights - Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020. (NCCN Continuing Education)

    • Patient-reported burden of intensified surveillance and surgery in high-risk individuals under pancreatic cancer surveillance.
    • Overbeek KA, Cahen DL, Kamps A, Konings ICAW, Harinck F, Kuenen MA, Koerkamp BG, Besselink MG, van Eijck CH, Wagner A, Ausems MGE, van der Vlugt M, Fockens P, Vleggaar FP, Poley JW, van Hooft JE, Bleiker EMA, Bruno MJ; Dutch Familial Pancreatic Cancer Surveillance Study Group.
    • Fam Cancer. 2020 Mar 19. doi: 10.1007/s10689-020-00171-8. [Epub ahead of print]
    • Hereditary and Sporadic Pancreatic Ductal Adenocarcinoma: Current Update on Genetics and Imaging.
    • Morani AC, Hanafy AK, Ramani NS, Katabathina VS, Yedururi S, Dasyam AK, Prasad SR.
    • Radiol Imaging Cancer. 2020 Mar 13;2(2):e190020. doi: 10.1148/rycan.2020190020.
    • The emotional impact of surveillance programs for pancreatic cancer on high-risk individuals: A prospective analysis.
    • Paiella S, Marinelli V, Secchettin E, Mazzi MA, Ferretto F, Casolino R, Bassi C, Salvia R.
    • Psychooncology. 2020 Feb 27. doi: 10.1002/pon.5370. [Epub ahead of print]
    • Health Care Provider Perceptions of Caring for Individuals with Inherited Pancreatic Cancer Risk.
    • Underhill ML, Pozzar R, Chung D, Sawhney M, Yurgelun M.
    • J Cancer Educ. 2020 Feb;35(1):194-203. doi: 10.1007/s13187-019-01623-1.
    • Update: Genetic causes of hereditary pancreatic cancer: BRCA and beyond
    • [No author given]
    • FORCE. XRAYS. 2019 Nov 26.
    • Surveillance of Individuals with a Family History of Pancreatic Cancer and Inherited Cancer Syndromes: A Strategy for Detecting Early Pancreatic Cancers.
    • Matsubayashi H, Kiyozumi Y, Ishiwatari H, Uesaka K, Kikuyama M, Ono H.
    • Diagnostics (Basel). 2019 Oct 31;9(4). pii: E169. doi: 10.3390/diagnostics9040169.
    • Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium.
    • Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman E, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M; International Cancer of the Pancreas Screening (CAPS) consortium.
    • Gut. 2019 Oct 31. pii: gutjnl-2019-319352. doi: 10.1136/gutjnl-2019-319352. [Epub ahead of print]

    Press: At-Risk Individuals Need Surveillance for Familial Pancreatic Cancer. (Medscape/Reuters)

    • Abdominal Imaging of Pancreatic Cysts and Cyst-Associated Pancreatic Cancer in BRCA1/2 Mutation Carriers: A Retrospective Cross-Sectional Study.
    • Cao CX, Sharib JS, Blanco AM, Goldberg D, Bracci P, Mukhtar RA, Esserman LJ, Kirkwood KS.
    • J Am Coll Surg. 2019 Oct 21. pii: S1072-7515(19)32137-4. doi: 10.1016/j.jamcollsurg.2019.09.019. [Epub ahead of print]
    • Long-term positive psychological outcomes in an Australian pancreatic cancer screening program.
    • O'Neill RS, Meiser B, Emmanuel S, Williams DB, Stoita A.
    • Fam Cancer. 2019 Oct 17. doi: 10.1007/s10689-019-00147-3. [Epub ahead of print]
    • Screening for Pancreatic Cancer.
    • Lucas AL, Kastrinos F.
    • JAMA. 2019 Aug 6;322(5):407-408. doi: 10.1001/jama.2019.9690.

    Guidelines:

    Screening for Pancreatic Cancer: US Preventive Services Task Force Reaffirmation Recommendation Statement.

    Editorial:

    Screening for Pancreatic Cancer Gets a D, But the Student Is Improving.

    Editorial:

    Screening for Pancreatic Cancer-Is There Hope?

    • Pilot study of rapid MR pancreas screening for patients with BRCA mutation.
    • Corrias G, Raeside MC, Agostini A, Huicochea-Castellanos S, Aramburu-Nunez D, Paudyal R, Shukla-Dave A, Smelianskaia O, Capanu M, Zheng J, Fung M, Kelsen DP, Mangino DA, Robson ME, Goldfrank DJ, Carter J, Allen PJ, Conti B, Monti S, Do RKG, Mannelli L.
    • Eur Radiol. 2019 Aug;29(8):3976-3985. doi: 10.1007/s00330-018-5975-0. Epub 2019 Jan 28.
    • Outcome of Pancreatic Cancer Surveillance Among High-Risk Individuals Tested for Germline Mutations in BRCA1 and BRCA2.
    • Saldia A, Olson SH, Nunes P, Liang X, Samson ML, Salo-Mullen E, Marcell V, Stadler ZK, Allen PJ, Offit K, Kurtz RC.
    • Cancer Prev Res (Phila). 2019 Jul 23. pii: canprevres.0272.2018. doi: 10.1158/1940-6207.CAPR-18-0272. [Epub ahead of print]
    • Pancreatic cancer in young adults: changes, challenges, and solutions.
    • Primavesi F, Stättner S, Schlick K, Kiesslich T, Mayr C, Klieser E, Urbas R, Neureiter D.
    • Onco Targets Ther. 2019 May 6;12:3387-3400. doi: 10.2147/OTT.S176700. eCollection 2019.
    • Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance.
    • Abe T, Blackford AL, Tamura K, Ford M, McCormick P, Chuidian M, Almario JA, Borges M, Lennon AM, Shin EJ, Klein AP, Hruban RH, Canto MI, Goggins M.
    • J Clin Oncol. 2019 May 1;37(13):1070-1080. doi: 10.1200/JCO.18.01512. Epub 2019 Mar 18.
    • Are BRCA1 and BRCA2 gene mutation patients underscreened for pancreatic adenocarcinoma?
    • Roch AM, Schneider J, Carr RA, Lancaster WP, House MG, Zyromski NJ, Nakeeb A, Schmidt CM, Ceppa EP.
    • J Surg Oncol. 2019 May;119(6):777-783. doi: 10.1002/jso.25376. Epub 2019 Jan 12.
    • Results of First-Round of Surveillance in Individuals at High-Risk of Pancreatic Cancer from the AISP (Italian Association for the Study of the Pancreas) Registry.
    • Paiella S, Capurso G, Cavestro GM, Butturini G, Pezzilli R, Salvia R, Signoretti M, Crippa S, Carrara S, Frigerio I, Bassi C, Falconi M, Iannicelli E, Giardino A, Mannucci A, Laghi A, Laghi L, Frulloni L, Zerbi A.
    • Am J Gastroenterol. 2019 Apr;114(4):665-670. doi: 10.1038/s41395-018-0414-z.
    • Chronic pancreatitis changes in high-risk individuals for pancreatic ductal adenocarcinoma.
    • Thiruvengadam SS, Chuang J, Huang R, Girotra M, Park WG.
    • Gastrointest Endosc. 2019 Apr;89(4):842-851.e1. doi: 10.1016/j.gie.2018.08.029. Epub 2018 Aug 24.
    • Familial Pancreatic Cancer and Surveillance of High-Risk Individuals.
    • Matsubayashi H, Takaori K, Morizane C, Kiyozumi Y.
    • Gut Liver. 2019 Mar 26. doi: 10.5009/gnl18449. [Epub ahead of print]
    • Genomic Features and Clinical Management of Patients with Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer.
    • Ohmoto A, Yachida S, Morizane C.
    • Int J Mol Sci. 2019 Jan 29;20(3). pii: E561. doi: 10.3390/ijms20030561.
    • Current Approaches to Pancreatic Cancer Screening.
    • Chhoda A, Lu L, Clerkin BM, Risch H, Farrell JJ.
    • Am J Pathol. 2019 Jan;189(1):22-35. doi: 10.1016/j.ajpath.2018.09.013.
    • The Role of BRCA Testing in Hereditary Pancreatic and Prostate Cancer Families.
    • Pilarski R.
    • Am Soc Clin Oncol Educ Book. 2019 Jan;(39):79-86. doi: 10.1200/EDBK_238977.
    • Sequencing Pancreatic Juice: Squeezing the Most Out of Surveillance.
    • Lipner MB, Yeh JJ.
    • Clin Cancer Res. 2018 Jun 15;24(12):2713-2715. doi: 10.1158/1078-0432.CCR-18-0215. Epub 2018 Mar 2.
    • Review
    • Malignant Abnormalities in Male BRCA Mutation Carriers: Results From a Prospectively Screened Cohort.
    • Mano R, Tamir S, Kedar I, Benjaminov O, Baniel J, Tabachnik T, Margel D.
    • JAMA Oncol. 2018 Jun 1;4(6):872-874. doi: 10.1001/jamaoncol.2018.0271.
    • Pancreatic cancer screening in high-risk individuals with germline genetic mutations.
    • DaVee T, Coronel E, Papafragkakis C, Thaiudom S, Lanke G, Chakinala RC, Nogueras González GM, Bhutani MS, Ross WA, Weston BR, Lee JH.
    • Gastrointest Endosc. 2018 Jun;87(6):1443-1450. doi: 10.1016/j.gie.2017.12.019. Epub 2018 Jan 5.
    • Results of surveillance in individuals at high-risk of pancreatic cancer: A systematic review and meta-analysis.
    • Signoretti M, Bruno MJ, Zerboni G, Poley JW, Delle Fave G, Capurso G.
    • United European Gastroenterol J. 2018 May;6(4):489-499. doi: 10.1177/2050640617752182. Epub 2018 Jan 8.
    • The importance of a well-structured pancreatic screening program for familial and hereditary pancreatic cancer.
    • Vasen HFA.
    • Fam Cancer. 2018 Jan;17(1):1-3. doi: 10.1007/s10689-017-0066-y.

    Development of a high risk pancreatic screening clinic using 3.0 T MRI.

    • Development of a high risk pancreatic screening clinic using 3.0 T MRI.
    • Barnes CA, Krzywda E, Lahiff S, McDowell D, Christians KK, Knechtges P, Tolat P, Hohenwalter M, Dua K, Khan AH, Evans DB, Geurts J, Tsai S.
    • Fam Cancer. 2018 Jan;17(1):101-111. doi: 10.1007/s10689-017-0057-z.

    Editorial, Research Introduction: The importance of a well-structured pancreatic screening program for familial and hereditary pancreatic cancer. (Familial Cancer)

    • Risk factors, biomarker and imaging techniques used for pancreatic cancer screening.
    • Thomas C.
    • Chin Clin Oncol. 2017 Dec;6(6):61. doi: 10.21037/cco.2017.12.06.
    • Pancreatic Cancer Screening.
    • Das KK, Early D.
    • Curr Treat Options Gastroenterol. 2017 Dec;15(4):562-575. doi: 10.1007/s11938-017-0149-8.
    • Review
    • Familial Pancreatic Cancer and the Future of Directed Screening.
    • Welinsky S, Lucas AL.
    • Gut Liver. 2017 Nov 15;11(6):761-770. doi: 10.5009/gnl16414.
    • Targeting reactive nitrogen species suppresses hereditary pancreatic cancer.
    • Li M, Chen Q, Ma T, Yu X.
    • Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7106-7111. doi: 10.1073/pnas.1702156114. Epub 2017 Jun 19.
    • Hereditary pancreatic cancer: related syndromes and clinical perspective.
    • Carrera S, Sancho A, Azkona E, Azkuna J, Lopez-Vivanco G.
    • Hered Cancer Clin Pract. 2017 Jun 28;15:9. doi: 10.1186/s13053-017-0069-6. eCollection 2017.
    • Pancreatic Adenocarcinoma: Improving Prevention and Survivorship.
    • Sohal DPS, Willingham FF, Falconi M, Raphael KL, Crippa S.
    • Am Soc Clin Oncol Educ Book. [Presented Monday, June 5, 2017.] 2017;37:301-310. doi: 10.14694/EDBK_175222.
    • Pancreatic Adenocarcinoma: Improving Prevention and Survivorship.
    • Sohal DPS, Willingham FF, Falconi M, Raphael KL, Crippa S.
    • Am Soc Clin Oncol Educ Book. 2017 May;(37):301-310. doi: 10.1200/EDBK_175222.
    • Germline mutations in pancreatic cancer and potential new therapeutic options.
    • Pihlak R, Valle JW, McNamara MG.
    • Oncotarget. 2017 Apr 20;8(42):73240-73257. doi: 10.18632/oncotarget.17291. eCollection 2017 Sep 22.
    • Familial pancreatic cancer: Concept, management and issues.
    • Matsubayashi H, Takaori K, Morizane C, Maguchi H, Mizuma M, Takahashi H, Wada K, Hosoi H, Yachida S, Suzuki M, Usui R, Furukawa T, Furuse J, Sato T, Ueno M, Kiyozumi Y, Hijioka S, Mizuno N, Terashima T, Mizumoto M, Kodama Y, Torishima M, Kawaguchi T, Ashida R, Kitano M, Hanada K, Furukawa M, Kawabe K, Majima Y, Shimosegawa T.
    • World J Gastroenterol. 2017 Feb 14;23(6):935-948. doi: 10.3748/wjg.v23.i6.935.
    • Pancreatic panniculitis as a paraneoplastic phenomenon of a pancreatic acinar cell carcinoma.
    • Naeyaert C, de Clerck F, De Wilde V.
    • Acta Clin Belg. 2016 Dec;71(6):448-450. Epub 2016 Apr 26.
    • Case report
    • Prevention and Screening in Hereditary Breast and Ovarian Cancer.
    • Zeichner SB, Stanislaw C, Meisel JL.
    • Oncology (Williston Park). 2016 Oct 15;30(10). pii: 219285.

    Commentary

    Clinical Hereditary Cancer Syndromes and Gene Panel Testing.

    • BRCA2: a grown-up cancer susceptibility gene.
    • Foulkes WD, Sugano K.
    • Endocr Relat Cancer. 2016 Oct;23(10):E1-E3.

    Review:

    BRCA2 functions: from DNA repair to replication fork stabilization.

    Review:

    Defects in homologous recombination repair behind the human diseases: FA and HBOC.

    Review:

    Synthetic lethality: the road to novel therapies for breast cancer.

    Review:

    Pancreatic ductal adenocarcinoma in BRCA2 mutation carriers.

    Review:

    Modifiers of breast and ovarian cancer risks for BRCA1 and BRCA2 mutation carriers.

    • Pancreatic ductal adenocarcinoma in BRCA2 mutation carriers.
    • de Mestier L, Danset JB, Neuzillet C, Rebours V, Cros J, Soufir N, Hammel P.
    • Endocr Relat Cancer. 2016 Oct;23(10):T57-T67. Epub 2016 Aug 10.

    Introductory article, Editorial:

    BRCA2: a grown-up cancer susceptibility gene.

    • Insights on Hereditary Pancreatic Cancer.
    • Michael J Hall
    • FORCE. Be Empowered Webinars. 2016 Sep 6.
    • Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers.
    • Vasen H, Ibrahim I, Ponce CG, Slater EP, Matthäi E, Carrato A, Earl J, Robbers K, van Mil AM, Potjer T, Bonsing BA, de Vos Tot Nederveen Cappel WH, Bergman W, Wasser M, Morreau H, Klöppel G, Schicker C, Steinkamp M, Figiel J, Esposito I, Mocci E, Vazquez-Sequeiros E, Sanjuanbenito A, Muñoz-Beltran M, Montans J, Langer P, Fendrich V, Bartsch DK.
    • J Clin Oncol. 2016 Jun 10;34(17):2010-9. doi: 10.1200/JCO.2015.64.0730. Epub 2016 Apr 25.

    Editorial

    Progress in the Earlier Detection of Pancreatic Cancer.

    Press: Pancreatic Cancer Surveillance Worth It in High-Risk Patients. (Medscape Oncology)

    • Screening for Pancreatic Cancer in High-risk Populations.
    • Grover S, Jajoo K.
    • Gastroenterol Clin North Am. 2016 Mar;45(1):117-27. doi: 10.1016/j.gtc.2015.10.001. Epub 2016 Jan 12.
    • Review
    • Diagnosis and Management of Hereditary Pancreatic Cancer.
    • Humphris JL, Biankin AV.
    • Recent Results Cancer Res. 2016;205:61-83. doi: 10.1007/978-3-319-29998-3_5.
    • Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations.
    • Chahla E, Cheesman A, Mahon SM, Garrett RW, Bradenham BP Jr, Schwartz TL, Omran L, Taylor JR, Alkaade S.
    • Scientifica (Cairo). 2016;2016:5619358. doi: 10.1155/2016/5619358. Epub 2016 Mar 16.
    • Screening for Pancreatic Adenocarcinoma in BRCA2 Mutation Carriers: Results of a Disease Simulation Model.
    • Pandharipande PV, Jeon A, Heberle CR, Dowling EC, Kong CY, Chung DC, Brugge WR, Hur C.
    • EBioMedicine. 2015 Nov 4;2(12):1980-6. doi: 10.1016/j.ebiom.2015.11.005. eCollection 2015.

    Comment

    Familial Pancreatic Cancer: To Screen or not to Screen?

    • BRCA2-associated pancreatic cancer and current screening guidelines.
    • Kasi PM, Pedersen KS, McWilliams RR.
    • Cancer. 2015 Sep 1;121(17):3046. doi: 10.1002/cncr.29447. Epub 2015 May 27.
    • Comment, Letter

    Comment

    Reply to BRCA2-associated pancreatic cancer and current screening guidelines.

    • Short-term Results of a Magnetic Resonance Imaging-Based Swedish Screening Program for Individuals at Risk for Pancreatic Cancer.
    • Del Chiaro M, Verbeke CS, Kartalis N, Pozzi Mucelli R, Gustafsson P, Hansson J, Haas SL, Segersvärd R, Andren-Sandberg Å, Löhr JM.
    • JAMA Surg. 2015 Jun 1;150(6):512-518. doi: 10.1001/jamasurg.2014.3852.

    Commentary

    Screening Strategies for Pancreatic Cancer in High-Risk Patients: Opportunities to Make a Real Impact But Many Questions and Challenges Still Ahead.

    • Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection.
    • Becker AE, Hernandez YG, Frucht H, Lucas AL.
    • World J Gastroenterol. 2014 Aug 28;20(32):11182-98. doi: 10.3748/wjg.v20.i32.11182.
    • Promising outcomes of screening for pancreatic cancer by genetic testing and endoscopic ultrasound.
    • Sud A, Wham D, Catalano M, Guda NM.
    • Pancreas. 2014 Apr;43(3):458-61. doi: 10.1097/MPA.0000000000000052.
    • Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts.
    • Kanda M, Knight S, Topazian M, Syngal S, Farrell J, Lee J, Kamel I, Lennon AM, Borges M, Young A, Fujiwara S, Seike J, Eshleman J, Hruban RH, Canto MI, Goggins M.
    • Gut. 2013 Jul;62(7):1024-33. doi: 10.1136/gutjnl-2012-302823. Epub 2012 Aug 2.

    Commentary:

    Early diagnosis of pancreatic cancer; looking for a needle in a haystack?