Alternative Approaches ~ Genetic Counseling
~ Genetics of Breast & Ovarian Cancer

Methods, tools, sessions beyond the traditional approach to HBOC genetic counseling and testing; includes test result disclosure alternatives, telegenetics, group counseling, video-teleconferencing, online counseling, etc. Also includes papers covering situations in which there may be little, no, or insufficient provision of genetic counseling, as in some circumstances of direct-to-consumer genetic testing, provision of testing by unqualified providers, etc.

List was last updated on Oct 12, 2019 @ 12:59 pm.

    • BRCA1/2 Molecular Assay for Ovarian Cancer Patients: A Survey through Italian Departments of Oncology and Molecular and Genomic Diagnostic Laboratories.
    • Capoluongo E, Verde N, Barberis M, Bella MA, Buttitta F, Carrera P, Colombo N, Cortesi L, Gion M, Guarneri V, Lorusso D, Marchetti A, Marchetti P, Normanno N, Pasini B, Pensabene M, Pignata S, Radice P, Ricevuto E, Sapino A, Tagliaferri P, Tassone P, Trevisiol C, Truini M, Varesco L, Russo A, Gori S.
    • Diagnostics (Basel). 2019 Oct 9;9(4). pii: E146. doi: 10.3390/diagnostics9040146.
    • Cancer Genetic Counseling—Current Practice and Future Challenges.
    • Schienda J, Stopfer J.
    • Cold Spring Harb Perspect Med. 2019 Sep 23. pii: a036541. doi: 10.1101/cshperspect.a036541. [Epub ahead of print]
    • Review
    • An update on genetic risk assessment and prevention: the role of genetic testing panels in breast cancer.
    • Piccinin C, Panchal S, Watkins N, Kim RH.
    • Expert Rev Anticancer Ther. 2019 Aug 30. doi: 10.1080/14737140.2019.1659730. [Epub ahead of print]
    • Review
    • Who's on third? Regulation of third-party genetic interpretation services.
    • Guerrini CJ, Wagner JK, Nelson SC, Javitt GH, McGuire AL.
    • Genet Med. 2019 Aug 12. doi: 10.1038/s41436-019-0627-6. [Epub ahead of print]
    • Review
    • Research participants' experiences with return of genetic research results and preferences for web-based alternatives.
    • Gaieski JB, Patrick-Miller L, Egleston BL, Maxwell KN, Walser S, DiGiovanni L, Brower J, Fetzer D, Ganzak A, McKenna D, Long JM, Powers J, Stopfer JE, Nathanson KL, Domchek SM, Bradbury AR.
    • Mol Genet Genomic Med. 2019 Aug 3:e898. doi: 10.1002/mgg3.898. [Epub ahead of print]
    • MAGENTA (Making Genetic testing accessible): a prospective randomized controlled trial comparing online genetic education and telephone genetic counseling for hereditary cancer genetic testing.
    • Rayes N, Bowen DJ, Coffin T, Nebgen D, Peterson C, Munsell MF, Gavin K, Lechner R, Crase J, Polinsky D, Romero I, Blank SV, Levine DA, Norquist BM, Swisher EM, Lu KH.
    • BMC Cancer. 2019 Jul 2;19(1):648. doi: 10.1186/s12885-019-5868-x.
    • Moving into the mainstream: healthcare professionals' views of implementing treatment focussed genetic testing in breast cancer care.
    • Hallowell N, Wright S, Stirling D, Gourley C, Young O, Porteous M.
    • Fam Cancer. 2019 Jul;18(3):293-301. doi: 10.1007/s10689-019-00122-y.
    • CancerIQ, GeneMatters Integrate Technology to Widen Access to Genetic Counselors.
    • [No author given]
    • GenomeWeb. 2019 Jun 27.
    • Current Genetic Service Delivery Models for the Provision of Genetic Testing in Europe: A Systematic Review of the Literature.
    • Unim B, Pitini E, Lagerberg T, Adamo G, De Vito C, Marzuillo C, Villari P.
    • Front Genet. 2019 Jun 19;10:552. doi: 10.3389/fgene.2019.00552. eCollection 2019.
    • Uptake of testing for germline BRCA mutations in patients with non-mucinous epithelial ovarian cancers in Western Australia: a comparison of different genetic counseling methods.
    • Stearnes G, Nichols CB, Schofield L, O'Sullivan S, Pachter N, Cohen PA.
    • Int J Gynecol Cancer. 2019 May 17. pii: ijgc-2019-000389. doi: 10.1136/ijgc-2019-000389. [Epub ahead of print]
    • Multidisciplinary interventions in a specialist Drug Development Unit to improve family history documentation and onward referral of patients with advanced cancer to cancer genetics services.
    • Moss CA, Cojocaru E, Hanwell J, Ward S, Xu W, van Zyl M, O'Leary L, de Bono JS, Banerji U, Kaye SB, Minchom A, George AJ, Lopez J, McVeigh TP.
    • Eur J Cancer. 2019 May 9;114:97-106. doi: 10.1016/j.ejca.2019.04.009. [Epub ahead of print]
    • Cases in Precision Medicine: When Patients Present With Direct-to-Consumer Genetic Test Results.
    • Artin MG, Stiles D, Kiryluk K, Chung WK.
    • Ann Intern Med. 2019 Apr 30. doi: 10.7326/M18-2356. [Epub ahead of print]
    • Case report
    • Evaluation of telephone genetic counselling to facilitate germline BRCA1/2 testing in women with high-grade serous ovarian cancer.
    • Tutty E, Petelin L, McKinley J, Young MA, Meiser B, Rasmussen VM, Forbes Shepherd R, James PA, Forrest LE.
    • Eur J Hum Genet. 2019 Apr 8. doi: 10.1038/s41431-019-0390-9. [Epub ahead of print]
    • 23andMe DTC Breast and Ovarian Cancer Risk Test Misses Almost 90 Percent of BRCA Mutation Carriers.
    • Karow J.
    • Precision Oncology News. 2019 Apr 5.
    • Direct Genetics Referral Pathway for High-Grade Serous Ovarian Cancer Patients: The "Opt-Out" Process.
    • McGee J, Peart TM, Foley N, Bertrand M, Prefontaine M, Sugimoto A, Ettler H, Welch S, Panabaker K.
    • J Oncol. 2019 Apr 2;2019:6029097. doi: 10.1155/2019/6029097. eCollection 2019.
    • Communication about genetic testing with breast and ovarian cancer patients: a scoping review.
    • Jacobs C, Patch C, Michie S.
    • Eur J Hum Genet. 2019 Apr;27(4):511-524. doi: 10.1038/s41431-018-0310-4. Epub 2018 Dec 20.
    • Ambry and My Gene Counsel Team Up on Tests to Confirm DTC Results, Counseling.
    • [No author given.]
    • Clinical OMICs. 2019 Mar 19.

    Original research:

    False-positive results released by direct-to-consumer genetic tests highlight the importance of clinical confirmation testing for appropriate patient care.

    • Negotiating jurisdictional boundaries in response to new genetic possibilities in breast cancer care: The creation of an 'oncogenetic taskscape'.
    • Wright S, Porteous M, Stirling D, Young O, Gourley C, Hallowell N.
    • Soc Sci Med. 2019 Mar;225:26-33. doi: 10.1016/j.socscimed.2019.02.020. Epub 2019 Feb 13.
    • Genetic Service Delivery Models: Exploring Approaches to Care for Families With Hereditary Cancer Risk.
    • Pierle JM, Mahon SM.
    • Clin J Oncol Nurs. 2019 Feb 1;23(1):60-67. doi: 10.1188/19.CJON.60-67.
    • Cancer-related distress in unselected women with newly diagnosed breast or ovarian cancer undergoing BRCA1/2 testing without pretest genetic counseling.
    • Høberg-Vetti H, Eide GE, Siglen E, Listøl W, Haavind MT, Hoogerbrugge N, Bjorvatn C.
    • Acta Oncol. 2019 Feb;58(2):175-181. doi: 10.1080/0284186X.2018.1502466. Epub 2018 Oct 18.
    • Preferences for in-person disclosure: Patients declining telephone disclosure characteristics and outcomes in the multicenter Communication Of GENetic Test Results by Telephone study.
    • Beri N, Patrick-Miller LJ, Egleston BL, Hall MJ, Domchek SM, Daly MB, Ganschow P, Grana G, Olopade OI, Fetzer D, Brandt A, Chambers R, Clark DF, Forman A, Gaber R, Gulden C, Horte J, Long J, Lucas T, Madaan S, Mattie K, McKenna D, Montgomery S, Nielsen S, Powers J, Rainey K, Rybak C, Savage M, Seelaus C, Stoll J, Stopfer JE, Yao XS, Bradbury AR.
    • Clin Genet. 2019 Feb;95(2):293-301. doi: 10.1111/cge.13474. Epub 2018 Dec 7.
    • Disseminating universal genetic testing to a diverse, indigent patient population at a county hospital gynecologic oncology clinic.
    • Bednar EM, Sun CC, Camacho B, Terrell J, Rieber AG, Ramondetta LM, Freedman RS, Lu KH.
    • Gynecol Oncol. 2019 Feb;152(2):328-333. doi: 10.1016/j.ygyno.2018.12.001. Epub 2018 Dec 8.
    • Strategies for Improving Access to Hereditary Cancer Testing: Recommendations from Stakeholders.
    • Ready K, Johansen Taber KA, Bonhomme N, Lichtenfeld JL.
    • Genet Med. 2019 Jan 28. doi: 10.1038/s41436-018-0430-9. [Epub ahead of print]
    • Knowledge, attitudes, and perceived barriers towards genetic testing across three rural Illinois communities.
    • Fogleman AJ, Zahnd WE, Lipka AE, Malhi RS, Ganai S, Delfino KR, Jenkins WD.
    • J Community Genet. 2019 Jan 23. doi: 10.1007/s12687-019-00407-w. [Epub ahead of print]
    • Food and drug administration's regulatory shift on direct-to-consumer genetic tests for cancer risk.
    • Yang YT, Zettler PJ.
    • Cancer. 2019 Jan 1;125(1):12-14. doi: 10.1002/cncr.31773. Epub 2018 Nov 2.
    • High patient satisfaction with a simplified BRCA1/2 testing procedure: long-term results of a prospective study.
    • Nilsson MP, Nilsson ED, Borg Å, Brandberg Y, Silfverberg B, Loman N.
    • Breast Cancer Res Treat. 2019 Jan;173(2):313-318. doi: 10.1007/s10549-018-5000-y. Epub 2018 Oct 11.
    • Development of Breast Cancer Choices: a decision support tool for young women with breast cancer deciding whether to have genetic testing for BRCA1/2 mutations.
    • Grimmett C, Brooks C, Recio-Saucedo A, Armstrong A, Cutress RI, Gareth Evans D, Copson E, Turner L, Meiser B, Wakefield CE, Eccles D, Foster C.
    • Support Care Cancer. 2019 Jan;27(1):297-309. doi: 10.1007/s00520-018-4307-x. Epub 2018 Jun 28.
    • Cancer communication research in the era of genomics and precision medicine: a scoping review.
    • Kaphingst KA, Peterson E, Zhao J, Gaysynsky A, Elrick A, Hong SJ, Krakow M, Pokharel M, Ratcliff CL, Klein WMP, Khoury MJ, Chou WS.
    • Genet Med. 2018 Dec 21. doi: 10.1038/s41436-018-0402-0. [Epub ahead of print]
    • Review
    • Next-Generation Service Delivery: A Scoping Review of Patient Outcomes Associated with Alternative Models of Genetic Counseling and Genetic Testing for Hereditary Cancer.
    • McCuaig JM, Armel SR, Care M, Volenik A, Kim RH, Metcalfe KA.
    • Cancers (Basel). 2018 Nov 13;10(11). pii: E435. doi: 10.3390/cancers10110435.
    • Huntsman Cancer Institute Wins $5M NCI Grant for Genetic Counseling Study.
    • [No author given]
    • Clinical Omics. 2018 Nov 12.
    • Direct-To-Consumer Genetic Testing: Is the Public Ready for Simple, At-Home DNA Tests to Detect Disease Risk?
    • Bates M.
    • IEEE Pulse. 2018 Nov-Dec;9(6):11-14. doi: 10.1109/MPUL.2018.2869315.
    • Comment
    • Hereditary Cancer Risk Assessment and Genetic Testing in the Community-Practice Setting.
    • DeFrancesco MS, Waldman RN, Pearlstone MM, Karanik D, Bernhisel R, Logan J, Alico L, Adkins RT.
    • Obstet Gynecol. 2018 Nov;132(5):1121-1129. doi: 10.1097/AOG.0000000000002916.
    • Ethical Implications of Direct-to-Consumer Hereditary Cancer Tests.
    • Kilbride MK, Domchek SM, Bradbury AR.
    • JAMA Oncol. 2018 Oct 1;4(10):1327-1328. doi: 10.1001/jamaoncol.2018.2439.
    • Editorial
    • Promoting guideline-based cancer genetic risk assessment for hereditary breast and ovarian cancer in ethnically and geographically diverse cancer survivors: Rationale and design of a 3-arm randomized controlled trial.
    • Kinney AY, Howell R, Ruckman R, McDougall JA, Boyce TW, Vicuña B, Lee JH, Guest DD, Rycroft R, Valverde PA, Gallegos KM, Meisner A, Wiggins CL, Stroup A, Paddock LE, Walters ST.
    • Contemp Clin Trials. 2018 Oct;73:123-135. doi: 10.1016/j.cct.2018.09.005. Epub 2018 Sep 18.
    • Direct-to-consumer genetic testing for breast cancer risk.
    • Reed EK, Edelman EA.
    • J Am Assoc Nurse Pract. 2018 Oct;30(10):548-550. doi: 10.1097/JXX.0000000000000146.
    • Review
    • Acceptability of Electronic Visits for Return of Research Results in the Mayo Clinic Biobank.
    • Olson JE, Ryu E, Lyke KJ, Bielinski SJ, Winkler EM, Hathcock MA, Bublitz JT, Takahashi PY, Cerhan JR.
    • Mayo Clin Proc Innov Qual Outcomes. 2018 Sep 15;2(4):352-358. doi: 10.1016/j.mayocpiqo.2018.07.004. eCollection 2018 Dec.
    • Randomized Noninferiority Trial of Telephone vs In-Person Disclosure of Germline Cancer Genetic Test Results.
    • Bradbury AR, Patrick-Miller LJ, Egleston BL, Hall MJ, Domchek SM, Daly MB, Ganschow P, Grana G, Olopade OI, Fetzer D, Brandt A, Chambers R, Clark DF, Forman A, Gaber R, Gulden C, Horte J, Long JM, Lucas T, Madaan S, Mattie K, McKenna D, Montgomery S, Nielsen S, Powers J, Rainey K, Rybak C, Savage M, Seelaus C, Stoll J, Stopfer JE, Yao XS.
    • J Natl Cancer Inst. 2018 Sep 1;110(9):985-993. doi: 10.1093/jnci/djy015.
    • Development and Pilot Testing of a Decision Aid for Genomic Research Participants Notified of Clinically Actionable Research Findings for Cancer Risk.
    • Willis AM, Smith SK, Meiser B, Ballinger ML, Thomas DM, Tattersall M; International Sarcoma Kindred Study (ISKS); Kathleen Cuningham National Consortium for Research into Familial Breast Cancer (kConFab), Young MA.
    • J Genet Couns. 2018 Sep;27(5):1055-1066. doi: 10.1007/s10897-018-0223-y. Epub 2018 Feb 17.
    • Evolution of genetic assessment for BRCA-associated gynaecologic malignancies: a Canadian multisociety roadmap.
    • McCuaig JM, Stockley TL, Shaw P, Fung-Kee-Fung M, Altman AD, Bentley J, Bernardini MQ, Cormier B, Hirte H, Kieser K, MacMillan A, Meschino WS, Panabaker K, Perrier R, Provencher D, Schrader KA, Serfas K, Tomiak E, Wong N, Young SS, Gotlieb WH, Hoskins P, Kim RH; BRCA TtoT Community of Practice.
    • J Med Genet. 2018 Sep;55(9):571-577. doi: 10.1136/jmedgenet-2018-105472. Epub 2018 Jul 24.
    • Randomized trial of proactive rapid genetic counseling versus usual care for newly diagnosed breast cancer patients.
    • Schwartz MD, Peshkin BN, Isaacs C, Willey S, Valdimarsdottir HB, Nusbaum R, Hooker G, O’Neill S, Jandorf L, Kelly SP, Heinzmann J, Zidell A, Khoury K.
    • Breast Cancer Res Treat. 2018 Aug;170(3):517-524. doi: 10.1007/s10549-018-4773-3. Epub 2018 Apr 2.
    • Evaluation of Breast Cancer Patients with Genetic Risk in a University Hospital: Before and After the Implementation of a Heredofamilial Cancer Unit.
    • Lobo M, López-Tarruella S, Luque S, Lizarraga S, Flores-Sánchez C, Bueno O, Solera J, Jerez Y, Del Val RG, Palomero MI, Cebollero M, Echavarría I, Torres G, Martín M, Márquez-Rodas I.
    • J Genet Couns. 2018 Aug;27(4):854-862. doi: 10.1007/s10897-017-0187-3. Epub 2017 Dec 15.
    • Improving comprehension of genetic counseling for hereditary breast and ovarian cancer clients with a visual tool.
    • Tea MM, Tan YY, Staudigl C, Eibl B, Renz R, Asseryanis E, Berger A, Pfeiler G, Singer CF.
    • PLoS One. 2018 Jul 12;13(7):e0200559. doi: 10.1371/journal.pone.0200559. eCollection 2018.
    • Cost-effectiveness evaluation of pre-counseling telephone interviews before face-to-face genetic counseling in cancer genetics.
    • Collet G, Parodi N, Cassinari K, Neviere Z, Cohen F, Gasnier C, Brahimi A, Lecoquierre F, Thery JC, Tennevet I, Lacaze E, Berthet P, Frebourg T.
    • Fam Cancer. 2018 Jul;17(3):451-457. doi: 10.1007/s10689-017-0049-z.
    • Evaluation of some direct-to-consumer genetic testing reveals inaccuracies and misinterpretations.
    • [No author given]
    • FORCE. XRAYS. 2018 Jun 28.

    False-positive results released by direct-to-consumer genetic tests highlight the importance of clinical confirmation testing for appropriate patient care.

    • Direct-to-Consumer Genetic Testing: The Implications of the US FDA's First Marketing Authorization for BRCA Mutation Testing.
    • Gill J, Obley AJ, Prasad V.
    • JAMA. 2018 Jun 19;319(23):2377-2378. doi: 10.1001/jama.2018.5330.
    • Commentary
    • Making Sense of SNPs: Women's Understanding and Experiences of Receiving a Personalized Profile of Their Breast Cancer Risks.
    • Young MA, Forrest LE, Rasmussen VM, James P, Mitchell G, Sawyer SD, Reeve K, Hallowell N.
    • J Genet Couns. 2018 Jun;27(3):702-708. doi: 10.1007/s10897-017-0162-z. Epub 2017 Nov 22.
    • Evaluation of a Streamlined Oncologist-Led BRCA Mutation Testing and Counseling Model for Patients With Ovarian Cancer.
    • Colombo N, Huang G, Scambia G, Chalas E, Pignata S, Fiorica J, Van Le L, Ghamande S, González-Santiago S, Bover I, Graña Suárez B, Green A, Huot-Marchand P, Bourhis Y, Karve S, Blakeley C.
    • J Clin Oncol. 2018 May 1;36(13):1300-1307. doi: 10.1200/JCO.2017.76.2781. Epub 2018 Mar 20.
    • Timing and Mode of Breast Care Nurse Consultation From the Patient's Perspective.
    • Brown J, Refeld G, Cooper A.
    • Oncol Nurs Forum. 2018 May 1;45(3):389-398. doi: 10.1188/18.ONF.389-398.
    • Impact of an embedded genetic counselor on breast cancer treatment.
    • Pederson HJ, Hussain N, Noss R, Yanda C, O'Rourke C, Eng C, Grobmyer SR.
    • Breast Cancer Res Treat. 2018 May;169(1):43-46. doi: 10.1007/s10549-017-4643-4. Epub 2018 Jan 18.
    • Direct-to-Consumer Test for BRCA Mutations Authorized.
    • [No authors listed]
    • Cancer Discov. 2018 May;8(5):OF5. doi: 10.1158/2159-8290.CD-NB2018-031. Epub 2018 Mar 14.
    • News
    • Genetic Counseling Referral Rates in Long-Term Survivors of Triple-Negative Breast Cancer.
    • Barcenas CH, Shafaee MN, Sinha AK, Raghavendra A, Saigal B, Murthy RK, Woodson AH, Arun B.
    • J Natl Compr Canc Netw. 2018 May;16(5):518-524. doi: 10.6004/jnccn.2018.7002.
    • Hereditary Cancer Genetic Testing in Community-Based Obstetrics and Gynecology Settings.
    • Obstet Gynecol. 2018 May;131(5):119s. doi: 10.1097/01.AOG.0000533506.01865.a1.
    • Risk Screening for Hereditary Cancer During Obstetrical Care: Barriers to Testing and Health Disparities.
    • Lua LL, Jackson D, Foggia M, Rosenbaum A.
    • Obstet Gynecol. 2018 May;131(5):148s. doi: 10.1097/01.AOG.0000533083.79347.8c.
    • Gaps in Receipt of Clinically Indicated Genetic Counseling After Diagnosis of Breast Cancer.
    • Katz SJ, Ward KC, Hamilton AS, Mcleod MC, Wallner LP, Morrow M, Jagsi R, Hawley ST, Kurian AW.
    • J Clin Oncol. 2018 Apr 20;36(12):1218-1224. doi: 10.1200/JCO.2017.76.2369. Epub 2018 Mar 12.

    Press: Many Breast Cancer Patients Not Receiving Genetic Evaluation. (Medscape)

    • Development of a Web-based Family Intervention for BRCA Carriers and Their Biological Relatives: Acceptability, Feasibility, and Usability Study.
    • Katapodi MC, Jung M, Schafenacker AM, Milliron KJ, Mendelsohn-Victor KE, Merajver SD, Northouse LL.
    • JMIR Cancer. 2018 Apr 13;4(1):e7. doi: 10.2196/cancer.9210.
    • False-positive results released by direct-to-consumer genetic tests highlight the importance of clinical confirmation testing for appropriate patient care.
    • Tandy-Connor S, Guiltinan J, Krempely K, LaDuca H, Reineke P, Gutierrez S, Gray P, Tippin Davis B.
    • Genet Med. 2018 Mar 22. doi: 10.1038/gim.2018.38. [Epub ahead of print]


    Attention: Direct-To-Consumer patrons: Proceed with caution.

    Research news: Evaluation of some direct-to-consumer genetic testing reveals inaccuracies and misinterpretations (FORCE. XRAYS.)

    Press: Wrangle Over DTC Results—Ambry Study Highlights 40% False Positives, 23andMe Defends Tests, and Experts Weigh In. (Clinical OMICs)

    Press: Ambry and My Gene Counsel Team Up on Tests to Confirm DTC Results, Counseling. (Clinical OMICs)

    • The Right Not to Know: When Ignorance Is Bliss but Deadly.
    • Clausen AM.
    • Global Health NOW. 2018 Mar 20.

    Commentary: The right not to know when not knowing is dangerous. (FORCE. XRAYS.)

    • Impact of a genetic counseling requirement prior to genetic testing.
    • Stenehjem DD, Au T, Sainski AM, Bauer H, Brown K, Lancaster J, Stevens V, Brixner DI.
    • BMC Health Serv Res. 2018 Mar 7;18(1):165. doi: 10.1186/s12913-018-2957-5.
    • NSGC Responds to U.S. Food and Drug Administration Approval of Direct-to-Consumer Cancer Test that Reports Three BRCA Mutations.
    • [No author given]
    • NSGC blog, 2018 Mar 6.

    FDA News Release: FDA authorizes, with special controls, direct-to-consumer test that reports three mutations in the BRCA breast cancer genes (U.S. Food & Drug Administration)

    • Genetic Testing: Multiple Problems to Solve.
    • Ramos E, Haidle JL.
    • J Clin Oncol. 2018 Feb 10;36(5):518-519. doi: 10.1200/JCO.2017.76.0942. Epub 2018 Jan 2.


    Genetic Testing: What Problem Are We Trying to Solve?

    Letter, Reply:

    Reply to E. Ramos et al.

    • Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017.
    • Giri VN, Knudsen KE, Kelly WK, Abida W, Andriole GL, Bangma CH, Bekelman JE, Benson MC, Blanco A, Burnett A, Catalona WJ, Cooney KA, Cooperberg M, Crawford DE, Den RB, Dicker AP, Eggener S, Fleshner N, Freedman ML, Hamdy FC, Hoffman-Censits J, Hurwitz MD, Hyatt C, Isaacs WB, Kane CJ, Kantoff P, Karnes RJ, Karsh LI, Klein EA, Lin DW, Loughlin KR, Lu-Yao G, Malkowicz SB, Mann MJ, Mark JR, McCue PA, Miner MM, Morgan T, Moul JW, Myers RE, Nielsen SM, Obeid E, Pavlovich CP, Peiper SC, Penson DF, Petrylak D, Pettaway CA, Pilarski R, Pinto PA, Poage W, Raj GV, Rebbeck TR, Robson ME, Rosenberg MT, Sandler H, Sartor O, Schaeffer E, Schwartz GF, Shahin MS, Shore ND, Shuch B, Soule HR, Tomlins SA, Trabulsi EJ, Uzzo R, Vander Griend DJ, Walsh PC, Weil CJ, Wender R, Gomella LG.
    • J Clin Oncol. 2018 Feb 1;36(4):414-424. doi: 10.1200/JCO.2017.74.1173. Epub 2017 Dec 13.
    • BRCAsearch: written pre-test information and BRCA1/2 germline mutation testing in unselected patients with newly diagnosed breast cancer.
    • Nilsson MP, Törngren T, Henriksson K, Kristoffersson U, Kvist A, Silfverberg B, Borg Å, Loman N.
    • Breast Cancer Res Treat. 2018 Feb;168(1):117-126. doi: 10.1007/s10549-017-4584-y. Epub 2017 Nov 21.
    • FDA Approval of PARP Inhibitors and the Impact on Genetic Counseling and Genetic Testing Practices.
    • Buchtel KM, Vogel Postula KJ, Weiss S, Williams C, Pineda M, Weissman SM.
    • J Genet Couns. 2018 Feb;27(1):131-139. doi: 10.1007/s10897-017-0130-7. Epub 2017 Aug 5.
    • Examination of the Patient-Focused Impact of Cancer Telegenetics Among a Rural Population: Comparison with Traditional In-Person Services.
    • Solomons NM, Lamb AE, Lucas FL, McDonald EF, Miesfeldt S.
    • Telemed J E Health. 2018 Feb;24(2):130-138. doi: 10.1089/tmj.2017.0073. Epub 2017 Jul 21.
    • Improving attendance to genetic counselling services for gynaecological oncology patients.
    • Pokharel HP, Hacker NF, Andrews L.
    • Gynecol Oncol Res Pract. 2018 Jan 10;5:2. doi: 10.1186/s40661-018-0059-z. eCollection 2018.
    • Your Genes: One Size Doesn't Fit All.
    • Freivogel ME, Cohen SA.
    • J Natl Compr Canc Netw. 2018 Jan 1;16(1):2-3. doi: 10.6004/jnccn.2017.7055.
    • Commentary


    Your Genes: Getting the Best Fit.

    • Comparing Outcomes of Genetic Counseling Options in Breast and Ovarian Cancer: An Integrative Review.
    • Fournier DM, Bazzell AF, Dains JE.
    • Oncol Nurs Forum. 2018 Jan 1;45(1):96-105. doi: 10.1188/18.ONF.96-105.
    • Review
    • A single visit multidisciplinary model for managing patients with mutations in moderate and high-risk genes in a community practice setting.
    • O'Leary MP, Goldner BS, Abboy S, Mercado PD, Plurad HY.
    • Fam Cancer. 2018 Jan;17(1):175-178. doi: 10.1007/s10689-017-0010-1.
    • National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer.
    • Childers CP, Childers KK, Maggard-Gibbons M, Macinko J.
    • J Clin Oncol. 2017 Dec 1;35(34):3800-3806. doi: 10.1200/JCO.2017.73.6314. Epub 2017 Aug 18.


    Genetic Testing: What Problem Are We Trying to Solve?


    Population-Based Genetic Testing for BRCA1 and BRCA2.

    Press: Huge Underuse of Genetic Testing Among Cancer Survivors. (Medscape Oncology)

    • Genetic Testing in a Population-Based Sample of Breast and Ovarian Cancer Survivors from the REACH Randomized Trial: Cost Barriers and Moderators of Counseling Mode.
    • Steffen LE, Du R, Gammon A, Mandelblatt JS, Kohlmann WK, Lee JH, Buys SS, Stroup AM, Campo RA, Flores KG, Vicuña B, Schwartz MD, Kinney AY.
    • Cancer Epidemiol Biomarkers Prev. 2017 Dec;26(12):1772-1780. doi: 10.1158/1055-9965.EPI-17-0389. Epub 2017 Sep 29.
    • Rapid genetic counseling and testing in newly diagnosed breast cancer: Patients' and health professionals' attitudes, experiences, and evaluation of effects on treatment decision making.
    • Wevers MR, Aaronson NK, Bleiker EMA, Hahn DEE, Brouwer T, van Dalen T, Theunissen EB, van Ooijen B, de Roos MA, Borgstein PJ, Vrouenraets BC, Vriens E, Bouma WH, Rijna H, Vente JP, Kuenen MA, van der Sanden-Melis J, Witkamp AJ, Rutgers EJT, Verhoef S, Ausems MGEM.
    • J Surg Oncol. 2017 Dec;116(8):1029-1039. doi: 10.1002/jso.24763. Epub 2017 Jul 13.
    • Genetic counseling by phone or face-to-face.
    • [No author given]
    • FORCE. XRAYS. 2017 Nov 29.
    • Genetic Testing: Challenges and Changes in Testing for Hereditary Cancer Syndromes.
    • King E, Mahon SM.
    • Clin J Oncol Nurs. 2017 Oct 1;21(5):589-598. doi: 10.1188/17.CJON.589-598.
    • Genetic consultation embedded in a gynecologic oncology clinic improves compliance with guideline-based care.
    • Senter L, O'Malley DM, Backes FJ, Copeland LJ, Fowler JM, Salani R, Cohn DE.
    • Gynecol Oncol. 2017 Oct;147(1):110-114. doi: 10.1016/j.ygyno.2017.07.141. Epub 2017 Aug 8.
    • Hereditary gynaecologic cancers in Nepal: a proposed model of care to serve high risk populations in developing countries.
    • Pokharel HP, Hacker NF, Andrews L.
    • Hered Cancer Clin Pract. 2017 Sep 18;15:12. doi: 10.1186/s13053-017-0072-y. eCollection 2017.
    • Randomized Noninferiority Trial of Telephone vs In-Person Genetic Counseling for Hereditary Breast and Ovarian Cancer: A 12-Month Follow-Up.
    • Interrante MK, Segal H, Peshkin BN, Valdimarsdottir HB, Nusbaum R, Similuk M, DeMarco T, Hooker G, Graves K, Isaacs C, Wood M, McKinnon W, Garber J, McCormick S, Heinzmann J, Kinney AY, Schwartz MD.
    • JNCI Cancer Spectr. 2017 Sep;1(1):pkx002. doi: 10.1093/jncics/pkx002. Epub 2017 Sep 22.
    • Implementation and utilization of the molecular tumor board to guide precision medicine.
    • Harada S, Arend R, Dai Q, Levesque JA, Winokur TS, Guo R, Heslin MJ, Nabell L, Nabors LB, Limdi NA, Roth KA, Partridge EE, Siegal GP, Yang ES.
    • Oncotarget. 2017 Jun 14;8(34):57845-57854. doi: 10.18632/oncotarget.18471. eCollection 2017 Aug 22.
    • Psychosocial and behavioral impact of breast cancer risk assessed by testing for common risk variants: protocol of a prospective study.
    • Yanes T, Meiser B, Young MA, Kaur R, Mitchell G, Barlow-Stewart K, Roscioli T, Halliday J, James P.
    • BMC Cancer. 2017 Jul 18;17(1):491. doi: 10.1186/s12885-017-3485-0.
    • Gaps in Incorporating Germline Genetic Testing Into Treatment Decision-Making for Early-Stage Breast Cancer.
    • Kurian AW, Li Y, Hamilton AS, Ward KC, Hawley ST, Morrow M, McLeod MC, Jagsi R, Katz SJ.
    • J Clin Oncol. 2017 Jul 10;35(20):2232-2239. doi: 10.1200/JCO.2016.71.6480. Epub 2017 Apr 12.

    Press: Lack of Understanding of Genetic Breast Cancer Testing. (Medscape)

    • Population screening for BRCA1/BRCA2 founder mutations in Ashkenazi Jews: proactive recruitment compared with self-referral.
    • Lieberman S, Tomer A, Ben-Chetrit A, Olsha O, Strano S, Beeri R, Koka S, Fridman H, Djemal K, Glick I, Zalut T, Segev S, Sklair M, Kaufman B, Lahad A, Raz A, Levy-Lahad E.
    • Genet Med. 2017 Jul;19(7):754-762. doi: 10.1038/gim.2016.182. Epub 2016 Dec 8.
    • Reproductive Decision-Making in Women with BRCA1/2 Mutations.
    • Chan JL, Johnson LN, Sammel MD, DiGiovanni L, Voong C, Domchek SM, Gracia CR.
    • J Genet Couns. 2017 Jun;26(3):594-603. doi: 10.1007/s10897-016-0035-x. Epub 2016 Oct 28.
    • Cancers de l’ovaire BRCA muté : consultation d’oncogénétique et prescription des inhibiteurs de PARP. [BRCA-mutated Ovarian Carcinomas: Genetic Counseling and PARP Inhibitors Prescription.]
    • Gladieff L, Lyonnet DS, Lortholary A, Leary A, Genestie C, Ray-Coquard I.
    • Bull Cancer. 2017 May;104 Suppl 1:S16-S23. doi: 10.1016/S0007-4551(17)30158-3.
    • Review, [Article in French]
    • Experiences from a pilot program bringing BRCA1/2 genetic screening to the US Ashkenazi Jewish population.
    • Wiesman C, Rose E, Grant A, Zimilover A, Klugman S, Schreiber-Agus N.
    • Genet Med. 2017 May;19(5):529-536. doi: 10.1038/gim.2016.154. Epub 2016 Oct 13.

    Press: New Study Highlights the Benefits of BRCA Testing for All People of Ashkenazi Jewish Descent. (Newswise, Montefiore Health System)

    • Deficit of Risk-Reducing Salpingo-Oophorectomies in BRCA1/2 Mutation Carriers After Telephone Genetic Counseling.
    • Benusiglio PR, Caron O.
    • J Clin Oncol. 2017 Apr 10;35(11):1255. doi: 10.1200/JCO.2016.70.5780. Epub 2017 Jan 23.

    Randomized Noninferiority Trial of Telephone Delivery of BRCA1/2 Genetic Counseling Compared With In-Person Counseling: 1-Year Follow-Up.

    • Streamlined genetic education is effective in preparing women newly diagnosed with breast cancer for decision making about treatment-focused genetic testing: a randomized controlled noninferiority trial.
    • Quinn VF, Meiser B, Kirk J, Tucker KM, Watts KJ, Rahman B, Peate M, Saunders C, Geelhoed E, Gleeson M, Barlow-Stewart K, Field M, Harris M, Antill YC, Cicciarelli L, Crowe K, Bowen MT, Mitchell G
    • Genet Med. 2017 Apr;19(4):448-456. doi: 10.1038/gim.2016.130. Epub 2016 Sep 29.
    • Mainstreaming cancer genetics: A model integrating germline BRCA testing into routine ovarian cancer clinics.
    • Kentwell M, Dow E, Antill Y, Wrede CD, McNally O, Higgs E, Hamilton A, Ananda S, Lindeman GJ, Scott CL.
    • Gynecol Oncol. 2017 Apr;145(1):130-136. doi: 10.1016/j.ygyno.2017.01.030. Epub 2017 Feb 3.
    • Homologous recombination deficiency (HRD) testing in ovarian cancer clinical practice: a review of the literature.
    • Frey MK, Pothuri B.
    • Gynecol Oncol Res Pract. 2017 Feb 22;4:4. doi: 10.1186/s40661-017-0039-8. eCollection 2017.
    • BRCA1/2 germline testing in non-mucinous epithelial ovarian carcinoma: changing international practice and implications for service provision.
    • Coakley M, Cleary V, Power N, O'Reilly S.
    • Eur J Hum Genet. 2017 Feb;25(2):167-168. doi: 10.1038/ejhg.2016.138. Epub 2016 Oct 19.
    • Identifying Needs: a Qualitative Study of women's Experiences Regarding Rapid Genetic Testing for Hereditary Breast and Ovarian Cancer in the DNA BONus Study.
    • Augestad MT, Høberg-Vetti H, Bjorvatn C, Sekse RJ
    • J Genet Couns. 2017 Feb;26(1):182-189. doi: 10.1007/s10897-016-9996-z. Epub 2016 Jul 28.
    • Anxiety and depression symptoms among women attending group-based patient education courses for hereditary breast and ovarian cancer.
    • Listøl W, Høberg-Vetti H, Eide GE, Bjorvatn C.
    • Hered Cancer Clin Pract. 2017 Jan 11;15:2. doi: 10.1186/s13053-016-0062-5. eCollection 2017.
    • Hereditary breast and ovarian cancer: successful systematic implementation of a group approach to genetic counselling.
    • Benusiglio PR, Di Maria M, Dorling L, Jouinot A, Poli A, Villebasse S, Le Mentec M, Claret B, Boinon D, Caron O.
    • Fam Cancer. 2017 Jan;16(1):51-56. doi: 10.1007/s10689-016-9929-x.
    • [Making better use of the clinical geneticist's expertise; treating physician could request a DNA test for most cancer patients].
    • Aalfs CM, Westermann AM, van El CG.
    • Ned Tijdschr Geneeskd. 2017;161(0):D1525.
    • [Article in Dutch], English Abstract
    • Design and Feasibility of an Intervention to Support Cancer Genetic Counselees in Informing their At-Risk Relatives.
    • de Geus E, Eijzenga W, Menko FH, Sijmons RH, de Haes HC, Aalfs CM, Smets EM.
    • J Genet Couns. 2016 Dec;25(6):1179-1187. Epub 2016 Apr 22.

    Webinar: June 2016 Webinar: Spreading the word: a review of two family communication intervention studies. (NSGC. Cancer SIG. Webinar Recordings. 2016 Jun 29.)

    • When knowledge of a heritable gene mutation comes out of the blue: treatment-focused genetic testing in women newly diagnosed with breast cancer.
    • Meiser B, Quinn VF, Gleeson M, Kirk J, Tucker KM, Rahman B, Saunders C, Watts KJ, Peate M, Geelhoed E, Barlow-Stewart K, Field M, Harris M, Antill YC, Mitchell G.
    • Eur J Hum Genet. 2016 Nov;24(11):1517-1523. doi: 10.1038/ejhg.2016.69. Epub 2016 Jun 22.
    • BRACAVENIR - impact of a psychoeducational intervention on expectations and coping in young women (aged 18-30 years) exposed to a high familial breast/ovarian cancer risk: study protocol for a randomized controlled trial.
    • Kwiatkowski F, Dessenne P, Laquet C, Daures JP, Gay-Bellile M, Bignon YJ.
    • Trials. 2016 Oct 21;17(1):509.
    • A collaborative approach to cancer risk assessment services using genetic counselor extenders in a multi-system community hospital.
    • Cohen SA, Nixon DM.
    • Breast Cancer Res Treat. 2016 Oct;159(3):527-34. doi: 10.1007/s10549-016-3964-z. Epub 2016 Aug 31.

    Comments from NSGC Discussion Forum Cancer SIG

    Subject: Assist physicians with ordering testing?

    • Patient and genetic counselor perceptions of in-person versus telephone genetic counseling for hereditary breast/ovarian cancer.
    • Jacobs AS, Schwartz MD, Valdimarsdottir H, Nusbaum RH, Hooker GW, DeMarco TA, Heinzmann JE, McKinnon W, McCormick SR, Davis C, Forman AD, Lebensohn AP, Dalton E, Tully DM, Graves KD, Similuk M, Kelly S, Peshkin BN.
    • Fam Cancer. 2016 Oct;15(4):529-39. doi: 10.1007/s10689-016-9900-x.
    • Communicating genetic test results within the family: Is it lost in translation? A survey of relatives in the randomized six-step study.
    • Daly MB, Montgomery S, Bingler R, Ruth K.
    • Fam Cancer. 2016 Oct;15(4):697-706. doi: 10.1007/s10689-016-9889-1.

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: Register for June Journal Club; Reminder, webinar this Friday

    Webinar: June 2016 Webinar: Spreading the word: a review of two family communication intervention studies (NSGC Cancer SIG: Webinar Recordings)

    • Evolution of Hereditary Breast Cancer Genetic Services: Are Changes Reflected in the Knowledge and Clinical Practices of Florida Providers?
    • Cragun D, Scherr C, Camperlengo L, Vadaparampil ST, Pal T.
    • Genet Test Mol Biomarkers. 2016 Oct;20(10):569-578. Epub 2016 Aug 15.
    • Video-assisted genetic counseling in patients with ovarian, fallopian and peritoneal carcinoma.
    • Watson CH, Ulm M, Blackburn P, Smiley L, Reed M, Covington R, Bokovitz L, Tillmanns T.
    • Gynecol Oncol. 2016 Oct;143(1):109-12. doi: 10.1016/j.ygyno.2016.07.094. Epub 2016 Jul 12.
    • Want A BRCA Test? Some Insurers Require Genetic Counseling First.
    • Michelle Andrews
    • NPR. Shots. 2016 Sep 14.
    • Insurers May Insist On Counseling Before Genetic Tests For Breast Cancer.
    • Michelle Andrews
    • Kaiser Health News. 2016 Sep 13.
    • Waiting for Cancer
    • Patricia Fall.
    • Well. NY Times. 2016 Sep 1.
    • Finding all BRCA pathogenic mutation carriers: best practice models.
    • Hoogerbrugge N, Jongmans MC.
    • Eur J Hum Genet. 2016 Sep;24 Suppl 1:S19-26. doi: 10.1038/ejhg.2016.95.
    • Randomized Noninferiority Trial of Telephone Delivery of BRCA1/2 Genetic Counseling Compared With In-Person Counseling: 1-Year Follow-Up.
    • Kinney AY, Steffen LE, Brumbach BH, Kohlmann W, Du R, Lee JH, Gammon A, Butler K, Buys SS, Stroup AM, Campo RA, Flores KG, Mandelblatt JS, Schwartz MD.
    • J Clin Oncol. 2016 Aug 20;34(24):2914-24. doi: 10.1200/JCO.2015.65.9557. Epub 2016 Jun 20.


    Deficit of Risk-Reducing Salpingo-Oophorectomies in BRCA1/2 Mutation Carriers After Telephone Genetic Counseling.

    Press: Telephone counseling can help make cancer genetic services more accessible to rural women (News Medical)

    • Implementing rapid, robust, cost-effective, patient-centred, routine genetic testing in ovarian cancer patients.
    • George A, Riddell D, Seal S, Talukdar S, Mahamdallie S, Ruark E, Cloke V, Slade I, Kemp Z, Gore M, Strydom A, Banerjee S, Hanson H, Rahman N.
    • Sci Rep. 2016 Jul 13;6:29506. doi: 10.1038/srep29506.

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: Are We Just A Bunch of Health Care Money-Wasters Who Are Indirectly Responsible For People Getting Preventable Cancers?


    Streamlined genetic testing pathway is developed for women with ovarian cancer.

    Press: Simplified the Process. (GenomeWeb)

    Press: All women with ovarian cancer should be offered genetic testing – so why aren’t they? (Science Blog)

    • Cluster-randomised non-inferiority trial comparing DVD-assisted and traditional genetic counselling in systematic population testing for BRCA1/2 mutations.
    • Manchanda R, Burnell M, Loggenberg K, Desai R, Wardle J, Sanderson SC, Gessler S, Side L, Balogun N, Kumar A, Dorkins H, Wallis Y, Chapman C, Tomlinson I, Taylor R, Jacobs C, Legood R, Raikou M, McGuire A, Beller U, Menon U, Jacobs I.
    • J Med Genet. 2016 Jul;53(7):472-80. doi: 10.1136/jmedgenet-2015-103740. Epub 2016 Mar 18.
    • The Unbearably Slow Adoption of Genetic Cancer Tests
    • [No author given]
    • The Atlantic. 2016 Jul.

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: Are We Just A Bunch of Health Care Money-Wasters Who Are Indirectly Responsible For People Getting Preventable Cancers?

    • June 2016 Webinar: Spreading the word: a review of two family communication intervention studies.
    • Ilana Solomon.
    • NSGC. Cancer SIG. Webinar Recordings. 2016 Jun 29.

    Communicating genetic test results within the family: Is it lost in translation? A survey of relatives in the randomized six-step study.

    Design and Feasibility of an Intervention to Support Cancer Genetic Counselees in Informing their At-Risk Relatives.

    • The integration of BRCA testing into oncology clinics.
    • Percival N, George A, Gyertson J, Hamill M, Fernandes A, Davies E, Rahman N, Banerjee S.
    • Br J Nurs. 2016 Jun 23;25(12):690-4. doi: 10.12968/bjon.2016.25.12.690.
    • The Quality of Genetic Counseling and Connected Factors as Evaluated by Male BRCA1/2 Mutation Carriers in Finland.
    • Kajula O, Kääriäinen M, Moilanen JS, Kyngäs H.
    • J Genet Couns. 2016 Jun;25(3):413-21. doi: 10.1007/s10897-015-9885-x. Epub 2015 Sep 29.
    • Predictive Genetic Testing and Alternatives to Face to Face Results Disclosure: A Retrospective Review of Patients Preference for Alternative Modes of BRCA 1 and 2 Results Disclosure in the Republic of Ireland.
    • O'Shea R, Meany M, Carroll C, Cody N, Healy D, Green A, Lynch SA.
    • J Genet Couns. 2016 Jun;25(3):422-31. doi: 10.1007/s10897-015-9887-8. Epub 2015 Sep 26.
    • Patient Perceptions of Telephone vs. In-Person BRCA1/BRCA2 Genetic Counseling.
    • Peshkin BN, Kelly S, Nusbaum RH, Similuk M, DeMarco TA, Hooker GW, Valdimarsdottir HB, Forman AD, Joines JR, Davis C, McCormick SR, McKinnon W, Graves KD, Isaacs C, Garber J, Wood M, Jandorf L, Schwartz MD.
    • J Genet Couns. 2016 Jun;25(3):472-82. doi: 10.1007/s10897-015-9897-6. Epub 2015 Oct 12.
    • High Satisfaction and Low Distress in Breast Cancer Patients One Year after BRCA-Mutation Testing without Prior Face-to-Face Genetic Counseling.
    • Sie AS, Spruijt L, van Zelst-Stams WA, Mensenkamp AR, Ligtenberg MJ, Brunner HG, Prins JB, Hoogerbrugge N.
    • J Genet Couns. 2016 Jun;25(3):504-14. doi: 10.1007/s10897-015-9899-4. Epub 2015 Nov 4.
    • Alternate Service Delivery Models in Cancer Genetic Counseling: A Mini-Review.
    • Buchanan AH, Rahm AK, Williams JL.
    • Front Oncol. 2016 May 13;6:120. doi: 10.3389/fonc.2016.00120. eCollection 2016.
    • The impact of an interventional counselling procedure in families with a BRCA1/2 gene mutation: efficacy and safety.
    • Sermijn E, Delesie L, Deschepper E, Pauwels I, Bonduelle M, Teugels E, De Grève J.
    • Fam Cancer. 2016 Apr;15(2):155-62. doi: 10.1007/s10689-015-9854-4.
    • A new paradigm of genetic testing for hereditary breast/ovarian cancers.
    • Kwong A, Chen JW, Shin VY.
    • Hong Kong Med J. 2016 Apr;22(2):171-7. doi: 10.12809/hkmj154634. Epub 2016 Mar 14.
    • Reaching high-risk underserved individuals for cancer genetic counseling by video-teleconferencing.
    • Mette LA, Saldívar AM, Poullard NE, Torres IC, Seth SG, Pollock BH, Tomlinson GE.
    • J Community Support Oncol. 2016 Apr;14(4):162-8. doi: 10.12788/jcso.0247.
    • A targeted approach to genetic counseling in breast cancer patients: the experience of an Italian local project.
    • La Verde N, Corsi F, Moretti A, Peissel B, Dalu D, Girelli S, Fasola C, Gambaro A, Roversi G, Azzollini J, Radice P, Pensotti V, Farina G, Manoukian S.
    • Tumori. 2016 Feb 4;102(1):45-50. doi: 10.5301/tj.5000407. Epub 2015 Sep 10.
    • Utilizing Remote Real-Time Videoconferencing to Expand Access to Cancer Genetic Services in Community Practices: A Multicenter Feasibility Study.
    • Bradbury A, Patrick-Miller L, Harris D, Stevens E, Egleston B, Smith K, Mueller R, Brandt A, Stopfer J, Rauch S, Forman A, Kim R, Fetzer D, Fleisher L, Daly M, Domchek S.
    • J Med Internet Res. 2016 Feb 1;18(2):e23. doi: 10.2196/jmir.4564.
    • Does rapid genetic counseling and testing in newly diagnosed breast cancer patients cause additional psychosocial distress? results from a randomized clinical trial.
    • Wevers MR, Ausems MG, Verhoef S, Bleiker EM, Hahn DE, Brouwer T, Hogervorst FB, van der Luijt RB, van Dalen T, Theunissen EB, van Ooijen B, de Roos MA, Borgstein PJ, Vrouenraets BC, Vriens E, Bouma WH, Rijna H, Vente JP, Kieffer JM, Valdimarsdottir HB, Rutgers EJ, Witkamp AJ, Aaronson NK.
    • Genet Med. 2016 Feb;18(2):137-144. doi: 10.1038/gim.2015.50. Epub 2015 Apr 23.
    • Sweeping Up after the Kardashians: What We Wish had been Covered in Their Genetic Testing Episode.
    • [No author given]
    • My Gene Counsel. 2016 Jan 22.
    • Genetic screening for gynecological cancer: where are we heading?
    • Manchanda R, Jacobs I.
    • Future Oncol. 2016 Jan;12(2):207-20. doi: 10.2217/fon.15.278. Epub 2015 Dec 7.
    • Editorial / Commentary
    • ReCAP: Economic Evaluation Alongside a Clinical Trial of Telephone Versus In-Person Genetic Counseling for BRCA1/2 Mutations in Geographically Underserved Areas.
    • Chang Y, Near AM, Butler KM, Hoeffken A, Edwards SL, Stroup AM, Kohlmann W, Gammon A, Buys SS, Schwartz MD, Peshkin BN, Kinney AY, Mandelblatt JS, Chang Y, Near AM, Butler KM, Hoeffken A, Edwards SL, Stroup AM, Kohlmann W, Gammon A, Buys SS, Schwartz MD, Peshkin BN, Kinney AY, Mandelblatt JS.
    • J Oncol Pract. 2016 Jan;12(1):59. doi: 10.1200/JOP.2015.004838.
    • Genetic Testing for BRCA Mutations Today and Tomorrow-About the ABOUT Study.
    • Narod S.
    • JAMA Oncol. 2015 Dec 1;1(9):1225-1226. doi: 10.1001/jamaoncol.2015.3269.
    • Comment

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: Dr. Narod's commentary on pre-test genetic counseling

    Utilization and Outcomes of BRCA Genetic Testing and Counseling in a National Commercially Insured Population: The ABOUT Study.

    • Strategies for recruitment of relatives of BRCA mutation carriers to a genetic testing program in the Bahamas.
    • Trottier M, Lunn J, Butler R, Curling D, Turnquest T, Royer R, Akbari MR, Donenberg T, Hurley J, Narod SA.
    • Clin Genet. 2015 Aug;88(2):182-6. doi: 10.1111/cge.12468. Epub 2014 Sep 6.
    • Aligning policy to promote cascade genetic screening for prevention and early diagnosis of heritable diseases.
    • George R, Kovak K, Cox SL.
    • J Genet Couns. 2015 Jun;24(3):388-99. doi: 10.1007/s10897-014-9805-5. Epub 2015 Jan 11.
    • Pre-test genetic counseling services for hereditary breast and ovarian cancer delivered by non-genetics professionals in the state of Florida.
    • Vadaparampil ST, Scherr CL, Cragun D, Malo TL, Pal T.
    • Clin Genet. 2015 May;87(5):473-7. doi: 10.1111/cge.12405. Epub 2014 May 9.


    Response to Cragun et al.


    Response to Cragun et al.

    • Pilot Testing of a Psycho-educational Telephone Intervention for Women Receiving Uninformative BRCA1/2 Genetic Test Results.
    • Maheu C, Meschino WS, Hu W, Honeyford J, Ambus I, Kidd M, Benea A, Gao X, Azadbakhsh M, Rochefort C, Esplen MJ.
    • Can J Nurs Res. 2015 Mar;47(1):53-71. doi: 10.1177/084456211504700105.
    • Accuracy of recall of information about a cancer-predisposing BRCA1/2 gene mutation among patients and relatives.
    • Jacobs C, Dancyger C, Smith JA, Michie S.
    • Eur J Hum Genet. 2015 Feb;23(2):147-51. doi: 10.1038/ejhg.2014.84. Epub 2014 May 21.
    • Genetic counseling for fanconi anemia: crosslinking disciplines.
    • Zierhut HA, Tryon R, Sanborn EM.
    • J Genet Couns. 2014 Dec;23(6):910-21. doi: 10.1007/s10897-014-9754-z. Epub 2014 Sep 20.
    • Review

    Research news: Fanconi Anemia: Genetic Counseling Research (Perspectives in Genetic Counseling)


    • Expanding Access to BRCA1/2 Genetic Counseling with Telephone Delivery: A Cluster Randomized Trial.
    • Kinney AY, Butler KM, Schwartz MD, Mandelblatt JS, Boucher KM, Pappas LM, Gammon A, Kohlmann W, Edwards SL, Stroup AM, Buys SS, Flores KG, Campo RA.
    • J Natl Cancer Inst. 2014 Nov 5;106(12). pii: dju328. doi: 10.1093/jnci/dju328. Print 2014 Dec.

    Press: Phone Counseling for BRCA1/2 Gene Tests 'Non-inferior' to In-Person. (Healthy Living/Reuters)

    • Development of a communication protocol for telephone disclosure of genetic test results for cancer predisposition.
    • Patrick-Miller LJ, Egleston BL, Fetzer D, Forman A, Bealin L, Rybak C, Peterson C, Corbman M, Albarracin J, Stevens E, Daly MB, Bradbury AR.
    • JMIR Res Protoc. 2014 Oct 29;3(4):e49. doi: 10.2196/resprot.3337.
    • Breast cancer risk counseling: a teachable moment?
    • Daly M.
    • J Natl Compr Canc Netw. 2014 Oct;12(10):1361-2.
    • Editorial

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: Article request

    Subject: Expanding risk counseling beyond genetics

    • Active approach for breast cancer genetic counseling during radiotherapy: long-term psychosocial and medical impact.
    • Baars JE, Bleiker EM, van Riel E, Rodenhuis CC, Velthuizen ME, Schlich KJ, Ausems MG.
    • Clin Genet. 2014 Jun;85(6):524-31. doi: 10.1111/cge.12335. Epub 2014 Feb 4.
    • More breast cancer patients prefer BRCA-mutation testing without prior face-to-face genetic counseling.
    • Sie AS, van Zelst-Stams WA, Spruijt L, Mensenkamp AR, Ligtenberg MJ, Brunner HG, Prins JB, Hoogerbrugge N.
    • Fam Cancer. 2014 Jun;13(2):143-51. doi: 10.1007/s10689-013-9686-z.
    • Randomized noninferiority trial of telephone versus in-person genetic counseling for hereditary breast and ovarian cancer.
    • Schwartz MD, Valdimarsdottir HB, Peshkin BN, Mandelblatt J, Nusbaum R, Huang AT, Chang Y, Graves K, Isaacs C, Wood M, McKinnon W, Garber J, McCormick S, Kinney AY, Luta G, Kelleher S, Leventhal KG, Vegella P, Tong A, King L.
    • J Clin Oncol. 2014 Mar 1;32(7):618-26. doi: 10.1200/JCO.2013.51.3226. Epub 2014 Jan 21.


    Is it time to embrace telephone genetic counseling in the oncology setting?

    • Impact of rapid genetic counselling and testing on the decision to undergo immediate or delayed prophylactic mastectomy in newly diagnosed breast cancer patients: findings from a randomised controlled trial.
    • Wevers MR, Aaronson NK, Verhoef S, Bleiker EM, Hahn DE, Kuenen MA, van der Sanden-Melis J, Brouwer T, Hogervorst FB, van der Luijt RB, Valdimarsdottir HB, van Dalen T, Theunissen EB, van Ooijen B, de Roos MA, Borgstein PJ, Vrouenraets BC, Vriens E, Bouma WH, Rijna H, Vente JP, Witkamp AJ, Rutgers EJ, Ausems MG.
    • Br J Cancer. 2014 Feb 18;110(4):1081-7. doi: 10.1038/bjc.2013.805. Epub 2014 Jan 14.
    • Fanconi anaemia, BRCA2 mutations and childhood cancer: a developmental perspective from clinical and epidemiological observations with implications for genetic counselling.
    • Meyer S, Tischkowitz M, Chandler K, Gillespie A, Birch JM, Evans DG.
    • J Med Genet. 2014 Feb;51(2):71-5. doi: 10.1136/jmedgenet-2013-101642. Epub 2013 Nov 20.
    • London hospital widens access to genetic tests for ovarian cancer.
    • Arie S.
    • BMJ. 2014 Jan 28;348:g1179. doi: 10.1136/bmj.g1179.
    • News
    • New genetic testing pathway for cancer patients.
    • Philippa Brice.
    • PHG Foundation, 2014 Jan 24.
    • A rapid genetic counselling and testing in newly diagnosed breast cancer is associated with high rate of risk-reducing mastectomy in BRCA1/2-positive Italian women.
    • Cortesi L, Razzaboni E, Toss A, De Matteis E, Marchi I, Medici V, Tazzioli G, Andreotti A, De Santis G, Pignatti M, Federico M.
    • Ann Oncol. 2014 Jan;25(1):57-63. doi: 10.1093/annonc/mdt422. Epub 2013 Nov 24.

    Viewpoint: Rapid BRCA Testing Informs Choice of Mastectomy. (Medscape Oncology)

    • Self administered screening for hereditary cancers in conjunction with mammography and ultrasound.
    • McDonnell CH, Seidenwurm DJ, McDonnell DE, Bobolis KA.
    • Fam Cancer. 2013 Dec;12(4):651-6. doi: 10.1007/s10689-013-9641-z.
    • Implementation and outcomes of telephone disclosure of clinical BRCA1/2 test results.
    • Patrick-Miller L, Egleston BL, Daly M, Stevens E, Fetzer D, Forman A, Bealin L, Rybak C, Peterson C, Corbman M, Bradbury AR.
    • Patient Educ Couns. 2013 Dec;93(3):413-9. doi: 10.1016/j.pec.2013.08.009. Epub 2013 Aug 19.
    • Variants of uncertain significance in BRCA testing: evaluation of surgical decisions, risk perception, and cancer distress.
    • Culver J, Brinkerhoff C, Clague J, Yang K, Singh K, Sand S, Weitzel J.
    • Clin Genet. 2013 Nov;84(5):464-472. doi: 10.1111/cge.12097. Epub 2013 Feb 20.
    • Has Myriad Learned Their Lesson?
    • Niki Lovick, Michelle Ernst.
    • Yale Cancer Genetic Counseling. 2013 Sep 11.
    • A focus group study on breast cancer risk presentation: one format does not fit all.
    • Dorval M, Bouchard K, Chiquette J, Glendon G, Maugard CM, Dubuisson W, Panchal S, Simard J.
    • Eur J Hum Genet. 2013 Jul;21(7):719-24. doi: 10.1038/ejhg.2012.248. Epub 2012 Nov 21.
    • Timing of referral for genetic counseling and genetic testing in patients with ovarian, fallopian tube, or primary peritoneal carcinoma.
    • Novetsky AP, Smith K, Babb SA, Jeffe DB, Hagemann AR, Thaker PH, Powell MA, Mutch DG, Massad LS, Zighelboim I.
    • Int J Gynecol Cancer. 2013 Jul;23(6):1016-21. doi: 10.1097/IGC.0b013e3182994365.

    Comments on NSGC Discussion Forum Cancer SIG

    Subject: Timing of referral for ovarian patients

    • Implementation of a breast cancer genetic service in South Africa - lessons learned.
    • Schoeman M, Apffelstaedt JP, Baatjes K, Urban M.
    • S Afr Med J. 2013 Jun 25;103(8):529-33. doi: 10.7196/samj.6814.
    • Star Power.
    • Robert Resta.
    • The DNA Exchange. 2013 Jun 16.
    • Dealing with the unexpected: consumer responses to direct-access BRCA mutation testing.
    • Francke U, Dijamco C, Kiefer AK, Eriksson N, Moiseff B, Tung JY, Mountain JL.
    • PeerJ. 2013 Feb 12;1:e8. doi: 10.7717/peerj.8. Print 2013.

    Comments on NSGC Discussion Forum

    Subject: Current thoughts on 23andme?

    Press: Consumers have few negative reactions to the results of genetic testing for cancer mutations. (EurekAlert!)

    Press: Get ready for the risks of genetic testing. (CNN)

    • How should we discuss genetic testing with women newly diagnosed with breast cancer? Design and implementation of a randomized controlled trial of two models of delivering education about treatment-focused genetic testing to younger women newly diagnosed with breast cancer.
    • Watts KJ, Meiser B, Mitchell G, Kirk J, Saunders C, Peate M, Duffy J, Kelly PJ, Gleeson M, Barlow-Stewart K, Rahman B, Friedlander M, Tucker K; TFGT Collaborative Group.
    • BMC Cancer. 2012 Jul 28;12:320. doi: 10.1186/1471-2407-12-320.
    • Grace Rock's consent.
    • Ross TS.
    • Endocr Relat Cancer. 2012 Jul 22;19(4):C29-31. doi: 10.1530/ERC-12-0186. Print 2012 Aug.
    • Psychological Distress with Direct-to-Consumer Genetic Testing: A Case Report of an Unexpected BRCA Positive Test Result.
    • Dohany L, Gustafson S, Ducaine W, Zakalik D.
    • J Genet Couns. 2012 Jun;21(3):399-401. Epub 2012 Jan 21.
    • Case Report
    • DNA-testing for BRCA1/2 prior to genetic counselling in patients with breast cancer: design of an intervention study, DNA-direct.
    • Sie AS, Spruijt L, van Zelst-Stams WA, Mensenkamp AR, Ligtenberg MJ, Brunner HG, Prins JB, Hoogerbrugge N.
    • BMC Womens Health. 2012 May 8;12:12. doi: 10.1186/1472-6874-12-12.
    • The introduction of a choice to learn pre-symptomatic DNA test results for BRCA or Lynch syndrome either face-to-face or by letter.
    • Voorwinden JS, Jaspers JP, ter Beest JG, Kievit Y, Sijmons RH, Oosterwijk JC.
    • Clin Genet. 2012 May;81(5):421-9. doi: 10.1111/j.1399-0004.2011.01811.x. Epub 2011 Dec 13.
    • A pre-visit website with question prompt sheet for counselees facilitates communication in the first consultation for breast cancer genetic counseling: findings from a randomized controlled trial.
    • Albada A, van Dulmen S, Ausems MG, Bensing JM.
    • Genet Med. 2012 May;14(5):535-42. doi: 10.1038/gim.2011.42. Epub 2012 Jan 12.
    • Effects of a pre-visit educational website on information recall and needs fulfilment in breast cancer genetic counselling, a randomized controlled trial.
    • Albada A, van Dulmen S, Bensing JM, Ausems MG.
    • Breast Cancer Res. 2012 Mar 6;14(2):R37.


    Retraction: Effects of a pre-visit educational website on information recall and needs fulfilment in breast cancer genetic counselling, a randomized controlled trial.

    • A pre-visit tailored website enhances counselees' realistic expectations and knowledge and fulfils information needs for breast cancer genetic counselling.
    • Albada A, van Dulmen S, Lindhout D, Bensing JM, Ausems MG.
    • Fam Cancer. 2012 Mar;11(1):85-95. doi: 10.1007/s10689-011-9479-1.
    • Patient outcomes associated with group and individual genetic counseling formats.
    • Rothwell E, Kohlmann W, Jasperson K, Gammon A, Wong B, Kinney A.
    • Fam Cancer. 2012 Mar;11(1):97-106. doi: 10.1007/s10689-011-9486-2.
    • Using tumour pathology to identify people at high genetic risk of breast and colorectal cancers.
    • Hopper JL, Jenkins MA, Dowty JG, Dite GS, Apicella C, Keogh L, Win AK, Young JP, Buchanan D, Walsh MD, Rosty C, Baglietto L, Severi G, Phillips KA, Wong EM, Dobrovic A, Waring P, Winship I, Ramus SJ, Giles GG, Southey MC.
    • Pathology. 2012 Feb;44(2):89-98. doi: 10.1097/PAT.0b013e32834e8e5b.
    • Review