Category: Provider Education

• Effectiveness of Secondary Risk-Reducing Strategies in Patients With Unilateral Breast Cancer With Pathogenic Variants of BRCA1 and BRCA2 Subjected to Breast-Conserving Surgery: Evidence-Based Simulation Study.
• Maksimenko J, Rodrigues PP, Nakazawa-Miklaševiča M, Pinto D, Miklaševičs E, Trofimovičs G, Gardovskis J, Cardoso F, Cardoso MJ.
• JMIR Form Res. 2022 Dec 29;6(12):e37144. doi: 10.2196/37144.

• PMID: 36580360
• PubMed abstract

• Free Full Text

• Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-negative advanced breast cancer from the United States, Europe, and Israel.
• Mahtani R, Niyazov A, Arondekar B, Lewis K, Rider A, Massey L, Lux MP.
• BMC Cancer. 2022 Dec 22;22(1):1343. doi: 10.1186/s12885-022-10325-9.

• PMID: 36550413
• PubMed abstract

• Free PMC article
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• Cancer prevention in cancer predisposition syndromes: A protocol for testing the feasibility of building a hereditary cancer research registry and nurse navigator follow up model.
• Etchegary H, Pike A, Puddester R, Watkins K, Warren M, Francis V, Woods M, Green J, Savas S, Seal M, Gao Z, Avery S, Curtis F, McGrath J, MacDonald D, Burry TN, Dawson L.
• PLoS One. 2022 Dec 22;17(12):e0279317. doi: 10.1371/journal.pone.0279317.

• PMID: 36548287
• PubMed abstract

• Study protocol
• Free PMC article
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• Deep learning identifies morphological patterns of homologous recombination deficiency in luminal breast cancers from whole slide images.
• Lazard T, Bataillon G, Naylor P, Popova T, Bidard FC, Stoppa-Lyonnet D, Stern MH, Decencière E, Walter T, Vincent-Salomon A..
• Cell Rep Med. 2022 Dec 20;3(12):100872. doi: 10.1016/j.xcrm.2022.100872. Epub 2022 Dec 13.

• PMID: 36516847
• PubMed abstract

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HRD-related morphology discovery in breast cancer by controlling for confounding factors.

• PMID: 36543118
• PubMed abstract
• Source abstract

• Australasian Genetic Counselors’ Perceptions of Their Role in Supporting Clients’ Behavior Change.
• Jacobs C, Turbitt E, McEwen A, Atkins L.
• J Pers Med. 2022 Dec 23;13(1):30. doi: 10.3390/jpm13010030.

• Free Full Text

• Psychological factors and the uptake of preventative measures in BRCA1/2 pathogenic variant carriers: results of a prospective cohort study.
• Dick J, Tüchler A, Brédart A, Vitinius F, Wassermann K, Rhiem K, Schmutzler RK.
• Hered Cancer Clin Pract. 2022 Dec 19;20(1):38. doi: 10.1186/s13053-022-00244-y.

• Free Full Text

• Informational needs of individuals from BRCA-harboring families: a systematic review and content analysis.
• Park SY, Kim Y, Kim S, Katapodi MC.
• Genet Med. 2022 Dec 18:S1098-3600(22)01068-1. doi: 10.1016/j.gim.2022.100001. Epub ahead of print.

• Source abstract

• Review
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• Dr. Rimel on the Importance of BRCA and HRD Testing in Ovarian Cancer.
• Rimel BJ.
• OncLive. OncLive TV. 2022 Dec 19.

• Video
• Free video

• Next-generation sequencing in breast pathology: real impact on routine practice over a decade since its introduction.
• Nourieh M, Vibert R, Saint-Ghislain M, Cyrta J, Vincent-Salomon A.
• Histopathology. 2023 Jan;82(1):162-169. doi: 10.1111/his.14794.

• PMID: 36482269
• PubMed abstract
• Source abstract

• Review
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• A Comparison of Patients’ and Physicians’ Knowledge and Expectations Regarding Precision Oncology Tests.
• Dehar N, Abedin T, Tang P, Bebb G, Cheung WY.
• Curr Oncol. 2022 Dec 16;29(12):9916-9927. doi: 10.3390/curroncol29120780.

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• Providers' perspectives on the reproductive decision-making of BRCA-positive women.
• Dason ES, Drost L, Greenblatt EM, Scheer AS, Han J, Sobel M, Allen L, Jacobson M, Doshi T, Wolff E, McMahon E, Jones CA.
• BMC Womens Health. 2022 Dec 8;22(1):506. doi: 10.1186/s12905-022-02093-2.

• PMID: 36482357
• PubMed abstract

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• Long-term response to olaparib in a patient with metastatic pancreatic cancer associated with hereditary breast and ovarian cancer syndrome.
• Tsuneizumi M, Terada S, Usui T, Yamaguchi K, Hayami R, Matsunuma R.
• Oxf Med Case Reports. 2022 Nov 24;2022(11):omac124. doi: 10.1093/omcr/omac124.

• PMID: 36447463
• PubMed abstract

• Case report
• Free PMC article
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• Testing a deliberative democracy method with citizens of African ancestry to weigh pros and cons of targeted screening for hereditary breast and ovarian cancer risk.
• Guan Y, Pathak S, Ballard D, Veluswamy JK, McCullough LE, McBride CM, Gornick MC.
• Front Public Health. 2022 Nov 8;10:984926. doi: 10.3389/fpubh.2022.984926.

• PMID: 36424974
• PubMed abstract

• Free PMC article
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• Stellenwert der genetischen Testung beim Prostatakarzinom [Importance of genetic testing in prostate cancer].
• Steinkellner L, Luger F, Loidl W.
• Urologie. 2022 Nov 15. German. doi: 10.1007/s00120-022-01977-3. Epub ahead of print.

• PMID: 36378280
• PubMed abstract
• Source abstract

• Review. [Article in German]

• Nest Genomics Building EHR-Integrated Clinical Decision Support for Genetics-Informed Care.
• Cohen JK.
• GenomeWeb. Disease Areas. Cancer. 2022 Oct 25.

• News
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