LitAlert ~~

    • Olaparib Maintenance Monotherapy in Asian Patients with Platinum-Sensitive Relapsed Ovarian Cancer: Phase III Trial (L-MOCA).
    • Gao Q, Zhu J, Zhao W, Huang Y, An R, Zheng H, Qu P, Wang L, Zhou Q, Wang D, Lou G, Wang J, Wang K, Low J, Kong B, Rozita AM, Sen LC, Yin R, Xie X, Liu J, Sun W, Su J, Zhang C, Zang R, Ma D.
    • Clin Cancer Res. 2022 Feb 7:clincanres.3023.2021. doi: 10.1158/1078-0432.CCR-21-3023. Epub ahead of print.
    • Varsity Pharmaceuticals Licenses Pol-Theta Inhibitor From Dana-Farber Cancer Institute.
    • [No author given]
    • Precision Oncology News. Biomarkers. BRCA. 2022 Feb 7.

    Original research:

    A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.

    • Clinical outcomes and Oncotype DX Breast Recurrence Score® in early-stage BRCA-associated hormone receptor-positive breast cancer.
    • Layman RM, Lin H, Gutierrez Barrera AM, Karuturi MS, Yam C, Arun BK.
    • Cancer Med. 2022 Feb 6. doi: 10.1002/cam4.4566. Epub ahead of print.
    • Recherche d’altérations des gènes de réparation de l’ADN dans le cancer de la prostate : mise au point pratique du Comité de cancérologie de l’association française d’urologie [DNA repair gene alterations testing in prostate cancer : A practical update by the prostate cancer committee of the french association of urology].
    • Ploussard G, Beauval JB, Mathieu R, Barret E, Brureau L, Créhange G, Dariane C, Fiard G, Gauthé M, Renard-Penna R, Ruffion A, Sargos P, Rouprêt M, Roubaud G, Fromont G.
    • Prog Urol. 2022 Feb 4:S1166-7087(22)00005-7. French. doi: 10.1016/j.purol.2021.12.007. Epub ahead of print.
    • Guideline. [Article in French]
    • The role of PARP inhibitors in gastrointestinal cancers.
    • Hanna D, Chopra N, Hochhauser D, Khan K.
    • Crit Rev Oncol Hematol. 2022 Feb 3:103621. doi: 10.1016/j.critrevonc.2022.103621. Epub ahead of print.
    • Review
    • DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR.
    • Swift ML, Azizkhan-Clifford J.
    • DNA Repair (Amst). 2022 Feb 1;111:103289. doi: 10.1016/j.dnarep.2022.103289. Epub ahead of print.
    • Exploratory analysis of biomarkers associated with clinical outcomes from the study of palbociclib plus endocrine therapy in premenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer.
    • Lee S, Park K, Kim GM, Jung KH, Kang SY, Park IH, Kim JH, Ahn HK, Park WY, Im SA, Park YH.
    • Breast. 2022 Jan 29;62:52-60. doi: 10.1016/j.breast.2022.01.014. Epub ahead of print.